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Income Taxes - Effective income tax rate reconciliation (Details)	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018
Income Taxes
Federal statutory rate	21.00%	21.00%
State tax rate, net of federal benefit	0.10%	0.30%
Permanent differences	(0.20%)	(0.80%)
Research & development tax credits	3.00%	2.80%
Prior period adjustments and other	(0.60%)	(2.60%)
Change in valuation allowance	(23.30%)	(20.70%)
Effective income tax rate	0.00%	0.00%

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other adjustments.

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