<SEC-DOCUMENT>0001104659-25-125202.txt : 20251230
<SEC-HEADER>0001104659-25-125202.hdr.sgml : 20251230
<ACCEPTANCE-DATETIME>20251230160022
ACCESSION NUMBER:		0001104659-25-125202
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20251229
FILED AS OF DATE:		20251230
DATE AS OF CHANGE:		20251230

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Jung Hyunsu
		CENTRAL INDEX KEY:			0002075658
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38365
		FILM NUMBER:		251614155

	MAIL ADDRESS:	
		STREET 1:		C/O EYENOVIA, INC.
		STREET 2:		23461 SOUTH POINTE DR., SUITE 390
		CITY:			LAGUNA HILLS
		STATE:			CA
		ZIP:			92653

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HYPERION DEFI, INC.
		CENTRAL INDEX KEY:			0001682639
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				471178401
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		295 MADISON AVENUE
		STREET 2:		SUITE 2400
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017
		BUSINESS PHONE:		833-393-6684

	MAIL ADDRESS:	
		STREET 1:		295 MADISON AVENUE
		STREET 2:		SUITE 2400
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EYENOVIA, INC.
		DATE OF NAME CHANGE:	20160818
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>tm2534508-1_4seq1.xml
<DESCRIPTION>OWNERSHIP DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2025-12-29</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001682639</issuerCik>
        <issuerName>HYPERION DEFI, INC.</issuerName>
        <issuerTradingSymbol>HYPD</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002075658</rptOwnerCik>
            <rptOwnerName>Jung Hyunsu</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O HYPERION DEFI, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>23461 SOUTH POINT DRIVE, SUITE 390</rptOwnerStreet2>
            <rptOwnerCity>LAGUNA HILLS</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92653</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>See Remarks</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.0001</value>
            </securityTitle>
            <transactionDate>
                <value>2025-12-29</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>F</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness></transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>82324</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1417676</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">These shares were withheld to satisfy tax withholding obligations incurred upon the vesting and settlement of a portion of a previously reported grant of restricted stock units held by the Reporting Person.</footnote>
    </footnotes>

    <remarks>Interim Chief Executive Officer and Chief Investment Officer</remarks>

    <ownerSignature>
        <signatureName>/s/ Hyunsu Jung</signatureName>
        <signatureDate>2025-12-30</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
