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Statements of Changes in Stockholders' (Deficit) Equity - USD ($) | Preferred Stock | Common Stock | Additional Paid-In Capital | Treasury Stock | Accumulated Deficit | Total
--- | --- | --- | --- | --- | --- | ---
Balance at the beginning at Dec. 31, 2023 |  |  | $ 57 |  | $ 154,490,596 |  | $ (145,491,559) | $ 8,999,094
Balance at the beginning (in shares) at Dec. 31, 2023 |  |  | 569,409 |  |  |  |  |
Issuance of common stock in At the Market offering | [1] |  | $ 7 |  | 6,047,362 |  |  | 6,047,369
Issuance of common stock in At the Market offering (in shares) | [1] |  | 70,381 |  |  |  |  |
Issuance of common stock as consideration for licensing agreement | [2] |  | $ 1 |  | 436,808 |  |  | 436,809
Issuance of common stock as consideration for licensing agreement (in shares) | [2] |  | 7,668 |  |  |  |  |
Issuance of common stock as consideration for reacquisition of licensing agreement | [3] |  | $ 3 |  | 2,322,388 |  |  | 2,322,391
Issuance of common stock as consideration for reacquisition of licensing agreement (in shares) | [3] |  | 28,742 |  |  |  |  |
Issuance of common stock and warrants in offerings | [4] |  | $ 66 |  | 17,011,256 |  |  | $ 17,011,322
Issuance of common stock and warrants in offerings (in shares) |  |  | 653,493 | [4] |  |  |  | 653,493
Issuance of common stock from exercise of warrants |  |  | $ 15 |  | 1,208 |  |  | $ 1,223
Issuance of common stock from exercise of warrants (in shares) |  |  | 152,905 |  |  |  |  |
Warrant modification and additional warrants - incremental value | [5] |  |  |  | 2,868,000 |  |  | 2,868,000
Warrants issued in consideration for debt modification | [6] |  |  |  | (2,868,000) |  |  | (2,868,000)
Issuance of common stock as consideration for modification of loan agreement |  |  | $ 2 |  | 199,998 |  |  | 200,000
Issuance of common stock as consideration for modification of loan agreement (in shares) |  |  | 23,771 |  |  |  |  |
Stock-based compensation: |  |  |  |  |  |  |  |
Amortization of stock option awards |  |  |  |  | 1,454,946 |  |  | 1,454,946
Amortization of restricted stock units |  |  |  |  | 249,327 |  |  | 249,327
Net loss |  |  |  |  |  |  | (49,818,433) | (49,818,433)
Balance at the end at Dec. 31, 2024 |  |  | $ 151 |  | 182,213,889 |  | (195,309,992) | (13,095,952)
Balance at the end (in shares) at Dec. 31, 2024 |  |  | 1,506,369 |  |  |  |  |
Issuance of preferred stock and warrants in private placement | [7] | $ 544 |  |  | 49,365,206 |  |  | 49,365,750
Issuance of preferred stock and warrants in private placement (in shares) | [7] | 5,435,897 |  |  |  |  |  |
Issuance of common stock in At the Market offering | [8] |  | $ 561 |  | 39,357,243 |  |  | 39,357,804
Issuance of common stock in At the Market offering (in shares) | [8] |  | 5,607,759 |  |  |  |  |
Issuance of common stock from exercise of warrants | [9] |  | $ 50 |  | 3,892,423 |  |  | 3,892,473
Issuance of common stock from exercise of warrants (in shares) | [9] |  | (502,125) |  |  |  |  |
Induced exercise of stock warrants | [10] |  | $ 19 |  | 922,731 |  |  | 922,750
Induced exercise of stock warrants (in shares) | [10] |  | 197,118 |  |  |  |  |
Issuance of common stock from the partial conversion of note payable |  |  | $ 41 |  | 640,295 |  |  | 640,336
Issuance of common stock from the partial conversion of note payable (in shares) |  |  | 404,820 |  |  |  |  |
Issuance of common stock from the delivery of vested restricted stock units |  |  | $ 53 |  | (53) |  |  |
Issuance of common stock from the delivery of vested restricted stock units (in shares) |  |  | 529,297 |  |  |  |  |
Warrant modification and additional warrants - incremental value |  |  |  |  | 858,270 |  |  | 858,270
Shares withheld for employee payroll taxes |  |  |  |  |  | $ 253,558 |  | 253,558
Shares withheld for employee payroll taxes (in shares) |  |  |  |  |  | 82,324 |  |
Reverse stock split settlement of fractional shares |  |  |  |  | (160) |  |  | (160)
Reverse stock split settlement of fractional shares (in shares) |  |  | (41) |  |  |  |  |
Stock-based compensation: |  |  |  |  |  |  |  |
Amortization of stock option awards |  |  |  |  | 533,062 |  |  | 533,062
Amortization of restricted stock units |  |  |  |  | 5,785,548 |  |  | 5,785,548
Issuance of common stock to vendors in consideration for service provided |  |  | $ 1 |  | 53,401 |  |  | 53,402
Issuance of common stock to vendors in consideration for service provided (in shares) |  |  | 14,882 |  |  |  |  |
Net loss |  |  |  |  |  |  | (45,314,435) | (45,314,435)
Preferred stock dividend ($0.59 per preferred share outstanding) |  |  |  |  | (1,684,783) |  |  | (1,684,783)
Balance at the end at Dec. 31, 2025 |  | $ 544 | $ 876 |  | $ 281,937,072 | $ (253,558) | $ (240,624,427) | $ 41,060,507
Balance at the end (in shares) at Dec. 31, 2025 |  | 5,435,897 | 8,762,329 |  |  |  |  |
Treasury stock balance at the end (in shares) at Dec. 31, 2025 |  |  |  |  |  | 82,324 |  | 82,324
[1] | Includes gross proceeds of $6,234,402 less total issuance costs of $187,033.
[2] | Shares issued as partial consideration for License Agreement with Formosa Pharmaceuticals Inc.
[3] | Shares issued as partial consideration for reversion of License Agreement with Bausch & Lomb Ireland Limited.
[4] | Includes gross proceeds of $19,385,015, less total cash issuance costs of $2,373,693.
[5] | Offering includes modification of warrants and additional warrants in the July 2024 offering.
[6] | Non-cash warrant modification and additional warrants issuance costs related to one of the offerings are shown on a separate line item for clarity.
[7] | Includes gross proceeds of $50,000,000 less total issuance costs of $634,250.
[8] | Includes gross proceeds of $40,645,265 less total issuance costs of $1,287,461.
[9] | Partial exercise of the Armistice warrants.
[10] | Includes gross proceeds of $1,039,206 less total issuance costs of $116,456. Also note that incremental value and non-cash warrant modification and additional warrants issuance costs related to the warrant inducement entered into on January 16, 2025 offset to a zero balance. See Note 13 – Stockholders’ Equity (Deficiency).

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