    <SEC-DOCUMENT>0001104659-26-055729-index.html : 20260505
    <SEC-HEADER>0001104659-26-055729.hdr.sgml : 20260505
    <ACCEPTANCE-DATETIME>20260505171320
    ACCESSION NUMBER:		0001104659-26-055729
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20251231
    FILED AS OF DATE:		20260505
    DATE AS OF CHANGE:		20260505
    EFFECTIVENESS DATE:		20260505

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			HYPERION DEFI, INC.
    		CENTRAL INDEX KEY:			0001682639
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				471178401
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-38365
    		FILM NUMBER:		26944580

    	BUSINESS ADDRESS:
    		STREET 1:		295 MADISON AVENUE
    		STREET 2:		SUITE 2400
    		CITY:			NEW YORK
    		STATE:			NY
    		ZIP:			10017
    		BUSINESS PHONE:		833-393-6684

    	MAIL ADDRESS:
    		STREET 1:		295 MADISON AVENUE
    		STREET 2:		SUITE 2400
    		CITY:			NEW YORK
    		STATE:			NY
    		ZIP:			10017

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	EYENOVIA, INC.
    		DATE OF NAME CHANGE:	20160818
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>tm2612201d2_ars.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: tm2612201d2_ars.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>