    <SEC-DOCUMENT>0001104659-26-055725-index.html : 20260505
    <SEC-HEADER>0001104659-26-055725.hdr.sgml : 20260505
    <ACCEPTANCE-DATETIME>20260505171028
    ACCESSION NUMBER:		0001104659-26-055725
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		21
    CONFORMED PERIOD OF REPORT:	20260630
    FILED AS OF DATE:		20260505
    DATE AS OF CHANGE:		20260505

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			HYPERION DEFI, INC.
    		CENTRAL INDEX KEY:			0001682639
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				471178401
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-38365
    		FILM NUMBER:		26944543

    	BUSINESS ADDRESS:
    		STREET 1:		295 MADISON AVENUE
    		STREET 2:		SUITE 2400
    		CITY:			NEW YORK
    		STATE:			NY
    		ZIP:			10017
    		BUSINESS PHONE:		833-393-6684

    	MAIL ADDRESS:
    		STREET 1:		295 MADISON AVENUE
    		STREET 2:		SUITE 2400
    		CITY:			NEW YORK
    		STATE:			NY
    		ZIP:			10017

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	EYENOVIA, INC.
    		DATE OF NAME CHANGE:	20160818
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>tm2611538-3_def14a.htm
    <DESCRIPTION>DEF 14A
    <TEXT>
    Document 1 - file: tm2611538-3_def14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.SCH
    <SEQUENCE>2
    <FILENAME>hypd-20251231.xsd
    <DESCRIPTION>XBRL TAXONOMY EXTENSION SCHEMA
    <TEXT>
    Document 2 - file: hypd-20251231.xsd

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.DEF
    <SEQUENCE>3
    <FILENAME>hypd-20251231_def.xml
    <DESCRIPTION>XBRL TAXONOMY EXTENSION DEFINITION LINKBASE
    <TEXT>
    Document 3 - file: hypd-20251231_def.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.LAB
    <SEQUENCE>4
    <FILENAME>hypd-20251231_lab.xml
    <DESCRIPTION>XBRL TAXONOMY EXTENSION LABEL LINKBASE
    <TEXT>
    Document 4 - file: hypd-20251231_lab.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.PRE
    <SEQUENCE>5
    <FILENAME>hypd-20251231_pre.xml
    <DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE
    <TEXT>
    Document 5 - file: hypd-20251231_pre.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>lg_hyperion-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: lg_hyperion-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>ic_member-bw.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: ic_member-bw.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>ic_commchair-bw.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 8 - file: ic_commchair-bw.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>sg_hyunsujung-bwlr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 9 - file: sg_hyunsujung-bwlr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>px_26hyperionproxy1pg01-4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 10 - file: px_26hyperionproxy1pg01-4c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>px_26hyperionproxy1pg02-4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 11 - file: px_26hyperionproxy1pg02-4c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>13
    <FILENAME>R1.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 13 - file: R1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>14
    <FILENAME>R2.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 14 - file: R2.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>15
    <FILENAME>R3.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 15 - file: R3.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>16
    <FILENAME>R4.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 16 - file: R4.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>17
    <FILENAME>report.css
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 17 - file: report.css

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>18
    <FILENAME>Show.js
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 18 - file: Show.js

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>20
    <FILENAME>FilingSummary.xml
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 20 - file: FilingSummary.html

    Document 20 - RAW XML: FilingSummary.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>JSON
    <SEQUENCE>22
    <FILENAME>MetaLinks.json
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 22 - file: MetaLinks.json

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>ZIP
    <SEQUENCE>23
    <FILENAME>0001104659-26-055725-xbrl.zip
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 23 - file: 0001104659-26-055725-xbrl.zip

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>24
    <FILENAME>tm2611538-3_def14a_htm.xml
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 24 - file: tm2611538-3_def14a_htm.html

    Document 24 - RAW XML: tm2611538-3_def14a_htm.xml

    </DOCUMENT>
    </SEC-DOCUMENT>