<SEC-DOCUMENT>0001104659-26-055727-index.html : 20260505
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<ACCEPTANCE-DATETIME>20260505171129
ACCESSION NUMBER:		0001104659-26-055727
CONFORMED SUBMISSION TYPE:	DEFA14A
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20260505
DATE AS OF CHANGE:		20260505

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HYPERION DEFI, INC.
		CENTRAL INDEX KEY:			0001682639
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				471178401
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEFA14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38365
		FILM NUMBER:		26944559

	BUSINESS ADDRESS:	
		STREET 1:		295 MADISON AVENUE
		STREET 2:		SUITE 2400
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017
		BUSINESS PHONE:		833-393-6684

	MAIL ADDRESS:	
		STREET 1:		295 MADISON AVENUE
		STREET 2:		SUITE 2400
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EYENOVIA, INC.
		DATE OF NAME CHANGE:	20160818
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEFA14A
<SEQUENCE>1
<FILENAME>tm2611538d5_defa14a.htm
<DESCRIPTION>DEFA14A
<TEXT>
Document 1 - file: tm2611538d5_defa14a.htm

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<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>tm2611538d5_defa14aimg001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: tm2611538d5_defa14aimg001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>tm2611538d5_defa14aimg002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: tm2611538d5_defa14aimg002.jpg

</DOCUMENT>
</SEC-DOCUMENT>