<SEC-DOCUMENT>0001104659-26-056233-index.html : 20260506
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<ACCEPTANCE-DATETIME>20260506160258
ACCESSION NUMBER:		0001104659-26-056233
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20260506
DATE AS OF CHANGE:		20260506

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HYPERION DEFI, INC.
		CENTRAL INDEX KEY:			0001682639
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				471178401
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-291570
		FILM NUMBER:		26948186

	BUSINESS ADDRESS:	
		STREET 1:		295 MADISON AVENUE
		STREET 2:		SUITE 2400
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017
		BUSINESS PHONE:		833-393-6684

	MAIL ADDRESS:	
		STREET 1:		295 MADISON AVENUE
		STREET 2:		SUITE 2400
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EYENOVIA, INC.
		DATE OF NAME CHANGE:	20160818
</SEC-HEADER>
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<SEQUENCE>1
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<DESCRIPTION>424B5
<TEXT>
Document 1 - file: tm2613429d2_424b5.htm

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Document 2 - file: tm2613429d2_424b5img001.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>tm2613429d2_424b5img003.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: tm2613429d2_424b5img003.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>tm2613429d2_424b5img002.jpg
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<TEXT>
Document 4 - file: tm2613429d2_424b5img002.jpg

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