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Jazz Collaboration Agreement - Narrative (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended
	Apr. 30, 2022	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research and development		$ 13,887	$ 7,265	$ 24,832	$ 12,082
Collaboration revenue		4,148	$ 0	4,148	$ 0
Deferred revenue, current		11,817		11,817		$ 0
Deferred revenue, net of current portion		$ 1,254		1,254		$ 0
Jazz Collaboration Agreement
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Non-refundable upfront cash payment received	$ 15,000
Development and regulatory milestones (up to)	520,000
Sales-Based Milestones (up to)	740,000
Transaction price	32,300
Estimated future reimbursable costs	$ 17,300
Upfront payment				1,900
Research and development				$ 2,200

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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