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Leases - Additional Information (Detail)
$ in Thousands
 3 Months Ended 9 Months Ended
Nov. 01, 2021
USD ($)
Oct. 26, 2021
USD ($)
Jan. 08, 2021
USD ($)
leaseExtensionOption
Sep. 30, 2021
USD ($)
Sep. 30, 2020
USD ($)
Sep. 30, 2021
USD ($)
Sep. 30, 2020
USD ($)
Oct. 29, 2021
USD ($)
Apr. 22, 2021
USD ($)
Dec. 31, 2020
USD ($)
Lessee, Lease, Description [Line Items]                    
Restricted cash       $ 5,284 $ 999 $ 5,284 $ 999     $ 999
Lease liability       101,065   101,065        
Total undiscounted lease payments       199,351   199,351        
Present value adjustment       75,629   75,629        
Operating lease right-of-use assets       100,174   100,174       $ 19,376
Impairment of long-lived assets       1,100   1,072 0      
Right-of-use asset, impairment loss       800   800        
Leasehold improvements, impairment loss       300   300        
Rent expense       4,300 1,300 8,500 4,400      
Variable lease costs       600 $ 400 1,300 $ 1,100      
Subsequent Event                    
Lessee, Lease, Description [Line Items]                    
Sublease income, full term of lease   $ 108,200                
Terminated Lease                    
Lessee, Lease, Description [Line Items]                    
Lease liability       21,500   21,500        
Total undiscounted lease payments       30,800   30,800        
Present value adjustment       9,300   9,300        
Operating lease right-of-use assets       15,900   15,900        
Terminated Lease | Subsequent Event                    
Lessee, Lease, Description [Line Items]                    
Lease termination fees $ 400                  
Sublease agreement, monthly cost               $ 100    
Office Building And Laboratory                    
Lessee, Lease, Description [Line Items]                    
Restricted cash       1,000   1,000        
Building                    
Lessee, Lease, Description [Line Items]                    
Restricted cash                 $ 2,500  
Lease term                 10 years  
Leasehold improvement allowance                 $ 10,200  
Lease renewal term                 8 years  
Manufacturing Facility                    
Lessee, Lease, Description [Line Items]                    
Restricted cash       $ 2,800   $ 2,800        
Lease renewal term     5 years              
Number of renewal contracts | leaseExtensionOption     2              
Tenant improvement allowance     $ 25,500              
Weighted-average remaining lease term       12 years 1 month 6 days   12 years 1 month 6 days        
Weighted-average IBR       6.79%   6.79%        
Manufacturing Facility | Subsequent Event                    
Lessee, Lease, Description [Line Items]                    
Cash released from restriction   $ 2,800