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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Cash flows from operating activities:    
Net loss $ (111,131) $ (79,875)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 3,323 3,081
Stock-based compensation expense 20,784 14,214
Amortization of premium/(discount) and accrued interest on marketable securities 2,273 (773)
Impairment of long-lived assets 1,072 0
Other (132) 25
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (3,493) 5,194
Other assets (109) (8)
Operating lease right-of-use asset 2,825 1,265
Accounts payable (587) 1,444
Accrued expenses and other current liabilities 3,253 (573)
Lease liability and lease incentive receivable (94) (1,061)
Net cash used in operating activities (82,016) (57,067)
Cash flows from investing activities:    
Purchases of marketable securities (328,275) (511,845)
Maturities of marketable securities 384,882 223,765
Sales of marketable securities 8,990 6,748
Purchases of property and equipment (10,771) (10,411)
Net cash provided by (used in) investing activities 54,826 (291,743)
Cash flows from financing activities:    
Proceeds from offerings of common stock, net of issuance costs 1,685 344,547
Proceeds from issuance of common stock pursuant to option exercises 51 12,653
Taxes paid related to net share settlement of restricted stock units 0 (2,043)
Proceeds from employee stock purchase plan 526 481
Repayment of loan (240) (29)
Net cash provided by financing activities 2,022 355,609
Net (decrease) increase in cash and cash equivalents and restricted cash (25,168) 6,799
Cash and cash equivalents and restricted cash at beginning of period 63,423 66,896
Cash and cash equivalents and restricted cash at end of period 38,255 73,695
Cash and cash equivalents 32,971 72,696
Restricted cash 5,284 999
Cash and cash equivalents and restricted cash at end of period 38,255 73,695
Supplemental schedule of noncash investing and financing information    
Right-of-use assets obtained in exchange for lease liability 84,005 0
Fixed assets in accounts payable, accrued expenses and other current liabilities $ 2,675 $ 325