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v3.22.1

Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities: |  |
Net loss | $ (145,540,000) | $ (117,507,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 4,645,000 | 4,158,000
Stock-based compensation expense | 25,194,000 | 20,391,000
Amortization of premium and discounts on marketable securities, net | 2,770,000 | 521,000
Accreted interest on BPI | 0 | 17,000
Impairment of long-lived assets | 1,063,000 | 0
Foreign currency remeasurement loss | 0 | 342,000
Other | (25,000) | 58,000
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | (2,257,000) | 5,854,000
Deposit and other long-term assets and deferred rent receivable | (990,000) | (18,000)
Operating lease right-of-use assets | 2,719,000 | 1,587,000
Accounts payable | (1,612,000) | 1,585,000
Accrued expenses, other current and non-current liabilities | 3,274,000 | 4,147,000
Other non-current liabilities | 0 | 1,114,000
Lease liability | 2,928,000 | (1,540,000)
Net cash used in operating activities | (107,831,000) | (79,291,000)
Cash flows from investing activities: |  |
Purchases of marketable securities | (407,514,000) | (570,386,000)
Maturities of marketable securities | 492,356,000 | 295,315,000
Sales of marketable securities | 8,990,000 | 6,748,000
Purchases of property and equipment | (15,123,000) | (11,844,000)
Net cash provided by (used in) by provided by investing activities | 78,709,000 | (280,167,000)
Cash flows from financing activities: |  |
Proceeds from offering of common stock, net of issuance costs | 1,685,000 | 344,302,000
Proceeds from issuance of common stock pursuant to option exercises | 51,000 | 12,687,000
Taxes paid related to net share settlement of restricted stock units | 0 | (2,043,000)
Proceeds from employee stock purchase plan | 901,000 | 1,100,000
Repayment of BPI loan | (240,000) | (61,000)
Net cash provided by financing activities | 2,397,000 | 355,985,000
Net decrease in cash and cash equivalents and restricted cash | (26,725,000) | (3,473,000)
Cash and cash equivalents and restricted cash at beginning of period | 63,423,000 | 66,896,000
Cash and cash equivalents and restricted cash at end of period | 36,698,000 | 63,423,000
Cash and cash equivalents | 34,195,000 | 62,424,000
Restricted cash | 2,503,000 | 999,000
Cash and cash equivalents and restricted cash at end of period | 36,698,000 | 63,423,000
Supplemental schedule of noncash investing information |  |
Right-of-use assets obtained in exchange for lease liability | 84,005,000 | 0
Decrease in right-of-use asset and lease liability due to termination | 15,768,000 | 0
Remeasurement of right-of-use asset on lease modification | 2,052,000 | 0
Fixed assets in accounts payable and current liabilities | $ 1,402,000 | $ 403,000

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