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Fair Value Measurements and Fair Value of Financial Instruments - Summary of Cash Equivalents and Short-term Investments (Detail) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Debt Securities, Available-for-sale [Line Items] |  |
Amortized Cost Basis | $ 271,309 | $ 367,191
Unrealized Gains | 1 | 121
Unrealized Loses | (317) | (7)
Estimated Fair Value | 270,993 | 367,305
Less: Cash equivalents, amortized cost basis | (25,808) | (58,894)
Less: Cash equivalents | 0 | 0
Less: Cash equivalents, unrealized losses | 1 | 3
Less: Cash equivalents, estimated fair value | (25,807) | (58,891)
Total cash equivalents and short-term investments |  |
Debt Securities, Available-for-sale [Line Items] |  |
Amortized Cost Basis | 297,117 | 426,085
Unrealized Gains | 1 | 121
Unrealized Loses | (318) | (10)
Estimated Fair Value | 296,800 | 426,196
Level 1 | Money market funds |  |
Debt Securities, Available-for-sale [Line Items] |  |
Amortized Cost Basis | 10,311 | 178
Unrealized Gains | 0 | 0
Unrealized Loses | 0 | 0
Estimated Fair Value | 10,311 | 178
Level 2 | U.S. government and agency securities |  |
Debt Securities, Available-for-sale [Line Items] |  |
Amortized Cost Basis | 62,268 | 328,583
Unrealized Gains | 0 | 121
Unrealized Loses | (218) | (5)
Estimated Fair Value | 62,050 | 328,699
Level 2 | Commercial paper |  |
Debt Securities, Available-for-sale [Line Items] |  |
Amortized Cost Basis | 177,215 | 97,324
Unrealized Gains | 1 | 0
Unrealized Loses | (61) | (5)
Estimated Fair Value | 177,155 | $ 97,319
Level 2 | Corporate bonds |  |
Debt Securities, Available-for-sale [Line Items] |  |
Amortized Cost Basis | 47,323 |
Unrealized Gains | 0 |
Unrealized Loses | (39) |
Estimated Fair Value | $ 47,284 |

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