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Stock Plans (Tables)

12 Months Ended

Dec. 31, 2021

Share-based Payment Arrangement [Abstract]

Summary of Stock Options Activity

The following table summarizes stock option activity under the Company’s stock plans and related information:

(In thousands, except exercise prices and years)			Options Outstanding						Weighted- Average Exercise Price						Weighted- Average Remaining Contract Life (in years)						Aggregate Intrinsic Value (a)
Balance at December 31, 2019			8,995						$	7.19					7.6						$	48,073
Granted			4,126						18.52
Exercised			(2,043)						6.21
Cancelled/forfeited			(646)						10.67
Balance at December 31, 2020			10,432						$	11.65					8.2						$	31,626
Granted			8,231						7.04
Exercised			(9)						5.86
Cancelled/forfeited			(5,366)						10.32
Balance at December 31, 2021			13,288						$	9.34					6.9						$	145
Vested and expected to vest as of December 31, 2021			13,288						$	9.34					6.9						$	145
Exercisable at December 31, 2021			5,579						$	10.32					3.9						$	145

(a)The aggregate intrinsic value is calculated as the difference between the stock option exercise price and the closing price of the Company’s common stock as quoted on a national exchange.

Schedule of Fair Value of Option Issued Valuation Assumptions

The fair value of each stock option issued was estimated at the date of grant using the Black-Scholes valuation model with the following weighted-average assumptions:

			Options												Employee Stock Purchase Plan
			Years ended December 31,												Years ended December 31,
			2021						2020												2021						2020
Expected volatility			91%						87%												122%						89%
Expected term (in years)			6.0						6.0												1.21						0.5
Expected dividend yield			—						—												—						—
Risk-free interest rate			1.0%						0.8%												0.1%						0.1%

Summary of Restricted Stock Units Activity

The following table summarizes the RSU activity under the Company’s stock plans and related information:

(In thousands, except grant date fair value and years)			Number of Units (in thousands)						Weighted- Average Grant Date Fair Value (in dollars)						Weighted- Average Remaining Contractual Term (in years)
Balance at December 31, 2019			1,121						$	4.59					0.9
Granted			105						15.75
Vested and released			(590)						4.49
Forfeited			(96)						7.17
Balance at December 31, 2020			540						$	6.41					0.8
Granted			2,585						3.90
Vested and released			(305)						5.26
Forfeited			(694)						5.68
Balance at December 31, 2021			2,126						$	3.76					1.44

Stock-Based Compensation Expense

The following table presents, by operating expense, the Company’s stock-based compensation expense:

			Years ended December 31,
			2021						2020
			(In thousands)
Research and development			$	8,875					$	7,120
General and administrative			16,319						13,271
Total share-based compensation expense			$	25,194					$	20,391

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