Fair Value Measurements and Fair Value of Financial Instruments - Summary of Cash Equivalents and Short-term Investments (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	$ 271,309	$ 367,191
Unrealized Gains	1	121
Unrealized Loses	(317)	(7)
Estimated Fair Value	270,993	367,305
Less: Cash equivalents, amortized cost basis	(25,808)	(58,894)
Less: Cash equivalents	0	0
Less: Cash equivalents, unrealized losses	1	3
Less: Cash equivalents, estimated fair value	(25,807)	(58,891)
Total cash equivalents and short-term investments
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	297,117	426,085
Unrealized Gains	1	121
Unrealized Loses	(318)	(10)
Estimated Fair Value	296,800	426,196
Level 1 \| Money market funds
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	10,311	178
Unrealized Gains	0	0
Unrealized Loses	0	0
Estimated Fair Value	10,311	178
Level 2 \| U.S. government and agency securities
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	62,268	328,583
Unrealized Gains	0	121
Unrealized Loses	(218)	(5)
Estimated Fair Value	62,050	328,699
Level 2 \| Commercial paper
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	177,215	97,324
Unrealized Gains	1	0
Unrealized Loses	(61)	(5)
Estimated Fair Value	177,155	$ 97,319
Level 2 \| Corporate bonds
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	47,323
Unrealized Gains	0
Unrealized Loses	(39)
Estimated Fair Value	$ 47,284

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Amount, before tax, of unrealized gain in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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Amortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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Fair value portion of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.

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