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Income Taxes - Schedule of Reconciliation of Income Tax Expense Computed Statutory Federal Income Tax and Financial Statements (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Income Tax Disclosure [Abstract]
Federal income tax expense at statutory rate	$ (30,563)	$ (24,442)
Stock compensation	1,662	(2,787)
Non-deductible expenses	28	941
Research and development tax credits	(2,672)	(3,150)
Change in valuation allowance	41,324	24,817
Foreign rate differential	(9)	595
Impact of internal reorganization	(9,763)	2,669
Uncertain tax positions	0	2,305
Other	(7)	166
Total income tax provision	$ 0	$ 1,114

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Income tax reconciliation change in state uncertain tax position.

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets.

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