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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Income Statement [Abstract]    
Collaboration and license revenue $ 7,500 $ 0
Operating expenses:    
Research and development 89,181 73,309
General and administrative 64,441 44,641
Total operating expenses 153,622 117,950
Operating loss (146,122) (117,950)
Other income, net 582 1,557
Net loss before income taxes (145,540) (116,393)
Income tax provision 0 (1,114)
Net loss (145,540) (117,507)
Other comprehensive income (loss):    
Net unrealized gain (loss) on marketable securities (428) 93
Transfer of currency translation adjustments balance to other income related to the liquidation of foreign subsidiaries 0 342
Foreign currency translation adjustment (25) 29
Comprehensive loss $ (145,993) $ (117,043)
Net loss per share - basic (in dollars per share) $ (1.48) $ (1.38)
Net loss per share - diluted (in dollars per share) $ (1.48) $ (1.38)
Weighted-average common shares outstanding - basic (in shares) 98,039 85,146
Weighted-average common shares outstanding - diluted (in shares) 98,039 85,146