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Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2019   67,329      
Beginning balance at Dec. 31, 2019 $ 174,957 $ 7 $ 560,704 $ (725) $ (385,029)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock net of issuance costs (in shares)   27,600      
Issuance of common stock net of issuance costs 344,298 $ 3 344,295    
Stock-based compensation expense $ 20,391   20,391    
Common stock issued upon exercise of stock options, shares (in shares) 2,043 2,043      
Common stock issued upon exercise of stock options $ 12,687   12,687    
Common stock issued upon net exercise of warrants (in shares) 36        
Common stock issued under employee stock purchase plan (in shares)   114      
Common stock issued under employee stock purchase plan $ 1,100   1,100    
Common stock issued upon release of restricted stock units (in shares)   591      
Restricted stock surrendered for taxes (in shares)   (164)      
Restricted stock surrendered for taxes (2,043)   (2,043)    
Net unrealized gain (loss) on marketable securities 93     93  
Transfer of currency translation adjustments balance to other income related to the liquidation of foreign subsidiaries 342     342  
Foreign currency translation adjustment 29     29  
Net loss (117,507)       (117,507)
Ending balance (in shares) at Dec. 31, 2020   97,549      
Ending balance at Dec. 31, 2020 434,347 $ 10 937,134 (261) (502,536)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock net of issuance costs (in shares)   121      
Issuance of common stock net of issuance costs 1,685 $ 0 1,685    
Stock-based compensation expense $ 25,194   25,194    
Common stock issued upon exercise of stock options, shares (in shares) 9 9      
Common stock issued upon exercise of stock options $ 51   51    
Common stock issued under employee stock purchase plan (in shares)   397      
Common stock issued under employee stock purchase plan 901   901    
Common stock issued upon release of restricted stock units (in shares)   305      
Net unrealized gain (loss) on marketable securities (428)     (428)  
Transfer of currency translation adjustments balance to other income related to the liquidation of foreign subsidiaries 0        
Foreign currency translation adjustment (25)     (25)  
Net loss (145,540)       (145,540)
Ending balance (in shares) at Dec. 31, 2021   98,381      
Ending balance at Dec. 31, 2021 $ 316,185 $ 10 $ 964,965 $ (714) $ (648,076)