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v3.22.2.2

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2022 | Sep. 30, 2021
Cash flows from operating activities: |  |
Net loss | $ (121,800) | $ (111,131)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 4,816 | 3,323
Stock-based compensation expense | 14,826 | 20,784
Amortization of premium and accrued interest on marketable securities | (277) | 2,273
Loss on disposal of property and equipment | 101 | 0
Impairment of long-lived assets | 2,011 | 1,072
Other | (1,526) | (132)
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | (3,468) | (3,493)
Other assets | 864 | (109)
Operating lease right-of-use asset | 3,092 | 2,825
Accounts payable | (543) | (587)
Accrued expenses and other current liabilities | (272) | 3,253
Other non-current liabilities | 55 | 0
Lease liability and lease incentive receivable | 12,505 | (94)
Net cash used in operating activities | (89,616) | (82,016)
Cash flows from investing activities: |  |
Purchases of marketable securities | (81,782) | (328,275)
Maturities of marketable securities | 232,899 | 384,882
Sales of marketable securities | 0 | 8,990
Purchases of property and equipment | (11,631) | (10,771)
Net cash provided by investing activities | 139,486 | 54,826
Cash flows from financing activities: |  |
Proceeds from offerings of common stock, net of issuance costs | 0 | 1,685
Proceeds from issuance of common stock pursuant to option exercises | 3 | 51
Proceeds from employee stock purchase plan | 362 | 526
Repayment of loan | 0 | (240)
Net cash provided by financing activities | 365 | 2,022
Net increase (decrease) in cash and cash equivalents and restricted cash | 50,235 | (25,168)
Cash and cash equivalents and restricted cash at beginning of period | 36,698 | 63,423
Cash and cash equivalents and restricted cash at end of period | 86,933 | 38,255
Cash and cash equivalents | 84,430 | 32,971
Restricted cash | 2,503 | 5,284
Cash and cash equivalents and restricted cash at end of period | 86,933 | 38,255
Supplemental schedule of noncash investing and financing information |  |
Right-of-use assets obtained in exchange for lease liability | 0 | 84,005
Remeasurement of operating right-of-use assets | 2,842 | 0
Fixed assets in accounts payable, accrued expenses and other current liabilities | $ 168 | $ 2,675

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