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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Cash flows from operating activities:    
Net loss $ (121,800) $ (111,131)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 4,816 3,323
Stock-based compensation expense 14,826 20,784
Amortization of premium and accrued interest on marketable securities (277) 2,273
Loss on disposal of property and equipment 101 0
Impairment of long-lived assets 2,011 1,072
Other (1,526) (132)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (3,468) (3,493)
Other assets 864 (109)
Operating lease right-of-use asset 3,092 2,825
Accounts payable (543) (587)
Accrued expenses and other current liabilities (272) 3,253
Other non-current liabilities 55 0
Lease liability and lease incentive receivable 12,505 (94)
Net cash used in operating activities (89,616) (82,016)
Cash flows from investing activities:    
Purchases of marketable securities (81,782) (328,275)
Maturities of marketable securities 232,899 384,882
Sales of marketable securities 0 8,990
Purchases of property and equipment (11,631) (10,771)
Net cash provided by investing activities 139,486 54,826
Cash flows from financing activities:    
Proceeds from offerings of common stock, net of issuance costs 0 1,685
Proceeds from issuance of common stock pursuant to option exercises 3 51
Proceeds from employee stock purchase plan 362 526
Repayment of loan 0 (240)
Net cash provided by financing activities 365 2,022
Net increase (decrease) in cash and cash equivalents and restricted cash 50,235 (25,168)
Cash and cash equivalents and restricted cash at beginning of period 36,698 63,423
Cash and cash equivalents and restricted cash at end of period 86,933 38,255
Cash and cash equivalents 84,430 32,971
Restricted cash 2,503 5,284
Cash and cash equivalents and restricted cash at end of period 86,933 38,255
Supplemental schedule of noncash investing and financing information    
Right-of-use assets obtained in exchange for lease liability 0 84,005
Remeasurement of operating right-of-use assets 2,842 0
Fixed assets in accounts payable, accrued expenses and other current liabilities $ 168 $ 2,675