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Stock Plans (Tables) | 12 Months Ended
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Dec. 31, 2022
Share-Based Payment Arrangement [Abstract] |
Schedule of Stock Options Activity | The following table summarizes stock option activity under the Company’s stock plans and related information:
(In thousands, except exercise prices and years) | Options Outstanding |  | Weighted- Average Exercise Price |  | Weighted- Average Remaining Contract Life (in years) |  | Aggregate Intrinsic Value (a)
Balance at December 31, 2020 | 10,432 |  |  | $ | 7.19 |  |  | 8.2 |  | $ | 31,626 |
Granted | 8,231 |  |  | 7.04 |  |  |  |  |
Exercised | (9) |  |  | 5.86 |  |  |  |  |
Cancelled/forfeited | (5,366) |  |  | 10.32 |  |  |  |  |
Balance at December 31, 2021 | 13,288 |  |  | $ | 5.83 |  |  | 6.9 |  | $ | 145 |
Granted | 10,933 |  |  | 1.24 |  |  |  |  |
Exercised | (15) |  |  | 0.19 |  |  |  |  |
Cancelled/forfeited | (4,886) |  |  | 5.29 |  |  |  |  |
Balance at December 31, 2022 | 19,320 |  |  | $ | 3.38 |  |  | 8.0 |  | $ | 29 |
Vested and expected to vest as of December 31, 2022 | 19,320 |  |  | $ | 5.79 |  |  | 8.0 |  | $ | 29 |
Exercisable at December 31, 2022 | 6,102 |  |  | $ | 11.03 |  |  | 6.4 |  | $ | 29 |
(a)The aggregate intrinsic value is calculated as the difference between the stock option exercise price and the closing price of the Company’s common stock as quoted on a national exchange.
Schedule of Fair Value of Option Issued Valuation Assumptions | The fair value of each stock option issued was estimated at the date of grant using the Black-Scholes valuation model with the following weighted-average assumptions:
| Options |  | Employee Stock Purchase Plan
| Years ended December 31, |  | Years ended December 31,
| 2022 |  | 2021 |  |  |  | 2022 |  | 2021 |  |
Expected volatility | 89% |  | 91% |  |  |  | 77% |  | 122% |  |
Expected term (in years) | 6.0 |  | 6.0 |  |  |  | 1.2 |  | 1.2 |  |
Expected dividend yield | — |  | — |  |  |  | — |  | — |  |
Risk-free interest rate | 2.6% |  | 1.0% |  |  |  | 3.0% |  | 0.1% |  |
Schedule of Restricted Stock Units Activity | The following table summarizes the RSU activity under the Company’s stock plans and related information:
(In thousands, except grant date fair value and years) | Number of Units |  | Weighted- Average Grant Date Fair Value |  | Weighted- Average Remaining Contractual Term (in years)
Balance at December 31, 2020 | 540 |  |  | $ | 6.41 |  |  | 0.8
Granted | 2,585 |  |  | 3.90 |  |  |
Vested and released | (305) |  |  | 5.26 |  |  |
Forfeited | (694) |  |  | 5.68 |  |  |
Balance at December 31, 2021 | 2,126 |  |  | 3.76 |  |  | 1.4
Granted | 857 |  |  | 1.43 |  |  |
Vested and released | (835) |  |  | 3.41 |  |  |
Forfeited | (455) |  |  | 3.21 |  |  |
Balance at December 31, 2022 | 1,693 |  |  | $ | 2.90 |  |  | 1.2
Schedule of Stock-based Compensation Expense | The following table presents the Company’s stock-based compensation expense:
| Years ended December 31,
| 2022 |  | 2021 |  |
| (In thousands)
Research and development | $ | 7,108 |  |  | $ | 8,875 |  |  |
General and administrative | 12,971 |  |  | 16,319 |  |  |
Total share-based compensation expense | $ | 20,079 |  |  | $ | 25,194 |  |  |

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