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Stock Plans (Tables)

12 Months Ended

Dec. 31, 2022

Share-Based Payment Arrangement [Abstract]

Schedule of Stock Options Activity

The following table summarizes stock option activity under the Company’s stock plans and related information:

(In thousands, except exercise prices and years)			Options Outstanding						Weighted- Average Exercise Price						Weighted- Average Remaining Contract Life (in years)						Aggregate Intrinsic Value (a)
Balance at December 31, 2020			10,432						$	7.19					8.2						$	31,626
Granted			8,231						7.04
Exercised			(9)						5.86
Cancelled/forfeited			(5,366)						10.32
Balance at December 31, 2021			13,288						$	5.83					6.9						$	145
Granted			10,933						1.24
Exercised			(15)						0.19
Cancelled/forfeited			(4,886)						5.29
Balance at December 31, 2022			19,320						$	3.38					8.0						$	29
Vested and expected to vest as of December 31, 2022			19,320						$	5.79					8.0						$	29
Exercisable at December 31, 2022			6,102						$	11.03					6.4						$	29

(a)The aggregate intrinsic value is calculated as the difference between the stock option exercise price and the closing price of the Company’s common stock as quoted on a national exchange.

Schedule of Fair Value of Option Issued Valuation Assumptions

The fair value of each stock option issued was estimated at the date of grant using the Black-Scholes valuation model with the following weighted-average assumptions:

			Options												Employee Stock Purchase Plan
			Years ended December 31,												Years ended December 31,
			2022						2021												2022						2021
Expected volatility			89%						91%												77%						122%
Expected term (in years)			6.0						6.0												1.2						1.2
Expected dividend yield			—						—												—						—
Risk-free interest rate			2.6%						1.0%												3.0%						0.1%

Schedule of Restricted Stock Units Activity

The following table summarizes the RSU activity under the Company’s stock plans and related information:

(In thousands, except grant date fair value and years)			Number of Units						Weighted- Average Grant Date Fair Value						Weighted- Average Remaining Contractual Term (in years)
Balance at December 31, 2020			540						$	6.41					0.8
Granted			2,585						3.90
Vested and released			(305)						5.26
Forfeited			(694)						5.68
Balance at December 31, 2021			2,126						3.76						1.4
Granted			857						1.43
Vested and released			(835)						3.41
Forfeited			(455)						3.21
Balance at December 31, 2022			1,693						$	2.90					1.2

Schedule of Stock-based Compensation Expense

The following table presents the Company’s stock-based compensation expense:

			Years ended December 31,
			2022						2021
			(In thousands)
Research and development			$	7,108					$	8,875
General and administrative			12,971						16,319
Total share-based compensation expense			$	20,079					$	25,194

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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