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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Income Statement [Abstract]    
Collaboration and license revenue $ 0 $ 7,500
Operating expenses:    
Research and development 99,277 89,181
General and administrative 57,858 64,441
Total operating expenses 157,135 153,622
Operating loss (157,135) (146,122)
Other income, net 2,673 582
Net loss before income taxes (154,462) (145,540)
Income tax provision (74) 0
Net loss (154,536) (145,540)
Other comprehensive loss:    
Net unrealized loss on marketable securities (788) (428)
Foreign currency translation adjustment (29) (25)
Comprehensive loss $ (155,353) $ (145,993)
Net loss per share - basic (in dollars per share) $ (1.56) $ (1.48)
Net loss per share - diluted (in dollars per share) $ (1.56) $ (1.48)
Weighted-average common shares outstanding - basic (in shares) 99,251 98,039
Weighted-average common shares outstanding - diluted (in shares) 99,251 98,039