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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Cash flows from operating activities:    
Net loss $ (154,536) $ (145,540)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 6,528 4,645
Stock-based compensation expense 20,079 25,194
Net (accretion) amortization of (discount) premium on marketable securities, net (880) 2,770
Loss on disposal of property and equipment 122 0
Impairment of long-lived assets 2,124 1,063
Other (1,417) (25)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 1,653 (2,257)
Deposit and other long-term assets and deferred rent receivable (394) (990)
Operating lease right-of-use assets 4,040 2,719
Accounts payable 845 (1,612)
Accrued expenses, other current and non-current liabilities 64 3,274
Other non-current liabilities 74 0
Lease liability 13,607 2,928
Net cash used in operating activities (108,091) (107,831)
Cash flows from investing activities:    
Purchases of marketable securities (104,363) (407,514)
Maturities of marketable securities 257,899 492,356
Sales of marketable securities 0 8,990
Purchases of property and equipment (11,816) (15,123)
Net cash provided by investing activities 141,720 78,709
Cash flows from financing activities:    
Proceeds from offering of common stock, net of issuance costs 0 1,685
Proceeds from issuance of common stock pursuant to option exercises 3 51
Proceeds from employee stock purchase plan 604 901
Repayment of BPI loan 0 (240)
Net cash provided by financing activities 607 2,397
Net increase (decrease) in cash, cash equivalents and restricted cash 34,236 (26,725)
Cash, cash equivalents and restricted cash at beginning of period 36,698 63,423
Cash, cash equivalents and restricted cash at end of period 70,934 36,698
Cash and cash equivalents 68,431 34,195
Restricted cash 2,503 2,503
Cash, cash equivalents and restricted cash at end of period 70,934 36,698
Supplemental schedule of noncash investing information    
Right-of-use assets obtained in exchange for lease liability 0 84,005
Decrease in right-of-use asset and lease liability due to termination 0 15,768
Remeasurement of right-of-use asset on lease modification 2,842 2,052
Fixed assets in accounts payable and current liabilities $ 64 $ 1,402