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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Cash flows from operating activities:    
Net loss $ (93,451) $ (121,800)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 4,635 4,816
Stock-based compensation expense 13,421 14,826
Net accretion of discount on marketable securities (1,835) (277)
Non-cash lease expense 12,466 3,092
Loss on disposal of property and equipment 85 101
Impairment of long-lived assets 0 2,011
Other (257) (1,526)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (923) (3,468)
Other assets 143 864
Accounts payable (62) (543)
Accrued expenses and other liabilities (1,452) (217)
Lease liability and lease incentive receivable (2,344) 12,505
Net cash used in operating activities (69,574) (89,616)
Cash flows from investing activities:    
Purchases of marketable securities (20,232) (81,782)
Maturities of marketable securities 127,601 232,899
Purchases of property and equipment (616) (11,631)
Net cash provided by investing activities 106,753 139,486
Cash flows from financing activities:    
Proceeds from issuance of common stock pursuant to option exercises 1 3
Payment of deferred offering costs (344) 0
Proceeds from employee stock purchase plan 246 362
Net cash (used in) provided by financing activities (97) 365
Net increase in cash and cash equivalents and restricted cash 37,082 50,235
Cash and cash equivalents and restricted cash at beginning of period 70,934 36,698
Cash and cash equivalents and restricted cash at end of period 108,016 86,933
Cash and cash equivalents 105,366 84,430
Restricted cash 2,650 2,503
Cash and cash equivalents and restricted cash at end of period 108,016 86,933
Supplemental schedule of noncash investing and financing information    
Non-cash settlement of operating lease liability 14,903 0
Remeasurement of operating lease right-of-use assets 13,711 2,842
Fixed assets in accounts payable, accrued expenses and other current liabilities 0 168
Deferred offering costs included in accounts payable $ 58 $ 0