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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Cash flows from operating activities:    
Net loss $ (117,165) $ (154,536)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 5,644 6,528
Stock-based compensation expense 17,569 20,079
Net accretion of discount on marketable securities, net (1,935) (880)
Non-cash lease expense 13,027 4,040
Loss on disposal of property and equipment 50 122
Impairment of long-lived assets 224 2,124
Other 1 (1,417)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 298 1,653
Deposit and other long-term assets and deferred rent receivable 182 (394)
Accounts payable (369) 845
Accrued expenses and other liabilities (5,206) 138
Lease liability (3,222) 13,607
Net cash used in operating activities (90,902) (108,091)
Cash flows from investing activities:    
Purchases of marketable securities (36,718) (104,363)
Maturities of marketable securities 134,401 257,899
Purchases of property and equipment (808) (11,816)
Net cash provided by investing activities 96,875 141,720
Cash flows from financing activities:    
Payment of deferred offering costs (420) 0
Proceeds from issuance of common stock pursuant to option exercises 1 3
Proceeds from employee stock purchase plan 488 604
Net cash provided by financing activities 69 607
Net increase in cash, cash equivalents and restricted cash 6,042 34,236
Cash, cash equivalents and restricted cash at beginning of period 70,934 36,698
Cash, cash equivalents and restricted cash at end of period 76,976 70,934
Cash and cash equivalents 75,000 68,431
Restricted cash 1,976 2,503
Cash, cash equivalents and restricted cash at end of period 76,976 70,934
Supplemental schedule of noncash investing information    
Non-cash settlement of operating lease liability 14,903 0
Remeasurement of operating lease right-of-use assets and liabilities 13,711 2,842
Fixed assets in accounts payable and current liabilities $ 91 $ 64