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Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2024 | Mar. 31, 2023
Cash flows from operating activities: |  |
Net loss | $ (24,787) | $ (29,056)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 997 | 1,592
Stock-based compensation expense | 4,166 | 4,563
Net accretion of discount on marketable securities, net | (333) | (960)
Non-cash lease expense | 506 | 1,427
Other | (19) | 19
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | 480 | 924
Deposit and other long-term assets and deferred rent receivable | 35 | 62
Accounts payable | (347) | 631
Accrued expenses and other liabilities | (3,391) | (749)
Lease liability | (552) | (865)
Net cash used in operating activities | (23,245) | (22,412)
Cash flows from investing activities: |  |
Purchases of marketable securities | (26,937) | (20,232)
Maturities of marketable securities | 5,000 | 41,850
Purchases of property and equipment | (90) | (85)
Net cash (used in) provided by investing activities | (22,027) | 21,533
Cash flows from financing activities: |  |
Proceeds from issuance of common stock and pre-funded warrants in private placements, net of issuance costs | 119,741 | 0
Proceeds from issuance of common stock pursuant to option exercises | 139 | 0
Net cash provided by financing activities | 119,880 | 0
Net increase (decrease) in cash and cash equivalents and restricted cash | 74,608 | (879)
Cash and cash equivalents and restricted cash at beginning of period | 76,976 | 70,934
Cash and cash equivalents and restricted cash at end of period | 151,584 | 70,055
Cash and cash equivalents | 149,608 | 67,552
Restricted cash | 1,976 | 2,503
Cash and cash equivalents and restricted cash at end of period | 151,584 | 70,055
Supplemental schedule of noncash investing and financing information |  |
Issuance costs included in accounts payable | 380 | 0
Remeasurement of operating lease right-of-use assets | 0 | 8,004
Property and equipment in accounts payable, accrued expenses and other current liabilities | $ 0 | $ 17

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