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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2024
Mar. 31, 2023
Cash flows from operating activities:    
Net loss $ (24,787) $ (29,056)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 997 1,592
Stock-based compensation expense 4,166 4,563
Net accretion of discount on marketable securities, net (333) (960)
Non-cash lease expense 506 1,427
Other (19) 19
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 480 924
Deposit and other long-term assets and deferred rent receivable 35 62
Accounts payable (347) 631
Accrued expenses and other liabilities (3,391) (749)
Lease liability (552) (865)
Net cash used in operating activities (23,245) (22,412)
Cash flows from investing activities:    
Purchases of marketable securities (26,937) (20,232)
Maturities of marketable securities 5,000 41,850
Purchases of property and equipment (90) (85)
Net cash (used in) provided by investing activities (22,027) 21,533
Cash flows from financing activities:    
Proceeds from issuance of common stock and pre-funded warrants in private placements, net of issuance costs 119,741 0
Proceeds from issuance of common stock pursuant to option exercises 139 0
Net cash provided by financing activities 119,880 0
Net increase (decrease) in cash and cash equivalents and restricted cash 74,608 (879)
Cash and cash equivalents and restricted cash at beginning of period 76,976 70,934
Cash and cash equivalents and restricted cash at end of period 151,584 70,055
Cash and cash equivalents 149,608 67,552
Restricted cash 1,976 2,503
Cash and cash equivalents and restricted cash at end of period 151,584 70,055
Supplemental schedule of noncash investing and financing information    
Issuance costs included in accounts payable 380 0
Remeasurement of operating lease right-of-use assets 0 8,004
Property and equipment in accounts payable, accrued expenses and other current liabilities $ 0 $ 17