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Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2024
Share-Based Payment Arrangement [Abstract] |
Schedule of Stock Options Activity | The following table summarizes stock option activity under the Company’s stock plans and related information:
(In thousands, except exercise prices and years) | Options Outstanding |  | Weighted- Average Exercise Price |  | Weighted- Average Remaining Contract Life (in years) |  | Aggregate Intrinsic Value (a)
Balance at December 31, 2023 | 2,303 |  |  | $ | 48.70 |  |  | 6.8 |  | $ | 99 |
Granted | 1,971 |  |  | 10.39 |  |  |  |  |
Exercised | (15) |  |  | 9.97 |  |  |  |  |
Canceled/forfeited | (350) |  |  | 50.28 |  |  |  |  |
Balance at December 31, 2024 | 3,909 |  |  | $ | 29.39 |  |  | 8.1 |  | $ | — |
Vested and expected to vest as of December 31, 2024 | 3,909 |  |  | $ | 29.39 |  |  | 8.1 |  | $ | — |
Exercisable at December 31, 2024 | 1,504 |  |  | $ | 58.95 |  |  | 6.5 |  | $ | — |
(a)The aggregate intrinsic value is calculated as the difference between the stock option exercise price and the closing price of the Company’s common stock as quoted on a national exchange.
Schedule of Fair Value of Option Issued Valuation Assumptions | The fair value of each stock option issued was estimated at the date of grant using the Black-Scholes valuation model with the following weighted-average assumptions:
| Options |  | Employee Stock Purchase Plan
| Years ended December 31, |  | Years ended December 31,
| 2024 |  | 2023 |  |  |  | 2024 |  | 2023 |  |
Expected volatility | 95% |  | 90% |  |  |  | 83% |  | 78% |  |
Expected term (in years) | 6.0 |  | 6.0 |  |  |  | 1.3 |  | 1.3 |  |
Expected dividend yield | — |  | — |  |  |  | — |  | — |  |
Risk-free interest rate | 3.9% |  | 4.2% |  |  |  | 4.3% |  | 5.0% |  |
Schedule of Restricted Stock Units Activity | The following table summarizes the RSU activity under the Company’s stock plans and related information:
(In thousands, except grant date fair value and years) | Number of Units |  | Weighted- Average Grant Date Fair Value |  | Weighted- Average Remaining Contractual Term (in years)
Balance at December 31, 2023 | 154 |  |  | 21.73 |  |  | 1.4
Granted | 160 |  |  | 12.04 |  |  |
Vested and released | (29) |  |  | 26.20 |  |  |
Forfeited | (26) |  |  | 14.22 |  |  |
Balance at December 31, 2024 | 259 |  |  | $ | 16.00 |  |  | 1.2
Schedule of Stock-based Compensation Expense | The following table presents the Company’s stock-based compensation expense:
| Years ended December 31,
| 2024 |  | 2023 |  |
| (In thousands)
Research and development | $ | 4,544 |  |  | $ | 4,969 |  |  |
General and administrative | 9,806 |  |  | 12,600 |  |  |
Total share-based compensation expense | $ | 14,350 |  |  | $ | 17,569 |  |  |

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