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Quarterly Financial Information (Unaudited) (Tables) | 12 Months Ended
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Dec. 31, 2024
Quarterly Financial Information Disclosure [Abstract] |
Schedule of Quarterly Financial Information | The unaudited interim financial statements reflect all adjustments which are, in the opinion of management, necessary for a fair statement of the results for the interim periods presented (in thousands, except per share data). Condensed Consolidated Balance Sheets
| September 30, 2024 (unaudited)
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated
Assets |  |  |  |  |  |  |
Current assets: |  |  |  |  |  |  |
Cash and cash equivalents | $ | 92,851 |  |  | $ | — |  |  |  |  | $ | 92,851 |
Short-term investments | 60,390 |  |  | — |  |  |  |  | 60,390 |
Prepaid expenses and other current assets | 7,839 |  |  | — |  |  |  |  | 7,839 |
Total current assets | 161,080 |  |  | — |  |  |  |  | 161,080 |
Operating lease right-of-use assets | 50,695 |  |  | (17,015) |  |  | (a) (d) |  | 33,680 |
Property and equipment, net | 12,215 |  |  | — |  |  |  |  | 12,215 |
Deferred rent receivable | 7,116 |  |  | (7,116) |  |  | (b) |  | — |
Restricted cash | 1,976 |  |  | — |  |  |  |  | 1,976 |
Deposit and other long-term assets | 1,293 |  |  | — |  |  |  |  | 1,293 |
Total assets | $ | 234,375 |  |  | $ | (24,131) |  |  |  |  | $ | 210,244 |
Liabilities and stockholders’ equity |  |  |  |  |  |  |
Current liabilities: |  |  |  |  |  |  |
Accounts payable | $ | 2,110 |  |  | — |  |  |  |  | $ | 2,110 |
Accrued expenses and other current liabilities | 14,886 |  |  | — |  |  |  |  | 14,886 |
Lease liability, current portion | 10,661 |  |  | (5,044) |  |  | (a) |  | 5,617 |
Total current liabilities | 27,657 |  |  | (5,044) |  |  |  |  | 22,613 |
Long-term liabilities: |  |  |  |  |  |  |
Lease liability, net of current portion | 62,602 |  |  | 16,759 |  |  | (a) (d) |  | 79,361 |
Total liabilities | 90,259 |  |  | 11,715 |  |  |  |  | 101,974 |
Commitments and contingencies |  |  |  |  |  |  |
Stockholders’ equity: |  |  |  |  |  |  |
Preferred stock | — |  |  | — |  |  |  |  | — |
Common stock | 2 |  |  | — |  |  |  |  | 2 |
Additional paid-in capital | 1,134,556 |  |  | — |  |  |  |  | 1,134,556 |
Accumulated other comprehensive loss | (268) |  |  | — |  |  |  |  | (268) |
Accumulated deficit | (990,174) |  |  | (35,846) |  |  | (a) (b) |  | (1,026,020) |
Total stockholders’ equity | 144,116 |  |  | (35,846) |  |  |  |  | 108,270 |
Total liabilities and stockholders’ equity | $ | 234,375 |  |  | $ | (24,131) |  |  |  |  | $ | 210,244 |
| June 30, 2024 (unaudited)
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated
Assets |  |  |  |  |  |  |
Current assets: |  |  |  |  |  |  |
Cash and cash equivalents | $ | 127,321 |  |  | $ | — |  |  |  |  | $ | 127,321 |
Short-term investments | 46,506 |  |  | — |  |  |  |  | 46,506 |
Prepaid expenses and other current assets | 5,591 |  |  | — |  |  |  |  | 5,591 |
Total current assets | 179,418 |  |  | — |  |  |  |  | 179,418 |
Operating lease right-of-use assets | 51,237 |  |  | (17,241) |  |  | (a) (d) |  | 33,996 |
Property and equipment, net | 13,047 |  |  |  |  |  |  | 13,047 |
Deferred rent receivable | 6,963 |  |  | (6,963) |  |  | (b) |  | — |
Restricted cash | 1,976 |  |  | — |  |  |  |  | 1,976 |
Deposit and other long-term assets | 1,162 |  |  | — |  |  |  |  | 1,162 |
Total assets | $ | 253,803 |  |  | $ | (24,204) |  |  |  |  | $ | 229,599 |
Liabilities and stockholders’ equity |  |  |  |  |  |  |
Current liabilities: |  |  |  |  |  |  |
Accounts payable | 1,973 |  |  | — |  |  |  |  | 1,973 |
Accrued expenses and other current liabilities | 9,912 |  |  | — |  |  |  |  | 9,912 |
Lease liability, current portion | 10,576 |  |  | (5,006) |  |  | (a) |  | 5,570 |
Total current liabilities | 22,461 |  |  | (5,006) |  |  |  |  | 17,455 |
Long-term liabilities: |  |  |  |  |  |  |
Lease liability, net of current portion | 63,313 |  |  | 11,431 |  |  | (a) (d) |  | 74,744 |
Total liabilities | 85,774 |  |  | 6,425 |  |  |  |  | 92,199 |
Commitments and contingencies |  |  |  |  |  |  |
Stockholders’ equity: |  |  |  |  |  |  |
Preferred stock | — |  |  | — |  |  |  |  | — |
Common stock | 2 |  |  | — |  |  |  |  | 2 |
Additional paid-in capital | 1,131,592 |  |  | — |  |  |  |  | 1,131,592 |
Accumulated other comprehensive loss | (525) |  |  | — |  |  |  |  | (525) |
Accumulated deficit | (963,040) |  |  | (30,629) |  |  | (a) (b) |  | (993,669) |
Total stockholders’ equity | 168,029 |  |  | (30,629) |  |  |  |  | 137,400 |
Total liabilities and stockholders’ equity | $ | 253,803 |  |  | $ | (24,204) |  |  |  |  | $ | 229,599 |
| March 31, 2024 (unaudited)
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated
Assets |  |  |  |  |  |  |
Current assets: |  |  |  |  |  |  |
Cash and cash equivalents | $ | 149,608 |  |  | $ | — |  |  |  |  | $ | 149,608 |
Short-term investments | 43,720 |  |  | — |  |  |  |  | 43,720 |
Prepaid expenses and other current assets | 5,802 |  |  | — |  |  |  |  | 5,802 |
Total current assets | 199,130 |  |  | — |  |  |  |  | 199,130 |
Operating lease right-of-use assets | 51,760 |  |  | (17,282) |  |  | (a) (d) |  | 34,478 |
Property and equipment, net | 13,766 |  |  | — |  |  |  |  | 13,766 |
Restricted cash | 1,976 |  |  | — |  |  |  |  | 1,976 |
Deposit and other long-term assets | 1,196 |  |  | — |  |  |  |  | 1,196 |
Total assets | $ | 267,828 |  |  | $ | (17,282) |  |  |  |  | $ | 250,546 |
Liabilities and stockholders’ equity |  |  |  |  |  |  |
Current liabilities: |  |  |  |  |  |  |
Accounts payable | 1,897 |  |  | — |  |  |  |  | 1,897 |
Accrued expenses and other current liabilities | 9,160 |  |  | — |  |  |  |  | 9,160 |
Lease liability, current portion | 10,492 |  |  | (4,971) |  |  | (a) |  | 5,521 |
Total current liabilities | 21,549 |  |  | (4,971) |  |  |  |  | 16,578 |
Long-term liabilities: |  |  |  |  |  |  |
Lease liability, net of current portion | 63,991 |  |  | 6,296 |  |  | (a) (d) |  | 70,287 |
Total liabilities | 85,540 |  |  | 1,325 |  |  |  |  | 86,865 |
Commitments and contingencies |  |  |  |  |  |  |
Stockholders’ equity: |  |  |  |  |  |  |
Preferred stock | — |  |  | — |  |  |  |  | — |
Common stock | 2 |  |  | — |  |  |  |  | 2 |
Additional paid-in capital | 1,127,383 |  |  | — |  |  |  |  | 1,127,383 |
Accumulated other comprehensive loss | (533) |  |  | — |  |  |  |  | (533) |
Accumulated deficit | (944,564) |  |  | (18,607) |  |  | (a) |  | (963,171) |
Total stockholders’ equity | 182,288 |  |  | (18,607) |  |  |  |  | 163,681 |
Total liabilities and stockholders’ equity | $ | 267,828 |  |  | $ | (17,282) |  |  |  |  | $ | 250,546 |
| September 30, 2023 (unaudited)
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated
Assets |  |  |  |  |  |  |
Current assets: |  |  |  |  |  |  |
Cash and cash equivalents | $ | 105,366 |  |  | $ | — |  |  |  |  | $ | 105,366 |
Short-term investments | 11,716 |  |  | — |  |  |  |  | 11,716 |
Prepaid expenses and other current assets | 7,514 |  |  | — |  |  |  |  | 7,514 |
Total current assets | 124,596 |  |  | — |  |  |  |  | 124,596 |
Operating lease right-of-use assets | 52,757 |  |  | (17,158) |  |  | (a) (d) |  | 35,599 |
Property and equipment, net | 15,497 |  |  | — |  |  |  |  | 15,497 |
Restricted cash | 2,650 |  |  | — |  |  |  |  | 2,650 |
Deposit and other long-term assets | 1,270 |  |  | — |  |  |  |  | 1,270 |
Total assets | $ | 196,770 |  |  | $ | (17,158) |  |  |  |  | $ | 179,612 |
Liabilities and stockholders’ equity |  |  |  |  |  |  |
Current liabilities: |  |  |  |  |  |  |
Accounts payable | 2,170 |  |  | — |  |  |  |  | 2,170 |
Accrued expenses and other current liabilities | 16,362 |  |  | — |  |  |  |  | 16,362 |
Lease liability, current portion | 10,324 |  |  | (4,897) |  |  | (a) |  | 5,427 |
Total current liabilities | 28,856 |  |  | (4,897) |  |  |  |  | 23,959 |
Long-term liabilities: |  |  |  |  |  |  |
Lease liability, net of current portion | 65,200 |  |  | 3,196 |  |  | (a) (d) |  | 68,396 |
Total liabilities | 94,056 |  |  | (1,701) |  |  |  |  | 92,355 |
Commitments and contingencies |  |  |  |  |  |  |
Stockholders’ equity: |  |  |  |  |  |  |
Preferred stock | — |  |  | — |  |  |  |  | — |
Common stock | 1 |  |  | — |  |  |  |  | 1 |
Additional paid-in capital | 999,328 |  |  | — |  |  |  |  | 999,328 |
Accumulated other comprehensive loss | (552) |  |  | — |  |  |  |  | (552) |
Accumulated deficit | (896,063) |  |  | (15,457) |  |  | (a) (c) |  | (911,520) |
Total stockholders’ equity | 102,714 |  |  | (15,457) |  |  |  |  | 87,257 |
Total liabilities and stockholders’ equity | $ | 196,770 |  |  | $ | (17,158) |  |  |  |  | $ | 179,612 |
| June 30, 2023 (unaudited)
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated
Assets |  |  |  |  |  |  |
Current assets: |  |  |  |  |  |  |
Cash and cash equivalents | $ | 111,187 |  |  | $ | — |  |  |  |  | $ | 111,187 |
Short-term investments | 30,266 |  |  | — |  |  |  |  | 30,266 |
Prepaid expenses and other current assets | 5,690 |  |  | — |  |  |  |  | 5,690 |
Total current assets | 147,143 |  |  | — |  |  |  |  | 147,143 |
Operating lease right-of-use assets | 58,287 |  |  | (17,054) |  |  | (a) (d) |  | 41,233 |
Property and equipment, net | 32,041 |  |  | — |  |  |  |  | 32,041 |
Restricted cash | 2,650 |  |  | — |  |  |  |  | 2,650 |
Deposit and other long-term assets | 1,308 |  |  | — |  |  |  |  | 1,308 |
Total assets | $ | 241,429 |  |  | $ | (17,054) |  |  |  |  | $ | 224,375 |
Liabilities and stockholders’ equity |  |  |  |  |  |  |
Current liabilities: |  |  |  |  |  |  |
Accounts payable | 1,418 |  |  | — |  |  |  |  | 1,418 |
Accrued expenses and other current liabilities | 17,704 |  |  | — |  |  |  |  | 17,704 |
Lease liability, current portion | 25,396 |  |  | (4,861) |  |  | (a) |  | 20,535 |
Total current liabilities | 44,518 |  |  | (4,861) |  |  |  |  | 39,657 |
Long-term liabilities: |  |  |  |  |  |  |
Lease liability, net of current portion | 65,756 |  |  | 2,734 |  |  | (a) (d) |  | 68,490 |
Total liabilities | 110,274 |  |  | (2,127) |  |  |  |  | 108,147 |
Commitments and contingencies |  |  |  |  |  |  |
Stockholders’ equity: |  |  |  |  |  |  |
Preferred stock | — |  |  | — |  |  |  |  | — |
Common stock | 1 |  |  | — |  |  |  |  | 1 |
Additional paid-in capital | 994,938 |  |  | — |  |  |  |  | 994,938 |
Accumulated other comprehensive loss | (606) |  |  | — |  |  |  |  | (606) |
Accumulated deficit | (863,178) |  |  | (14,927) |  |  | (a) (c) |  | (878,105) |
Total stockholders’ equity | 131,155 |  |  | (14,927) |  |  |  |  | 116,228 |
Total liabilities and stockholders’ equity | $ | 241,429 |  |  | $ | (17,054) |  |  |  |  | $ | 224,375 |
| March 31, 2023 (unaudited)
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated
Assets |  |  |  |  |  |  |
Current assets: |  |  |  |  |  |  |
Cash and cash equivalents | $ | 67,552 |  |  | $ | — |  |  |  |  | $ | 67,552 |
Short-term investments | 96,733 |  |  | — |  |  |  |  | 96,733 |
Prepaid expenses and other current assets | 4,588 |  |  | — |  |  |  |  | 4,588 |
Total current assets | 168,873 |  |  | — |  |  |  |  | 168,873 |
Operating lease right-of-use assets | 69,503 |  |  | (22,905) |  |  | (a) (d) |  | 46,598 |
Property and equipment, net | 33,347 |  |  | — |  |  |  |  | 33,347 |
Restricted cash | 2,503 |  |  | — |  |  |  |  | 2,503 |
Deposit and other long-term assets | 1,351 |  |  | — |  |  |  |  | 1,351 |
Total assets | $ | 275,577 |  |  | $ | (22,905) |  |  |  |  | $ | 252,672 |
Liabilities and stockholders’ equity |  |  |  |  |  |  |
Current liabilities: |  |  |  |  |  |  |
Accounts payable | 2,863 |  |  | — |  |  |  |  | 2,863 |
Accrued expenses and other current liabilities | 17,344 |  |  | — |  |  |  |  | 17,344 |
Lease liability, current portion | 26,265 |  |  | (5,531) |  |  | (a) |  | 20,734 |
Total current liabilities | 46,472 |  |  | (5,531) |  |  |  |  | 40,941 |
Long-term liabilities: |  |  |  |  |  |  |
Lease liability, net of current portion | 71,348 |  |  | (3,462) |  |  | (a) (d) |  | 67,886 |
Total liabilities | 117,820 |  |  | (8,993) |  |  |  |  | 108,827 |
Commitments and contingencies |  |  |  |  |  |  |
Stockholders’ equity: |  |  |  |  |  |  |
Preferred stock | — |  |  | — |  |  |  |  | — |
Common stock | 1 |  |  | — |  |  |  |  | 1 |
Additional paid-in capital | 990,223 |  |  | — |  |  |  |  | 990,223 |
Accumulated other comprehensive loss | (799) |  |  | — |  |  |  |  | (799) |
Accumulated deficit | (831,668) |  |  | (13,912) |  |  | (a) (c) |  | (845,580) |
Total stockholders’ equity | 157,757 |  |  | (13,912) |  |  |  |  | 143,845 |
Total liabilities and stockholders’ equity | $ | 275,577 |  |  | (22,905) |  |  |  |  | $ | 252,672 |
Quarterly and Year to Date Condensed Consolidated Statements of Operations and Comprehensive Loss
| Three Months Ended |  | Nine Months Ended
| September 30, 2024 (unaudited) |  | September 30, 2024 (unaudited)
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated |  | As Previously Reported |  | Adjustment |  | Reference |  | As Restated
License revenue | $ | 1,000 |  |  | $ | — |  |  |  |  | $ | 1,000 |  |  | $ | 1,000 |  |  | $ | — |  |  |  |  | $ | 1,000 |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development | 20,439 |  |  | — |  |  |  |  | 20,439 |  |  | 52,946 |  |  | — |  |  |  |  | 52,946 |
General and administrative | 9,782 |  |  | 5,217 |  |  | (a) |  | 14,999 |  |  | 24,996 |  |  | 19,599 |  |  | (a) (b) |  | 44,595 |
Total operating expenses | 30,221 |  |  | 5,217 |  |  |  |  | 35,438 |  |  | 77,942 |  |  | 19,599 |  |  |  |  | 97,541 |
Operating loss | (29,221) |  |  | (5,217) |  |  |  |  | (34,438) |  |  | (76,942) |  |  | (19,599) |  |  |  |  | (96,541) |
Other income, net | 2,087 |  | — |  |  |  |  | 2,087 |  | 6,545 |  | — |  |  |  |  | 6,545
Net loss | (27,134) |  |  | (5,217) |  |  |  |  | (32,351) |  |  | (70,397) |  |  | (19,599) |  |  |  |  | (89,996) |
Other comprehensive gain (loss): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net unrealized gain on marketable securities | 241 |  |  | — |  |  |  |  | 241 |  |  | 198 |  |  | — |  |  |  |  | 198 |
Foreign currency translation adjustment | 16 |  |  | — |  |  |  |  | 16 |  |  | 7 |  |  | — |  |  |  |  | 7 |
Comprehensive loss | $ | (26,877) |  |  | $ | (5,217) |  |  |  |  | $ | (32,094) |  |  | $ | (70,192) |  |  | $ | (19,599) |  |  |  |  | $ | (89,791) |
Net loss per share — basic and diluted | $ | (1.30) |  |  | — |  |  |  |  | $ | (1.55) |  |  | $ | (3.63) |  |  | — |  |  |  |  | $ | (4.64) |
Weighted-average common shares used to compute net loss per share - basic and diluted | 20,876 |  |  | — |  |  |  |  | 20,876 |  |  | 19,408 |  |  | — |  |  |  |  | 19,408 |
| Three Months Ended |  | Six Months Ended
| June 30, 2024 (unaudited) |  | June 30, 2024 (unaudited)
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated |  | As Previously Reported |  | Adjustment |  | Reference |  | As Restated
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development | $ | 17,097 |  |  | $ | — |  |  |  |  | $ | 17,097 |  |  | $ | 32,507 |  |  | $ | — |  |  |  |  | $ | 32,507 |
General and administrative | 3,785 |  |  | 12,022 |  |  | (a) (b) |  | 15,807 |  |  | 15,214 |  |  | 14,382 |  |  | (a) (b) |  | 29,596 |
Total operating expenses | 20,882 |  |  | 12,022 |  |  |  |  | 32,904 |  |  | 47,721 |  |  | 14,382 |  |  |  |  | 62,103 |
Operating loss | (20,882) |  |  | (12,022) |  |  |  |  | (32,904) |  |  | (47,721) |  |  | (14,382) |  |  |  |  | (62,103) |
Other income, net | 2,406 |  |  | — |  |  |  |  | 2,406 |  |  | 4,458 |  |  | — |  |  |  |  | 4,458 |
Net loss | (18,476) |  |  | (12,022) |  |  |  |  | (30,498) |  |  | (43,263) |  |  | (14,382) |  |  |  |  | (57,645) |
Other comprehensive gain (loss): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net unrealized loss on marketable securities | (2) |  |  | — |  |  |  |  | (2) |  |  | (43) |  |  | — |  |  |  |  | (43) |
Foreign currency translation adjustment | 10 |  |  | — |  |  |  |  | 10 |  |  | (9) |  |  | — |  |  |  |  | (9) |
Comprehensive loss | $ | (18,468) |  |  | (12,022) |  |  |  |  | $ | (30,490) |  |  | $ | (43,315) |  |  | $ | (14,382) |  |  |  |  | $ | (57,697) |
Net loss per share — basic and diluted | $ | (0.89) |  |  | — |  |  |  |  | $ | (1.46) |  |  | $ | (2.31) |  |  | — |  |  |  |  | $ | (3.08) |
Weighted-average common shares used to compute net loss per share - basic and diluted | 20,852 |  |  | — |  |  |  |  | 20,852 |  |  | 18,713 |  |  | — |  |  |  |  | 18,713 |
| Three Months Ended |  |
| March 31, 2024 (unaudited) |  |  |  |  |  |
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated |  |  |  |  |  |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development | $ | 15,410 |  |  | $ | — |  |  |  |  | $ | 15,410 |  |  |  |  |  |  |
General and administrative | 11,429 |  |  | 2,360 |  |  | (a) |  | 13,789 |  |  |  |  |  |  |
Total operating expenses | 26,839 |  |  | 2,360 |  |  |  |  | 29,199 |  |  |  |  |  |  |
Operating loss | (26,839) |  |  | (2,360) |  |  |  |  | (29,199) |  |  |  |  |  |  |
Other income, net | 2,052 |  |  | — |  |  |  |  | 2,052 |  |  |  |  |  |  |
Net loss | (24,787) |  |  | (2,360) |  |  |  |  | (27,147) |  |  |  |  |  |  |
Other comprehensive gain (loss): |  |  |  |  |  |  |  |  |  |  |  |  |
Net unrealized loss on marketable securities | (41) |  |  | — |  |  |  |  | (41) |  |  |  |  |  |  |
Foreign currency translation adjustment | (19) |  |  | — |  |  |  |  | (19) |  |  |  |  |  |  |
Comprehensive loss | $ | (24,847) |  |  | $ | (2,360) |  |  |  |  | $ | (27,207) |  |  |  |  |  |  |
Net loss per share — basic and diluted | $ | (1.50) |  |  | — |  |  |  |  | $ | (1.65) |  |  |  |  |  |  |
Weighted-average common shares used to compute net loss per share - basic and diluted | 16,479 |  |  | — |  |  |  |  | 16,479 |  |  |  |  |  |  |
| Three Months Ended |  | Nine Months Ended
| September 30, 2023 (unaudited) |  | September 30, 2023 (unaudited)
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated |  | As Previously Reported |  | Adjustment |  | Reference |  | As Restated
License revenue | $ | — |  |  | $ | — |  |  |  |  | $ | — |  |  | $ | 3,600 |  |  | $ | — |  |  |  |  | $ | 3,600 |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development | 20,740 |  |  | — |  |  |  |  | 20,740 |  |  | 62,398 |  |  | (190) |  |  | (c) |  | 62,208 |
General and administrative | 13,789 |  |  | 530 |  |  | (a) |  | 14,319 |  |  | 39,035 |  |  | 4,351 |  |  | (a) |  | 43,386 |
Total operating expenses | 34,529 |  |  | 530 |  |  |  |  | 35,059 |  |  | 101,433 |  |  | 4,161 |  |  |  |  | 105,594 |
Operating loss | (34,529) |  |  | (530) |  |  |  |  | (35,059) |  |  | (97,833) |  |  | (4,161) |  |  |  |  | (101,994) |
Other income, net | 1,661 |  | — |  |  |  |  | 1,661 |  | 4,437 |  | — |  |  |  |  | 4,437
Net loss before income taxes | (32,868) |  |  | (530) |  |  |  |  | (33,398) |  |  | (93,396) |  |  | (4,161) |  |  |  |  | (97,557) |
Income tax provision | (17) |  |  |  |  |  |  | (17) |  |  | (55) |  |  |  |  |  |  | (55) |
Net loss | (32,885) |  |  | (530) |  |  |  |  | (33,415) |  |  | (93,451) |  |  | (4,161) |  |  |  |  | (97,612) |
Other comprehensive gain (loss): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net unrealized gain on marketable securities | 66 |  |  | — |  |  |  |  | 66 |  |  | 1,003 |  |  | — |  |  |  |  | 1,003 |
Foreign currency translation adjustment | (12) |  |  | — |  |  |  |  | (12) |  |  | (24) |  |  | — |  |  |  |  | (24) |
Comprehensive loss | $ | (32,831) |  |  | (530) |  |  |  |  | $ | (33,361) |  |  | $ | (92,472) |  |  | $ | (4,161) |  |  |  |  | $ | (96,633) |
Net loss per share — basic and diluted | $ | (3.26) |  |  | — |  |  |  |  | $ | (3.31) |  |  | $ | (9.28) |  |  | — |  |  |  |  | $ | (9.69) |
Weighted-average common shares used to compute net loss per share - basic and diluted | 10,099 |  |  | — |  |  |  |  | 10,099 |  |  | 10,069 |  |  | — |  |  |  |  | 10,069 |
| Three Months Ended |  | Six Months Ended
| June 30, 2023 (unaudited) |  | June 30, 2023 (unaudited)
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated |  | As Previously Reported |  | Adjustment |  | Reference |  | As Restated
License revenue | $ | — |  |  | $ | — |  |  |  |  | $ | — |  |  | $ | 3,600 |  |  | $ | — |  |  |  |  | $ | 3,600 |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development | $ | 20,599 |  |  | $ | — |  |  |  |  | $ | 20,599 |  |  | $ | 41,658 |  |  | $ | (190) |  |  | (c) |  | $ | 41,468 |
General and administrative | 12,466 |  |  | 1,015 |  |  | (a) |  | 13,481 |  |  | 25,246 |  |  | 3,821 |  |  | (a) |  | 29,067 |
Total operating expenses | 33,065 |  |  | 1,015 |  |  |  |  | 34,080 |  |  | 66,904 |  |  | 3,631 |  |  |  |  | 70,535 |
Operating loss | (33,065) |  |  | (1,015) |  |  |  |  | (34,080) |  |  | (63,304) |  |  | (3,631) |  |  |  |  | (66,935) |
Other income, net | 1,576 |  |  | — |  |  |  |  | 1,576 |  |  | 2,776 |  |  | — |  |  |  |  | 2,776 |
Net loss before income taxes | (31,489) |  |  | (1,015) |  |  |  |  | (32,504) |  |  | (60,528) |  |  | (3,631) |  |  |  |  | (64,159) |
Income tax provision | (21) |  |  |  |  |  |  | (21) |  |  | (38) |  |  |  |  |  |  | (38) |
Net loss | (31,510) |  |  | (1,015) |  |  |  |  | (32,525) |  |  | (60,566) |  |  | (3,631) |  |  |  |  | (64,197) |
Other comprehensive gain (loss): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net unrealized gain on marketable securities | 198 |  |  | — |  |  |  |  | 198 |  |  | 937 |  |  | — |  |  |  |  | 937 |
Foreign currency translation adjustment | (5) |  |  | — |  |  |  |  | (5) |  |  | (12) |  |  | — |  |  |  |  | (12) |
Comprehensive loss | $ | (31,317) |  |  | (1,015) |  |  |  |  | $ | (32,332) |  |  | $ | (59,641) |  |  | $ | (3,631) |  |  |  |  | $ | (63,272) |
Net loss per share — basic and diluted | $ | (3.13) |  |  | — |  |  |  |  | $ | (3.23) |  |  | $ | (6.02) |  |  | — |  |  |  |  | $ | (6.39) |
Weighted-average common shares used to compute net loss per share - basic and diluted | 10,076 |  |  | — |  |  |  |  | 10,076 |  |  | 10,053 |  |  | — |  |  |  |  | 10,053 |
| Three Months Ended |  |
| March 31, 2023 (unaudited) |  |  |  |  |  |
| As Previously Reported |  | Adjustment |  | Reference |  | As Restated |  |  |  |  |  |
License revenue | $ | 3,600 |  |  | $ | — |  |  |  |  | $ | 3,600 |  |  |  |  |  |  |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development | $ | 21,059 |  |  | $ | (190) |  |  | (c) |  | $ | 20,869 |  |  |  |  |  |  |
General and administrative | 12,780 |  |  | 2,806 |  |  | (a) |  | 15,586 |  |  |  |  |  |  |
Total operating expenses | 33,839 |  |  | 2,616 |  |  |  |  | 36,455 |  |  |  |  |  |  |
Operating loss | (30,239) |  |  | (2,616) |  |  |  |  | (32,855) |  |  |  |  |  |  |
Other income, net | 1,200 |  |  | — |  |  |  |  | 1,200 |  |  |  |  |  |  |
Net loss before income taxes | (29,039) |  |  | (2,616) |  |  |  |  | (31,655) |  |  |  |  |  |  |
Income tax provision | (17) |  |  | — |  |  |  |  | (17) |  |  |  |  |  |  |
Net loss | (29,056) |  |  | (2,616) |  |  |  |  | (31,672) |  |  |  |  |  |  |
Other comprehensive gain (loss): |  |  |  |  |  |  |  |  |  |  |  |  |
Net unrealized gain on marketable securities | 739 |  |  | — |  |  |  |  | 739 |  |  |  |  |  |  |
Foreign currency translation adjustment | (7) |  |  | — |  |  |  |  | (7) |  |  |  |  |  |  |
Comprehensive loss | $ | (28,324) |  |  | (2,616) |  |  |  |  | $ | (30,940) |  |  |  |  |  |  |
Net loss per share — basic and diluted | $ | (2.90) |  |  | — |  |  |  |  | $ | (3.16) |  |  |  |  |  |  |
Weighted-average common shares used to compute net loss per share - basic and diluted | 10,030 |  |  | — |  |  |  |  | 10,030 |  |  |  |  |  |  |
Condensed Consolidated Statements of Cash Flows The effects of this restatement on certain line items of the condensed consolidated statements of cash flows are summarized in the following tables (in thousands). There was no impact on net cash used in operating activities or within any line items within investing and financing activities.
| Nine Months Ended September 30, 2024
| As Previously Reported |  | Adjustments |  | Reference |  | As Restated
Cash flows from operating activities: |  |  |  |  |  |  |
Net loss | $ | (70,397) |  |  | $ | (19,599) |  |  | (a) (b) |  | $ | (89,996) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |
Non-cash lease expense | 1,571 |  |  | 4,006 |  |  | (a) |  | 5,577 |
Non-cash sublease loss | — |  |  | 8,477 |  |  | (a) |  | 8,477 |
Changes in operating assets and liabilities: |  |  |  |  |  |  |
Deposit and other long-term assets and deferred rent receivable | (7,178) |  |  | 7,116 |  |  | (b) |  | (62) |
| Six Months Ended June 30, 2024
| As Previously Reported |  | Adjustments |  | Reference |  | As Restated
Cash flows from operating activities: |  |  |  |  |  |  |
Net loss | $ | (43,263) |  |  | $ | (14,382) |  |  | (a) (b) |  | $ | (57,645) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |
Non-cash lease expense | 1,029 |  |  | 2,654 |  |  | (a) |  | 3,683 |
Non-cash sublease loss | — |  |  | 4,765 |  |  | (a) |  | 4,765 |
Changes in operating assets and liabilities: |  |  |  |  |  |  |
Deposit and other long-term assets and deferred rent receivable | (6,894) |  |  | 6,963 |  |  | (b) |  | 69 |
| Three Months Ended March 31, 2024
| As Previously Reported |  | Adjustments |  | Reference |  | As Restated
Cash flows from operating activities: |  |  |  |  |  |  |
Net loss | $ | (24,787) |  |  | $ | (2,360) |  |  | (a) |  | $ | (27,147) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |
Non-cash lease expense | 506 |  |  | 1,314 |  |  | (a) |  | 1,820 |
Non-cash sublease loss | — |  |  | 1,046 |  |  | (a) |  | 1,046 |
| Nine Months Ended September 30, 2023
| As Previously Reported |  | Adjustments |  | Reference |  | As Restated
Cash flows from operating activities: |  |  |  |  |  |  |
Net loss | $ | (93,451) |  |  | $ | (4,161) |  |  | (a) (c) |  | $ | (97,612) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |
Non-cash lease expense | 12,466 |  |  | 3,916 |  |  | (a) |  | 16,382 |
Non-cash sublease loss | — |  |  | 435 |  |  | (a) |  | 435 |
Changes in operating assets and liabilities: |  |  |  |  |  |  | — |
Accrued expenses and other liabilities | (1,452) |  |  | (190) |  |  | (c) |  | (1,642) |
Supplemental schedule of noncash information |  |  |  |  |  |  |
Remeasurement of operating lease right-of-use assets | $ | 13,711 |  |  | $ | (6,079) |  |  |  |  | $ | 7,632 |
| Six Months Ended June 30, 2023
| As Previously Reported |  | Adjustments |  | Reference |  | As Restated
Cash flows from operating activities: |  |  |  |  |  |  |
Net loss | $ | (60,566) |  |  | $ | (3,631) |  |  | (a) (c) |  | (64,197) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |
Non-cash lease expense | 6,936 |  |  | 2,602 |  |  | (a) |  | 9,538 |
Non-cash sublease loss | — |  |  | 1,219 |  |  | (a) |  | 1,219 |
Changes in operating assets and liabilities: |  |  |  |  |  |  |
Accrued expenses and other liabilities | (525) |  |  | (190) |  |  | (c) |  | (715) |
Supplemental schedule of noncash information |  |  |  |  |  |  |
Remeasurement of operating lease right-of-use assets | $ | 13,711 |  |  | $ | (6,079) |  |  |  |  | $ | 7,632 |
| Three Months Ended March 31, 2023
| As Previously Reported |  | Adjustments |  | Reference |  | As Restated
Cash flows from operating activities: |  |  |  |  |  |  |
Net loss | $ | (29,056) |  |  | $ | (2,616) |  |  | (a) (c) |  | $ | (31,672) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |
Non-cash lease expense | 1,427 |  |  | 1,239 |  |  | (a) |  | 2,666 |
Non-cash sublease loss | — |  |  | 1,567 |  |  |  |  | 1,567 |
Changes in operating assets and liabilities: |  |  |  |  |  |  | — |
Accrued expenses and other liabilities | (749) |  |  | (190) |  |  | (c) |  | (939) |
Supplemental schedule of noncash information |  |  |  |  |  |  |
Remeasurement of operating lease right-of-use assets | $ | 8,004 |  |  | $ | (104) |  |  |  |  | $ | 7,900 |

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