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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Cash flows from operating activities:    
Net loss $ (143,862) $ (89,996)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,683 2,843
Stock-based compensation expense 7,550 11,075
Net accretion of discount on marketable securities (544) (1,293)
Non-cash lease expense 165 1,343
Non-cash sublease loss 982 8,477
Loss on disposal of property and equipment 8 2
Other 13 7
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 2,703 (1,592)
Deposit and other long-term assets (676) (62)
Accounts payable 10,842 187
Accrued expenses and other liabilities 10,815 2,335
Lease liability 668 2,461
Net cash used in operating activities (109,653) (64,213)
Cash flows from investing activities:    
Purchases of marketable securities (1,976) (82,773)
Maturities of marketable securities 67,500 45,400
Purchases of property and equipment (482) (327)
Net cash provided by (used in) investing activities 65,042 (37,700)
Cash flows from financing activities:    
Proceeds from issuance of common stock and pre-funded warrants in private placements, net of issuance costs 9,899 119,361
Proceeds from issuance of common stock pursuant to option exercises 0 139
Proceeds from employee stock purchase plan 120 264
Net cash provided by financing activities 10,019 119,764
Net (decrease) increase in cash and cash equivalents and restricted cash (34,592) 17,851
Cash and cash equivalents and restricted cash at beginning of period 62,628 76,976
Cash and cash equivalents and restricted cash at end of period 28,036 94,827
Cash and cash equivalents 26,060 92,851
Restricted cash 1,976 1,976
Cash and cash equivalents and restricted cash at end of period 28,036 94,827
Supplemental schedule of noncash investing and financing information    
Remeasurement of operating lease right-of-use assets 4,415 0
Issuance costs included in accrued expenses 41 0
Property and equipment in accounts payable, accrued expenses and other current liabilities $ 195 $ 60