<SEC-DOCUMENT>0001415889-25-017864.txt : 20250620
<SEC-HEADER>0001415889-25-017864.hdr.sgml : 20250620
<ACCEPTANCE-DATETIME>20250620162801
ACCESSION NUMBER:		0001415889-25-017864
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250617
FILED AS OF DATE:		20250620
DATE AS OF CHANGE:		20250620

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Ozden Rabia Gurses
		CENTRAL INDEX KEY:			0001814883
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36579
		FILM NUMBER:		251061786

	MAIL ADDRESS:	
		STREET 1:		C/O ADVERUM BIOTECHNOLOGIES, INC.
		STREET 2:		100 CARDINAL WAY
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Adverum Biotechnologies, Inc.
		CENTRAL INDEX KEY:			0001501756
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				205258327
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		100 CARDINAL WAY
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
		BUSINESS PHONE:		(650) 649-1004

	MAIL ADDRESS:	
		STREET 1:		100 CARDINAL WAY
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Avalanche Biotechnologies, Inc.
		DATE OF NAME CHANGE:	20100921
</SEC-HEADER>
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<SEQUENCE>1
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    <periodOfReport>2025-06-17</periodOfReport>

    <issuer>
        <issuerCik>0001501756</issuerCik>
        <issuerName>Adverum Biotechnologies, Inc.</issuerName>
        <issuerTradingSymbol>ADVM</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001814883</rptOwnerCik>
            <rptOwnerName>Ozden Rabia Gurses</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ADVERUM BIOTECHNOLOGIES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>100 CARDINAL WAY</rptOwnerStreet2>
            <rptOwnerCity>REDWOOD CITY</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94063</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>Chief Medical Officer</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable></nonDerivativeTable>

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            </securityTitle>
            <conversionOrExercisePrice>
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                <footnoteId id="F1"/>
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                <transactionAcquiredDisposedCode>
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            </transactionAmounts>
            <exerciseDate>
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            <expirationDate>
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            <underlyingSecurity>
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        </derivativeTransaction>
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        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
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                    <footnoteId id="F1"/>
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                <underlyingSecurityTitle>
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                </underlyingSecurityTitle>
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                    <value>4000</value>
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                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Effective March 21, 2024, the Issuer effected a reverse stock split (the &quot;Reverse Split&quot;) whereby every ten shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase ten shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by ten.</footnote>
        <footnote id="F2">The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the &quot;old&quot; option and the grant of a replacement option. The option was originally granted on March 17, 2022 and is fully vested.</footnote>
        <footnote id="F3">The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the &quot;old&quot; option and the grant of a replacement option. The option was originally granted on June 9, 2023 and is fully vested.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Aneta Fergson, Attorney-in-Fact</signatureName>
        <signatureDate>2025-06-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
