<SEC-DOCUMENT>0001193125-25-249438.txt : 20251024
<SEC-HEADER>0001193125-25-249438.hdr.sgml : 20251024
<ACCEPTANCE-DATETIME>20251024091959
ACCESSION NUMBER:		0001193125-25-249438
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		18
CONFORMED PERIOD OF REPORT:	20251024
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant
ITEM INFORMATION:		Regulation FD Disclosure
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20251024
DATE AS OF CHANGE:		20251024

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Adverum Biotechnologies, Inc.
		CENTRAL INDEX KEY:			0001501756
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				205258327
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36579
		FILM NUMBER:		251414495

	BUSINESS ADDRESS:	
		STREET 1:		100 CARDINAL WAY
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
		BUSINESS PHONE:		(650) 649-1004

	MAIL ADDRESS:	
		STREET 1:		100 CARDINAL WAY
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Avalanche Biotechnologies, Inc.
		DATE OF NAME CHANGE:	20100921
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<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"> <p style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Title of each class</p></td>
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<td style="width:11%;vertical-align:top;text-align:left"><span style="font-weight:bold">Item&#8201;1.01</span></td>
<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold;text-align:left">Entry into a Material Definitive Agreement. </p></td></tr></table> <p style="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold"><span style="font-style:italic">Agreement and Plan of Merger </span></p> <p style="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">On October&#160;24, 2025, Adverum Biotechnologies, Inc., a Delaware corporation (&#8220;Adverum Biotechnologies&#8221; or the &#8220;Company&#8221;), entered into an Agreement and Plan of Merger (the &#8220;Merger Agreement&#8221;) with Eli Lilly and Company, an Indiana corporation (&#8220;Parent&#8221;), and Flying Tigers Acquisition Corporation, a Delaware corporation and direct wholly owned subsidiary of Parent (&#8220;Purchaser&#8221;). </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Pursuant to the Merger Agreement, and upon the terms and subject to the conditions thereof, Purchaser will commence a tender offer (the &#8220;Offer&#8221;) to purchase all of the issued and outstanding shares (the &#8220;Shares&#8221;) of common stock, par value $0.0001 per share (the &#8220;Company Common Stock&#8221;), of the Company in exchange for (i)&#160;$3.56 per Share, net to the stockholder in cash, without interest (the &#8220;Closing Amount&#8221;) and less any applicable tax withholding, plus <span style="white-space:nowrap">(ii)&#160;one&#160;non-tradable&#160;contingent</span> value right (each, a &#8220;CVR&#8221;), which represents the contractual right to receive up to two contingent cash payments of up to an aggregate of $8.91 per CVR, net to the stockholder in cash, without interest and less any applicable tax withholding, upon the achievement of both specified milestones in accordance with the terms and subject to the conditions of a contingent value rights agreement (the &#8220;CVR Agreement&#8221;) to be entered into with a rights agent selected by Parent and reasonably acceptable to the Company (the &#8220;Rights Agent&#8221;) (the Closing Amount plus one CVR, collectively, the &#8220;Offer Price&#8221;). </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Following the consummation of the Offer, and subject to the terms and conditions of the Merger Agreement, Purchaser will merge with and into the Company as provided in the Merger Agreement (the &#8220;Merger&#8221;), with the Company being the surviving corporation of the Merger (the &#8220;Surviving Corporation&#8221;). The Merger Agreement contemplates that the Merger will be effected pursuant to Section&#160;251(h) of the General Corporation Law of the State of Delaware (the &#8220;DGCL&#8221;), which permits completion of the Merger without a stockholder vote promptly following consummation of the Offer. At the effective time of the Merger (the &#8220;Effective Time&#8221;), each Share (other than (i)&#160;Shares held in the treasury of the Company or owned by the Company, (ii)&#160;Shares owned by Parent, Purchaser or any direct or indirect wholly owned subsidiary of Parent or Purchaser or (iii)&#160;Shares held by stockholders who are entitled to demand and properly exercised and perfected their respective demands for appraisal for such Shares in accordance with Section&#160;262 of the DGCL (the &#8220;Dissenting Shares&#8221;)) will be automatically cancelled and converted into the right to receive the Offer Price from Purchaser (the &#8220;Merger Consideration&#8221;). </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The obligation of Parent and Purchaser to consummate the Offer is subject to the condition that there be validly tendered and not validly withdrawn prior to the expiration of the Offer a number of Shares that, together with the number of Shares, if any, then owned beneficially by Parent and Purchaser (together with their wholly owned subsidiaries) represents a majority of the Shares outstanding as of the consummation of the Offer (the &#8220;Minimum Tender Condition&#8221;). The Minimum Tender Condition may not be waived by Purchaser without the prior written consent of the Company. The obligation of Purchaser to consummate the Offer is also conditioned upon, among other things, the absence of governmental injunctions or other legal restraints prohibiting the Merger, the accuracy of the representations and warranties of the Company (subject to certain materiality exceptions), material compliance by the Company with its covenants under the Merger Agreement and no triggering event under the Note (as defined below) having occurred. Consummation of the Merger and the Offer is not subject to a financing condition. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Merger Agreement provides for the following treatment of the Company&#8217;s equity awards: </p> <p style="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
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<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt;text-align:left">at the Effective Time, each option to purchase Shares granted under a Company Equity Plan (as defined in the Merger Agreement) (each, a &#8220;Company Stock Option&#8221;), with a per share exercise price that is less than the Closing Amount, that is outstanding immediately prior to the Effective Time, whether or not vested (each such option, a &#8220;Company <span style="white-space:nowrap">Cash-Out</span> Stock Option&#8221;), will be cancelled and converted into the right to receive (i)&#160;an amount in cash, without interest and less any applicable tax withholdings, equal to the product of (x)&#160;the total number of Shares subject to such Company <span style="white-space:nowrap">Cash-Out</span> Stock Option immediately prior to the Effective Time multiplied by (y)&#160;the excess, if any, of the Closing Amount over the applicable exercise price per Share under such Company <span style="white-space:nowrap">Cash-Out</span> Stock Option and (ii)&#160;one CVR for each Share subject to such Company <span style="white-space:nowrap">Cash-Out</span> Stock Option immediately prior to the Effective Time (without regard to vesting); </p></td></tr></table> <p style="font-size:18pt; margin-top:0pt; margin-bottom:0pt">&#160;</p>
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<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt;text-align:left">each Company Stock Option that has an exercise price equal to or greater than the Closing Amount that is outstanding immediately prior to the Effective Time (each such Company Stock Option, an <span style="white-space:nowrap"><span style="white-space:nowrap"><span style="white-space:nowrap">&#8220;Out-of-the-Money</span></span></span> Option&#8221;), to the extent not vested, will become fully vested as of prior to the Effective Time, and the Company shall permit the holders of <span style="white-space:nowrap"><span style="white-space:nowrap"><span style="white-space:nowrap">Out-of-the-Money</span></span></span> Options to exercise such options prior to the Effective Time on a basis that allows such holders to participate in the Merger, as a holder of Shares, with respect to any Shares acquired under such <span style="white-space:nowrap"><span style="white-space:nowrap"><span style="white-space:nowrap">Out-of-the-Money</span></span></span> Options. Any <span style="white-space:nowrap"><span style="white-space:nowrap"><span style="white-space:nowrap">Out-of-the-Money</span></span></span> Options that remain outstanding and unexercised as of the Effective Time will be cancelled for no consideration at the Effective Time; </p></td></tr></table> <p style="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
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<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt;text-align:left">at the Effective Time, each restricted stock unit granted under a Company Equity Plan that is subject solely to time-based vesting (&#8220;Company RSU&#8221;) that is outstanding and unvested immediately prior to the Effective Time shall be cancelled and in exchange for such cancellation, the holder of such cancelled Company RSU will be entitled to receive (i)&#160;an amount in cash, without interest and less any applicable tax withholdings, equal to the product of (x)&#160;the total number of Shares subject to such Company RSU immediately prior to the Effective Time, multiplied by (y)&#160;the Closing Amount and (ii)&#160;one CVR for each share of Company Common Stock subject to such Company RSU immediately prior to the Effective Time (without regard to vesting); </p></td></tr></table> <p style="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
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<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt;text-align:left">at the Effective Time, each restricted stock unit granted under a Company Equity Plan that is subject solely to performance-based vesting (&#8220;Company PSU&#8221;) that is outstanding and unvested immediately prior to the Effective Time, shall be cancelled and in exchange for such cancellation, the holder of such cancelled Company PSU will be entitled to receive (i)&#160;an amount in cash, without interest and less any applicable tax withholdings, equal to the product of (x)&#160;the total number of Shares subject to such Company PSU immediately prior to the Effective Time, multiplied by (y)&#160;the Closing Amount and (ii)&#160;one CVR for each share of Company Common Stock subject to such Company PSU immediately prior to the Effective Time (without regard to vesting); and </p></td></tr></table> <p style="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
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<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt;text-align:left">each Company Equity Plan and award agreement thereunder shall be terminated effective as of the Effective Time. </p></td></tr></table> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">In early&#160;September 2025, the Compensation Committee of the Company Board approved the grant of Company PSUs to employees and a consultant, effective following the public announcement of the earlier of a significant <span style="white-space:nowrap">out-licensing</span> transaction or a change of control of the Company.&#160;Accordingly, in connection with the Merger, Company PSU grants covering a total of 1,959,880 shares of Company Common Stock will become effective. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Pursuant to the terms and conditions of the Merger Agreement, each warrant to purchase Shares specified in the Merger Agreement (the &#8220;Warrants&#8221;) that is issued and outstanding immediately prior to the Effective Time, unless the holder of any such Warrant elects otherwise, shall be issued a replacement warrant. The replacement warrant shall be exercisable for (A)&#160;an amount in cash (less applicable tax withholdings) equal to the product of (1)&#160;the total number of Shares in respect of such Warrant; multiplied by (2)&#160;the excess, if any, of the Closing Amount over the per Share exercise price under such Warrant and (B)&#160;one CVR for each Share in respect of such Warrant immediately prior to the Effective Time. If the per share exercise price under any Warrant is equal to or greater than the Merger Consideration, such Warrant shall be cancelled as of the Effective Time without payment. The Company is required to use reasonable best efforts to cause each holder of a Warrant to exercise such Warrant prior to the Effective Time. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Merger Agreement includes customary representations, warranties and covenants of the Company, Parent and Purchaser. The Company has agreed, among other things, to operate its business in the ordinary course until the earlier of the time at which Purchaser irrevocably accepts for purchase all Shares validly tendered (and not validly withdrawn) pursuant to the Offer (the &#8220;Acceptance Time&#8221;) or the date the Merger Agreement is terminated, and not to engage in specified types of transactions during such period. The Company has also agreed to <span style="white-space:nowrap">customary&#160;non-solicitation&#160;restrictions,</span> including not to initiate, solicit, encourage or facilitate discussions with third parties regarding other alternative acquisition proposals involving the Company or change the recommendation of the Company&#8217;s board of directors (the &#8220;Company Board&#8221;) to the Company&#8217;s stockholders regarding the Offer, in each case, except as otherwise permitted by the Merger Agreement, including to enter into an alternative transaction that constitutes a Superior Proposal (as defined in the Merger Agreement) in compliance with the Company Board&#8217;s fiduciary duties under applicable law and subject to payment of a termination fee of $4,000,000. </p> <p style="font-size:18pt; margin-top:0pt; margin-bottom:0pt">&#160;</p>
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 <p style="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Merger Agreement also includes customary termination provisions for both the Company and Parent, including, among others, the right of both parties to terminate for failure to consummate the Offer on or before January&#160;22, 2026, being the 90<sup style="font-size:75%; vertical-align:top">th</sup> day after the date of the Merger Agreement. If the Merger Agreement is terminated under certain circumstances specified in the Merger Agreement, the Company will be required to pay Parent a termination fee of $4,000,000 (including under specified circumstances in connection with the Company&#8217;s entry into an agreement with respect to a Superior Proposal or the Company Board&#8217;s change of recommendation in favor of the Offer). The Merger Agreement also provides that the Company, on the one hand, or Parent and Purchaser, on the other hand, may specifically enforce the obligations under the Merger Agreement. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Company Board has unanimously (i)&#160;determined that the transactions contemplated by the Merger Agreement, the CVR Agreement and the Note (as defined below), including the Offer and the Merger, are advisable and fair to, and in the best interests of, the Company and its stockholders, (ii)&#160;approved the execution, delivery and performance by the Company of the Merger Agreement and the consummation of transactions contemplated thereby, including the Offer and the Merger, approved the CVR Agreement and the transactions contemplated thereby and approved the execution, delivery and performance by the Company of the Note and the transactions contemplated thereby, (iii)&#160;resolved that the Merger will be effected under Section&#160;251(h) of the DGCL, and (iv)&#160;resolved to recommend that the Company&#8217;s stockholders accept the Offer and tender their Shares pursuant to the Offer. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The foregoing description of the Merger Agreement and the transactions contemplated thereunder does not purport to be complete and is qualified in its entirety by reference to the Merger Agreement, a copy of which is filed as Exhibit 2.1 hereto and which is incorporated herein by reference. The Merger Agreement has been filed to provide information to investors regarding its terms. The Merger Agreement is not intended to provide any other factual information about the Company, Parent or Purchaser, their respective businesses, or the actual conduct of their respective businesses during the period prior to the consummation of the Offer, the Merger or otherwise. The Merger Agreement and this summary should not be relied upon as disclosure about the Company or Parent. None of the Company&#8217;s stockholders or any other third parties should rely on the representations, warranties and covenants or any descriptions thereof as characterizations of the actual state of facts or conditions of the Company, Parent, Purchaser or any of their respective subsidiaries or affiliates. The Merger Agreement contains representations and warranties that are the product of negotiations among the parties thereto and that the parties made to, and solely for the benefit of, each other as of specified dates. The assertions embodied in those representations and warranties are subject to qualifications and limitations agreed to by the respective parties and are also qualified in important part by confidential disclosure schedules delivered by the Company to Parent and Purchaser in connection with the Merger Agreement. The representations and warranties may have been made for the purpose of allocating contractual risk among the parties to the Merger Agreement and may be subject to standards of materiality applicable to the contracting parties that differ from those applicable to stockholders or investors. Accordingly, investors should consider the information in the Merger Agreement in conjunction with the entirety of the factual disclosure about the Company in the Company&#8217;s public reports filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;). Information concerning the subject matter of the representations and warranties may change after the date of the Merger Agreement, which subsequent information may or may not be fully reflected in the Company&#8217;s public disclosures if such updates are not required by law. </p> <p style="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold"><span style="font-style:italic">Contingent Value Rights Agreement </span></p> <p style="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">At or prior to the Acceptance Time, Parent and the Rights Agent will enter into the CVR Agreement. Pursuant to and subject to the terms and conditions of the Merger Agreement, holders of Shares (other than (i)&#160;Shares held in the treasury of the Company or owned by the Company, (ii)&#160;Shares owned by Parent, Purchaser or any direct or indirect wholly owned subsidiary of Parent or Purchaser and (iii)&#160;Dissenting Shares), Company RSUs, Company PSUs, Company <span style="white-space:nowrap">Cash-Out</span> Stock Options and Warrants (other than Warrants that have an exercise price that equals or exceeds the Merger Consideration) will be entitled to one CVR for each Share outstanding (A)&#160;that Purchaser accepts for payment from such holder pursuant to the Offer or (B)&#160;owned by or issued to such holder as of immediately prior to the Effective Time and converted into the right to receive the Merger Consideration pursuant to the Merger Agreement. Each holder of a Company <span style="white-space:nowrap">Cash-Out</span> Stock Option, whether or not vested, will be entitled to </p> <p style="font-size:18pt; margin-top:0pt; margin-bottom:0pt">&#160;</p>
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one CVR for each Share subject to such Company <span style="white-space:nowrap">Cash-Out</span> Stock Option. The CVRs are contractual rights only and not transferable except under certain limited circumstances, will not be certificated or evidenced by any instrument and will not be registered with the SEC or listed for trading. The CVRs will not have any voting or dividend rights and will not represent any equity or ownership interest in Parent, Purchaser or the Company or any of their affiliates. </p> <p style="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Each CVR represents a <span style="white-space:nowrap">non-tradable</span> contractual contingent right to receive up to two contingent cash payments (each a &#8220;Milestone Payment,&#8221; and collectively, the &#8220;Milestone Payments&#8221;) upon the achievement of certain specified milestones related to the development of any pharmaceutical product that contains or incorporates ixoberogene soroparvovec, formerly referred to as <span style="white-space:nowrap">ADVM-022,</span> alone or in combination with one or more other therapeutically active ingredients, including all formulations, dosages, or modes of delivery thereof (the <span style="white-space:nowrap">&#8220;Ixo-vec</span> Product&#8221;). </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Milestone Payments comprise the First Milestone Payment and the Second Milestone Payment, each payable upon the achievement of certain specified regulatory and commercial milestones within specified time periods, as follows: </p> <p style="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
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<td style="width:6%;vertical-align:top;text-align:left">(i)</td>
<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">the First Milestone Payment is an amount equal to $1.78 per CVR minus any Milestone Offset Amount (as defined below), if any, in cash, without interest, payable if regulatory approval is received in the United States for the <span style="white-space:nowrap">Ixo-vec</span> Product for the treatment of wet <span style="white-space:nowrap">age-related</span> macular degeneration prior to the earlier of (a) 12:00 a.m. New York City Time on the seventh (7th) anniversary of the Closing Date (as defined in the Merger Agreement), and (b)&#160;termination of the CVR Agreement (&#8220;Milestone 1&#8221;); and </p></td></tr></table> <p style="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
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<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">the Second Milestone Payment is an amount equal to $7.13 per CVR minus any Milestone Offset Amount, if any and to the extent not deducted from the First Milestone Payment, in cash, without interest, payable if annual worldwide net sales of the <span style="white-space:nowrap">Ixo-vec</span> Product sold by Parent or its affiliates or licensees first exceed $1.0&#160;billion prior to the earlier of (a)&#160;the tenth (10th) anniversary of the Closing Date, and (b)&#160;termination of the CVR Agreement. </p></td></tr></table> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Milestone Offset Amount is an amount equal to 50% of any payments that Parent or any of its affiliates or their respective successors or permitted assigns makes or is obligated to make in exchange for any license to, or other right to use or practice any necessary intellectual property that is necessary or reasonably useful to develop, manufacture or commercialize an <span style="white-space:nowrap">Ixo-vec</span> Product, divided by the total number of CVRs held by all eligible holders. The Milestone Offset Amount shall in no event exceed a maximum of $0.50 per CVR. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The CVR Agreement provides that Parent will use a contractually defined level of efforts to achieve Milestone 1. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Any potential payouts of the CVR are subject to various risks and uncertainties related to the development of the <span style="white-space:nowrap">Ixo-vec</span> Product, regulatory approvals related to commercialization of the <span style="white-space:nowrap">Ixo-vec</span> Product including any approval of a Biologics License Application or New Drug Application, and third-party patent claims as more fully described in the Company&#8217;s periodic reports filed with the SEC. The Company is not currently aware of any third-party patent claims related to the <span style="white-space:nowrap">Ixo-vec</span> Product that the Company believes would materially impact the payouts of the CVR. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">There can be no assurance that either of the Milestones will be achieved prior to their respective expiration dates. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The foregoing description of the form of CVR Agreement does not purport to be complete and is qualified in its entirety by reference to the form of CVR Agreement, a copy of which is included as Annex IV to the Merger Agreement filed as Exhibit 2.1 to this report and incorporated by reference herein. </p> <p style="font-size:18pt; margin-top:0pt; margin-bottom:0pt">&#160;</p>
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 <p style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold"><span style="font-style:italic">Secured Promissory Note </span></p> <p style="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">On October&#160;24, 2025, in connection with the Merger Agreement, the Company also entered into a Secured Promissory Note (the &#8220;Note&#8221;) with Parent, pursuant to which Parent agreed to provide up to $65.0&#160;million in secured debt financing to the Company. Under the terms of the Note, Parent will make up to four advances to the Company in the following amounts and on the following dates: (i) $5.0&#160;million on October&#160;28, 2025, (ii) $15.0&#160;million on November&#160;7, 2025, (iii) $20.0&#160;million on November&#160;21, 2025, and (iv) $25.0&#160;million on December&#160;5, 2025, in each case subject to the prior satisfaction of certain funding conditions specified in the Note, including conditions relating to the Company&#8217;s adherence to an agreed funding plan and the absence of a change in the Company Board&#8217;s recommendation under the Merger Agreement. Advances will not be available following the termination of the Merger Agreement. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Advances under the Note bear interest at a rate equal to SOFR plus 10.0% per annum, compounded <span style="white-space:nowrap">bi-weekly.</span> The maturity date of the Note is January&#160;22, 2026. The Note includes a 5.0% prepayment premium applicable to any prepayment or acceleration of the obligations under the Note. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Note contains customary representations, warranties, covenants, and events of default, including restrictions on incurring additional indebtedness, granting liens, making investments, and transferring assets. Upon the occurrence of certain triggering events, including payment defaults, breaches of covenants, insolvency proceedings, or any termination of the Merger Agreement, Parent may accelerate the obligations under the Note. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Company&#8217;s obligations under the Note are guaranteed by each of its subsidiaries and are secured by a first-priority lien on substantially all of the Company&#8217;s and such guarantors&#8217; assets, including intellectual property, accounts, inventory, equipment, and other collateral as defined in the Note. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The proceeds of the Note are to be used exclusively to fund the Company&#8217;s working capital needs in accordance with an agreed-upon itemized funding plan and to support clinical development activities as outlined in the operating plan attached to the Note. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The foregoing description of the Note does not purport to be complete and is qualified in its entirety by reference to the full text of the Note, a copy of which is attached as Exhibit 10.1 hereto, and incorporated by reference herein. </p> <p style="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
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<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold;text-align:left">Creation of a Direct Financial Obligation or an Obligation under an <span style="white-space:nowrap">Off-Balance</span> Sheet Arrangement of a Registrant. </p></td></tr></table> <p style="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The information set forth in Item 1.01 of this report under the caption titled &#8220;Secured Promissory Note&#8221;, including Exhibit 10.1 attached hereto, is incorporated by reference in this Item 2.03. </p> <p style="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
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<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold;text-align:left">Regulation FD Disclosure. </p></td></tr></table> <p style="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">On October&#160;24, 2025, the Company and Parent issued a joint press release announcing the execution of the Merger Agreement. A copy of the joint press release is attached as Exhibit 99.1 hereto and is incorporated herein by reference. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The information contained in this Item 7.01 of this report, including Exhibit 99.1 attached hereto, is furnished pursuant to Item 7.01 of <span style="white-space:nowrap">Form&#160;8-K&#160;and</span> shall not be deemed &#8220;filed&#8221; for purposes of Section&#160;18 of the Securities Exchange Act of 1934, as amended, or subject to the liabilities of that section. The information shall not be deemed incorporated by reference into any other filing with the SEC made by the Company regardless of any general incorporation language in such filing, except as shall be expressly set forth by specific reference in such filing. </p> <p style="font-size:18pt; margin-top:0pt; margin-bottom:0pt">&#160;</p>
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<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold;text-align:left">Financial Statements and Exhibits. </p></td></tr></table> <p style="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">(d) Exhibits. </p> <p style="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
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<td style="vertical-align:top"><a href="d70157dex21.htm">Agreement and Plan of Merger, dated October&#160;24, 2025, by and among Eli Lilly and Company, Flying Tigers Acquisition Corporation and Adverum Biotechnologies, Inc.</a></td></tr>
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<td style="vertical-align:top"><a href="d70157dex101.htm">Secured Promissory Note, dated October&#160;24, 2025, by and between Eli Lilly and Company and Adverum Biotechnologies, Inc.</a></td></tr>
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<td style="vertical-align:top"><a href="d70157dex991.htm">Joint Press Release of Eli Lilly and Company and Adverum Biotechnologies, Inc., dated October&#160;24, 2025.</a></td></tr>
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<td style="vertical-align:top;white-space:nowrap">104</td>
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<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">Certain annexes, exhibits and schedules have been omitted pursuant to Item 601(a)(5) or Item 601(b)(2) of Regulation <span style="white-space:nowrap">S-K.</span> The Company agrees to furnish supplementally a copy of any omitted exhibit or schedule to the SEC upon request; provided, however, that the Company may request confidential treatment pursuant to Rule <span style="white-space:nowrap">24b-2</span> of the Exchange Act for any schedule so furnished. </p></td></tr></table> <p style="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold"><span style="text-decoration:underline">Cautionary Note Regarding Forward-Looking Statements </span></p> <p style="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">This Current Report on Form <span style="white-space:nowrap">8-K</span> contains forward-looking statements that involve risks and uncertainties relating to future events and the future performance of the Company and Parent, including statements relating to the ability to complete and the timing of completion of the transactions contemplated by the Merger Agreement, including the anticipated occurrence, manner and timing of the proposed Offer, the parties&#8217; ability to satisfy the conditions to the consummation of the Offer and the other conditions to the consummation of the subsequent merger set forth in the Merger Agreement, the possibility of any termination of the Merger Agreement, the prospective benefits of the proposed transaction, the Company&#8217;s cash runway and prospects, the potential availability of financing under the Note, the Company&#8217;s product candidates and ongoing clinical and preclinical development, Parent&#8217;s development of programs for ophthalmology and advancement of gene therapies and other statements that are not historical facts. 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and its ability to continue as a going concern; and other risks and uncertainties affecting the Company and Parent, including those described from time to time under the caption &#8220;Risk Factors&#8221; and elsewhere in the Company&#8217;s filings and reports with the SEC, including the Company&#8217;s Annual Report on Form <span style="white-space:nowrap">10-K</span> for the fiscal year ended December&#160;31, 2024 and Quarterly Reports on Form <span style="white-space:nowrap">10-Q</span> for the quarterly periods ended March&#160;31, 2025, and June&#160;30, 2025 as well as the Tender Offer Statement on Schedule TO and related tender offer documents to be filed by Parent and its acquisition subsidiary, and the Solicitation/Recommendation Statement on Schedule <span style="white-space:nowrap">14D-9</span> to be filed by the Company. Any forward-looking statements are made based on the current beliefs and judgments of the Company&#8217;s and Parent&#8217;s management, and the reader is cautioned not to rely on any forward-looking statements made by the Company or Parent. 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The description contained in this Current Report on Form <span style="white-space:nowrap">8-K</span> is for informational purposes only, is not a recommendation and is neither an offer to purchase nor a solicitation of an offer to sell any securities, nor is it a substitute for the tender offer materials that Parent and Purchaser will file with the SEC upon commencement of the tender offer. The solicitation and offer to buy outstanding shares of the Company&#8217;s common stock will only be made pursuant to the tender offer materials that Parent and Purchaser will file with the SEC. At the time the Offer is commenced, Parent and Purchaser will file a tender offer statement on Schedule TO and thereafter the Company will file a solicitation/recommendation statement on Schedule <span style="white-space:nowrap">14D-9</span> with the SEC with respect to the Offer. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">THE TENDER OFFER MATERIALS (INCLUDING AN OFFER TO PURCHASE, A RELATED LETTER OF TRANSMITTAL AND CERTAIN OTHER OFFER DOCUMENTS) AND THE SOLICITATION/RECOMMENDATION STATEMENT ON SCHEDULE <span style="white-space:nowrap">14D-9WILL</span> CONTAIN IMPORTANT INFORMATION ABOUT THE PROPOSED ACQUISITION AND THE PARTIES THERETO. INVESTORS AND STOCKHOLDERS OF THE COMPANY ARE URGED TO READ THESE DOCUMENTS CAREFULLY WHEN THEY BECOME AVAILABLE (AND EACH AS IT MAY BE AMENDED OR SUPPLEMENTED FROM TIME TO TIME) BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION THAT INVESTORS AND STOCKHOLDERS SHOULD CONSIDER BEFORE MAKING ANY DECISION REGARDING TENDERING THEIR SHARES OF COMMON STOCK IN THE OFFER. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The tender offer materials (including the offer to purchase and the related the letter of transmittal) as well as the solicitation/recommendation statement, will be made available to all stockholders of the Company at no expense to them at the Company&#8217;s website at https://investors.adverum.com and (once they become available) will be mailed to stockholders of the Company free of charge. The information contained in, or that can be accessed through, the Company&#8217;s website is not a part of, or incorporated by reference in, this filing. The tender offer materials (including the offer to purchase and the related the letter of transmittal) as well as the solicitation/recommendation statement, will also be available for free at the SEC&#8217;s website at www.sec.gov. </p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">In addition to the offer to purchase, the related letter of transmittal and certain other tender offer documents, as well as the solicitation/recommendation statement, the Company and Parent file annual, quarterly and current reports, proxy statements and other information with the SEC. 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<td style="vertical-align:bottom" colspan="3"><span style="font-weight:bold">ADVERUM BIOTECHNOLOGIES, INC.</span></td></tr>
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<td style="vertical-align:bottom">Date: October&#160;24, 2025</td>
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<td style="vertical-align:top">By:</td>
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<td style="vertical-align:bottom"> <p style="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Laurent Fischer</p></td></tr>
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<td style="vertical-align:bottom"> <p style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Laurent Fischer, M.D.</p> <p style="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">President and Chief Executive Officer</p></td></tr>
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<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Exhibit 2.1 </B></P>
<P STYLE="font-size:24pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #000000">&nbsp;
</DIV><DIV STYLE="line-height:3.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000">&nbsp;</DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>AGREEMENT AND PLAN OF
MERGER </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">among </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ELI
LILLY AND COMPANY, </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>FLYING TIGERS ACQUISITION CORPORATION </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ADVERUM BIOTECHNOLOGIES,
INC. </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">Dated as of October&nbsp;24, 2025 </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #000000">&nbsp;
</DIV><DIV STYLE="line-height:3.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000">&nbsp;</DIV> <P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>TABLE OF CONTENTS </B></P>
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<TD VALIGN="bottom" COLSPAN="2" ALIGN="center"><B>Page</B></TD>
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<TD VALIGN="top" COLSPAN="3"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">ARTICLE I THE OFFER</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">2</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1.1.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>The Offer</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">2</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1.2.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Company Consent; Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">4</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1.3.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Stockholder Lists</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">5</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD VALIGN="top" COLSPAN="3"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">ARTICLE II THE MERGER</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">5</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.1.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>The Merger</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">5</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.2.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Closing; Effective Time</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">6</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.3.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Effects of the Merger</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">6</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.4.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Certificate of Incorporation and Bylaws of the Surviving Corporation.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">6</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.5.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Directors</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">6</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.6.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Merger Without a Vote of Stockholders</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">6</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD HEIGHT="8" COLSPAN="3"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">ARTICLE III EFFECT OF THE MERGER ON THE CAPITAL STOCK OF THE CONSTITUENT
CORPORATIONS</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.1.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Conversion of Securities</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.2.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Treatment of Equity Awards.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.4.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Dissenting Shares.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">9</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.5.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Surrender of Shares.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">10</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.6.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Section&nbsp;16 Matters</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">12</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.7.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Withholding</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">12</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.8.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Transfer Taxes</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">12</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD HEIGHT="8" COLSPAN="3"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">ARTICLE IV REPRESENTATIONS AND WARRANTIES OF THE COMPANY</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">12</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
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<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.1.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Organization and Corporate Power; Subsidiaries.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">13</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.2.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Authorization; Valid and Binding Agreement</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">13</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.3.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Capital Stock.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">14</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.4.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>No Breach</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">16</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.5.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Consents</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">16</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.6.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>SEC Reports; Disclosure Controls and Procedures.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">16</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.7.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>No Undisclosed Liabilities</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.8.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Absence of Certain Developments.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.9.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Compliance with Laws.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.10.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Title to Tangible Properties.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">19</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.11.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Tax Matters.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.12.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Contracts and Commitments.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">21</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.13.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Intellectual Property.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">24</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.14.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Litigation</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">26</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.15.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Insurance</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">26</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.16.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Employee Benefit Plans.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">27</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.17.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Environmental Compliance and Conditions</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">29</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.18.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Employment and Labor Matters.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">29</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.19.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Regulatory and Compliance Matters.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">31</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.21.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Brokerage</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">36</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.22.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>No Rights Agreement; Anti-Takeover Provisions</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">36</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.23.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Opinion</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">36</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.24.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>No Vote Required</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">36</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">i </P>

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<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
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<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


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<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="86%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
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<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.25.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Affiliate Transactions</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">36</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.26.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>No Other Representations and Warranties</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">37</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8" COLSPAN="3"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">ARTICLE V REPRESENTATIONS AND WARRANTIES OF PARENT AND PURCHASER</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">37</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.1.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Organization and Corporate Power</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">37</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.2.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Authorization; Valid and Binding Agreement</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">37</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.3.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>No Breach</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">38</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.4.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Consents</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">38</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.5.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Litigation</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">38</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.6.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Brokerage</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">38</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.7.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Operations of Purchaser</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">38</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.8.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Ownership of Shares</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">38</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.9.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Vote/Approval Required</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">38</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.10.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Funds</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">38</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.11.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Other Agreements</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">39</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.12.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Investment Intention</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">39</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.13.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>No Other Representations and Warranties</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">39</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8" COLSPAN="3"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">ARTICLE VI COVENANTS</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">40</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.1.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Covenants of the Company.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">40</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.2.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Access to Information; Confidentiality.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">44</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.3.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Acquisition Proposals.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">44</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.4.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Employment and Employee Benefits Matters.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">47</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.5.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Directors&#8217; and Officers&#8217; Indemnification and Insurance.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">48</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.6.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Further Action; Efforts.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">49</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.7.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Public Announcements</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.8.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Approval of Compensation Actions</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.9.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>No Control of the Company&#8217;s Business</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.10.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Stockholder Litigation</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.11.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Regulatory Matters</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">51</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.12.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Cash Management</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">51</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.13.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Stock Exchange <FONT STYLE="white-space:nowrap">De-listing</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">51</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.14.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Termination of Certain Agreements</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">51</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.15.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Merger Without a Stockholders Meeting</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">51</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.16.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>FIRPTA Certificate</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">52</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8" COLSPAN="3"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">ARTICLE VII CONDITIONS OF MERGER</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">52</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;7.1.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Conditions to Obligation of Each Party to Effect the Merger</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">52</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8" COLSPAN="3"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">ARTICLE VIII TERMINATION, AMENDMENT AND WAIVER</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">52</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.1.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Termination by Mutual Agreement</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">52</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.2.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Termination by Either Parent or the Company</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">52</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.3.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Termination by the Company</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">52</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.4.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Termination by Parent</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">53</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.5.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Effect of Termination.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">53</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.6.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Expenses</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">55</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.7.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Amendment and Waiver</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">55</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8" COLSPAN="3"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">ARTICLE IX GENERAL PROVISIONS</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">55</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.1.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP><FONT STYLE="white-space:nowrap">Non-Survival</FONT> of Representations, Warranties, Covenants and Agreements</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">55</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.2.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Notices</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">55</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">ii </P>

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<TD WIDTH="10%"></TD>

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<TD WIDTH="86%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.3.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Certain Definitions</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">56</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.4.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Terms Defined Elsewhere</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">68</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.5.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Severability</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">70</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.6.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Assignment</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">70</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.7.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Entire Agreement; Third-Party Beneficiaries</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">71</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.8.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Governing Law</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">71</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.9.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Headings</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">71</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.10.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Counterparts</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">71</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.11.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Performance Guaranty</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">71</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.12.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Jurisdiction; Waiver of Jury Trial.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">71</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.13.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Service of Process</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">72</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.14.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Remedies</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">72</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.15.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Cooperation</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">72</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.16.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Specific Performance.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">72</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.17.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP>Interpretation</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">73</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><U>Annexes </U></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Annex I</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Conditions to the Offer</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Annex II</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Certificate of Incorporation of the Surviving Corporation</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Annex III</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Bylaws of the Surviving Corporation</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">Annex IV</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Contingent Value Rights Agreement</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">iii </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>AGREEMENT AND PLAN OF MERGER </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">This AGREEMENT AND PLAN OF MERGER, dated as of October&nbsp;24, 2025 (this &#8220;<U>Agreement</U>&#8221;), is entered into by and among Eli
Lilly and Company, an Indiana corporation (&#8220;<U>Parent</U>&#8221;), Flying Tigers Acquisition Corporation, a Delaware corporation and direct wholly owned Subsidiary of Parent (&#8220;<U>Purchaser</U>&#8221;), and Adverum Biotechnologies, Inc.,
a Delaware corporation (the &#8220;<U>Company</U>&#8221;). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">WHEREAS, the boards of directors of Purchaser and the Company each have
approved the acquisition of the Company on the terms and subject to the conditions set forth in this Agreement and, accordingly, Purchaser has agreed to commence a tender offer (as it may be amended from time to time as permitted by this Agreement,
the &#8220;<U>Offer</U>&#8221;) to purchase any (subject to the Minimum Tender Condition) and all of the issued and outstanding shares (each, a &#8220;<U>Share</U>&#8221; and, collectively, &#8220;<U>Shares</U>&#8221;) of common stock, par value
$0.0001 per share, of the Company (&#8220;<U>Company Common Stock</U>&#8221;), for $3.56 per Share, net to the seller in cash, without interest (the &#8220;<U>Closing Amount</U>&#8221;) and <U>less</U> any applicable Tax withholding, <U>plus</U> one
contingent value right per Share (each, a &#8220;<U>CVR</U>&#8221; and, collectively, the &#8220;<U>CVRs</U>&#8221;) which shall represent the right to receive the Milestone Payments (as such term is defined in the Contingent Value Rights Agreement
in the form attached hereto as <U>Annex IV</U> (the &#8220;<U>CVR Agreement</U>&#8221;) to be entered into between Parent and an agent selected by Parent and reasonably acceptable to the Company (the &#8220;<U>Rights Agent</U>&#8221;)), if any, at
the time provided for in the CVR Agreement, net to the seller in cash, without interest (the Closing Amount <U>plus</U> one CVR, collectively, or any higher amount per Share paid pursuant to the Offer, the &#8220;<U>Offer Price</U>&#8221;) and
<U>less</U> any applicable Tax withholding; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">WHEREAS, as soon as practicable following the consummation of the Offer, Purchaser will merge
with and into the Company (the &#8220;<U>Merger</U>&#8221;) in accordance with Section&nbsp;251(h) of the General Corporation Law of the State of Delaware (the &#8220;<U>DGCL</U>&#8221;), with the Company continuing as the Surviving Corporation, and
each Share that is issued and outstanding immediately prior to the Effective Time (other than Shares described in <U>Section</U><U></U><U>&nbsp;3.1(b)</U> and any Dissenting Shares) will be converted into the right to receive the Merger
Consideration, net to the holder of Shares in cash and without interest and less any applicable Tax withholding, upon the terms and conditions set forth herein; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">WHEREAS, the board of directors of the Company (the &#8220;<U>Company Board</U>&#8221;) has unanimously (i)&nbsp;determined that this
Agreement and the Contemplated Transactions are advisable, fair to, and in the best interests of the Company and the holders of the Shares, (ii)&nbsp;duly authorized and approved the execution and delivery of this Agreement by the Company, the
performance by the Company of its covenants and other obligations hereunder, and the consummation of the Contemplated Transactions upon the terms and subject to the conditions set forth herein, (iii)&nbsp;resolved that this Agreement and the
Contemplated Transactions shall be governed by and effected under Section&nbsp;251(h) and other relevant provisions of the DGCL and (iv)&nbsp;resolved to recommend that the holders of the Shares accept the Offer and tender their Shares pursuant to
the Offer; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">WHEREAS, the board of directors of Purchaser has, on the terms and subject to the conditions set forth herein, adopted this
Agreement and approved the Contemplated Transactions, including the Offer and the Merger; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">WHEREAS, the sole stockholder of Purchaser will
approve this Agreement immediately following its execution; and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">WHEREAS, concurrently with the execution of this Agreement, the Company
has executed and delivered to Parent a Secured Promissory Note pursuant to which Parent has agreed to lend to the Company an aggregate principal amount of up to $65,000,000 for the Company&#8217;s working capital funding requirements and other
general corporate purposes (the &#8220;<U>Promissory Note</U>&#8221;). </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">1 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">NOW, THEREFORE, in consideration of the foregoing and the mutual covenants and agreements
herein contained, and intending to be legally bound hereby, Parent, Purchaser and the Company hereby agree as follows: </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE I
</B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>THE OFFER </B></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1.1. <U>The Offer</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) <U>Commencement and Term of the Offer</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(i) Subject to the terms and conditions of this Agreement (and <U>provided</U> that this Agreement shall not have been terminated in
accordance with <U>Article VIII</U>), Purchaser shall, and Parent shall cause Purchaser to, as promptly as practicable after the date of this Agreement (but in no event later than ten (10)&nbsp;Business Days following the date of this Agreement),
commence (within the meaning of Rule <FONT STYLE="white-space:nowrap">14d-2</FONT> under the Securities Exchange Act of 1934, as amended (the &#8220;<U>Exchange Act</U>&#8221;)) the Offer to purchase for cash any (subject to the Minimum Tender
Condition) and all Shares at the Offer Price; <U>provided</U> that if, at the time Purchaser intends to commence the Offer, the Company is not prepared to file with the U.S. Securities and Exchange Commission (the &#8220;<U>SEC</U>&#8221;) and to
disseminate to holders of Shares the Schedule <FONT STYLE="white-space:nowrap">14D-9,</FONT> Purchaser may, but until such time as the Company is so prepared, shall not be obligated to, commence the Offer. The obligation of Purchaser to accept for
payment and to pay for any Shares validly tendered and not validly withdrawn pursuant to the Offer shall be subject only to the satisfaction or waiver (to the extent permitted hereunder) of those conditions set forth in <U>Annex I</U> (the
&#8220;<U>Offer Conditions</U>&#8221;). Unless extended in accordance with <U>Section</U><U></U><U>&nbsp;1.1(a)(ii)</U>, the Offer will expire at one minute after 11:59 p.m. New York City Time on the twentieth (20th) Business Day (calculated as set
forth in Rule <FONT STYLE="white-space:nowrap">14d-1(g)(3)</FONT> under the Exchange Act) following (and including the day of) the commencement of the Offer (the &#8220;<U>Initial Expiration Date</U>&#8221;), or, if the Offer has been extended in
accordance with <U>Section</U><U></U><U>&nbsp;1.1(a)(ii)</U>, at the time and date to which the Offer has been so extended (the Initial Expiration Date, or such later time and date to which the Offer has been extended in accordance with
<U>Section</U><U></U><U>&nbsp;1.1(a)(ii)</U>, the &#8220;<U>Expiration Date</U>&#8221;). Purchaser expressly reserves the right at any time or from time to time, in its sole discretion, to waive any Offer Condition or modify or amend the terms of
the Offer, in whole or in part, including the Offer Price, except that, without the prior written consent of the Company (which consent will not be unreasonably withheld, conditioned or delayed), Purchaser may not (A)&nbsp;decrease the Closing
Amount or amend the terms of the CVRs or the CVR Agreement, (B)&nbsp;change the form of the consideration payable in the Offer, (C)&nbsp;decrease the maximum number of Shares sought pursuant to the Offer, (D)&nbsp;amend or waive the Minimum Tender
Condition or the condition set forth in <U>clause 2(e)</U> of <U>Annex I</U>, (E)&nbsp;add to the conditions set forth on <U>Annex I</U>, (F)&nbsp;modify the conditions set forth on <U>Annex I</U> in a manner adverse to the holders of Shares (as a
group in their capacity as such), (G) extend the Expiration Date of the Offer except as required or expressly permitted by <U>Section</U><U></U><U>&nbsp;1.1(a)(ii)</U> or provide any &#8220;subsequent offering period&#8221; (or any extension
thereof) within the meaning of Rule <FONT STYLE="white-space:nowrap">14d-11</FONT> promulgated under the Exchange Act or (H)&nbsp;make any other change in the terms or conditions of the Offer that is adverse in any material respect to the holders of
Shares (as a group in their capacity as such). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(ii) Subject to the terms and conditions of this Agreement and to the satisfaction or
waiver (to the extent permitted hereunder) by Purchaser of the Offer Conditions as of any scheduled Expiration Date, Purchaser shall accept for purchase any and all Shares validly tendered and not validly withdrawn pursuant to the Offer as promptly
as practicable after such scheduled Expiration Date, which shall be the next Business Day after the expiration of the Offer absent extenuating circumstances and, in any event, no more than three (3)&nbsp;Business Days after the expiration of the
Offer (the date and time of acceptance for payment, the &#8220;<U>Acceptance Time</U>&#8221;). Purchaser shall promptly (and in any event within </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">2 </P>

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three (3)&nbsp;Business Days (calculated as set forth in Rule <FONT STYLE="white-space:nowrap">14d-1(g)(3)</FONT> under the Exchange Act)) after the Acceptance Time pay, or cause the Paying Agent
to pay, for all Shares validly tendered and not validly withdrawn pursuant to the Offer. Purchaser shall not permit holders of Shares to tender Shares pursuant to the Offer pursuant to guaranteed delivery procedures that have not been
&#8220;received&#8221; (as defined by Section&nbsp;251(h)(6) of the DGCL) by Purchaser&#8217;s transfer agent. Purchaser shall (A)&nbsp;extend the Offer for one or more periods of time of up to five (5)&nbsp;Business Days per extension (or for such
longer period as may be agreed to by Parent and the Company) if at any scheduled Expiration Date any Offer Condition (other than solely (x)&nbsp;the Minimum Tender Condition and (y)&nbsp;any such conditions that by their nature are to be satisfied
at the expiration of the Offer) is not satisfied and has not been waived (to the extent permitted hereunder) and (B)&nbsp;extend the Offer for any period required by any rule, regulation, interpretation or position of the SEC, the staff thereof, or
The Nasdaq Global Select Market (&#8220;<U>Nasdaq</U>&#8221;) applicable to the Offer; <U>provided</U> that Purchaser is not required to extend the Offer beyond the Outside Date. In addition, if at the otherwise scheduled Expiration Date, each Offer
Condition (other than the Minimum Tender Condition and any such conditions that by their nature are to be satisfied at the expiration of the Offer) shall have been satisfied or waived and the Minimum Tender Condition shall not have been satisfied,
Purchaser may elect to (and if so requested by the Company, Purchaser shall) extend the Offer for one or more consecutive increments of such duration as requested by the Company (or if not so requested by the Company, as determined by Purchaser),
but not more than five (5)&nbsp;Business Days each (or for such longer period as may be agreed to by Parent and the Company); <U>provided</U> that the Company shall not request Purchaser to, and Purchaser shall not be required to, extend the Offer
pursuant to this sentence on more than two (2)&nbsp;occasions in consecutive periods of five (5)&nbsp;Business Days each (or such longer or shorter period as the Company and Purchaser may agree in writing); <U>provided</U>, <U>further</U>, that
Purchaser shall not without the prior written consent of the Company, and shall not be required to, extend the Offer beyond the Outside Date. The Company shall register (and shall instruct its transfer agent to register) the transfer of the Shares
accepted for payment by Purchaser effective immediately after the Acceptance Time. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) On the date of commencement of the Offer, Parent
and Purchaser shall file or cause to be filed with the SEC a Tender Offer Statement on Schedule TO (collectively with all amendments and supplements thereto, the &#8220;<U>Schedule TO</U>&#8221;) with respect to the Offer that includes as exhibits
the offer to purchase and related letter of transmittal and summary advertisement and other ancillary documents and instruments pursuant to which the Offer will be made (collectively with all amendments and supplements thereto, the &#8220;<U>Offer
Documents</U>&#8221;) and shall disseminate the Offer Documents to holders of Shares, in each case, as and to the extent required by applicable federal securities Laws and shall otherwise comply with the filing requirements of Rule <FONT
STYLE="white-space:nowrap">14d-3(a)</FONT> promulgated under the Exchange Act and the disclosure requirements of <FONT STYLE="white-space:nowrap">Rule14d-6(a)</FONT> promulgated under the Exchange Act, in each case, as and to the extent required by
applicable Law. The Company shall furnish promptly to Parent and Purchaser all information reasonably requested by Parent and Purchaser concerning the Company or required by applicable federal securities Laws to be set forth in the Offer Documents.
Except from and after a Change of Board Recommendation, Parent and Purchaser shall (i)&nbsp;afford the Company a reasonable opportunity to review and comment on the Offer Documents prior to their filing with the SEC, (ii)&nbsp;promptly provide the
Company and its counsel with a copy of any written comments (and a description of any oral comments) received by Parent, Purchaser or their counsel from the SEC or its staff with respect to the Offer Documents, (iii)&nbsp;consult with the Company
regarding any such comments prior to responding thereto, and (iv)&nbsp;promptly provide the Company with copies of any written responses to any such comments. Parent and Purchaser shall cause the Offer Documents filed by either Parent or Purchaser
with the SEC to comply in all material respects with the requirements of applicable Law and, on the date first filed with the SEC and on the date first published, sent or given to the holders of Shares, not to contain any untrue statement of a
material fact or omit to state any material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading, except that no covenant is made by Parent
or Purchaser with respect to information supplied by or on behalf of the Company for inclusion or incorporation by reference in the Offer Documents. Each of Parent, Purchaser and the Company shall </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">3 </P>

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promptly correct any information provided by it for use in the Offer Documents as well as any material omissions from the Offer Documents if and to the extent that it has become aware that such
information has become false or misleading in any material respect. Parent and Purchaser shall take all steps necessary to cause the Offer Documents as so corrected to be promptly filed with the SEC and disseminated to holders of Shares, in each
case, as and to the extent required by applicable federal securities Laws. Parent and Purchaser shall respond reasonably promptly to any comments of the SEC or its staff with respect to the Offer Documents. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) Parent shall provide or cause to be provided to Purchaser on a timely basis the funds necessary to purchase any Shares that Purchaser
becomes obligated to purchase pursuant to the Offer. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) Purchaser shall not terminate the Offer prior to any scheduled Expiration Date
without the prior written consent of the Company, except if this Agreement is terminated pursuant to <U>Article VIII</U>. If this Agreement is terminated pursuant to <U>Article VIII</U>, Purchaser shall terminate the Offer promptly (and in any event
within one (1)&nbsp;Business Day of such termination of this Agreement pursuant to <U>Article VIII</U>), and Purchaser shall not acquire any Shares pursuant to the Offer. If the Offer is terminated by Purchaser, or if this Agreement is terminated
pursuant to <U>Article VIII</U> prior to the acquisition of Shares in the Offer, Purchaser shall promptly (and in any event within two (2)&nbsp;Business Days of such termination) return, and shall cause any depositary or other agent acting on behalf
of Purchaser to return, in accordance with applicable Law, all Shares tendered into the Offer to the registered holders thereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) (e)
The (i)&nbsp;Offer Price and (ii)&nbsp;Merger Consideration will be adjusted appropriately to reflect any reclassification, recapitalization, division or subdivision of shares, consolidation of shares, stock split (including a reverse stock split),
or combination, exchange, or readjustment of shares, or any stock dividend or stock distribution occurring (or for which a record date is established) or other similar transaction after the date of this Agreement and prior to (A)&nbsp;the payment by
Purchaser for Shares validly tendered and not validly withdrawn in connection with the Offer (with respect to the Offer Price) or (B)&nbsp;the Effective Time (with respect to the Merger Consideration). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(f) Parent shall, and shall cause the Rights Agent to, at or prior to the Acceptance Time, duly authorize, execute and deliver the CVR
Agreement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(g) To the extent reasonably requested by the Company, Parent shall use commercially reasonable efforts to keep the Company
reasonably informed on a reasonably prompt basis of the status of the Offer, including with respect to the number of Shares that have been validly tendered and not validly withdrawn in accordance with the terms of the Offer and, upon the
Company&#8217;s reasonable written request, use commercially reasonable efforts to provide the Company as soon as reasonably practicable with the most recent report then available detailing the number of Shares that have been validly tendered and
not validly withdrawn in accordance with the terms of the Offer. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1.2. <U>Company Consent; Schedule <FONT
STYLE="white-space:nowrap">14D-9</FONT></U>. On the date of the filing of the Offer Documents, the Company shall file with the SEC a Solicitation/Recommendation Statement on Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT> (together with all
amendments and supplements thereto, the &#8220;<U>Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT></U>&#8221;) containing, subject to the conditions set forth herein, the Company Board Recommendation. The Company shall include in the Schedule <FONT
STYLE="white-space:nowrap">14D-9</FONT> (a) the information required by Section&nbsp;262(d)(2) of the DGCL such that the Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT> constitutes a notice of appraisal rights under Section&nbsp;262(d)(2) of
the DGCL and (b)&nbsp;the fairness opinion delivered by Aquilo Partners, L.P. (together with a description of such firm&#8217;s related analyses). The Company shall establish the Stockholder List Date as the record date for the purpose of receiving
the notice required by Section&nbsp;262(d)(2) of the DGCL; <U>provided</U>, that such record date will not be more than ten (10)&nbsp;calendar days prior to the date that the Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT> is first mailed.
The Company hereby consents to the inclusion of the Company Board Recommendation in the Offer Documents and, absent a Change of </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">4 </P>

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Board Recommendation, to the inclusion of a copy of the Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT> with the Offer Documents mailed or furnished to the holders of Shares. Parent and
Purchaser shall, absent a Change of Board Recommendation, disseminate a copy of the Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT> with the Offer Documents mailed or furnished to the holders of Shares. Parent and Purchaser shall furnish
promptly to the Company all information concerning Parent and Purchaser reasonably requested by the Company and required by applicable federal securities Laws to be set forth in the Schedule <FONT STYLE="white-space:nowrap">14D-9.</FONT> Except with
respect to any amendments filed in connection with an Acquisition Proposal or a Change of Board Recommendation, the Company shall give Parent and Purchaser reasonable opportunity to review and comment on the Schedule
<FONT STYLE="white-space:nowrap">14D-9</FONT> (including any amendments or supplements thereto) prior to its filing with the SEC and shall give reasonable and good faith consideration to any such comments. The Company shall (i)&nbsp;promptly provide
Parent, Purchaser and their counsel with a copy of any written comments (or a description of any oral comments) received by the Company or its counsel from the SEC or its staff with respect to the Schedule
<FONT STYLE="white-space:nowrap">14D-9,</FONT> (ii) consult with Parent and Purchaser regarding any such comments prior to responding thereto, and give reasonable and good faith consideration to any comments of Parent and Purchaser, and
(iii)&nbsp;promptly provide Parent and Purchaser with copies of any written responses to any such comments, in each case, except with respect to comments related to an Acquisition Proposal or in connection with a Change of Board Recommendation. The
Company shall cause the Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT> to comply in all material respects with the requirements of applicable Law and, on the date first filed with the SEC and on the date first published, sent or given to the
holders of Shares, not to contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were
made, not misleading, except that no covenant is made by the Company with respect to information supplied by or on behalf of Parent or Purchaser specifically for inclusion or incorporation by reference in the Schedule
<FONT STYLE="white-space:nowrap">14D-9.</FONT> Each of the Company, Parent and Purchaser shall promptly correct any information provided by it for use in the Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT> if and to the extent that it has
become aware that such information has become false or misleading in any material respect. The Company shall take all steps necessary to cause the Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT> as so corrected to be filed with the SEC and
disseminated to holders of Shares, in each case, as and to the extent required by applicable federal securities Laws. The Company shall respond reasonably promptly to any comments of the SEC or its staff with respect to the Schedule <FONT
STYLE="white-space:nowrap">14D-9.</FONT> </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1.3. <U>Stockholder Lists</U>. In connection with the Offer, the Company shall
cause its transfer agent to promptly furnish Parent and Purchaser with mailing labels, security position listings and computer files containing the names and addresses of the record holders of the Shares as of a recent practicable date (such date,
the &#8220;<U>Stockholder List Date</U>&#8221;), and the Company shall furnish or cause to be furnished to Parent and Purchaser such information and assistance (including periodic updates of such information) as Parent or Purchaser or their agents
may reasonably request for the purpose of communicating the Offer to the record and beneficial holders of the Shares. Except for such actions as are reasonably necessary to disseminate the Offer Documents, each of Parent and Purchaser shall hold and
use all information and documents provided to it under this <U>Section</U><U></U><U>&nbsp;1.3</U> in accordance with the Confidentiality Agreement. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE II </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>THE MERGER
</B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.1. <U>The Merger</U>. Upon the terms and subject to the conditions of this Agreement and in accordance with
Section&nbsp;251(h) of the DGCL, at the Effective Time, Purchaser will be merged with and into the Company. As a result of the Merger, the separate corporate existence of Purchaser will cease, and the Company will continue as the surviving
corporation of the Merger (the &#8220;<U>Surviving Corporation</U>&#8221;). </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">5 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.2. <U>Closing; Effective Time</U>. Subject to the provisions of this
Agreement and pursuant to the DGCL (including Section&nbsp;251 of the DGCL), the closing of the Merger (the &#8220;<U>Closing</U>&#8221;) will take place remotely by exchange of documents and signatures (or their electronic counterparts), as soon as
practicable following consummation of the Offer, but in no event later than the first (1st) Business Day, after the satisfaction or (to the extent permitted by Law) waiver of the conditions set forth in <U>Article VII</U> (excluding conditions that,
by their terms, cannot be satisfied until the Closing, but subject to the satisfaction or (to the extent permitted by Law) waiver of such conditions at the Closing), or at such other place or on such other date as Parent and the Company may mutually
agree (such date, the &#8220;<U>Closing Date</U>&#8221;). At the Closing, the parties hereto shall cause the Merger to be consummated by filing a certificate of merger (the &#8220;<U>Certificate of Merger</U>&#8221;) with the Secretary of State of
the State of Delaware, in such form as required by, and executed in accordance with, the relevant provisions of the DGCL (the date and time of the filing of the Certificate of Merger with the Secretary of State of the State of Delaware, or such
later time as is specified in the Certificate of Merger and agreed to by Purchaser and the Company, being hereinafter referred to as the &#8220;<U>Effective Time</U>&#8221;) and shall make all other filings, recordings or publications required under
the DGCL in connection with the Merger. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.3. <U>Effects of the Merger</U>. The Merger will have the effects set forth herein
and as set forth in the applicable provisions, including Section&nbsp;259, of the DGCL. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.4. <U>Certificate of Incorporation
and Bylaws of the Surviving Corporation</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) At the Effective Time, the certificate of incorporation of the Company will, by virtue
of the Merger, be amended and restated in its entirety to read in the form of <U>Annex II</U>, and as so amended, will be the certificate of incorporation of the Surviving Corporation until thereafter amended in accordance with its terms and as
provided by applicable Law. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) At the Effective Time, and without any further action on the part of the Company or Purchaser, the bylaws
of the Company will be amended and restated in their entirety so as to read in the form of <U>Annex III</U>, and, as so amended, will be the bylaws of the Surviving Corporation until thereafter amended in accordance with their terms, in accordance
with the certificate of incorporation of the Surviving Corporation and as provided by applicable Law. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.5. <U>Directors</U>.
The directors of Purchaser immediately prior to the Effective Time will be the initial directors of the Surviving Corporation until the earlier of his or her death, resignation, or removal, or until his or her successor is duly elected and
qualified. The Company shall request that each director of the Company immediately prior to the Effective Time execute and deliver a letter effectuating his or her resignation as a member of the Company Board and all committees thereof to be
effective as of the Effective Time. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.6. <U>Merger Without a Vote of Stockholders</U>. The Merger will be governed by and
effected under Section&nbsp;251(h) of the DGCL. The parties hereto shall take all necessary and appropriate action to cause the Merger to become effective as soon as practicable following the consummation of the Offer, without a vote of the holders
of the Shares in accordance with Section&nbsp;251(h) of the DGCL. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE III </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>EFFECT OF THE MERGER ON THE CAPITAL STOCK OF THE CONSTITUENT CORPORATIONS </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.1. <U>Conversion of Securities</U>. At the Effective Time, by virtue of the Merger and without any further action on the part
of Parent, Purchaser, the Company or the holders of any of the following securities, the following will occur: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) each Share issued and
outstanding immediately prior to the Effective Time (other than any Shares described in <U>Section</U><U></U><U>&nbsp;3.1(b)</U> and any Dissenting Shares) will be converted into the right to receive the Offer Price, without interest (the
&#8220;<U>Merger Consideration</U>&#8221;), less any applicable Tax withholding. As of the Effective Time, all such Shares shall no longer be outstanding and shall cease to exist, and each holder of any such Shares shall cease to have any rights
with respect thereto, except the right to receive the Merger Consideration in accordance with <U>Section</U><U></U><U>&nbsp;3.5</U> and the CVR Agreement, without interest; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) each Share held in the treasury of the Company or owned by the Company and each Share owned by Parent, Purchaser or any direct or indirect
wholly owned Subsidiary of Parent or Purchaser immediately prior to the Effective Time will be cancelled and shall cease to exist, and no consideration shall be delivered or deliverable in exchange therefor; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) each share of common stock of Purchaser issued and outstanding immediately prior to the Effective Time will be converted into one fully
paid and <FONT STYLE="white-space:nowrap">non-assessable</FONT> share of common stock of the Surviving Corporation, which shares shall constitute the only outstanding shares of capital stock of the Surviving Corporation; and </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) each Dissenting Share immediately prior to the Effective Time will be cancelled and shall cease to exist, and Dissenting Shares will
thereafter only represent the right to receive payment pursuant to Section&nbsp;262 of the DGCL and as described in <U>Section</U><U></U><U>&nbsp;3.4</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.2. <U>Treatment of Equity Awards</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) As soon as practicable following the date of this Agreement (and, in any event, prior to the Effective Time), the Company Board (or, if
appropriate, the committee administering the Company Equity Plans) shall adopt resolutions and shall take other necessary or desirable action to provide that: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(i) at the Effective Time, and without any action on the part of Purchaser, the Company or any other Person, each Company Stock Option with a
per share exercise price that is less than the Closing Amount that is outstanding immediately prior to the Effective Time, whether or not vested (each such Company Stock Option, a &#8220;<U>Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT>
Stock Option</U>&#8221;), will be cancelled, and, in exchange therefor, the holder of such cancelled Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock Option will be entitled to receive, in consideration of the cancellation of such
Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock Option, (A)&nbsp;an amount in cash (without interest and <U>less</U> applicable Tax withholdings pursuant to <U>Section</U><U></U><U>&nbsp;3.7</U>) equal to the product of (1)&nbsp;the
total number of shares subject to such Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock Option immediately prior to the Effective Time <U>multiplied</U> by (2)&nbsp;the excess, if any, of the Closing Amount over the applicable exercise
price per share under such Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock Option and (B)&nbsp;one CVR for each Share subject to such Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock Option immediately prior to the
Effective Time (without regard to vesting); </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(ii) each Company Stock Option that has an exercise price equal to or greater than the
Closing Amount that is outstanding immediately prior to the Effective Time (each such Company Stock Option, an
&#8220;<U><FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">Out-of-the-Money</FONT></FONT></FONT> Option</U>&#8221;), to the extent not vested, will become fully vested as of prior to the Effective
Time, and the Company shall permit the holders of <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">Out-of-the-Money</FONT></FONT></FONT> Options to exercise such <FONT STYLE="white-space:nowrap"><FONT
STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">Out-of-the-Money</FONT></FONT></FONT> Options prior to the Effective Time on a basis that allows such holders to participate in the Merger with respect to any Shares acquired under such <FONT
STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">Out-of-the-Money</FONT></FONT></FONT> Options as a holder of Shares, with any <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap"><FONT
STYLE="white-space:nowrap">Out-of-the-Money</FONT></FONT></FONT> Options that remain outstanding and unexercised as of the Effective Time cancelled for no consideration at the Effective Time, without any action on the part of Purchaser, the Company
or any other Person; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(iii) at the Effective Time, and without any action on the part of Purchaser, the Company or any other Person, each
Company RSU that is outstanding and unvested immediately prior to the Effective Time shall be cancelled, and, in exchange therefor, the holder of such cancelled Company RSU will be entitled to receive, in consideration of the cancellation of such
Company RSU, (A)&nbsp;an amount in cash (without interest and <U>less</U> applicable Tax withholdings pursuant to <U>Section</U><U></U><U>&nbsp;3.7</U>) equal to the product of (1)&nbsp;the total number of shares subject to such Company RSU
immediately prior to the Effective Time, <U>multiplied</U> by (2)&nbsp;the Closing Amount and (B)&nbsp;one CVR for each share of Company Common Stock subject to such Company RSU immediately prior to the Effective Time (without regard to vesting);
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(iv) at the Effective Time, and without any action on the part of Purchaser, the Company, or any other person, each Company PSU that is
outstanding and unvested immediately prior to the Effective Time shall be cancelled, and, in exchange therefor, the holder of such cancelled Company PSU will be entitled to receive, in consideration of the cancellation of such Company PSU,
(A)&nbsp;an amount in cash (without interest and less applicable Tax withholdings pursuant to <U>Section</U><U></U><U>&nbsp;3.7</U>) equal to the product of (1)&nbsp;the total number of shares subject to such Company PSU immediately prior to the
Effective Time, <U>multiplied</U> by (2)&nbsp;the Closing Amount and (B)&nbsp;one CVR for each share of Company Common Stock subject to such Company RSU immediately prior to the Effective Time (without regard to vesting); and </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(v) each Company Equity Plan and award agreement thereunder shall be terminated effective as of the Effective Time. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Subject to <U>Section</U><U></U><U>&nbsp;3.7</U>, Parent shall cause the Surviving Corporation to make all payments to former holders of
Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock Options, Company RSUs, and Company PSUs required under <U>Section</U><U></U><U>&nbsp;3.2(a)</U> who were granted such interests as an employee of the Company or one of its Subsidiaries
as promptly as practicable after the Effective Time or the applicable Milestone Payment Date (as defined in the CVR Agreement), as applicable, and, in any event, no later than the second (2nd) regularly scheduled payroll date that follows
(i)&nbsp;with respect to the Closing Amount, the Effective Time and (ii)&nbsp;with respect to cash consideration payable upon satisfaction of a Milestone (as defined in the CVR Agreement) pursuant to the CVR Agreement, such time as the Rights Agent
pays the applicable Milestone Payment Amount (as defined in the CVR Agreement) in accordance with <U>Section</U><U></U><U>&nbsp;2.4(b)</U> of the CVR Agreement. Notwithstanding anything to the contrary in this Agreement, no Milestone Payments that
constitute nonqualified deferred compensation subject to Section&nbsp;409A of the Code shall be allocated or paid in respect of any Company Stock Option, Company RSU, or Company PSU except to the extent permissible under Treasury Regulation <FONT
STYLE="white-space:nowrap">Section&nbsp;1.409A-3(i)(5)(iv)(A),</FONT> including that no such Milestone Payments that constitute nonqualified deferred compensation subject to Section&nbsp;409A of the Code shall be allocated or paid in respect of any
Company Stock Option, Company RSU, or Company PSU following the fifth (5th)&nbsp;anniversary of the Closing Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) As soon as
practicable after the date hereof, the Company Board (or, if appropriate, the committee administering the ESPP) shall pass such resolutions and shall take all actions with respect to the Company ESPP that are necessary to provide that: (i)&nbsp;with
respect to the Offering Period (as defined in the Company ESPP) in effect as of the date hereof, if any, no individual who was not a participant in the Company ESPP as of the date hereof may enroll in the Company ESPP with respect to such Offering
Period </P>
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and no participant may increase the percentage amount of his or her payroll deduction election from that in effect on the date hereof for such Offering Period; (ii)&nbsp;no new Offering Period
shall commence following the date hereof unless and until this Agreement is terminated; (iii)&nbsp;if the applicable purchase date with respect to the Offering Period would otherwise occur on or after the Closing Date, then (A)&nbsp;the Offering
Period will be shortened and the New Exercise Date (as defined in the Company ESPP) with respect to such Offering Period will occur no later than three (3)&nbsp;Business Days prior to Closing Date and (B)&nbsp;each outstanding Share obtained through
the exercise of any outstanding right under the Company ESPP shall receive the Merger Consideration pursuant to <U>Section</U><U></U><U>&nbsp;3.1(a)</U>; and (iv)&nbsp;the Company ESPP shall terminate as of or prior to the Effective Time. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) No later than ten (10)&nbsp;Business Days prior to the Effective Time, the Company Board (or, if appropriate, the committee administering
the Company Equity Plans) shall provide Purchaser a copy of all resolutions, notices and other documentation effectuating the provisions set forth in this <U>Section</U><U></U><U>&nbsp;3.2</U> and shall incorporate all reasonable comments made by
Purchaser to such resolutions, notices and other documentation. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.3. <U>Treatment of Warrants</U>. At the Effective Time,
and in accordance with the terms of each warrant to purchase Shares that is listed on <U>Section</U><U></U><U>&nbsp;3.3</U> of the Company Disclosure Letter (collectively, the &#8220;<U>Warrants</U>&#8221;) and that is issued and outstanding
immediately prior to the Effective Time, unless otherwise elected by the holder of any such Warrant, Parent shall cause the Surviving Corporation to issue a replacement warrant to each holder thereof providing that such replacement warrant shall be
exercisable for (A)&nbsp;an amount in cash (less applicable Tax withholdings pursuant to <U>Section</U><U></U><U>&nbsp;3.7</U>) equal to the product of (1)&nbsp;the total number of Shares in respect of such Warrant; <U>multiplied</U> by (2)&nbsp;the
excess, if any, of the Closing Amount over the per Share exercise price under such Warrant and (B)&nbsp;one CVR for each Share in respect of such Warrant immediately prior to the Effective Time. For the avoidance of doubt, in the event that the per
share exercise price under any Warrant is equal to or greater than the Merger Consideration, such Warrant shall be cancelled as of the Effective Time without payment therefor and shall have no further force or effect. As soon as reasonably
practicable following the date of this Agreement, the Company shall provide, in accordance with the terms of each Warrant, any notices required to be provided to the holder of such Warrant, the form of which shall be given to Parent and its counsel
for a reasonable opportunity to review and comment before such notice is provided to the holder of such Warrant, and take all such other actions that may be required in accordance with the terms of such Company Warrant in connection with the
transaction contemplated by this Agreement prior to the Effective Time. The Company shall use reasonable best efforts to cause each holder of a Warrant to exercise such Warrant prior to the Effective Time. From and after the Closing, Parent shall
cause the Surviving Corporation to comply with all of the terms and conditions set forth in each such replacement warrant, including the obligation to make the payments contemplated thereby upon exercise thereof. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.4. <U>Dissenting Shares</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) Notwithstanding anything in this Agreement to the contrary, Shares outstanding immediately prior to the Effective Time and held by a
holder who is entitled to demand and properly exercised and perfected their respective demands for appraisal for such Shares in accordance with Section&nbsp;262 of the DGCL (the &#8220;<U>Dissenting Shares</U>&#8221;) will not be converted into a
right to receive the Merger Consideration unless such holder fails to perfect or effectively withdraws or otherwise loses his, her, or its right to appraisal. Instead, at the Effective Time, the Dissenting Shares shall no longer be outstanding and
shall automatically be cancelled and shall cease to exist, and from and after the Effective Time, a holder of Dissenting Shares who has properly exercised appraisal rights will not have any rights of a stockholder of the Company or the Surviving
Corporation with respect to such Dissenting Shares, except those provided under Section&nbsp;262 of the DGCL. A holder of Dissenting Shares will be entitled only to receive payment of the appraised value of such Dissenting Shares in accordance with
Section&nbsp;262 of the DGCL, unless, after </P>
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the Effective Time, such holder fails to perfect, effectively withdraws or otherwise loses his, her, or its right to appraisal in accordance with Section&nbsp;262 of the DGCL, in which case such
Dissenting Shares will be treated as if such Dissenting Shares had been converted as of the Effective Time into the right to receive the Merger Consideration, without interest thereon and less any applicable Tax withholding, in accordance with
<U>Section</U><U></U><U>&nbsp;3.5</U>, pursuant to <U>Section</U><U></U><U>&nbsp;3.1</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) The Company shall provide Parent with
prompt written notice of any demands for appraisal (including copies of any written demands), withdrawals of such demands, and any other instruments received by the Company from holders of Shares relating to rights of appraisal, and Parent will have
the opportunity and right to direct the conduct of all negotiations and proceedings with respect to demands for appraisal. Except with the prior written consent of Parent, the Company shall not voluntarily make any payment with respect to any
demands for appraisal or settle or offer to settle any such demands for appraisal, or agree to do any of the foregoing. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.5.
<U>Surrender of Shares</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) At or immediately after the Acceptance Time, Parent shall deposit or cause to be deposited with a bank or
trust company reasonably acceptable to the Company (the &#8220;<U>Paying Agent</U>&#8221;), pursuant to a Paying Agent Agreement that shall be in form and substance reasonably acceptable to the Company, cash in an amount sufficient to pay the
aggregate Closing Amount (calculated for the purposes of this <U>Section</U><U></U><U>&nbsp;3.5(a)</U> assuming that all outstanding Shares (other than Dissenting Shares) are tendered into the Offer), and Parent shall cause the Paying Agent to
timely make all payments contemplated in <U>Section</U><U></U><U>&nbsp;3.5(b)</U>. Such cash may be invested by the Paying Agent as directed by Parent; <U>provided</U> that (i)&nbsp;such investments must be in short-term obligations of the United
States of America with maturities of no more than thirty (30)&nbsp;days or guaranteed by the United States of America and backed by the full faith and credit of the United States of America or in commercial paper obligations rated <FONT
STYLE="white-space:nowrap">A-1</FONT> or <FONT STYLE="white-space:nowrap">P-1</FONT> or better by Moody&#8217;s Investors Service, Inc. or Standard&nbsp;&amp; Poor&#8217;s Corporation, respectively, (ii)&nbsp;no such investment will relieve Parent,
Purchaser, or the Paying Agent from making the payments required by this <U>Article III</U> and (iii)&nbsp;no such investment will have maturities that could prevent or delay payments to be made pursuant to this Agreement. Any interest or income
produced by such investments will be payable to, and for U.S. federal (and any applicable state or local) income tax purposes reported as earned by, the Surviving Corporation or Parent, as Parent directs. No loss incurred with respect to such
investments will decrease the amounts payable pursuant to this Agreement. In the event that the amount of cash held by the Paying Agent is insufficient to pay the aggregate Closing Amount, Parent shall promptly deposit, or cause to be deposited,
additional funds with the Paying Agent in an amount which is equal to the deficiency in the amount required to make all such payment pursuant to <U>Section</U><U></U><U>&nbsp;3.5(b)</U>. The aggregate Closing Amount as so deposited with the Paying
Agent will not be used for any purpose other than to fund payments pursuant to <U>Section</U><U></U><U>&nbsp;3.5(b)</U>, except as expressly provided for in this Agreement. Any portion of the cash made available to the Paying Agent in respect of any
Dissenting Shares will be returned to Parent, upon demand. Parent shall not be required to deposit any funds related to any CVR with the Rights Agent, unless and until such deposit is required pursuant to the terms of the CVR Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) As promptly as practicable after the Effective Time (and in any event within three (3)&nbsp;Business Days thereafter), Parent shall cause
the Paying Agent to mail to each holder of record of a certificate (a &#8220;<U>Certificate</U>&#8221;) or book-entry shares (each, a &#8220;<U>Book-Entry Share</U>&#8221;), which immediately prior to the Effective Time represented outstanding
Shares that were converted pursuant to <U>Section</U><U></U><U>&nbsp;3.1</U> into the right to receive the Merger Consideration, (i)&nbsp;a letter of transmittal in customary form (which will (x)&nbsp;specify that delivery will be effected, and risk
of loss and title to the Certificate will pass, only upon delivery of such Certificate to the Paying Agent and (y)&nbsp;contain such other provisions as are customary and reasonably acceptable to Parent and the Company) or a customary agent&#8217;s
message with respect to Book-Entry Shares, as applicable and (ii)&nbsp;instructions for effecting the surrender of the Certificate or Book-Entry Share in </P>
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exchange for payment of the Merger Consideration. Upon surrender of a Certificate or Book-Entry Share for cancellation to the Paying Agent or to such other agent or agents as may be appointed by
Parent, together with such letter of transmittal, duly executed and properly completed (in the case of surrender of a Certificate), the holder of such Certificate or Book-Entry Share will be entitled to receive in exchange therefor the Merger
Consideration for each Share formerly represented by such Certificate or Book-Entry Share, and the Certificate or Book-Entry Share so surrendered will be cancelled. Until surrendered as contemplated by this <U>Section</U><U></U><U>&nbsp;3.5(b)</U>,
each Certificate will be deemed at any time after the Effective Time to represent only the right to receive the Merger Consideration and will not evidence any interest in, or any right to exercise the rights of a stockholder or other equity holder
of, the Company or the Surviving Corporation. No interest shall be paid or accrue on the cash payable upon surrender of any Certificate. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) No holder of record of a Book-Entry Share, which immediately prior to the Effective Time represented outstanding Shares that were
converted pursuant to <U>Section</U><U></U><U>&nbsp;3.1</U> into the right to receive the Merger Consideration, shall be required to deliver a Certificate or an executed letter of transmittal to the Paying Agent to receive the Merger Consideration
in respect of such Book-Entry Shares. In lieu thereof, such holder of record shall, upon receipt by the Paying Agent of an &#8220;agent&#8217;s message&#8221; in customary form (or such other evidence, if any, as the Paying Agent may reasonably
request), be entitled to receive in exchange therefor, the Merger Consideration for each Share formerly represented by such Book-Entry Share, and such Book-Entry Share will be cancelled. Payment of the Merger Consideration with respect to Book-Entry
Shares shall only be made to the Person in whose name such Book-Entry Shares are registered. Until such &#8220;agent&#8217;s message&#8221; (or such other evidence) is received, each Book-Entry Share will be deemed at any time after the Effective
Time to represent only the right to receive the Merger Consideration and will not evidence any interest in, or any right to exercise the rights of a stockholder or other equity holder of, the Company or the Surviving Corporation. No interest shall
be paid or accrue on the cash payable in respect of a Book-Entry Share. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) At any time following the date that is six (6)&nbsp;months
after the Effective Time, Parent may require the Paying Agent to deliver to Parent or its designated Affiliate any funds (including any interest received with respect thereto) that have been made available to the Paying Agent and that have not been
disbursed to holders of Certificates and Book-Entry Shares, and thereafter such holders will be entitled to look to the Surviving Corporation (subject to abandoned property, escheat or other similar laws) with respect to the Merger Consideration
payable to the holder of a Certificate or Book-Entry Share. The Surviving Corporation shall pay all charges and expenses, including those of the Paying Agent, in connection with the exchange of Shares for the Merger Consideration. None of Parent,
Purchaser, the Company, the Surviving Corporation or the Paying Agent shall be liable to any Person in respect of any cash delivered to a public official pursuant to any applicable abandoned property, escheat or similar Law. If any Certificate has
not been surrendered, or the applicable &#8220;agent&#8217;s message&#8221; or other evidence is not received in respect of a Book-Entry Share, immediately prior to the date on which the Merger Consideration in respect of such Certificate or
Book-Entry Share would otherwise escheat to or become the property of any Governmental Body, any Merger Consideration in respect of such Certificate or Book-Entry Share will, to the extent permitted by applicable Law, immediately prior to such time
become the property of the Surviving Corporation, free and clear of all claims or interest of any individual, corporation, partnership, limited liability company, association, trust, unincorporated organization, other entity or group (as defined in
Section&nbsp;13(d)(3) of the Exchange Act) previously entitled thereto. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) From and after the Effective Time, the stock transfer books
of the Company will be closed, and no subsequent transfers of Shares that were issued prior to the Effective Time will be registered. After the Effective Time, any Certificate or Book-Entry Share presented to the Surviving Corporation for transfer
will be cancelled and exchanged for the consideration provided for, and in accordance with the procedures set forth in, this <U>Article III</U>. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(f) In the event that any Certificate has been lost, stolen or destroyed, upon the
holder&#8217;s delivery of an affidavit of loss to the Paying Agent (and, if required by Parent or the Paying Agent, the posting by such holder of a bond in customary amount and upon such terms as may be reasonably required by Parent or the Paying
Agent as indemnity against any claim that may be made against it or the Surviving Corporation with respect to such Certificate), Parent shall cause the Paying Agent to deliver as consideration for the lost, stolen or destroyed Certificate the
applicable Merger Consideration payable in respect of the Shares represented by such Certificate, without interest and less any applicable Tax withholding. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.6. <U>Section </U><U>16</U><U> Matters</U>. Prior to the Acceptance Time, the Company Board shall take all necessary and
appropriate action to approve, for purposes of Section&nbsp;16(b) of the Exchange Act and the related rules and regulations thereunder, the disposition by Company directors and officers of Shares, Company Stock Options and Company RSUs in the
Contemplated Transactions. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.7. <U>Withholding</U>. The parties hereto and the Paying Agent are entitled to deduct and
withhold from any amounts payable or otherwise deliverable pursuant to this Agreement such amounts as are required to be deducted and withheld therefrom under the United States Internal Revenue Code of 1986, as amended (the
&#8220;<U>Code</U>&#8221;), or the Treasury Regulations thereunder (the &#8220;<U>Treasury Regulations</U>&#8221;), or any other applicable Tax Law. Any compensatory amounts payable pursuant to or as contemplated by this Agreement (which, for the
avoidance of doubt, shall exclude amounts payable in respect of Shares and Warrants), including pursuant to <U>Section</U><U></U><U>&nbsp;3.2</U>, will be remitted to the applicable payor for payment to the applicable Person through regular payroll
procedures, as applicable. To the extent that any amounts are so deducted and withheld and paid over to the appropriate Governmental Body, such amounts will be treated for all purposes under this Agreement as having been paid to the Person to whom
such amounts would otherwise have been paid. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.8. <U>Transfer Taxes</U>. Except as otherwise provided in this
<U>Section</U><U></U><U>&nbsp;3.8</U>, all Transfer Taxes imposed on the Offer or the Merger shall be paid by the Surviving Corporation, and the Company shall cooperate with Purchaser and Parent in preparing, executing and filing any Tax Returns
with respect to such Transfer Taxes. Notwithstanding the foregoing, if any payment pursuant to the Offer or the Merger is to be made to a Person other than the Person in whose name the surrendered Certificate is registered, it will be a condition to
such payment that (a)&nbsp;such Certificate so surrendered must be properly endorsed or must otherwise be in proper form and (b)&nbsp;the Person presenting such Certificate to the Paying Agent for payment must pay to the Paying Agent any Transfer
Taxes or other Taxes required as a result of such payment to a Person other than the registered holder of such Certificate or must establish to the satisfaction of the Paying Agent and Parent that such Tax has been paid or is not required to be
paid. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE IV </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>REPRESENTATIONS AND WARRANTIES OF THE COMPANY </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Except as otherwise disclosed in (a)&nbsp;Company SEC Documents publicly available at least two (2)&nbsp;Business Days prior to the date of
this Agreement (excluding any disclosures in &#8220;risk factors&#8221; or otherwise relating to &#8220;forward-looking statements&#8221; to the extent that they are cautionary, predictive or forward-looking in nature) (<U>provided</U> that nothing
disclosed in the Company SEC Documents shall be deemed a qualification of, or modification to, the representations and warranties set forth in <U>Section</U><U></U><U>&nbsp;4.1(a)</U> (Organization and Corporate Power),
<U>Section</U><U></U><U>&nbsp;4.2</U> (Authorization; Valid and Binding Agreement), <U>Section</U><U></U><U>&nbsp;4.3</U> (Capital Stock), <U>Section</U><U></U><U>&nbsp;4.4</U> (No Breach), <U>Section</U><U></U><U>&nbsp;4.8(a)</U> (Absence of
Certain Developments), <U>Section</U><U></U><U>&nbsp;4.11</U> (Tax Matters), <U>Section</U><U></U><U>&nbsp;4.22</U> (No Rights Agreement; Anti-Takeover Provisions) and <U>Section</U><U></U><U>&nbsp;4.24</U> (No Vote Required)) or (b)&nbsp;the
disclosure letter delivered by the Company to Parent and Purchaser prior to the execution and delivery of this Agreement (which shall be arranged and in numbered and lettered sections </P>
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corresponding to the numbered and lettered sections contained in this <U>Article IV</U>, and the disclosure in any section shall be deemed to qualify or apply to other sections in this <U>Article
IV</U> to the extent that it is reasonably apparent on its face that such disclosure also qualifies or applies to such other sections) (the &#8220;<U>Company Disclosure Letter</U>&#8221;), the Company represents and warrants to Parent and Purchaser
as follows: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.1. <U>Organization and Corporate Power; Subsidiaries</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) The Company is a corporation validly existing and in good standing under the Laws of the State of Delaware, with full corporate power and
authority to enter into this Agreement and the Promissory Note and perform its obligations hereunder and thereunder. The Company has all requisite corporate power and authority and all Permits necessary to own, lease and operate its properties and
to carry on its business as it is now being conducted (and all such Permits are in full force and effect), except where the failure to hold such Permits would not have a Company Material Adverse Effect. The Company is duly qualified or authorized to
do business and is in good standing in every jurisdiction (to the extent such concept exists in such jurisdiction) in which its ownership of property or the conduct of business as now conducted requires it to qualify, except where the failure to be
so qualified, authorized or in good standing would not have a Company Material Adverse Effect. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Each of the Subsidiaries of the
Company is duly incorporated or organized, validly existing and in good standing under the Laws of its jurisdiction of incorporation or organization and has all requisite corporate or similar power and authority and all Permits necessary to own,
lease and operate its properties and to carry on its business as it is now being conducted (and all such Permits are in full force and effect), except where the failure to hold such Permits would not have a Company Material Adverse Effect. Each of
the Subsidiaries of the Company is duly qualified or authorized to do business and is in good standing in every jurisdiction (to the extent such concept exists in such jurisdiction) in which its ownership of property or the conduct of business as
now conducted requires it to qualify, except where the failure to be so qualified, authorized or in good standing would not have a Company Material Adverse Effect. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) True and complete copies of the certificate of incorporation or formation and bylaws or similar governing document of the Company and each
of its Subsidiaries (the &#8220;<U>Company </U><U>Organizational Documents</U>&#8221;), as in effect as of the date of this Agreement, have been heretofore made available to Parent and Purchaser, and neither the Company nor any Subsidiary of the
Company is in violation of any provisions of its Organizational Documents. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.2. <U>Authorization; Valid and Binding
Agreement</U>. Assuming the Contemplated Transactions are consummated and the Merger becomes effective in accordance with Section&nbsp;251(h) of the DGCL, the Company has all requisite corporate power and authority to execute and deliver this
Agreement and the Promissory Note, to perform its obligations hereunder and thereunder and to consummate the Offer and the Merger. The Company Board, at a meeting duly called and held, duly and unanimously adopted resolutions, that
(a)&nbsp;determined that this Agreement, the Promissory Note and the Contemplated Transactions are advisable, fair to and in the best interests of, the Company and the holders of the Shares, (b)&nbsp;duly authorized and approved the execution and
delivery of this Agreement and the Promissory Note by the Company, the performance by the Company of its covenants and other obligations hereunder and thereunder, and the consummation of the Contemplated Transactions upon the terms and subject to
the conditions set forth herein, (c)&nbsp;resolved that this Agreement and the Contemplated Transactions shall be governed by and effected under Section&nbsp;251(h) and other relevant provisions of the DGCL and (d)&nbsp;resolved to recommend that
the holders of the Shares accept the Offer and tender their Shares pursuant to the Offer (the &#8220;<U>Company Board Recommendation</U>&#8221;), which actions have not, as of the date of this Agreement, been rescinded, modified or withdrawn. No
other corporate action pursuant to the Laws of the State of Delaware, on the part of the Company, is necessary to authorize this Agreement or the Promissory Note. The Company </P>
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has duly executed and delivered this Agreement and the Promissory Note and, assuming the due authorization, execution and delivery by Purchaser and Parent of this Agreement and the due
authorization, execution and delivery by Parent of the Promissory Note, this Agreement and the Promissory Note constitutes its legal, valid and binding obligation, enforceable against it in accordance with its terms except as enforcement may be
limited by bankruptcy, insolvency, reorganization or similar laws affecting creditors&#8217; rights generally and by general principles of equity. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.3. <U>Capital Stock</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) The authorized capital stock of the Company consists of 300,000,000 Shares and 5,000,000 shares of preferred stock, $0.0001 par value per
share, of which, as of October&nbsp;21, 2025 (the &#8220;<U>Measurement Date</U>&#8221;), 21,998,132 Shares were issued and outstanding and no shares of preferred stock were issued and outstanding. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) <U>Section 4.3(b)</U> of the Company Disclosure Letter sets forth a true and complete list of each award of incentive equity or
equity-based award granted by the Company that is outstanding as of the Measurement Date, including Company Stock Options, Company RSUs, and Company PSUs (each, an &#8220;<U>Equity Award</U>&#8221;), that includes, as applicable, (i)&nbsp;the holder
thereof, (ii)&nbsp;the type of award (e.g., incentive stock option, <FONT STYLE="white-space:nowrap">non-qualified</FONT> stock option, restricted stock unit, performance stock unit), (iii) the number of vested and unvested Shares subject thereto,
(iv)&nbsp;the per Share exercise price, (v)&nbsp;the date of grant, (vi)&nbsp;the vesting terms (including performance vesting conditions), (vii) the Company Equity Plan under which the Equity Award was granted, and (viii)&nbsp;in the case of each
Company Stock Option, the expiration date. There is no agreement or arrangement (whether in writing or otherwise) to which the Company or any of its Subsidiaries is a party or with respect to which the Company or any of its Subsidiaries has or could
expect to have Liability, in each case, that contains a promise or commitment to grant an incentive equity award or equity-based award under the Company Equity Plans or otherwise that has not been satisfied by the Company as of the date of this
Agreement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) All Equity Awards were granted and have at all times been administered in compliance with the terms of the applicable
Company Equity Plan and award agreement governing the terms of such Equity Award. Each Company Stock Option&nbsp;has a per Share exercise price that was no less than the fair market value of a share of Company Common Stock on the date of grant as
determined in accordance with Section&nbsp;409A and Section&nbsp;422 of the Code, as applicable. Each Company Stock Option, Company RSU, and Company PSU is exempt from Section&nbsp;409A of the Code. Each Company Stock Option that is intended to
qualify as an &#8220;incentive stock option&#8221; satisfies the requirements of Section&nbsp;422 of the Code. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) As of the Measurement
Date, there were 477,429 Shares reserved for issuance under the Company ESPP, of which a maximum of 60,244 are scheduled to be purchased on November&nbsp;20, 2025. At all times, the Company ESPP has qualified as an &#8220;employee stock purchase
plan&#8221; under Section&nbsp;423 of the Code, and all options to purchase Shares under the Company ESPP (now outstanding or previously exercised or forfeited) have satisfied the requirements of Section&nbsp;423 of the Code. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) The Subsidiaries set forth on <U>Section</U><U></U><U>&nbsp;4.3(e)</U> of the Company Disclosure Letter are the only Subsidiaries of the
Company. Each Subsidiary of the Company is wholly owned by the Company, free and clear of any Liens (other than Permitted Liens), and its outstanding capital stock is set forth opposite the name of such Subsidiary on
<U>Section</U><U></U><U>&nbsp;4.3(e)</U> of the Company Disclosure Letter. The Company does not own, directly or indirectly, any capital stock or restricted stock of, or other equity interest or voting security in, or any interest convertible into
or exchangeable or exercisable for any capital stock or restricted stock of, or other equity interest or voting security in, any Person other than the Subsidiaries of the Company. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(f) Except as disclosed in <U>Section</U><U></U><U>&nbsp;4.3</U> of the Company Disclosure
Letter, neither the Company nor any of its Subsidiaries has any outstanding (i)&nbsp;shares of capital stock, restricted stock or other equity interests or voting securities, (ii)&nbsp;securities convertible, exchangeable or exercisable, directly or
indirectly, into or for capital stock, restricted stock or other equity interests or voting securities of the Company or its Subsidiaries (as applicable), (iii) options, warrants, purchase rights, subscription rights, preemptive rights,
anti-dilutive rights, conversion rights, exchange rights, exercise rights, calls, puts, rights of first refusal or other Contracts that require the Company or its Subsidiaries (as applicable) to issue, sell or otherwise cause to become outstanding
or to acquire, repurchase or redeem capital stock, restricted stock or other equity interests or voting securities of the Company or its Subsidiaries (as applicable) (other than pursuant to the cashless exercise of Company Stock Options or the
withholding of taxes with respect to Company Stock Options, Company RSUs, or Company PSUs), or securities convertible, exchangeable or exercisable, directly or indirectly, into or for capital stock, restricted stock or other equity interests,
equity-based awards or voting securities of the Company or its Subsidiaries (as applicable), (iv) obligation to grant, extend or enter into any options, warrants, purchase rights, subscription rights, preemptive rights, conversion rights, exchange
rights, exercise rights, calls, puts, rights of first refusal or other Contracts that require the Company or its Subsidiaries (as applicable) to issue, sell or otherwise cause to become outstanding or to acquire, repurchase or redeem capital stock,
restricted stock or other equity interests or voting securities of the Company or its Subsidiaries (as applicable), or securities convertible, exchangeable or exercisable, directly or indirectly, into or for capital stock, restricted stock or other
equity interests or voting securities of the Company or its Subsidiaries (as applicable), (v) stock appreciation, phantom stock, restricted stock units, performance stock units, profit participation or similar rights with respect to the Company or
its Subsidiaries (as applicable), (vi) options to purchase Shares under the Company ESPP, (vii)&nbsp;bonds, debentures, notes or other indebtedness of the Company or its Subsidiaries (as applicable) having the right to vote on any matters on which
the Company&#8217;s or any of its Subsidiaries&#8217; (as applicable) stockholders may vote, or (viii)&nbsp;obligations by the Company or its Subsidiaries to make any payments based on the price or value of any of the foregoing securities or
interests covered in clauses (i)&nbsp;through (vii) above (collectively, including the Shares and equity interests of the Company&#8217;s Subsidiaries, the &#8220;<U>Company Securities</U>&#8221;). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(g) There are no outstanding agreements of any kind which obligate the Company or its Subsidiaries to repurchase, redeem or otherwise acquire
any Company Securities or obligate the Company to grant, extend or enter into any such agreements relating to any Company Securities, including any agreements granting any preemptive rights, subscription rights, anti-dilutive rights, call or rights
of first refusal or similar rights with respect to any Company Securities. No Subsidiary of the Company owns any Company Securities. Neither the Company nor any of its Subsidiaries is party to any stockholders&#8217; agreement, voting trust
agreement, registration rights agreement or other similar agreement or understanding with respect to any Company Securities or any other agreement with respect to the disposition or voting of, or dividends with respect to, any Company Securities.
All outstanding Shares are, and all Shares to be purchased pursuant to the Company ESPP and all Shares issued upon exercise of Company Stock Options or settlement of Company RSUs and Company PSUs will be, when issued, duly authorized and validly
issued, and are, or will be, as applicable, fully paid, <FONT STYLE="white-space:nowrap">non-assessable</FONT> and free of preemptive rights. Neither the Company nor any of its Subsidiaries has any Contract pursuant to which it is obligated to make
any equity investment (in the form of a capital contribution or otherwise) in any Person (other than the Company with respect to its wholly owned Subsidiaries). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(h) Except as disclosed in <U>Section</U><U></U><U>&nbsp;4.3(h)</U> of the Company Disclosure Letter, (i)&nbsp;the Company has not delivered
an issuance notice to the Sales Agent; (ii)&nbsp;there are no pending or active issuance notices pursuant to the Sales Agreement; and (iii)&nbsp;no documentation relating to, or notice of, this Agreement is required to be provided to the Sales
Agent. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.4. <U>No Breach</U>. The execution, delivery and performance of this
Agreement and the Promissory Note by the Company and the consummation of the Offer and the Merger do not (a)&nbsp;conflict with or violate the Company Organizational Documents, (b)&nbsp;assuming all consents, approvals, authorizations and other
actions described in <U>Section</U><U></U><U>&nbsp;4.5</U> have been obtained, and all filings and obligations described in <U>Section</U><U></U><U>&nbsp;4.5</U> have been made, conflict with or violate any Law, order, judgment or decree to which
the Company or any of its properties or assets is subject, except any conflicts or violations which would not have a Company Material Adverse Effect, or (c)&nbsp;conflict with or result in any breach of, constitute a default under (with or without
notice or lapse of time), result in a violation of, give rise to a right of termination, cancellation or acceleration or result in the creation of a Lien (other than a Permitted Lien) upon any of the properties or assets of the Company or any of its
Subsidiaries under, any Company Material Contract, except any conflicts, breaches, defaults, violations, terminations, cancellations or accelerations that would not have a Company Material Adverse Effect. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.5. <U>Consents</U>. Except for (a)&nbsp;any applicable requirements of Antitrust and FDI Laws, (b)&nbsp;applicable requirements
of the Exchange Act, (c)&nbsp;any filings required by Nasdaq, (d)&nbsp;the filing of the Certificate of Merger, (e)&nbsp;the filing of applications, consents, approvals, authorizations and notices, as required by the FDA and any other federal,
state, local or foreign Governmental Body that is concerned with or regulates the research, development, marketing, sale, use, handling and control, safety, efficacy, reliability or manufacturing of drug or biological products or medical devices or
is concerned with or regulates public health care programs and (f)&nbsp;any filings with the relevant authorities of jurisdictions in which the Company or any of its Subsidiaries is qualified to do business, in each case, neither the Company nor any
of its Subsidiaries are required to submit any notice, report or other filing with any Governmental Body in connection with the execution, delivery or performance by it of this Agreement or the Promissory Note or the consummation of the Contemplated
Transactions and, other than as stated above, no consent, approval or authorization of any Governmental Body or any other party or Person is required to be obtained by the Company or any of its Subsidiaries in connection with its execution, delivery
and performance of this Agreement or the Promissory Note or the consummation of the Contemplated Transactions, except for those filings, consents, approvals and authorizations the failure of which to obtain would not have a Company Material Adverse
Effect. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.6. <U>SEC Reports; Disclosure Controls and Procedures</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) The Company has timely filed and furnished all reports, schedules, forms, statements and other documents (including exhibits thereto and
all other information incorporated by reference therein) required to be filed or furnished by the Company with the SEC since January&nbsp;1, 2023 (such reports, schedules, forms, statements and other documents, the &#8220;<U>Company SEC
Documents</U>&#8221;). As of their respective filing dates (or, if amended, supplemented or superseded by a filing, then on the date of such amendment, supplement or superseding filing) (and, in the case of registration statements on the dates of
effectiveness): (i) each of the Company SEC Documents complied in all material respects with the applicable requirements of the Securities Act of 1933 as amended (the &#8220;<U>Securities Act</U>&#8221;), the Exchange Act or Sarbanes-Oxley, as
applicable to such Company SEC Documents, and the rules and regulations of the SEC promulgated thereunder applicable to such Company SEC Documents, as in effect on the date of effectiveness (in the case registration statements) and as of their
respective SEC filing dates or, if amended, supplemented or superseded prior to the date hereof, the date of the filing of such amendment, supplement or superseding filing with respect to the portions that are amended, supplemented or superseded (in
the case of all other Company SEC Documents) so filed, and (ii)&nbsp;none of the Company SEC Documents when filed or furnished contained any untrue statement of a material fact or omitted to state a material fact required to be stated therein or
necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading. As of the date hereof, there are no outstanding or unresolved comments in any comment letters of the staff of the SEC
relating to the Company SEC Documents and none of the Company SEC Documents is, to the Knowledge of the Company, the subject of ongoing SEC review. None of the Subsidiaries of the Company are required to file or furnish any forms, reports,
schedules, statements or other documents with the SEC or any foreign equivalent agency. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) The consolidated financial statements (including any notes thereto) contained or
incorporated by reference in the Company SEC Documents (i)&nbsp;complied as to form in all material respects with the published rules and regulations of the SEC applicable thereto, (ii)&nbsp;were prepared in accordance with GAAP, applied on a
consistent basis throughout the periods covered (except as may be indicated in the notes to such financial statements or, in the case of unaudited statements, as permitted by Form <FONT STYLE="white-space:nowrap">10-Q</FONT> of the SEC) and
(iii)&nbsp;fairly presented in all material respects the consolidated financial position of the Company and its Subsidiaries as of the respective dates thereof and the consolidated results of operations and cash flows of the Company and its
Subsidiaries for the periods covered thereby (subject, in the case of unaudited statements, to the absence of footnote disclosure and to normal and recurring <FONT STYLE="white-space:nowrap">year-end</FONT> audit adjustments not material in amount).
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) The Company has designed and maintains, and at all times since January&nbsp;1, 2023 has maintained, a system of internal control over
financial reporting (as defined in Rules 13a&#8211;15(f) and 15d&#8211;15(f) of the Exchange Act) sufficient to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external
purposes in accordance with GAAP, and includes those policies and procedures that: (i)&nbsp;pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of the assets of the Company;
(ii)&nbsp;provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in conformity with GAAP and that receipts and expenditures are being made only in accordance with authorizations of
management and directors of the Company; and (iii)&nbsp;provide reasonable assurance regarding prevention or timely detection of unauthorized acquisitions, use or disposition of the assets of the Company that could have a material effect on the
financial statements. Since January&nbsp;1, 2023, neither the Company nor, to the Knowledge of the Company, the Company&#8217;s independent registered accountant has identified or been made aware of: (i)&nbsp;any &#8220;significant deficiency&#8221;
or &#8220;material weakness&#8221; in the design or operation of internal control over financial reporting utilized by the Company; (ii)&nbsp;with respect to the management or other employees of the Company who have a significant role in the
Company&#8217;s internal control over financial reporting, any illegal act (with respect to or pertaining to the Company or when acting in his or her capacity as an employee of the Company) or fraud, whether or not material; or (iii)&nbsp;any claim
or allegation regarding any of the foregoing. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) The Company (i)&nbsp;has designed and maintains, and at all times since January&nbsp;1,
2023 has maintained, disclosure controls and procedures (as defined in Rules 13a&#8211; 15(e) and 15d&#8211;15(e) of the Exchange Act) to provide reasonable assurance that all information required to be disclosed by the Company in the reports that
it files or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC&#8217;s rules and forms and is accumulated and communicated to the Company&#8217;s management as appropriate to
allow timely decisions regarding required disclosure and (ii)&nbsp;has disclosed, based on its most recent evaluation of its disclosure controls and procedures and internal control over financial reporting prior to the date of this Agreement, to the
Company&#8217;s auditors and the audit committee of the Company Board (A)&nbsp;any significant deficiencies and material weaknesses in the design or operation of its internal control over financial reporting that are reasonably likely to adversely
affect in any material respect the Company&#8217;s ability to record, process, summarize and report financial information and (B)&nbsp;any fraud, whether or not material, that involves management or other employees who have a significant role in the
Company&#8217;s internal control over financial reporting. Since January&nbsp;1, 2023, any material change in internal control over financial reporting required to be disclosed in any Company SEC Document has been so disclosed. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) Since January&nbsp;1, 2023, neither the Company, nor any of its Subsidiaries or, to the
Knowledge of the Company, any director, officer, employee, auditor, accountant or Representative of the Company, has received a material complaint, allegation, assertion or claim regarding the accounting or auditing practices, procedures,
methodologies or methods of the Company, or its internal accounting controls, including any material complaint, allegation, assertion or claim that the Company or any of its Subsidiaries has engaged in questionable accounting or auditing practices,
or any related material allegation regarding management or other employees who have a significant role in the Company&#8217;s internal control over financial reporting. Neither the Company nor its principal executive officer or principal financial
officer has received notice from any Governmental Body challenging or questioning the Company&#8217;s accounting practices, methodologies or methods or the accuracy, completeness, form or manner of filing of any certifications required by Rules <FONT
STYLE="white-space:nowrap">13a-14</FONT> and <FONT STYLE="white-space:nowrap">15d-14</FONT> under the Exchange Act and Sections 302 and 906 of Sarbanes-Oxley. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(f) Neither the Company nor any of its Subsidiaries has effected, entered into or created any securitization transaction or <FONT
STYLE="white-space:nowrap">&#8220;off-balance</FONT> sheet arrangement&#8221; (as defined in Item 303(c) or Regulation <FONT STYLE="white-space:nowrap">S-K</FONT> under the Exchange Act). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.7. <U>No Undisclosed Liabilities</U>. Except (a)&nbsp;as and to the extent disclosed or reserved against on the consolidated
unaudited balance sheet of the Company and its Subsidiaries as of the Company Balance Sheet Date, that is included in the Company SEC Documents, (b)&nbsp;as incurred after the date thereof in the ordinary course of business and similar in nature,
scope and magnitude to actions customarily taken in the ordinary course of the normal <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">day-to-day</FONT></FONT> operations of other Persons that are in the same line of business,
(c)&nbsp;incurred in connection with this Agreement or the Contemplated Transactions, or (d)&nbsp;as set forth in <U>Section</U><U></U><U>&nbsp;4.7</U> of the Company Disclosure Letter, the Company does not have any material liabilities or
obligations of any nature, whether known or unknown, absolute, accrued, contingent or otherwise and whether due or to become due, in each case required by GAAP to be reflected or reserved against in the balance sheet of the Company (or disclosed in
the notes to such balance sheet). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.8. <U>Absence of Certain Developments</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) From the Company Balance Sheet Date to the date of this Agreement, the Company and its Subsidiaries have not experienced a Company
Material Adverse Effect. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Except in connection with the Contemplated Transactions, from the Company Balance Sheet Date to the date of
this Agreement, the Company and each of its Subsidiaries has carried on and operated its business in all material respects in the ordinary course of business and similar in nature, scope and magnitude to actions customarily taken in the ordinary
course of the normal <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">day-to-day</FONT></FONT> operations of other Persons that are in the same line of business (except for discussions, negotiations and transactions related to this
Agreement or other potential strategic transactions), and neither the Company nor any of its Subsidiaries have taken, committed or agreed to take any actions that would have been prohibited by <U>Section</U><U></U><U>&nbsp;6.1(b)</U> (other than
<U>Sections 6.1(b)(i)</U> (<I>Dividends; Acquisition of Company Securities</I>), <U>(ii)</U> (<I>Issuance of Company Securities</I>) and <U>(iii)</U> (<I>Compensation; Benefits</I>)) if such covenants had been in effect as of the Company Balance
Sheet Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.9. <U>Compliance with Laws</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) Each of the Company and its Subsidiaries is, and their respective Products are and have been, since January&nbsp;1, 2023, in compliance,
in all material respects, with all Laws applicable to it, any of its properties or other assets, or its business or operations. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Since January&nbsp;1, 2023, (i) neither the Company nor any of its Subsidiaries has
received any notice from any Governmental Body, or written notice from any Person, that alleges (A)&nbsp;any material violation or noncompliance (or reflects that the Company or any of its Subsidiaries is under investigation or the subject or target
of an inquiry or has threatened to be charged by any such Governmental Body for such alleged noncompliance) with any applicable Law or (B)&nbsp;any material fine, assessment or cease and desist order, or the suspension, revocation or limitation or
restriction of any Permit, and (ii)&nbsp;neither the Company nor any of its Subsidiaries entered into any agreement or settlement with any Governmental Body or Person with respect to its alleged noncompliance with, or violation of, any applicable
Law. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) Since January&nbsp;1, 2023, each of the Company and its Subsidiaries has timely filed all regulatory reports, schedules,
statements, documents, filings, submissions, forms, registrations and other documents, together with any amendments required to be made with respect thereto, and has maintained all records, that each was required to file with any Governmental Body,
including state health and regulatory authorities and any applicable federal regulatory authorities, and have timely paid all fees and assessments due and payable in connection therewith. All such regulatory reports, schedules, statements,
documents, filings, submissions, forms, registrations, other documents and records were complete and accurate in all material respects, or were subsequently updated, changed, corrected or modified. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) The Company, its Subsidiaries and each of their respective officers and directors are in material compliance with, and have complied in
all material respects with, (i)&nbsp;the applicable provisions of the Sarbanes-Oxley Act of 2002 and the related rules and regulations promulgated under such act (&#8220;<U>Sarbanes-Oxley</U>&#8221;) or the Exchange Act and (ii)&nbsp;the applicable
listing and corporate governance rules and regulations of Nasdaq. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.10. <U>Title to Tangible Properties</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) The Company and its Subsidiaries have good and valid title to, or hold pursuant to good, valid and enforceable leases or other comparable
contract rights, all tangible personal property and other tangible assets necessary for the conduct of the business of the Company and its Subsidiaries, as currently conducted, in each case free and clear of any Liens (other than Permitted Liens),
except where the absence of such title or rights would not have a Company Material Adverse Effect. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) <U>Section 4.10(b)</U> of the
Company Disclosure Letter sets forth a true and complete list of all Company Real Property leases (including all amendments, extensions, renewals, and material waivers as of the date of this Agreement), together with the addresses of such Company
Real Property and any security deposits or letters of credit provided by the Company thereunder, which constitute all real property used, occupied, or leased by the Company or its Subsidiaries (the &#8220;<U>Company Real Property</U>&#8221;). The
Company has made available true and correct copies of all Company Real Property leases, together with all related amendments, extensions, renewals, and material waivers or changes. There are no subleases, licenses, occupancy agreements, consents,
purchase agreements, or other contracts granting any person (other than the Company) the right to use or occupy the Company Real Property, and no person (other than the Company and its Subsidiaries) is in possession of the Company Real Property. The
Company has not collaterally assigned or granted a security interest in any Company Real Property lease. Each Company Real Property lease is in full force and effect and is valid, binding and enforceable against the Company or its Subsidiaries (as
applicable) and, to the Knowledge of the Company, the other parties thereto, subject to applicable bankruptcy, insolvency, reorganization, fraudulent conveyance or transfer, moratorium or other similar laws affecting creditors&#8217; rights
generally, and general principles of equity. The Company and its Subsidiaries have performed all material obligations required under each Company Real Property lease to date. The Company has not given or received written notice of any violation,
breach, or default (with or without notice or lapse of time) under any Company Real Property lease. None of the Company, its Subsidiaries, or, to the Knowledge of the Company, any other party to the Company Real Property leases is in material
default under any such lease. Neither the Company nor its Subsidiaries has given or received written notice of termination or cancellation of, or any intention to terminate or cancel, any Company Real
</P>
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Property lease (whether as a result of the Contemplated Transactions or otherwise). No event has occurred which, if not remedied, would result in a material default by the Company or its
Subsidiaries under any Company Real Property lease, and, to the Knowledge of the Company, no event has occurred which, if not remedied, would result in a material default by any other party under any such lease. There are no outstanding options,
rights of first offer, or rights of first refusal in favor of any other party to purchase, lease, sublease, use, or occupy the Company Real Property or any portion or interest therein. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) Neither the Company nor any of its Subsidiaries currently owns or has previously owned any real property. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.11. <U>Tax Matters</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) (i) Each of the Company and its Subsidiaries has timely filed (taking into account any applicable extensions) all material Tax Returns
required to be filed by it and such Tax Returns are true, complete and correct in all material respects, and (ii)&nbsp;each of the Company and its Subsidiaries has timely paid all material Taxes whether or not shown as due and payable on any Tax
Return. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) There are no material Liens for Taxes (other than Taxes not yet due and payable or the amount or validity of which is being
contested in good faith by appropriate proceedings and for which appropriate reserves are established in the financial statements in accordance with GAAP) upon any of the assets of the Company or any of its Subsidiaries. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) The Company and its Subsidiaries have withheld and paid over all material Taxes required to have been withheld and paid over in connection
with any amounts paid or owing to any employee, independent contractor, creditor, stockholder or other third party. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) Neither the
Company nor any of its Subsidiaries has been a party to any &#8220;listed transaction&#8221; within the meaning of Treasury Regulation <FONT STYLE="white-space:nowrap">Section&nbsp;1.6011-4(b)(2).</FONT> </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) No deficiency for any material Tax has been asserted or assessed by a Governmental Body in writing (or, to the Knowledge of the Company,
otherwise) against the Company or any of its Subsidiaries which deficiency has not been paid, settled or withdrawn or is not being contested in good faith in appropriate proceedings. No material U.S., federal, state, local or foreign Actions
relating to Taxes are pending or being conducted with respect to the Company or any of its Subsidiaries. Neither the Company nor any of its Subsidiaries has received written notice of any claim made by a Governmental Body in a jurisdiction where the
Company or such Subsidiary does not pay a certain Tax or file a certain type of Tax Return that the Company or such Subsidiary is subject to taxation by that jurisdiction or required to file a certain type of Tax Return in that jurisdiction. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(f) There has been no waiver or extension of any applicable statute of limitations for the assessment or collection of any material Tax of the
Company or any of its Subsidiaries that is currently in force. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(g) Neither the Company nor any of its Subsidiaries (i)&nbsp;is a party to
or bound by any Tax allocation, sharing or similar agreement (other than any commercial agreement entered into in the ordinary course of business that does not relate primarily to Taxes), (ii) has been a member of an affiliated group filing a
combined, consolidated or unitary Tax Return (other than a group the common parent of which is the Company) or (iii)&nbsp;has liability for the Taxes of any other Person (other than the Company or its Subsidiaries) under Treasury Regulation <FONT
STYLE="white-space:nowrap">Section&nbsp;1.1502-6</FONT> (or any similar provision of state, local or <FONT STYLE="white-space:nowrap">non-U.S.</FONT> Law) or as a successor or transferee. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(h) Neither the Company nor any of its Subsidiaries will be required to include any material
item of income in, or exclude any material item of deduction from, taxable income for any taxable period (or portion thereof) ending after the Closing Date as a result of (i)&nbsp;any change in the method of accounting made prior to the Closing,
(ii)&nbsp;any &#8220;closing agreement&#8221; as described in Section&nbsp;7121 of the Code (or any corresponding or similar provision of state, local or <FONT STYLE="white-space:nowrap">non-U.S.</FONT> Law) or any other agreement with a
Governmental Body regarding Taxes executed on or prior to the Closing Date, (iii)&nbsp;any installment sale or open transaction disposition entered into on or prior to the Closing or (iv)&nbsp;any prepaid amount received or deferred revenue accrued
prior to the Closing outside of the ordinary course of business. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(i) Neither the Company nor any of its Subsidiaries (i)&nbsp;has been a
&#8220;distributing corporation&#8221; or &#8220;controlled corporation&#8221; in a transaction intended to qualify under Section&nbsp;355 of the Code within the two (2)&nbsp;years prior to the date hereof or (ii)&nbsp;has been a United States real
property holding corporation within the meaning of Section&nbsp;897(c) of the Code during the applicable period specified in Section&nbsp;897(c)(1)(A)(ii) of the Code. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.12. <U>Contracts and Commitments</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) <U>Section 4.12(a)</U> of the Company Disclosure Letter identifies each Contract that constitutes a Company Material Contract as of the
date of this Agreement. For purposes of this Agreement, each of the following shall be deemed a &#8220;<U>Company Material Contract</U>&#8221;: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(i) &#8220;material contract&#8221; (as such term is defined in Item 601 (b)(10) of Regulation <FONT STYLE="white-space:nowrap">S-K</FONT> of
the SEC) with respect to the Company or its Subsidiaries that was required to be, but has not been, filed with the SEC with the Company&#8217;s Annual Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for the year ended December&nbsp;31,
2024, or any Company SEC Documents filed after the date of filing of such Form <FONT STYLE="white-space:nowrap">10-K;</FONT> </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(ii)
collective bargaining agreement or Contract with any labor union, trade organization, works council or other employee representative body (other than any statutorily mandated agreement in <FONT STYLE="white-space:nowrap">non-U.S.</FONT>
jurisdictions) (&#8220;<U>Labor Agreements</U>&#8221;); </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(iii) Contract establishing or relating to the formation, creation, operation,
management or control of any joint venture, partnership, collaboration or similar arrangement; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(iv) Contract (A)&nbsp;prohibiting or
materially limiting the right of the Company or any of its Affiliates (including, following the Closing, Parent or any of its Affiliates) to compete in any line of business or to conduct business with any Person or in any geographical area,
(B)&nbsp;obligating the Company or any of its Affiliates (including, following the Closing, Parent or any of its Affiliates) to purchase or otherwise obtain any material product or service exclusively from a single party, to purchase a specified
minimum amount of goods or services with a value in excess of $500,000, or to sell any material product or service exclusively to a single party, (C)&nbsp;under which any Person has been granted the (1)&nbsp;exclusive right to develop, manufacture,
sell, market or distribute the Products, or <FONT STYLE="white-space:nowrap">(2)&nbsp;non-exclusive</FONT> right to develop, manufacture, sell, market or distribute the Products (excluding, solely for subclause (C)(2), any Routine Services Contracts
entered into in the ordinary course of business), (D) provides for &#8220;exclusivity&#8221; or any similar requirement in favor of any Person or group of Persons or in any geographical area or (E)&nbsp;requiring the Company or any of its Affiliates
(including, following the Closing, Parent or any of its Affiliates) to conduct any business on a &#8220;most favored nations&#8221; basis with any Person; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(v) Contract containing any <FONT STYLE="white-space:nowrap">&#8220;non-solicitation&#8221;</FONT> or
<FONT STYLE="white-space:nowrap">&#8220;no-hire&#8221;</FONT> provision that restricts the Company or and of its Subsidiaries; </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(vi) Contract in respect of Indebtedness of $500,000 or more, or any loan by the Company to
any other Person; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(vii) Contract (other than a Company Plan) between the Company or any of its Subsidiaries, on the one hand, and any
Affiliate of the Company, on the other hand; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(viii) Contract relating to the voting or registration of any securities; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(ix) Contract containing a right of first refusal, right of first negotiation or right of first offer with respect to any equity interests or
assets; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(x) Contract that contains any standstill or similar agreement pursuant to which the Company or any of its Subsidiaries has
agreed not to acquire assets or securities of another Person; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xi) (A) Contract and (B)&nbsp;open purchase order, in each case, for
payments that remain or may become due of $500,000 or more (such Contracts and purchase orders, or work orders, change orders or master services agreements relating to the same, the &#8220;<U>Purchase Orders</U>&#8221;) other than, in each case, a
Company Plan; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xii) Corporate integrity agreement, consent decree, deferred prosecution agreement,
<FONT STYLE="white-space:nowrap">non-prosecution</FONT> agreement, or other similar type of agreement with Governmental Bodies that have existing or contingent performance obligations; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xiii) Contract of the Company or any of its Subsidiaries relating to the settlement, conciliation or similar agreement with any Governmental
Body or Person, or that provides for any continuing material obligations on the part of the Company or any of its Subsidiaries; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xiv)
Contract of the Company or any of its Subsidiaries that prohibit, limit or restrict the payment of dividends or distributions in respect of the Company Securities, or otherwise prohibit, limit or restrict the pledging of Company Securities, or
prohibit, limit or restrict the issuance of guarantees by the Company or any of its Subsidiaries other than the Company Equity Plans or any Contracts evidencing awards granted under the Company Equity Plans; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xv) stockholders&#8217;, investors rights&#8217;, registration rights or similar Contract (excluding Contracts governing Company Stock
Options or Company RSUs); </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xvi) Contract (including all amendments, extensions and renewals with respect thereto) pursuant to which the
Company or any of its Subsidiaries leases, subleases, uses or occupies any real property; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xvii) Contract with or binding upon the
Company, any of its Subsidiaries or any of its respective properties or assets that is of the type that would be required to be disclosed under Item 404 of Regulation <FONT STYLE="white-space:nowrap">S-K</FONT> under the Securities Act; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xviii) IP Contract; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xix)
Contract with any academic institution, research center or Governmental Body that relates to any Owned Intellectual Property or any other material Company Intellectual Property (or the research or development of any of the foregoing or the funding
for such research or development activities); </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xx) Contract with respect to commercialization, manufacturing, supply, service,
maintenance, collaboration, <FONT STYLE="white-space:nowrap">co-promotion,</FONT> discovery, research, development or profit sharing (including any such Contracts with any third-party payor or any third party contract research organization or third
party contract manufacturing organization that develops, manufactures or supplies any Products and/or that directly conducts clinical trials), in each case, with a value in excess of $500,000; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxi) Contract pursuant to which the Company or any of its Subsidiaries has continuing guarantee,
<FONT STYLE="white-space:nowrap">&#8220;earn-out&#8221;</FONT> or similar contingent payment obligations (other than indemnification or performance guarantee obligations provided for in the ordinary course of business), including (A)&nbsp;milestone
or similar payments, including upon the achievement of regulatory or commercial milestones or (B)&nbsp;payment of royalties or other amounts calculated based upon any revenues or income of the Company or its Subsidiaries, in each case, that could
result in payments in excess of $500,000; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxii) Contract that obligates the Company or any of its Subsidiaries to make any capital
commitment or capital expenditure in an amount in excess of $500,000; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxiii) Contract or offer letter that is for the employment of any
directors, officers or employees at annual base salary in excess of $250,000; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxiv) Contract with any independent contractor or
consultant involving annual payments in excess of $250,000; and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxv) Contract or arrangement to enter into any of the foregoing. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) A true and correct copy of all written Company Material Contracts, together with all material amendments, waivers or other changes
thereto, and a correct and complete written summary setting forth the terms and conditions of each oral Company Material Contract has been made available to Parent. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) (i) Neither the Company nor any of its Subsidiaries (A)&nbsp;is, or has received written notice that any other party to any Company
Material Contract is, in violation or breach of or default (with or without notice or lapse of time or both) under and (B)&nbsp;has waived or failed to enforce any rights or benefits under any Company Material Contract to which it is a party or any
of its properties or other assets is subject, (ii)&nbsp;there has occurred no event giving to others any right of termination, amendment or cancellation of (with or without notice or lapse of time or both) any such Company Material Contract
(excluding expiration of any Contract in accordance with its terms) and (iii)&nbsp;each such Company Material Contract is in full force and effect and is a legal, valid and binding agreement of, and enforceable against, the Company or its
Subsidiaries, as applicable, and, to the Knowledge of the Company, each other party thereto. As of the date of this Agreement, no party to any Company Material Contract has given any notice of termination or cancellation of any Company Material
Contract or that it intends to seek to terminate or cancel any Company Material Contract (whether as a result of the Contemplated Transactions or otherwise). The Company has not deferred payment under any Material Contract, received notice of an
overdue invoice with respect to any Material Contract, or agreed with any counterparty to any Material Contract that payment of amounts owed by the Company under such Material Contract may be deferred or delayed. The Company has timely paid all
amounts due and payable under each Material Contract in accordance with its terms. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.13. <U>Intellectual Property</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) <U>Section 4.13(a)</U> of the Company Disclosure Letter sets forth, as of the date of this Agreement, a complete and correct list of all
Patents, Trademarks, Copyrights, domain names and social media accounts and handles, in each case owned or purported to be owned by, or exclusively licensed to, the Company or any of its Subsidiaries, in each case, that have been registered with or
issued by a Governmental Body, or with respect to which the Company or any of its Subsidiaries has filed an application for registration (collectively, for clarity even if not listed on the Company Disclosure Letter, &#8220;<U>Company Registered
Intellectual Property</U>&#8221;), indicating for each such item as of the date of this Agreement as applicable, the name of the current legal owner(s), the jurisdiction of application/registration, the application/registration number and the
filing/issuance date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Except as expressly indicated on <U>Section</U><U></U><U>&nbsp;4.13(a)</U> of the Company Disclosure Letter,
all registrations within the Company Registered Intellectual Property are subsisting and in full force and effect and, to the Knowledge of the Company, are valid and enforceable, and all applications within the Company Registered Intellectual
Property are subsisting and, to the Knowledge of the Company, will be valid and enforceable upon issuance. The Company and its Subsidiaries (with respect to the Company Registered Intellectual Property that is owned or purported to be owned by the
Company or such Subsidiary) and, to the Knowledge of the Company, the third parties that own the Company Registered Intellectual Property that is exclusively licensed to the Company (with respect to the Company Registered Intellectual Property that
is exclusively licensed to the Company)&nbsp;(i) have made all necessary filings and paid all necessary registration, maintenance, renewal and other fees required for registering and maintaining the Company Registered Intellectual Property and
(ii)&nbsp;have timely filed all necessary documents and certificates in connection therewith with the relevant Patent, Trademark, Copyright, domain name registrar or other authorities in the United States or foreign jurisdictions, as the case may
be, for the purpose of registering and maintaining in full force and effect such Company Registered Intellectual Property. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) The
Company or a Subsidiary of the Company is the exclusive owner of all rights, title and interests in and to all Owned Intellectual Property, free and clear of all Liens (except for Permitted Liens), and possesses legally sufficient and enforceable
rights pursuant to written agreements to use all other Company Intellectual Property as such Intellectual Property is used in the conduct of the Company&#8217;s business; <U>provided</U>, <U>however</U>, that this sentence will not be interpreted as
a representation of <FONT STYLE="white-space:nowrap">non-infringement</FONT> of third-party Intellectual Property, which is dealt with exclusively in <U>Section</U><U></U><U>&nbsp;4.13(e)</U> below. Except as expressly set forth in
<U>Section</U><U></U><U>&nbsp;4.13(c)</U> of the Company Disclosure Letter, no third party has any joint ownership in any inventions claimed by any issued Patents or pending claims in any applications for Patents included in the Owned Intellectual
Property (or to the Knowledge of the Company, any licensed Company Registered Intellectual Property). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) The Company and each of its
Subsidiaries has diligently prepared or is diligently preparing to file patent applications for all potentially patentable inventions within the Owned Intellectual Property, except where, in the exercise of reasonable business judgment, the Company
or such Subsidiary (as applicable) has decided not to file or has decided to defer filing, a patent application on a potentially patentable invention. The Company and its Subsidiaries have complied in all material respects with all Laws regarding
the duty of disclosure, candor and good faith in connection with each Patent included in the Owned Intellectual Property (or otherwise in the Company Registered Intellectual Property to the extent the Company controls filing or prosecution thereof).
No public disclosure bar by the Company or its Subsidiaries has occurred or on sale bar by the Company or its Subsidiaries has arisen which has rendered or would reasonably be expected to render any material Patent contained in the Owned
Intellectual Property (or otherwise in the Company Registered Intellectual Property to the extent the Company controls filing or prosecution thereof) unenforceable or invalid. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) To the Knowledge of the Company, the conduct of the Company&#8217;s and its
Subsidiaries&#8217; business, including the research, development, and manufacture of the Products, has not infringed, misappropriated or otherwise violated and is not infringing, misappropriating or otherwise violating any Intellectual Property of
any Person. Neither the Company nor any of its Subsidiaries has received any written notice from any Person (i)&nbsp;claiming any infringement, misappropriation or violation of the Intellectual Property of such Person or (ii)&nbsp;contesting the
use, ownership, scope, validity or enforceability of any of the Company Intellectual Property. As of the date of this Agreement, there is no Action pending, or, to the Knowledge of the Company, threatened, against the Company or any of its
Subsidiaries (or to the Knowledge of the Company, any other Person) claiming or contesting any of the foregoing (other than, for clarity, office actions initiated by the U.S. Patent and Trademark Office or any foreign equivalent in the ordinary
course of prosecution). None of the Owned Intellectual Property, and to the Knowledge of the Company, other Company Intellectual Property is subject to any pending or outstanding judgment that adversely restricts the use, transfer or registration
of, or adversely affects the validity or enforceability of, any such Intellectual Property. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(f) To the Knowledge of the Company, no
Person has misappropriated, infringed or otherwise violated or is infringing, misappropriating or otherwise violating any Owned Intellectual Property or Exclusive Intellectual Property, and no such claims have been made against any other Person by
the Company or any of its Subsidiaries. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(g) <U>Section 4.13(g)</U> of the Company Disclosure Letter sets forth, as of the date of this
Agreement, a complete and correct list of all IP Contracts to which the Company is a party. The Company has made available to Parent and Purchaser true and complete copies of all such IP Contracts. To the Knowledge of the Company, (i)&nbsp;each
other party to any such IP Contracts has performed all material obligations required to be performed by such party as of the date of this Agreement and (ii)&nbsp;neither the Company nor any of its Subsidiaries is in violation, breach or default of
or under any such IP Contracts. Except as set forth on <U>Section</U><U></U><U>&nbsp;4.13(g)</U> of the Company Disclosure Letter, neither the execution and delivery of this Agreement nor the consummation of the Contemplated Transactions will
(A)&nbsp;result in the breach of, or create on behalf of any third party the right to terminate or modify any IP Contract, (B)&nbsp;result in or require the grant, assignment or transfer to any other Person (other than Parent, Purchaser or any of
their respective Affiliates) of any license or other right or interest under, to or in any of the Company Intellectual Property or any of the Intellectual Property of Parent, Purchaser or any of their respective Affiliates or (C)&nbsp;cause a
material loss or impairment of any Company Intellectual Property. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(h) No past or present director, officer, employee, consultant or
independent contractor of the Company or any of its Subsidiaries owns (or has any claim, or any right (whether or not currently exercisable) to any ownership interest, in or to) any Owned Intellectual Property or, to the Knowledge of the Company,
any other Company Intellectual Property that is or could be material to the operation of the Company or its Subsidiaries. Each current and former employee, officer and director of the Company or any of its Subsidiaries, each current and former
independent contractor and consultant of the Company or any of its Subsidiaries, and any other Person who is or has been involved in the creation or development of any Intellectual Property for or on behalf of the Company or any of its Subsidiaries
has executed a valid and enforceable written agreement (i)&nbsp;requiring such Person to maintain the confidentiality of all confidential information of the Company or its Subsidiaries, (ii)&nbsp;permitting such Person to use such information only
for the benefit of the Company or its Subsidiaries in the scope of such Person&#8217;s employment or engagement by the Company or any of its Subsidiaries (as the case may be) and (iii)&nbsp;providing for the effective assignment to the Company or
any of its Subsidiaries of all rights, title and interests in and to all Intellectual Property created or developed for the Company or any of its Subsidiaries in the course of such Person&#8217;s employment or retention thereby. There is no material
uncured breach by the Company or any of its Subsidiaries, or, to the Knowledge of the Company, the counterparty, under any such agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(i) The Company and its Subsidiaries have taken commercially reasonable steps to prevent the unauthorized disclosure or use of its material
Trade Secrets (and to maintain the secrecy and value thereof). To the Knowledge of the Company, no Trade Secret that is material to the business of the Company and its Subsidiaries as presently conducted has been disclosed to any Person, other than
pursuant to a <FONT STYLE="white-space:nowrap">non-disclosure</FONT> agreement restricting the disclosure and use of such Trade Secret. </P> <P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(j) No funding, facilities or personnel of any Governmental Body or any university, college,
research institute or other educational institution (i)&nbsp;has been or is being used to create, in whole or in part, any Owned Intellectual Property (or, to the Knowledge of the Company, other Company Intellectual Property), except for any such
funding or use of facilities or personnel that does not result in such Governmental Body or institution obtaining ownership of, or use rights to (except for use rights during the term of the applicable agreement between the Company or any of its
Subsidiaries, on the one hand, and such Governmental Body or educational institution, on the other hand, solely to conduct activities within the scope of such applicable agreement or <FONT STYLE="white-space:nowrap">non-exclusive</FONT> licenses
solely for internal education or research use) such Company Intellectual Property or (ii)&nbsp;requires or otherwise obligates the Company or any of its Subsidiaries to grant or offer to any such Governmental Body or institution any license or other
right to such Company Intellectual Property (except for use rights during the term of the applicable agreement between the Company and such Governmental Body or institution solely to conduct activities within the scope of such applicable agreement
or <FONT STYLE="white-space:nowrap">non-exclusive</FONT> licenses solely for internal education or research use). No current or former employee, consultant or independent contractor of the Company or any of its Subsidiaries who contributed to the
creation or development of any Company Intellectual Property has, to the Knowledge of the Company, performed services for a Governmental Body or any university, college, research institute or other educational institution related to the
Company&#8217;s or its Subsidiaries&#8217; business as presently conducted during a period of time during which such employee, consultant or independent contractor was also performing services for the Company or any of its Subsidiaries. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(k) (i) The computer systems, including the software, firmware, hardware, networks, interfaces, platforms and related systems, owned, leased
or licensed by the Company or any of its Subsidiaries (collectively, the &#8220;<U>Company Systems</U>&#8221;) are sufficient for the conduct of its business as presently conducted by Company and its Subsidiaries, (ii)&nbsp;since January&nbsp;1,
2023, there have been no failures, breakdowns, breaches, defects, continued substandard performance or other adverse events affecting any such Company Systems that have caused or could reasonably be expected to result in the substantial disruption
or interruption in or to the use of such Company Systems or the conduct of the business of the Company and its Subsidiaries as presently conducted, and (iii)&nbsp;since January&nbsp;1, 2023, there have not been any incidents of unauthorized access
or other security breaches of the Company Systems. The Company and its Subsidiaries (i)&nbsp;have taken, and take, commercially reasonable efforts (including maintaining policies and procedures) to maintain and protect the integrity, security and
operation of the Company Systems owned or controlled by the Company and its Subsidiaries, and (ii)&nbsp;have implemented and maintain backup and disaster recovery technology and procedures consistent with reasonable information technology security
practices for a company of its size and nature. To the Knowledge of the Company, as of the date hereof, the Company Systems do not contain any malware, &#8220;Trojan horses,&#8221; viruses, or other malicious code. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.14. <U>Litigation</U>. As of the date of this Agreement, there are no material Actions pending or threatened against or by the
Company or any of its Subsidiaries, or, to the Knowledge of the Company, against another Person for which the Company or any of its Subsidiaries is providing indemnification or other support, at law or in equity, or before or by any Governmental
Body or any Person, and neither the Company nor any of its Subsidiaries is subject to or in violation of any outstanding material judgment, injunction, rule, order or decree of any court or Governmental Body or Person. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.15. <U>Insurance</U>. <U>Section</U><U></U><U>&nbsp;4.15</U> of the Company Disclosure Letter sets forth each material
insurance policy (including policies providing casualty, liability, medical and works compensation coverage) to which the Company or any of its Subsidiaries is a party as of the date of this Agreement. As of the date of this Agreement, each
insurance policy under which the Company or any of its Subsidiaries is </P>
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an insured or otherwise the principal beneficiary of coverage is in full force and effect, and (i)&nbsp;neither the Company nor any of its Subsidiaries is in breach or default under any such
insurance policy, (ii)&nbsp;no notice of cancellation or termination has been received with respect to any insurance policy and (iii)&nbsp;no event has occurred which, with notice or lapse of time, would constitute such breach or default, or permit
termination, or modification, under any such insurance policy, except as would not have a Company Material Adverse Effect. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.16. <U>Employee Benefit Plans</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) <U>Section 4.16(a)</U> of the Company Disclosure Letter lists all material Company Plans. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) With respect to each Company Plan, the Company has made available to Parent and Purchaser true and complete copies of the following (as
applicable) prior to the date of this Agreement: (i)&nbsp;the current plan document, including all amendments thereto or, with respect to any unwritten plan, a written summary of all material terms thereof, (ii)&nbsp;the current summary plan
description along with all summaries of material modifications thereto, (iii)&nbsp;all related trust instruments, custodial agreements, insurance policies, administrative agreements, advisory agreements or other funding-related documents,
(iv)&nbsp;a copy of the most recent financial statements, (v)&nbsp;the three (3)&nbsp;most recent annual reports on Form 5500, including all schedules and attachments, required to be filed with the Internal Revenue Service, (vi)&nbsp;a copy of all <FONT
STYLE="white-space:nowrap">non-routine</FONT> correspondence with any Governmental Body relating to a Company Plan received or sent within the last six (6)&nbsp;years, (vii) results of <FONT STYLE="white-space:nowrap">non-discrimination</FONT>
testing for each of the last three (3)&nbsp;years (including details of any related corrections), (viii) all Forms <FONT STYLE="white-space:nowrap">1094-C</FONT> for the Company and any of its Subsidiaries that served as an employing entity from
2018 to 2024, and (ix)&nbsp;the current Internal Revenue Service determination, advisory or opinion letter. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) Each Company Plan that is
intended to be &#8220;qualified&#8221; under Section&nbsp;401(a) of the Code is the subject of a favorable determination letter or is covered by a favorable opinion or advisory letter from the Internal Revenue Service as to its qualification, each
trust created thereunder has been determined by the Internal Revenue Service to be exempt from Tax under the provisions of Section&nbsp;501(a) of the Code, and no event has occurred with respect to any such Company Plan, either by reason of any
action or failure to act, that could reasonably be expected to cause the loss of any such qualification, registration or <FONT STYLE="white-space:nowrap">tax-exempt</FONT> status or result in material Liability to the Company or any of its
Subsidiaries. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) Each Company Plan, including any associated trust or fund, has been established, maintained, operated, funded and
administered in compliance with its terms and complies, in all material respects, in form and in operation with the requirements of the Code, the Employee Retirement Income Security Act of 1974, as amended (&#8220;<U>ERISA</U>&#8221;), and other
applicable Laws. There are no, and for the last six (6)&nbsp;years there have not been, any audits or investigations by any Governmental Body involving any Company Plan or the assets thereof. With respect to each Company Plan or the assets thereof,
there are no Actions or claims pending or, to the Knowledge of the Company, threatened, other than routine claims for benefits in the ordinary course, and to the Knowledge of the Company no fact or circumstance exists that would be reasonably likely
to give rise to any such Action or claim. No Company Plan is, or within the last six (6)&nbsp;years has been, the subject of an examination or audit by a Governmental Body, or the subject of an application or filing under, or a participant in, a
government-sponsored amnesty, voluntary compliance, self-correction or similar program. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) No Company Plan is and none of the Company,
its Subsidiaries or any of their respective ERISA Affiliates has at any time sponsored, contributed to or been required to contribute to, or had or otherwise has any Liability or obligation under or in respect of, a plan that is or was at any
relevant time (i)&nbsp;subject to Section&nbsp;302 or Title IV of ERISA or Section&nbsp;412 of the Code or is otherwise a defined benefit plan (as defined in Section&nbsp;3(35) of ERISA), (ii) a &#8220;multiemployer plan&#8221; within the meaning of
</P>
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Section&nbsp;3(37) of ERISA, (iii)&nbsp;a &#8220;multiple employer plan&#8221; as described in Section&nbsp;413(c) of the Code or Section&nbsp;210 of ERISA, (iv)&nbsp;a &#8220;multiple employer
welfare arrangement&#8221; within the meaning of Section&nbsp;3(40) of ERISA or (v)&nbsp;a plan that has two (2)&nbsp;or more contributing sponsors, at least two (2)&nbsp;of whom are not under common control, within the meaning of Section&nbsp;4063
of ERISA. Neither the Company nor any of its Subsidiaries has any Liability by reason of at any time being considered a single employer under Section&nbsp;414 of the Code with any Person other than the Company or its Subsidiaries. The Company Plans
do not obligate, and neither the Company not any of its Subsidiaries otherwise have any Liability to provide a current or former employee or other service provider (or any spouse or dependent thereof) any life insurance or medical or welfare
benefits after his or her termination of employment or service with the Company or any of its Subsidiaries, other than as required under Part 6 of Subtitle B of Title I of ERISA, Section&nbsp;4980B of the Code or any other Law at the sole expense of
the participant. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(f) All contributions, reimbursements, distributions, premiums and benefit payments that are due under any Company Plan
have been timely made and all such amounts for any period ending on or before the Closing Date that are not yet due have been made or properly accrued. Neither the Company nor any of its Subsidiaries has incurred any Tax (whether or not assessed)
pursuant to Sections 4980B, 4980D, 4980H, 6721 or 6722 of the Code. There has been no &#8220;prohibited transaction&#8221; within the meaning of Section&nbsp;4975 of the Code or Section&nbsp;406 of ERISA, breach of fiduciary duty (as determined
under ERISA) with respect to any Company Plan, or other transaction with respect to any Company Plan that could subject the Company or any of its Subsidiaries to any tax or other penalty under the Code, ERISA, or any other applicable Laws. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(g) Except as set forth in <U>Section</U><U></U><U>&nbsp;3.2</U> of this Agreement or in <U>Section</U><U></U><U>&nbsp;4.16(g)</U> of the
Company Disclosure Letter, neither the execution or delivery of this Agreement, nor the consummation of the Contemplated Transactions, could, either individually or together with the occurrence of some other event (including a termination of
employment or service), (i) result in any compensatory payment (including severance, bonus or other similar payment) becoming due to any current or former officer, director, employee or individual service provider of the Company or any of its
Subsidiaries, or under a Company Plan or otherwise, (ii)&nbsp;increase or otherwise enhance any benefits or compensation otherwise payable under any Company Plan or otherwise to a current or former officer, employee or individual service provider of
the Company or any of its Subsidiaries, (iii)&nbsp;result in the acceleration of the time of payment or vesting of any payments or benefits or trigger any other obligation under any Company Plan, (iv)&nbsp;require the Company or any of its
Subsidiaries to set aside any assets to fund or trigger any payment or funding of any benefits under any Company Plan, (v)&nbsp;result in any violation of, or default under, any Company Plan, (vi)&nbsp;limit or restrict the right of the Company to
merge, amend or terminate any Company Plan or (vii)&nbsp;result in the payment of any &#8220;excess parachute payment&#8221; within the meaning of Section&nbsp;280G of the Code or in the imposition of an excise Tax under Section&nbsp;4999 of the
Code. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(h) Neither the Company nor any of its Subsidiaries has any obligation to pay any <FONT STYLE="white-space:nowrap">gross-up,</FONT>
reimbursement or other payment in respect of any Tax imposed under Section&nbsp;4999 or Section&nbsp;409A of the Code (or any corresponding provisions of state or local Law relating to Tax). The Company will provide to Parent as soon as reasonably
practicable, but in no event later than twenty (20)&nbsp;Business Days prior to the Closing Date, calculations regarding whether any payments made or which may be made to &#8220;disqualified individuals&#8221; are &#8220;excess parachute
payments&#8221;, as such terms are defined in Section&nbsp;280G of the Code. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(i) Each &#8220;nonqualified deferred compensation
plan&#8221; (as defined in Section&nbsp;409A(d)(1) of the Code) of the Company or any of its Subsidiaries has been documented and operated in material compliance with Section&nbsp;409A of the Code and the applicable guidance and regulations
thereunder. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.17. <U>Environmental Compliance and Conditions</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) Each of the Company and its Subsidiaries is, and since January&nbsp;1, 2020 has been, in material compliance with all Environmental Laws;
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Each of the Company and its Subsidiaries holds, and is in material compliance with, all Permits required under Environmental Laws to
operate their business at the Company Real Property as presently conducted and there are no Actions, suits, claims, investigations or other legal proceedings pending or, to the Knowledge of the Company, threatened that would reasonably be expected
to result in the suspension, termination, or material and adverse modification of any such Permit; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) Since January&nbsp;1, 2020,
neither the Company nor any of its Subsidiaries has received any claim, notice or complaint, or been subject to any Action from any Governmental Body or third party regarding any actual or alleged violation of Environmental Laws or any Liabilities
or potential Liabilities under Environmental Laws, and neither the Company nor any of its Subsidiaries have any unresolved obligations under any judgment or consent decree or other agreement resolving any alleged violation of or Liability under
Environmental Laws; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) To the Knowledge of the Company, neither the Company nor any of its Subsidiaries has released any Hazardous
Substance on, under or about the Company Real Property or any other real property now or formerly occupied or used by the Company or any of its Subsidiaries in a manner that reasonably could be expected to give rise to Liability for the Company or
any of its Subsidiaries under any Environmental Laws; and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) The Company has made available to Parent true and complete copies of all
environmental reports, audits, assessments, correspondence, or studies in the Company&#8217;s possession or control relating to the environmental condition of the Company Real Property or to the compliance of the Company or any of its Subsidiaries
with Environmental Laws. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.18. <U>Employment and Labor Matters</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) Neither the Company nor any of its Subsidiaries is a party to or bound by any Labor Agreement, and no employees of the Company nor any of
its Subsidiaries are represented by a labor union, works council or other employee representative body. Neither the Company nor any of its Subsidiaries has experienced any actual or, to the Knowledge of the Company, threatened labor disruptions,
arbitrations, picketing, strikes, slowdowns, handbilling, work stoppages, lockouts, material labor grievances, claims of unfair labor practices, or other collective bargaining or labor disputes since January&nbsp;1, 2023, and, to the Knowledge of
the Company, has not experienced union organization attempts since such date. Since January&nbsp;1, 2023, no labor union, works council, other labor organization, or group of employees of the Company or any of its Subsidiaries has made a demand or
petition for recognition or certification, and there are no representation or certification proceedings presently pending or threatened to be brought or filed with the National Labor Relations Board or any other labor relations tribunal or
authority. Neither the Company nor any of its Subsidiaries has any notice or consultation obligations to any labor union, labor organization or works council in connection with the execution of this Agreement or consummation of the Contemplated
Transactions. There are and since January&nbsp;1, 2023 have been no Actions pending or threatened by or before any Governmental Body against or affecting the Company or any of its Subsidiaries concerning employment-related matters (including any
grievances or unfair labor practice charges) or brought by or on behalf of any current or former applicant, employee or independent contractor of the Company or any of its Subsidiaries. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Each of the Company and its Subsidiaries is and, since January&nbsp;1, 2023, has been in
compliance, in all material respects, with all Laws relating to labor and employment, including all such Laws relating to wages and hours (including minimum wage and overtime wages), human rights, discrimination, harassment, retaliation, pay equity,
employment equity, paid sick days/leave entitlements and benefits, family and medical leave and other leaves of absence (including the federal Emergency Family and Medical Leave Expansion Act), workers&#8217; compensation, safety and health,
immigration and work authorization (including the completion and retention of Forms <FONT STYLE="white-space:nowrap">I-9</FONT> for all employees and the proper confirmation of employee visas), worker classification and payment (including
employee-independent contractor classification and the proper classification of employees as exempt employees and <FONT STYLE="white-space:nowrap">non-exempt</FONT> employees), plant closures and layoffs (including the Worker Adjustment and
Retraining Notification Act of 1988, as amended, and any similar foreign, state, provincial or local &#8220;mass layoff&#8221; or &#8220;plant closing&#8221; Laws (&#8220;<U>WARN</U>&#8221;)), terms and conditions of employment, whistleblowing,
disability rights or benefits, employee trainings and notices, background checks and drug testing, labor relations, employee leave issues, affirmative action and unemployment insurance. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) There has been no &#8220;mass layoff&#8221; or &#8220;plant closing&#8221; (as defined by WARN or any similar foreign, state, provincial
or local Laws) with respect to the Company or any of its Subsidiaries since January&nbsp;1, 2023. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) No current employee with annualized
compensation at or above $250,000 has given notice of termination of employment or, to the Knowledge of the Company, otherwise intends to terminate employment with the Company or any of its Subsidiaries within the twelve (12)&nbsp;months following
the Closing. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) All employees are employed on an <FONT STYLE="white-space:nowrap">&#8220;at-will&#8221;</FONT> basis and their
employment can be terminated at any time for any reason without any material amounts being owed to such individual other than with respect to wages accrued before termination, vested benefits under the Company Plans, and severance under Company
Plans disclosed on <U>Section</U><U></U><U>&nbsp;4.16(a)</U> of the Company Disclosure Letter or amounts required by applicable Law. The relationships with all individuals who act on their own as contractors or as other service providers can be
terminated for any reason with no greater than thirty (30)&nbsp;days&#8217; prior written notice, without any amounts being owed to such individuals, other than with respect to payments earned before the notice of termination. Neither the Company
nor any of its Subsidiaries sponsors any employee for, or otherwise knowingly engage any employee working pursuant to, a nonimmigrant visa. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(f) The Company has made available to Parent a true and complete list of (i)&nbsp;the employee identification number, name, current
compensation rate (including salary and target annual bonus or commission opportunity), date of hire, work location, visa status, leave status and current job title or position of each officer and employee of the Company and each of its
Subsidiaries, (ii)&nbsp;the names of each other individual who has accepted an offer of employment made by the Company or any of its Subsidiaries but whose employment has not yet commenced and (iii)&nbsp;the names of each other individual to whom an
offer of employment is outstanding by the Company or any of its Subsidiaries, together with each such individual&#8217;s actual or offered position or function, date of hire, location, status as active or inactive, whether such individual is on a
time limited visa, base pay, bonus target, whether such position is exempt or <FONT STYLE="white-space:nowrap">non-exempt,</FONT> leave status and expected return to work date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(g) <U>Section 4.18(g)</U> of the Company Disclosure Letter lists all individual independent contractors to the Company or any of its
Subsidiaries who have performed services for the Company or any of its Subsidiaries within the past twelve (12)&nbsp;months, including name, date of engagement, current rate of payment and any incentive compensation opportunities, term of
engagement, and work location. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(h) The Company has made available to Parent a complete and accurate copy of each material written
personnel policy and material written personnel rule or procedure generally applicable to employees of the Company and each of its Subsidiaries. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(i) No executive or key employee of the Company or any of its Subsidiaries has been the
subject of any sexual or other type of discrimination, harassment, or misconduct allegations during his or her tenure at the Company or any of its Subsidiaries. Each of the Company and its Subsidiaries has reasonably investigated all sexual
harassment, or other discrimination, retaliation or policy violation allegations of which it is aware. With respect to each such allegation with potential merit, each of the Company and its Subsidiaries has taken prompt corrective action that is
reasonably calculated to prevent further improper action. Neither the Company nor any of its Subsidiaries reasonably expects any material Liabilities with respect to any such allegations and is not aware of any allegations relating to officers,
directors, employees, contractors, or agents of the Company or such Subsidiary, that, if known to the public, would bring the Company or such Subsidiary into material disrepute. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(j) To the Knowledge of the Company, no current or former employee or independent contractor of the Company or any of its Subsidiaries is in
any material respect in violation of any term of any nondisclosure agreement, noncompetition agreement, nonsolicitation agreement, or other restrictive covenant agreement or obligation: (i)&nbsp;owed to the Company or any of its Subsidiaries; or
(ii)&nbsp;owed to any third party with respect to such person&#8217;s right to be employed or engaged by the Company or any of its Subsidiaries. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(k) Each of the Company and its Subsidiaries is, and since January&nbsp;1, 2023, has been, in compliance in all material respects with all
applicable immigration Laws, including, the Immigration Reform and Control Act of 1986 and any amendments thereto. Each of the Company and its Subsidiaries has properly completed and retained Form <FONT STYLE="white-space:nowrap">I-9</FONT>
(Employment Eligibility Verification) for all current and former employees hired to perform services in the United States, as required by applicable Law. All individuals employed by the Company or any of its Subsidiaries in the United States are
authorized to work in the United States. Neither the Company nor any of its Subsidiaries sponsors any employee for, or otherwise knowingly engage any employee working pursuant to, a nonimmigrant visa. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.19. <U>Regulatory and Compliance Matters</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) Each of the Company and its Subsidiaries holds all material Permits, is operating and has since January&nbsp;1, 2023 operated in
compliance with such material Permits, and has submitted written notices to, all Governmental Bodies, including all authorizations under the Healthcare Laws, and all other similar Laws necessary for the lawful operation of the business of the
Company and its Subsidiaries as currently conducted, including any BLAs, INDs, NDAs and MAAs (the &#8220;<U>Regulatory Authorizations</U>&#8221;), and as of the date of this Agreement, all such Regulatory Authorizations are (i)&nbsp;in full force
and effect,(ii) in compliance with all material filing and maintenance requirements and (iii)&nbsp;in material good standing, valid and enforceable. There has not occurred any material violation of, or default (with or without written notice or
lapse of time or both) under any Regulatory Authorization. Each of the Company and its Subsidiaries has fulfilled and performed all of their respective material obligations with respect to such Regulatory Authorizations, and is in compliance in all
material respects with the terms of all Regulatory Authorizations. <U>Section</U><U></U><U>&nbsp;4.19(a)</U> of the Company Disclosure Letter lists all current Permits, including all Regulatory Authorizations, held by the Company and its Subsidiary.
There have been no occurrences, events, or Actions that are pending, under investigation, or, to the Knowledge of the Company, threatened, nor has the Company or its Subsidiary received any written notification, which has resulted in or would
reasonably be expected to result in the material limitation, adverse modification, revocation, withdrawal, cancellation, lapse, integrity review, suspension, or any other materially adverse Action against any Permits, including any Regulatory
Authorization. To the Knowledge of the Company, no event has occurred which allows, or after written notice or lapse of time would allow, revocation or termination thereof. Since January&nbsp;1, 2023, neither the Company nor any of its Subsidiaries
has received notice of any pending or, to the Knowledge of the Company, threatened claim, suit, proceeding, hearing, enforcement, audit, investigation, arbitration or other Action from any Governmental Body alleging that any operation or activity of
the Company or any of its Subsidiaries is in material violation of any Law that applies to a Regulatory Authorization. The Contemplated Transactions, in and of themselves, will not cause the revocation or cancellation of any Regulatory Authorization
pursuant to the terms of any such Regulatory Authorization. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Since January&nbsp;1, 2023, all of the Company&#8217;s and each of its
Subsidiaries&#8217; Products that are subject to the jurisdiction of the FDA, EMA, MHRA, or other Governmental Body have been and are being manufactured, packaged, imported, exported, processed, developed, labeled, stored, shipped, handled,
warehoused, distributed, and tested by or on behalf of the Company or any of its Subsidiaries in material compliance with all applicable requirements under any Permit or Law, including but not limited to Healthcare Laws. None of the Company&#8217;s
nor any of its Subsidiaries&#8217; Products have been marketed by or on behalf of the Company, any of its Subsidiaries, or any of its Affiliates. None of the Company&#8217;s nor any of its Subsidiaries&#8217; Products have been adulterated,
misbranded, or prohibited from introduction into interstate commerce under applicable Laws. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) Since January&nbsp;1, 2023, the Company
and its Subsidiaries have filed, maintained or furnished all material applications, reports, documents, claims, Regulatory Authorizations, amendments, modifications, notices, declarations, listings, registrations, reports and other information
required to be filed, maintained or furnished to the FDA, EMA, MHRA, or any other Governmental Body in connection with the Products or the operation of the business. Since January&nbsp;1, 2023, all applications, documents, all applications,
notifications, submissions, information, claims, amendments, modifications, declarations, listings, registrations, reports and data utilized by the Company and its Subsidiaries as the basis for, or submitted by the Company or any of its Subsidiaries
in connection with, any and all requests for the Regulatory Authorizations relating to the Company or any of its Subsidiaries were to the Knowledge of the Company, in compliance in all material respects with applicable Healthcare Laws when filed,
maintained, or furnished, and were complete and correct in all material respects as of the date of submission (or were corrected in or supplemented by a subsequent filing), and no material deficiencies have been asserted by any applicable
Governmental Body with respect to any such applications, documents, notifications, submissions, information, claims, amendments, modifications, declarations, listings, registrations, reports, and data. To the Company&#8217;s Knowledge, no facts or
circumstances exist that would be reasonably likely to cause any Governmental Body to take action to materially limit, suspend, materially modify, or revoke and material Regulatory Authorization. Any material updates, changes, corrections, or
modifications to such documents required under applicable Healthcare Laws have been submitted in a timely and complete manner. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) Since
January&nbsp;1, 2023, neither the Company nor any of its Subsidiaries nor any of their respective officers or employees, or, to the Knowledge of the Company, any agents or clinical investigator acting for the Company, has (i)&nbsp;made an untrue
statement of a material fact or fraudulent statement to any Governmental Body, (ii)&nbsp;failed to disclose a material fact required to be disclosed to any Governmental Body, or (iii)&nbsp;committed any act, made any statement, or failed to make any
statement that would reasonably be expected to provide a basis for the FDA or any other Governmental Body to invoke its policy respecting &#8220;Fraud, Untrue Statements of Material Facts, Bribery, and Illegal Gratuities&#8221;, set forth in 56 Fed.
Reg. 46191 (September 10, 1991), and any amendments thereto, or any similar policy or Law regarding the communication or submission of false information to any applicable Governmental Body. Neither the Company nor any of its Subsidiaries has
committed or engaged in any fraud or falsification or forgery of any research or development data, report, studies or publications or of any document or statement voluntarily submitted or required to be submitted to any Governmental Body. There have
been no allegations of, or investigations into, research misconduct (i.e., falsification or fabrication of data or plagiarism) with respect to any nonclinical studies, tests or clinical trials with which the Company or any of its Subsidiaries has
been involved. None of the Company, its Subsidiaries nor any of their respective officers or employees, or, to the Knowledge of the Company, any agents, clinical investigators, institutional review boards, or other individuals or institutions
involved in Company business, including the conduct or </P>
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oversight of clinical trials, is or has been debarred or disqualified by the FDA, or is listed on the U.S. General Services Administration or the Department of Health and Human Services Office of
Inspector General excluded individuals and entities listings, nor has the Company or any of its Subsidiaries received written notice of an impending or potential exclusion, debarment or listing. None of the Company, its Subsidiaries nor any of their
respective officers or employees, or, to the Knowledge of the Company, contractors, agents, or clinical investigators, or institutional review boards involved in Company business, including the conduct or oversight of clinical trials, has been
convicted of any crime or engaged in any conduct that has resulted in, or would reasonably be expected to result in, debarment from participation in any program related to pharmaceutical products pursuant to 21 U.S.C. Section&nbsp;335a(a) or (b),
exclusion from participation in any Federal Health Care Program pursuant to 42 U.S.C. <FONT STYLE="white-space:nowrap">Section&nbsp;1320a-7</FONT> or disqualification from serving as an investigator under 21 C.F.R. Parts 312 or 812. No Action that
would reasonably be likely to result in such a debarment, exclusion or disqualification is pending or threatened against the Company, its Subsidiaries or any of their respective officers, employees, contractors, or agents. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) Since January&nbsp;1, 2023, the manufacture of Products, including the Products used in any clinical trials, by or on behalf of the
Company or any of its Subsidiaries has been and is being conducted in material compliance with all applicable Laws including the current Good Manufacturing Practices. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(f) Since January&nbsp;1, 2023, all clinical and preclinical studies and other studies and tests conducted by or, to the Knowledge of the
Company, on behalf of the Company or any of its Subsidiaries with respect to the Products have been, and if still pending are being, conducted in material compliance with all applicable research protocols, patient privacy requirements, corrective
action plans, Good Clinical Practices, Good Laboratory Practices, institutional review board requirements and all applicable Healthcare Laws. No preclinical research, clinical study or other study or test conducted by, or to the Company&#8217;s
Knowledge, or on behalf of the Company or any of its Subsidiaries with respect to the Products has been terminated or suspended prior to completion. Neither the Company nor any of its Subsidiaries has, as of the date hereof, received any written
notice or other communication that any Governmental Body, investigator, or any relevant institutional review board, independent ethics committee or any other similar body has (i)&nbsp;refused to approve any preclinical or nonclinical research or
clinical study, or any substantial amendment to a protocol for any preclinical or nonclinical research or clinical study, conducted or proposed to be conducted by or on behalf of the Company or any of its Subsidiaries, or (ii) has initiated, or
threatened to initiate, any action to (1)&nbsp;suspend any preclinical or nonclinical research or clinical study conducted by or on behalf of the Company or any of its Subsidiaries, as applicable, with respect to the Products, (2)&nbsp;place any
clinical study of the Products on &#8220;clinical hold,&#8221; (3) suspend or terminate any IND related to the Products, as applicable, or (4)&nbsp;recall, import or export or suspend the manufacture of the Products (collectively,
&#8220;<U>Healthcare Correspondence</U>&#8221;). There exist no facts or circumstances related to the Products that, to the Knowledge of the Company, would warrant issuance by the FDA, EMA, MHRA, or any other Governmental Body of any Healthcare
Correspondence related to the Products. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(g) Since January&nbsp;1, 2023, none of the Company, its Subsidiaries or, to the Knowledge of the
Company, any person acting on its behalf has, with respect to the Products, (i)&nbsp;been subject to a Governmental Body shutdown or import or export prohibition or (ii)&nbsp;received any FDA Form 483, or other Governmental Body notice of
inspectional observations, &#8220;warning letters,&#8221; &#8220;untitled letters&#8221; or any similar written correspondence from any Governmental Body in respect of the Company or any of its Subsidiaries alleging or asserting material
noncompliance with any applicable Law, including Healthcare Laws, or Permit, including Regulatory Authorizations and, to the Knowledge of the Company, no Governmental Body is considering such Action. Between January&nbsp;1, 2023 and the date of this
Agreement, neither the Company nor any of its Subsidiaries has either voluntarily or involuntarily, initiated, conducted or issued, or caused to be initiated, conducted or issued, any investigator notice, or other notice or Action relating to an
alleged lack of safety or efficacy or material regulatory compliance of the Products. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(h) Each of the Company and its Subsidiaries is, and at all times between January&nbsp;1,
2023 and the date of this Agreement has been, in material compliance with all applicable Healthcare Laws and, as of the date of this Agreement, there is no civil, criminal, administrative, or other Action, subpoena, civil investigative demand, suit,
claim, hearing, proceeding, notice or demand pending, received by or threatened in writing against the Company or any of its Subsidiaries related to such Healthcare Laws. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(i) Neither the Company nor any of its Subsidiaries is a party to any corporate integrity agreements, monitoring agreements, consent decrees,
deferred prosecution agreements, <FONT STYLE="white-space:nowrap">non-prosecution</FONT> agreements, settlement orders or similar agreements with or imposed by any Governmental Body or Person. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(j) The Company and each of its Subsidiaries have implemented a compliance program that conforms to, and materially ensures compliance with,
applicable Healthcare Laws and conforms in all material respects to industry standards. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(k) The compensation that the Company and each of
its Subsidiaries pay, and have paid, to licensed health care professionals (i)&nbsp;is for bona fide purposes, (ii)&nbsp;is for commercially reasonable services required by the Company or any of its Subsidiaries for their respective business or
operations, and (iii)&nbsp;contemplates compensation consistent with fair market value for such services. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(l) Neither the Company nor any
of its Subsidiaries (i)&nbsp;is or has been a &#8220;Covered Entity&#8221; or a &#8220;Business Associate,&#8221; as those terms are defined under HIPAA, or (ii)&nbsp;has entered into a &#8220;Business Associate&#8221; contract with any
&#8220;Covered Entity,&#8221; as such terms are defined under HIPAA. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(m) Neither the Company nor any of its Subsidiaries has, at any time
since January&nbsp;1, 2023, in any material respect, (i)&nbsp;violated or been in violation of any provision of the U.S. Foreign Corrupt Practices Act of 1977 (the &#8220;<U>FCPA</U>&#8221;), (ii) violated or been in violation of any applicable Law
enacted in any jurisdiction in connection with or arising under the OECD Convention Combating Bribery of Foreign Public Officials in International Business Transactions (the &#8220;<U>OECD Convention</U>&#8221;), (iii) violated or been in violation
of any provision of the UK Bribery Act of 2010 (the &#8220;<U>UK Bribery Act</U>&#8221;), (iv) violated any anti-bribery or anti-corruption Law in any foreign jurisdiction, or (v)&nbsp;violated or been in violation of any other Laws regarding use of
funds for political activity or commercial bribery. The Company and its Subsidiaries have instituted and maintained policies and procedures designed to prevent such actions to the extent such Laws are applicable to the Company or any of its
Subsidiaries. Neither the Company nor any of its Subsidiaries has, at any time since January&nbsp;1, 2023, (i) made, offered to make, promised to make, or authorized the payment or giving of, directly or indirectly, any bribe, rebate, payoff,
influence payment, kickback or other unlawful payment or gift of money or anything of value prohibited under any applicable Law addressing matters comparable to those addressed by the FCPA, the UK Bribery Act, or the OECD Convention implementing
legislation concerning such payments or gifts in any jurisdiction (any such payment, a &#8220;<U>Prohibited Payment</U>&#8221;) or (ii)&nbsp;received written notice that it is subject to any investigation by any Governmental Body with regard to any
Prohibited Payment. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(n) Neither the Company nor any of its Subsidiaries, nor any of their respective directors, officers, managers or
employees, or, to the Knowledge of the Company, any of their respective agents, contractors or any other Person acting on behalf of the Company or any of its Subsidiaries, is currently or has since April&nbsp;24, 2019 been: (i)&nbsp;a Sanctioned
Person, or (ii)&nbsp;except as may be authorized by Law, operating in, conducting business with, or otherwise engaging in dealings, whether directly or indirectly (A)&nbsp;with or for the benefit of any Sanctioned Person, or (B)&nbsp;in or for the
benefit of any Sanctioned Country; or (iii)&nbsp;in violation in any material respect of any Sanctions Laws, <FONT STYLE="white-space:nowrap">Ex-Im</FONT> Laws or U.S. anti-boycott laws. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">34 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(o) Between January&nbsp;1, 2023 and the date of this Agreement, the Company has complied in
all material respects with all applicable (i)&nbsp;Privacy Laws, including providing any notice, obtaining any consent or prior authorization, and conducting any assessment, in each case to the extent material, required under applicable Privacy Laws
(including the Personal Information of clinical trial participants, patients, patient family members, caregivers or advocates, employees, physicians and other health care professionals, clinical trial investigators, researchers and pharmacists),
(ii) externally published policies, procedures, notices, and/or statements related to privacy, security or the Processing of Personal Information (each, a &#8220;<U>Privacy Policy</U>&#8221;), and (iii)&nbsp;contractual commitments related to
privacy, security, or the Processing of Personal Information (collectively as to (i), (ii), and (iii), the &#8220;<U>Privacy Requirements</U>&#8221;). To the extent required by Privacy Laws, the Company and each of its Subsidiaries have provided a
Privacy Policy to individuals prior to the collection of any Personal Information. As of the date of this Agreement, there are no pending claims or complaints that have been asserted or threatened in writing against the Company by any Governmental
Body or Person alleging a violation of Privacy Laws or Privacy Policies and neither the Company nor any of its Subsidiaries have been the subject of any investigation or enforcement Action by any Governmental Body alleging violations of Privacy Laws
or Privacy Policies. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(p) The Company and each of its Subsidiaries have implemented and maintain (i)&nbsp;appropriate written policies and
procedures, and (ii)&nbsp;commercially reasonable technical, physical, and organizational measures designed to protect Personal Information in their possession or under their control from unlawful or unauthorized access, use, loss, modification, or
disclosure (&#8220;<U>Security Incident</U>&#8221;). The Company and each of its Subsidiaries periodically assess risks to privacy and the confidentiality and security of Personal Information. Neither the Company, its Subsidiaries, nor any of their
respective vendors that Process Personal Information on their behalf have experienced a Security Incident in the prior two (2)&nbsp;years that would require notification of individuals or to any Governmental Body under any applicable Privacy Law.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(q) The Company and each of its Subsidiaries (i)&nbsp;have obtained or will obtain all rights, permissions, and consents necessary to
permit the transfer of Personal Information to Parent and Purchaser in connection with the transactions contemplated by this Agreement, or (ii)&nbsp;have otherwise verified that applicable Law permits them to transfer Personal Information to Parent
and Purchaser in connection with the transactions contemplated by this Agreement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(r) Between January&nbsp;1, 2023 and the date of this
Agreement, neither the Company nor any of its Subsidiaries or their respective owners, directors, officers, managers, employees or any other Person acting at the direction of or on behalf of the Company or any of its Subsidiaries, including to the
Knowledge of the Company, contractors, vendors, or other personnel: (i)&nbsp;has been charged with, convicted of, or entered into a plea of guilty or <I>nolo contendere</I> to any criminal or civil offense relating to the delivery of an item or
service under any Federal Health Care Program, (ii)&nbsp;has been debarred, excluded or suspended from participation in any Federal Health Care Program, (iii)&nbsp;has had a civil monetary penalty assessed against it, him or her under 42 U.S.C.
&#167; <FONT STYLE="white-space:nowrap">1320a-7a,</FONT> (iv)&nbsp;is, or has been listed on the list of parties excluded from federal procurement programs and <FONT STYLE="white-space:nowrap">non-procurement</FONT> programs as maintained in the
Government Services Administration&#8217;s System for Award Management or other federal agencies, (v)&nbsp;has received notice that it is the target or subject of any current or potential investigation relating to any Federal Health Care
Program-related offense or (vi)&nbsp;has engaged in any activity that is in violation of, or is cause for civil penalties, debarment, or mandatory or permissive exclusion under federal or state Laws. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">35 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(s) With respect to the Products, there is no material clinical data or material written
correspondence between the Company and applicable Governmental Bodies that has not been made available to Parent as of the date of this Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.20. <U>Suppliers</U>. <U>Section</U><U></U><U>&nbsp;4.20</U> of the Company Disclosure Schedule sets forth a complete and
accurate list (including dollar amounts and percentages) of the top ten (10)&nbsp;suppliers of materials, products or services related to the business of the Company and its Subsidiaries (measured by the aggregate amount purchased by the Company or
its Subsidiaries) for the fiscal year ended December&nbsp;31, 2024 (the &#8220;<U>Material Suppliers</U>&#8221;). None of the Material Suppliers has, as of the date of this Agreement, cancelled, terminated or otherwise materially and adversely
altered (including any material reduction in the rate or amount of sales or purchases or material increase in the prices charged or paid, as the case may be) or notified the Company or any of its Subsidiaries in writing of any intention to do any of
the foregoing or, to the Knowledge of the Company, threatened in writing to cancel, terminate or materially and adversely alter (including any material reduction in the rate or amount of sales or material increase in the prices charged) its
relationship with the Company. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.21. <U>Brokerage</U>. Other than Aquilo Partners, L.P., no broker, investment banker,
financial advisor or other Person is entitled to any broker&#8217;s, finder&#8217;s, financial advisor&#8217;s or other similar fee or commission in connection with the Contemplated Transactions based on any arrangement or agreement made by or on
behalf of the Company or any of its Affiliates. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.22. <U>No Rights Agreement; Anti-Takeover Provisions</U>. As of the date
of this Agreement, the Company is not party to a stockholder rights agreement, &#8220;poison pill&#8221; or similar anti-takeover agreement or plan. Assuming the accuracy of the representations and warranties set forth in
<U>Section</U><U></U><U>&nbsp;5.8</U>, the Company Board has taken all action necessary to render Section&nbsp;203 of the DGCL and any other takeover, anti-takeover, moratorium, &#8220;fair price,&#8221; &#8220;control share,&#8221; or similar Law
inapplicable to the Offer and the Merger. Assuming the accuracy of the representations and warranties set forth in <U>Section</U><U></U><U>&nbsp;5.8</U>, no restrictions of any other &#8220;business combination,&#8221; &#8220;control share
acquisition,&#8221; &#8220;fair price,&#8221; &#8220;moratorium&#8221; or other anti-takeover Laws apply or will apply to the Company pursuant to this Agreement, the CVR Agreement or the Contemplated Transactions. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.23. <U>Opinion</U>. The Company Board has received, on or prior to the date of this Agreement, the oral opinion, to be
subsequently confirmed in writing, of Aquilo Partners, L.P. that, as of the date of such opinion and based upon and subject to the matters set forth therein, including the various assumptions made, procedures followed, matters considered, and
qualifications and limitations set forth therein, the Offer Price and Merger Consideration are fair, from a financial point of view, to the holders of the Shares. The Company shall provide an executed copy of such written opinion to Parent solely
for informational purposes promptly after receipt thereof by the Company; <U>provided</U> that it is agreed and understood that such opinion is for the benefit of the Company Board and may not be relied on by Parent or Purchaser. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.24. <U>No Vote Required</U>. Assuming the Contemplated Transactions are consummated in accordance with Section&nbsp;251(h) of
the DGCL and assuming the accuracy of the representations and warranties set forth in <U>Section</U><U></U><U>&nbsp;5.8</U>, no stockholder votes or consents are needed to authorize this Agreement or for the consummation of the Contemplated
Transactions. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.25. <U>Affiliate Transactions</U>. No present or former officer or director of the Company or any of its
Subsidiaries, or any Person owning five percent (5%) or more of the Company Common Stock, and no Affiliate of such Person or family member of any such natural Person, is a party to any Contract with or binding upon the Company, its Subsidiaries or
any of its or their respective properties or assets, or has any material interest in any property or asset owned, leased, licensed, sublicensed, used or occupied by </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">36 </P>

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the Company or any of its Subsidiaries, and neither the Company and nor any of its Subsidiaries have engaged in any material transaction with any of the foregoing within the twelve
(12)&nbsp;months preceding the date of this Agreement (each, an &#8220;<U>Affiliate Transaction</U>&#8221;), other than (a)&nbsp;compensation of directors and executive officers of the Company or any of its Subsidiaries in the ordinary course and
(b)&nbsp;equity interests granted to directors and executive officers of the Company or any of its Subsidiaries. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.26. <U>No
Other Representations and Warranties</U>. EXCEPT FOR THE REPRESENTATIONS AND WARRANTIES CONTAINED IN <U>ARTICLE IV</U> OF THIS AGREEMENT (AS MODIFIED BY THE COMPANY DISCLOSURE LETTER) OR IN ANY CERTIFICATE DELIVERED PURSUANT TO THIS AGREEMENT, THE
COMPANY MAKES NO EXPRESS OR IMPLIED REPRESENTATION OR WARRANTY AND THE COMPANY HEREBY DISCLAIMS (AND PARENT ACKNOWLEDGES THAT IT HAS NOT RELIED UPON) ANY SUCH REPRESENTATION OR WARRANTY. IN CONNECTION WITH PARENT&#8217;S INVESTIGATION OF THE
COMPANY, PARENT MAY HAVE RECEIVED FROM OR ON BEHALF OF THE COMPANY CERTAIN PROJECTIONS. THE COMPANY MAKES NO REPRESENTATIONS OR WARRANTIES WHATSOEVER WITH RESPECT TO ESTIMATES, PROJECTIONS AND OTHER FORECASTS AND PLANS (INCLUDING THE REASONABLENESS
OF THE ASSUMPTIONS UNDERLYING ESTIMATES, PROJECTIONS AND FORECASTS). </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE V </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>REPRESENTATIONS AND WARRANTIES </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>OF PARENT AND PURCHASER </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Parent and Purchaser, jointly and severally, hereby represent and warrant to the Company as follows: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.1. <U>Organization and Corporate Power</U>. Each of Parent and Purchaser is validly existing and in good standing under the
Laws of the jurisdiction in which it was organized. Each of Parent and Purchaser has all requisite corporate power and authority and all authorizations, licenses and Permits necessary to own, lease and operate its properties and to carry on its
business as it is now being conducted, except where the failure to hold such authorizations, licenses and Permits would not have a Purchaser Material Adverse Effect. Parent, directly or indirectly, owns beneficially and of record all of the
outstanding capital stock of Purchaser free and clear of all Liens (other than any transfer restrictions arising under applicable securities Laws). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.2. <U>Authorization; Valid and Binding Agreement</U>. Except for the approval of the sole stockholder of Purchaser, each of
Parent and Purchaser has all requisite corporate power and authority to execute and deliver this Agreement, the Promissory Note and the CVR Agreement, to perform the obligations thereunder and to consummate the Offer and the Merger. No other
corporate action pursuant to the Laws of the jurisdictions in which Parent or Purchaser is organized, on the part of the Parent and Purchaser, is necessary to authorize this Agreement, the Promissory Note or the CVR Agreement. Each of Parent and
Purchaser has duly executed and delivered this Agreement and, the Promissory Note and, assuming the due authorization, execution and delivery by the Company, this Agreement and the Promissory Note constitute, and at the Acceptance Time, assuming the
due authorization, execution and delivery by the Rights Agent, the CVR Agreement will constitute, its legal, valid and binding obligations, enforceable against it in accordance with their terms except as enforcement may be limited by bankruptcy,
insolvency, reorganization or similar laws affecting creditors&#8217; rights generally and by general principles of equity. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">37 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.3. <U>No Breach</U>. The execution, delivery and performance of this
Agreement by Parent and Purchaser and the consummation of the Offer and the Merger do not, and the execution, delivery and performance of, the Promissory Note and the CVR Agreement by Parent will not (a)&nbsp;conflict with or violate their
respective certificates of incorporation or bylaws (or similar governing documents) and (b)&nbsp;assuming all consents, approvals, authorizations and other actions described in <U>Section</U><U></U><U>&nbsp;5.4</U> have been obtained, and all
filings and obligations described in <U>Section</U><U></U><U>&nbsp;5.4</U> have been made, conflict with or violate any Law or order, judgment or decree to which Parent, Purchaser, either of their Subsidiaries or any of their properties or assets is
subject, except any conflicts, breaches, defaults, violations, terminations, cancellations or accelerations that would not have a Purchaser Material Adverse Effect. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.4. <U>Consents</U>. Except for (a)&nbsp;any applicable requirements of Antitrust and FDI Laws, (b)&nbsp;applicable requirements
of the Exchange Act, (c)&nbsp;any filings required by the New York Stock Exchange and (d)&nbsp;the filing of the Certificate of Merger, the Parent and Purchaser are not required to submit any notice, report or other filing with any Governmental Body
in connection with the execution, delivery or performance by it of this Agreement, the Promissory Note, the CVR Agreement or the consummation of the Contemplated Transactions. Other than as stated above, no consent, approval or authorization of any
Governmental Body or any other party or Person is required to be obtained by the Parent or Purchaser in connection with its execution, delivery and performance of this Agreement, the Promissory Note, the CVR Agreement or the consummation of the
Contemplated Transactions. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.5. <U>Litigation</U>. As of the date of this Agreement, there are no material Actions pending
or, to the Knowledge of Parent, threatened in writing against Parent or any of its Subsidiaries that seeks to enjoin the Offer, the Merger or the other Contemplated Transactions, other than any such proceedings that have not had and would not have a
Purchaser Material Adverse Effect. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.6. <U>Brokerage</U>. No broker, investment banker, financial advisor or other Person is
entitled to any broker&#8217;s, finder&#8217;s financial advisor&#8217;s or other similar fee or commission in connection with the Contemplated Transactions based on any arrangement or agreement made by or on behalf of Parent or Purchaser. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.7. <U>Operations of Purchaser</U>. Purchaser has been formed solely for the purpose of engaging in the Contemplated
Transactions and has engaged in no business activities and will have incurred no liabilities or obligations except as contemplated by this Agreement or incident to its formation and performance of its obligations hereunder. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.8. <U>Ownership of Shares</U>. As of the date of this Agreement, neither Parent nor Purchaser owns any Shares of the Company.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.9. <U>Vote/Approval Required</U>. No vote or consent of the holders of any class or series of capital stock of Parent is
necessary to approve the Offer or the Merger. The vote or consent of the sole stockholder of Purchaser (which will occur promptly following the execution and delivery of this Agreement) is the only vote or consent of the holders of any class or
series of capital stock of Purchaser necessary to approve this Agreement, the Offer or the Merger. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.10. <U>Funds</U>.
Parent has sufficient cash or other liquid financial resources as of the Acceptance Time and the Effective Time to, and at the Acceptance Time and at the Effective Time, Parent has caused Purchaser to have, available the cash necessary to,
consummate the Contemplated Transactions, including payment in cash of the aggregate Closing Amount at the Acceptance Time and the portion of the aggregate Merger Consideration due at the Effective Time, the funding of all amounts under the
Promissory Note and to pay all related fees and expenses. Parent and Purchaser acknowledge that their obligations under this Agreement are not contingent or conditioned in any manner on obtaining any financing. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.11. <U>Other Agreements</U>. Parent and Purchaser have disclosed to the
Company all contracts, agreements, or understandings (and, with respect to those that are written, Parent and Purchaser has furnished to the Company correct and complete copies thereof) between or among Parent, Purchaser, or any controlled Affiliate
of Parent, on the one hand, and any member of the Company Board or officers or employees of the Company or any of its Subsidiaries, on the other hand. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.12. <U>Investment Intention</U>. Parent is acquiring through the Offer the shares of capital stock of the Company for its own
account, for investment purposes only and not with a view to the distribution (as such term is used in Section&nbsp;2(11) of the Securities Act) thereof. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.13. <U>No Other Representations and Warranties</U>. EXCEPT FOR THE REPRESENTATIONS AND WARRANTIES CONTAINED IN <U>ARTICLE V</U>
OF THIS AGREEMENT OR IN ANY CERTIFICATE DELIVERED PURSUANT TO THIS AGREEMENT, NEITHER PARENT NOR PURCHASER MAKES ANY EXPRESS OR IMPLIED REPRESENTATION OR WARRANTY WITH RESPECT TO PARENT, PURCHASER OR ANY OF THEIR RESPECTIVE SUBSIDIARIES, AND THE
COMPANY IS NOT RELYING ON ANY REPRESENTATION OR WARRANTY OTHER THAN THOSE EXPRESSLY SET FORTH IN THIS AGREEMENT AND EACH OF PARENT AND PURCHASER HEREBY DISCLAIMS ANY SUCH REPRESENTATION OR WARRANTY. WITHOUT LIMITING THE FOREGOING, THE PARTIES AGREE
THAT THE MILESTONES AS SET FORTH IN THE CVR AGREEMENT OR THAT HAVE OTHERWISE BEEN DISCUSSED BY THE PARTIES ARE MERELY INTENDED TO DEFINE THE MILESTONE PAYMENTS IF SUCH MILESTONES ARE ACHIEVED. NONE OF PARENT OR PURCHASER OWES ANY DUTY, AS A
FIDUCIARY OR OTHERWISE, TO THE COMPANY, ANY EQUITYHOLDER OR ANY OTHER PERSON IN CONNECTION WITH ITS OPERATION OF THE SURVIVING CORPORATION&#8217;S BUSINESS FOLLOWING THE CLOSING. THE COMPANY&nbsp;ACKNOWLEDGES THAT (A)&nbsp;PARENT AND PURCHASER MAKE
(I)&nbsp;NO GUARANTEES OR PROMISES THAT ANY MILESTONE WILL BE ACHIEVED AT ALL OR BY A SPECIFIC DATE OR IS ACHIEVABLE AND (II)&nbsp;NO ASSESSMENTS OR PREDICTIONS REGARDING THE LIKELIHOOD OF ANY MILESTONES BEING ACHIEVED, (B)&nbsp;THERE IS NO
ASSURANCE THAT THE EQUITYHOLDERS WILL RECEIVE ANY MILESTONE PAYMENTS, (C)&nbsp;PARENT AND PURCHASER HAVE NOT, PRIOR TO OR AFTER THE DATE HEREOF, PROMISED OR PROJECTED ANY AMOUNTS TO BE RECEIVED BY THE EQUITYHOLDERS IN RESPECT OF ANY MILESTONE
PAYMENT, (D)&nbsp;NEITHER THE COMPANY NOR ANY EQUITYHOLDER IS RELYING ON OR HAS RELIED ON ANY PROMISES, PROJECTIONS, REPRESENTATION OR WARRANTY OF ANY KIND OR OTHER INFORMATION, DOCUMENTS OR MATERIALS (OR ABSENCE THEREOF)&nbsp;IN RESPECT OF ANY
MILESTONE PAYMENTS, INCLUDING WITH RESPECT TO THE OPERATION OF THE SURVIVING CORPORATION&#8217;S BUSINESS FOLLOWING THE CLOSING, (E)&nbsp;EXCEPT FOR PARENT&#8217;S OBLIGATION TO USE COMMERCIALLY REASONABLE EFFORTS (AS DEFINED IN THE CVR AGREEMENT)
IN RESPECT OF THE FIRST MILESTONE (AS DEFINED IN THE CVR AGREEMENT), PARENT SHALL HAVE THE RIGHT TO OWN, OPERATE, USE, LICENSE, DEVELOP AND OTHERWISE COMMERCIALIZE THE ASSETS OF THE SURVIVING CORPORATION&#8217;S BUSINESS IN ANY WAY THAT PARENT DEEMS
APPROPRIATE, IN ITS SOLE DISCRETION AND (F)&nbsp;EXCEPT FOR PARENT&#8217;S OBLIGATION TO USE COMMERCIALLY REASONABLE EFFORTS (AS DEFINED IN THE CVR AGREEMENT) IN RESPECT OF THE FIRST MILESTONE (AS DEFINED IN THE CVR AGREEMENT), PARENT DOES NOT HAVE
ANY OBLIGATION, EXPRESS OR IMPLIED, TO OWN, OPERATE, USE, LICENSE, DEVELOP OR OTHERWISE COMMERCIALIZE THE ASSETS OF THE SURVIVING CORPORATION&#8217;S BUSINESS IN ORDER TO MAXIMIZE OR EXPEDITE THE MILESTONE PAYMENTS, INCLUDING ANY OBLIGATION TO
PURSUE PARTICULAR BUSINESS OPPORTUNITIES, ENGAGE IN PARTICULAR ADVERTISING OR MARKETING CAMPAIGNS OR OTHERWISE. THE COMPANY&nbsp;HEREBY (X)&nbsp;SPECIFICALLY DISCLAIMS RELIANCE ON ANY SUCH PROMISES, </P>

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PROJECTIONS, REPRESENTATIONS, WARRANTIES OR OTHER INFORMATION, DOCUMENTS OR MATERIALS (OR ABSENCE THEREOF), (Y)&nbsp;UNDERSTANDS AND AGREES THAT ANY SUCH PROMISES, REPRESENTATIONS, WARRANTIES,
PROJECTIONS, FORWARD-LOOKING STATEMENTS, BUSINESS PLANS AND OTHER INFORMATION, DOCUMENTS AND MATERIALS (OR ABSENCE THEREOF)&nbsp;ARE SPECIFICALLY DISCLAIMED BY PARENT AND (Z)&nbsp;WAIVES ANY RIGHT IT MAY OTHERWISE HAVE WITH RESPECT TO ANY SUCH
PROMISES, PROJECTIONS, REPRESENTATIONS, WARRANTIES OR OTHER INFORMATION, DOCUMENTS OR MATERIALS (OR ABSENCE THEREOF). THE COMPANY FURTHER ACKNOWLEDGES AND AGREES THAT PARENT OWES NO OBLIGATION OR DUTY, AS A FIDUCIARY OR OTHERWISE, TO THE RIGHTS
AGENT, ANY HOLDER OR ANY OTHER PERSON IN CONNECTION WITH ITS OPERATION OF THE SURVIVING CORPORATION&#8217;S BUSINESS FOLLOWING CLOSING EXCEPT AS EXPRESSLY STATED IN THE CVR AGREEMENT, AND ACKNOWLEDGES PARENT&#8217;S DISCLAIMER SET FORTH IN SECTION
4.3(B) OF THE CVR AGREEMENT. THE PARTIES INTEND THE EXPRESS PROVISIONS OF THIS AGREEMENT AND THE CVR AGREEMENT TO GOVERN THEIR CONTRACTUAL RELATIONSHIP AND TO SUPERSEDE ANY STANDARD OF EFFORTS OR IMPLIED COVENANT OF GOOD FAITH AND FAIR DEALING THAT
MIGHT OTHERWISE BE IMPOSED BY ANY COURT OR OTHER GOVERNMENTAL BODY OR OTHERWISE. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE VI </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>COVENANTS </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.1. <U>Covenants of the Company</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) Except (i)&nbsp;as required by applicable Law, (ii)&nbsp;as required by this Agreement or the Promissory Note, or (iii)&nbsp;with the
prior written consent of Parent (which consent will not be unreasonably delayed, withheld or conditioned), from the date of this Agreement until the earlier of the Acceptance Time or the date this Agreement is terminated (the &#8220;<U><FONT
STYLE="white-space:nowrap">Pre-Closing</FONT> Period</U>&#8221;), the Company shall, and shall cause its Subsidiaries to (A)&nbsp;carry on its business in the ordinary course of business, (B)&nbsp;otherwise maintain and preserve intact its current
business organization and keep available the services of its current officers, employees and consultants, (C)&nbsp;preserve its relationships with customers, suppliers, partners, licensors, licensees, distributors, Governmental Bodies and any others
having business dealings with it with the intention that its goodwill and ongoing business will not be materially impaired on the Closing Date, and (D)&nbsp;comply with all Laws and perform its obligations under all Material Contracts. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Except (x)&nbsp;as set forth in <U>Section</U><U></U><U>&nbsp;6.1(b)</U> of the Company Disclosure Letter, (y)&nbsp;as required by
applicable Law or (z)&nbsp;as required by this Agreement or the Promissory Note, during the <FONT STYLE="white-space:nowrap">Pre-Closing</FONT> Period, the Company shall not, and shall cause its Subsidiaries not to, without the prior written consent
of Parent (which consent will not be unreasonably delayed, withheld or conditioned): </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(i) (A) authorize, declare, set aside or pay any
dividends on or make other distributions (whether in cash, stock or property) in respect of any Company Securities or (B)&nbsp;directly or indirectly redeem, repurchase, adjust, split, reverse split, combine, subdivide or otherwise acquire or
reclassify any Company Securities, except, in each case, as a result of net share settlement of any Company Stock Option, Company RSU or Company PSU outstanding on the date of this Agreement to satisfy the applicable exercise price or applicable
withholding Tax obligations, in each case, in accordance with the terms thereof as of the date of this Agreement; </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(ii) issue, sell, pledge, modify, transfer, dispose of or otherwise encumber or grant, or
authorize the issuance, sale, pledge, modification, transfer, disposition or other encumbrance or grant of, any incentive equity awards (including Company Stock Options, Company RSUs, and Company PSUs), equity based awards, or Company Securities,
except for issuances of Company Common Stock in respect of the exercise of a Company Stock Option or the settlement of Company RSUs or Company PSUs, in either case with respect to Company Stock Options, Company RSUs, or Company PSUs outstanding on
the date of this Agreement (and in accordance with the terms thereof as of the date of this Agreement) or issued in accordance with the terms of this Agreement; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(iii) except as required by the terms of a Company Plan as in effect as of the date of this Agreement, (A)&nbsp;increase or decrease the
wages, salary or other compensation or benefits with respect to any of the Company&#8217;s or its Subsidiaries&#8217; officers, directors, employees or other individual service providers, (B)&nbsp;pay or award, or commit to pay or award, any
bonuses, commissions or other incentive compensation or severance, separation, retention or transaction-related payments or benefits, (C)&nbsp;accelerate any rights or benefits, or the vesting or funding of any payments or benefits, under any
Company Plan or otherwise, (D)&nbsp;establish, adopt, enter into, modify, amend or terminate any Company Plan (or plan or arrangement that would be a Company Plan if in effect on the date hereof) or (E)&nbsp;hire, engage, promote, terminate (without
cause), furlough, or temporarily layoff any employee with annual compensation in excess of $200,000 or any individual independent contractor or consultant with annual compensation in excess of $250,000; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(iv) take any action that would constitute a &#8220;mass layoff&#8221; or &#8220;plant closing&#8221; (as defined by WARN) or require notice
to employees, or trigger any other obligations or liabilities under WARN or any similar state, local or foreign Law; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(v) waive or
release any noncompetition, nonsolicitation, nondisclosure, noninterference, nondisparagement, or other restrictive covenant obligation of any current or former employee or independent contractor; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(vi) amend, or propose to amend, any Company Organizational Document (including by merger, consolidation or otherwise) or adopt a
stockholders&#8217; rights plan, or enter into any agreement with respect to the voting of any Company Securities; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(vii) effect a
recapitalization, reclassification of shares, stock split, reverse stock split or similar transaction or authorize the issuance of any other securities in respect of, in lieu of, or in substitution for shares of any Company Securities; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(viii) adopt a plan or agreement of complete or partial liquidation, dissolution, merger, consolidation, restructuring, recapitalization or
other reorganization of the Company or any Subsidiary of the Company (other than the Merger); </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(ix) subject to <U>clause (xi)</U>, make
any capital expenditures that are above amounts indicated in the capital expenditure budget set forth on <U>Section</U><U></U><U>&nbsp;6.1(b)(ix)</U> of the Company Disclosure Letter; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(x) acquire or agree to acquire (by merger, consolidation or acquisition of stock or assets or otherwise) any other Person, by purchase of
stock, securities or assets, or enter into any joint venture, partnership, strategic alliance, limited liability company or similar arrangement with any third Person in any one transaction or series of related transactions; </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xi) (A) incur, create, assume, become liable for, or materially modify the terms of
(including by extending the maturity date thereof) any Indebtedness, renew or extend any existing credit or loan arrangements, enter into any &#8220;keep well&#8221; or other agreement to maintain any financial condition of another Person, issue or
sell any debt securities, warrants, calls or other rights to acquire any debt securities of the Company or any of its Subsidiaries, or enter into any agreement or arrangement having the economic effect of any of the foregoing, (B)&nbsp;make or
forgive any loans or advances to any other Person (including any Affiliate) (other than advances to employees and other service providers for business and travel expenses in the ordinary course of business) or change its existing borrowing or
lending arrangements for or on behalf of such Persons or Affiliates, (C)&nbsp;make any capital contributions to, or investments in, any other Person or (D)&nbsp;repurchase, prepay, refinance or otherwise reduce or materially change the commitments
of any Indebtedness; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xii) sell, pledge, transfer, license, sublicense, assign, mortgage, encumber, lease (as lessor), subject to any
Lien (other than Permitted Liens) (including under any sale-leaseback transaction or an asset securitization transaction) or otherwise abandon, withdraw or dispose of, in a single transaction or a series of related transactions, any tangible assets
with a fair market value in excess of $250,000 in the aggregate; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xiii) (1) sell, transfer, assign, license, sublicense, lease or
otherwise encumber or dispose of (whether by merger, stock or asset sale or otherwise) to any Person (including any Affiliate) any rights to any Company Intellectual Property, except for <FONT STYLE="white-space:nowrap">non-exclusive</FONT> licenses
or sublicenses to Intellectual Property granted in the ordinary course of business consistent with past practice, (2)&nbsp;cancel, dedicate to the public, disclaim, forfeit, reissue, reexamine or abandon without filing a substantially identical
counterpart in the same jurisdiction with the same priority or allow to lapse (except with respect to Patents expiring in accordance with their terms) any Company Intellectual Property, (3)&nbsp;fail to make any filing, pay any fee, or take any
other action necessary to prosecute and maintain in full force and effect any Registered Company Intellectual Property, (4)&nbsp;make any change in Company Intellectual Property that does or would reasonably be expected to materially impair such
Company Intellectual Property or the Company&#8217;s or any rights of any Subsidiaries of the Company with respect thereto, (5)&nbsp;disclose to any Person (other than Representatives of Parent and Purchaser) any Trade Secrets, <FONT
STYLE="white-space:nowrap">know-how</FONT> or confidential or proprietary information, except, in the case of confidential or proprietary information, in the ordinary course of business to a Person that is subject to customary confidentiality
obligations or (6)&nbsp;fail to take or maintain reasonable measures to protect the confidentiality and value of the Trade Secrets included in any of the Company Intellectual Property; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xiv) commence, pay, discharge, settle, compromise or satisfy any Action that is unrelated to the Contemplated Transactions, other than
solely for monetary consideration not to exceed $250,000; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xv) change its fiscal year, revalue any of its material assets or change any
of its material financial, actuarial, reserving or Tax accounting methods or practices in any respect, except as required by GAAP or Law; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xvi) write up, write down or write off the book value of any material assets; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xvii) (A) make, change or revoke any material Tax election with respect to the Company or any of its Subsidiaries (including any election or
accounting method change in respect of expenditures described in Section&nbsp;174 of the Code (or any similar provision of state or local Law)), (B) file any material amended Tax Return, (C)&nbsp;enter into any &#8220;closing agreement&#8221; as
described in Section&nbsp;7121 of the Code (or any corresponding or similar provision of state, local or <FONT STYLE="white-space:nowrap">non-U.S.</FONT> law), Tax allocation agreement or Tax sharing agreement (other than any commercial agreement
entered into in the ordinary course of business that does not relate primarily to Taxes) or any other agreement with any Governmental Body relating to or affecting any material Tax liability of the Company or any of its Subsidiaries, (D)&nbsp;extend
or waive the application of any statute of limitations regarding the assessment or collection of any material Tax with respect to the Company or any of its Subsidiaries, (E)&nbsp;settle or compromise any material Tax liability or Tax refund claim
with respect to the Company or any of its Subsidiaries, or (F)&nbsp;fail to pay Taxes when due (including any estimated Taxes), except, in each case, as required by applicable Law; </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xviii) waive, release or assign any material rights or claims under, or negotiate, enter
into, renew, materially amend, materially modify, exercise any material options or material rights of first offer or refusal under or terminate, or defer or delay making any payment under, any Company Material Contract or any Contract that, if
existing as of the date of this Agreement, would have been a Company Material Contract, except (A)&nbsp;for the expiry of any Contracts on their terms or the entry into or renewal of Contracts in the ordinary course of business and (B)&nbsp;with
respect to Purchase Orders in the ordinary course of business; <U>provided</U> that in no event shall the Company or any of its Subsidiaries be permitted to enter into any Contract that would be a Company Material Contract under
<U>Section</U><U></U><U>&nbsp;4.12(a)(iii)</U> (<I>Joint Venture Agreements; Partnership Agreements</I>), <U>Section</U><U></U><U>&nbsp;4.12(a)(iv)</U><I></I>&nbsp;(<I>Contracts with Restrictive Covenants</I>),
<U>Section</U><U></U><U>&nbsp;4.12(a)(ix)</U> (<I>Contracts with Rights of First Refusal or Offer</I>), <U>Section</U><U></U><U>&nbsp;4.12(a)(xiv)</U> (<I>Contracts Restricting Dividends</I>) or <U>Section</U><U></U><U>&nbsp;4.12(a)(xx)</U>
(<I>Contracts Relating to Commercialization, <FONT STYLE="white-space:nowrap">Co-Promotion,</FONT> etc.</I>); </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xix) negotiate, amend,
modify, extend, enter into or terminate any Labor Agreement; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xx) abandon, withdraw, terminate, suspend, abrogate, amend or modify in
any material respect any material Permits; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxi) enter into a research or collaboration arrangement (except for Routine Services
Contracts) that contemplates payments by or to the Company or any of its Subsidiaries in excess of $250,000 in any twelve (12)-month period; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxii) amend, cancel or terminate any material insurance policy naming the Company or any of its Subsidiaries as an insured, a beneficiary or
a loss payable payee without obtaining substitute insurance coverage; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxiii) participate in any scheduled meetings or teleconferences
with, or correspond in writing, communicate, or consult with the FDA or any similar Governmental Body without providing Parent with prior written notice and, within one Business Day from the time such written notice is delivered, the opportunity to
consult with the Company with respect to such correspondence, communication or consultation, in each case to the extent permitted by applicable Law; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxiv) enter into any new material line of business, create any new Subsidiary, or enter into any agreement or commitment that materially
limits or otherwise materially restricts the Company or its Affiliates, including, following the Closing, Parent and its Affiliates from time to time engaging or competing in any line of business or in any geographic area or otherwise enter into any
agreements, arrangements or commitments imposing material restrictions on its assets, operations or business; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxv) (A) commence any
clinical trial of which Parent has not been informed prior to the date of this Agreement, (B)&nbsp;unless mandated by any Governmental Body, discontinue, terminate, suspend or materially modify any ongoing clinical trial, (C)&nbsp;discontinue,
terminate, suspend or materially modify any <FONT STYLE="white-space:nowrap">IND-enabling</FONT> preclinical studies or other material preclinical development activities without first consulting with Parent in good faith, or (D)&nbsp;accelerate or
delay public disclosure of the results of any ongoing clinical trial from any release dates publicly announced prior to the date hereof without first consulting with Parent in good faith; </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxvi) enter into an Affiliate Transaction; or </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(xxvii) authorize, agree or commit to take any of the actions described in <U>clauses</U> <U>(i)</U>&nbsp;through <U>(xxiv)</U> of this
<U>Section</U><U></U><U>&nbsp;6.1(b)</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.2. <U>Access to Information; Confidentiality</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) From and after the date of this Agreement until the earlier of the Acceptance Time and the termination of this Agreement in accordance
with its terms, the Company shall, and shall cause its Subsidiaries to, (i)&nbsp;upon reasonable advance notice, (A)&nbsp;give Parent and Purchaser and their respective Representatives reasonable access during normal business hours to relevant
employees and facilities and to relevant books, contracts and records of the Company and its Subsidiaries, (B)&nbsp;permit Parent and Purchaser to make such <FONT STYLE="white-space:nowrap">non-invasive</FONT> inspections as they may reasonably
request and (C)&nbsp;cause its officers to furnish Parent and Purchaser with such financial and operating data and other information with respect to the business, properties and personnel of the Company and its Subsidiaries as Parent or Purchaser
may from time to time reasonably request, in each case of <U>clauses (A)</U>-<U>(C)</U>, solely for the purpose of effectuating the Contemplated Transactions and integration planning and (ii)&nbsp;reasonably promptly notify Parent of any Healthcare
Correspondence. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Subject to <U>Section</U><U></U><U>&nbsp;9.7</U>, Parent, Purchaser and the Company hereby acknowledge and agree that
the Confidentiality Agreement will continue in full force and effect in accordance with its terms. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) Nothing in
<U>Section</U><U></U><U>&nbsp;6.2(a)</U> requires the Company to permit any inspection, or to disclose any information, that in the reasonable judgment of the Company would (i)&nbsp;violate any of its or its Affiliates&#8217; respective obligations
with respect to confidentiality existing as of the date hereof, (ii)&nbsp;result in a violation of applicable Law or (iii)&nbsp;result in loss of legal protection, including the attorney-client privilege and work product doctrine; <U>provided</U>
that the Company will use its reasonable best efforts to obtain any required consents for the disclosure of such information and take such other reasonable action (including entering into a joint defense agreement or similar arrangement to avoid
loss of attorney-client privilege) with respect to such information as is necessary to permit disclosure to Parent without (x)&nbsp;jeopardizing such attorney-client privilege or work product doctrine or (y)&nbsp;violating applicable Law or any of
the Company&#8217;s or its Affiliates&#8217; respective obligations with respect to confidentiality, as applicable. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.3.
<U>Acquisition Proposals</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) The Company shall not, and shall cause its directors and officers not to, and shall instruct its
Representatives not to: (i)&nbsp;directly or indirectly initiate, solicit, or knowingly encourage or knowingly facilitate (including by way of providing information) any inquiries, proposals or offers, or the making of any submission or announcement
of any inquiry, proposal or offer that constitutes or would reasonably be expected to lead to any Acquisition Proposal, (ii)&nbsp;directly or indirectly engage in, enter into or participate in any discussions or negotiations with any Person with
respect to any Acquisition Proposal or (iii)&nbsp;provide any <FONT STYLE="white-space:nowrap">non-public</FONT> information to, or afford access to the business, properties, assets, books or records of the Company and its Subsidiaries to, any
Person (other than Parent, Purchaser, or any designees of Parent or Purchaser) in connection with any Acquisition Proposal. The Company shall and shall cause its directors and officers to, and shall direct its Representatives to,
(x)&nbsp;immediately cease any solicitation, discussions, or negotiations with any Person (other than Parent, Purchaser, or any designees of Parent or Purchaser) with respect to any Acquisition Proposal, (y)&nbsp;as soon as reasonably practicable
(and in any event within one Business Day) request in writing the prompt return or destruction of all confidential information provided by or on behalf of the Company or its Subsidiaries to any such Person or developed using any such information and
(z)&nbsp;as soon as reasonably practicable (and in any event within one Business Day) </P>
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terminate access to any physical or electronic data rooms relating to a possible Acquisition Proposal. Notwithstanding the foregoing, the Company and its Representatives may, solely in response
to a <I>bona fide</I> inquiry or proposal that did not result from a material breach of this <U>Section</U><U></U><U>&nbsp;6.3(a)</U>, inform a Person that has made or, to the Knowledge of the Company, is considering making an Acquisition Proposal
of the provisions of this <U>Section</U><U></U><U>&nbsp;6.3</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Notwithstanding <U>Section</U><U></U><U>&nbsp;6.3(a)</U> or any
other provision of this Agreement, if at any time following the date of this Agreement and prior to the Acceptance Time, (i)&nbsp;the Company has received a written <I>bona fide </I>Acquisition Proposal that did not, directly or indirectly, result
from a material breach of <U>Section</U><U></U><U>&nbsp;6.3(a)</U> and (ii)&nbsp;the Company Board or a committee thereof determines in good faith, after consultation with outside counsel and a financial advisor, that such Acquisition Proposal
constitutes or is reasonably likely to lead to or result in a Superior Proposal, then the Company may (A)&nbsp;furnish information with respect to the Company to the Person making such Acquisition Proposal and its Representatives and
(B)&nbsp;participate in discussions or negotiations with such Person and its Representatives regarding such Acquisition Proposal; <U>provided</U> that the Company may only take the actions described in <U>clauses (A)</U>&nbsp;or <U>(B)</U> above if
the Company Board determines in good faith, after consultation with outside counsel, that the failure to take any such action would be, or would reasonably be expected to be, inconsistent with its fiduciary duties under applicable Law;
<U>provided</U>, <U>further</U>, that (1)&nbsp;the Company shall not, and shall instruct its Representatives not to, disclose any material <FONT STYLE="white-space:nowrap">non-public</FONT> information to such Person unless the Company has, or first
enters into, a confidentiality agreement with such Person with terms governing confidentiality that, taken as a whole, are not materially less restrictive or materially more favorable to the other Person than those contained in the Confidentiality
Agreement, and that does not prohibit the Company from providing any information to Parent in accordance with this <U>Section</U><U></U><U>&nbsp;6.3</U> or otherwise prohibit the Company from complying with its obligations under this
<U>Section</U><U></U><U>&nbsp;6.3</U>, and (2)&nbsp;the Company shall, concurrently therewith or as promptly as reasonably practicable thereafter, and in any event within one Business Day, provide or make available to Parent any material <FONT
STYLE="white-space:nowrap">non-public</FONT> information concerning the Company provided or made available to such other Person that was not previously provided or made available to Parent and Purchaser. The Company shall not, directly or
indirectly, release any Person from, or waive, amend or modify any provision of, or grant permission under or fail to enforce, any standstill provision in any agreement to which the Company is a party. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) The Company shall promptly (and in any event within one Business Day) notify Parent in writing (email being acceptable) of the receipt by
the Company of any Acquisition Proposal, inquiry, request for information or other indication by any Person that it is considering making an Acquisition Proposal, or any inquiry, proposal or offer that could reasonably be expected to lead to an
Acquisition Proposal. The Company shall (i)&nbsp;provide Parent promptly (and in any event within such one Business Day period) the material terms and conditions of any such inquiry or Acquisition Proposal (including any subsequent amendments,
modifications or supplements thereto), together with copies of all material documents related thereto, and the identity of the Person making any such inquiry or Acquisition Proposal and (ii)&nbsp;keep Parent reasonably informed of any material
developments, discussions or negotiations regarding any Acquisition Proposal (including any changes to the terms thereof). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) The
Company Board and each committee thereof shall not, subject to the terms and conditions of this Agreement, (i)&nbsp;approve or recommend, or propose publicly to approve or recommend, or authorize, cause or permit the Company to enter into any letter
of intent, memorandum of understanding, agreement in principle, acquisition agreement, license agreement, merger agreement, joint venture agreement, partnership agreement, collaboration agreement, revenue-sharing agreement or similar definitive
agreement (other than a confidentiality agreement referred to and entered into in compliance with <U>Section</U><U></U><U>&nbsp;6.3(b)</U>) relating to, or that would reasonably be expected to lead to, any Acquisition Proposal (an
&#8220;<U>Alternative Acquisition Agreement</U>&#8221;) or (ii)&nbsp;make a Change of Board Recommendation. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">45 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) Notwithstanding <U>Section</U><U></U><U>&nbsp;6.3(d)</U> or any other provision of this
Agreement, prior to the Acceptance Time: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(i) the Company may terminate this Agreement to enter into an Alternative Acquisition Agreement
if (A)&nbsp;the Company receives an Acquisition Proposal that did not, directly or indirectly, result from a material breach of <U>Section</U><U></U><U>&nbsp;6.3(a)</U> and that the Company Board or a committee thereof determines in good faith,
after consultation with outside counsel, constitutes a Superior Proposal, (B)&nbsp;the Company has notified Parent in writing that it intends to terminate this Agreement to enter into an Alternative Acquisition Agreement and (C)&nbsp;no earlier than
the end of the Notice Period, the Company Board or any committee thereof determines in good faith that the Acquisition Proposal that is subject of the Determination Notice continues to constitute a Superior Proposal and that the failure to terminate
this Agreement would reasonably be expected to be inconsistent with its fiduciary duties under applicable Law, after consultation with outside counsel and taking into consideration the terms of any proposed amendment or modification to this
Agreement that Parent has irrevocably committed to make during the Notice Period; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(ii) the Company Board or a committee thereof may make
a Change of Board Recommendation if (A)&nbsp;the Company receives an Acquisition Proposal that did not, directly or indirectly, result from a material breach of <U>Section</U><U></U><U>&nbsp;6.3(a)</U>, and the Company Board or a committee thereof
determines in good faith, after consultation with outside counsel, that the Acquisition Proposal constitutes a Superior Proposal, (B)&nbsp;the Company has notified Parent in writing that it intends to effect a Change of Board Recommendation and
(C)&nbsp;no earlier than the end of the Notice Period, the Company Board or a committee thereof determines in good faith that the failure to make a Change of Board Recommendation would reasonably be expected to be inconsistent with its fiduciary
duties under applicable Law and that the Acquisition Proposal that is subject of the Determination Notice continues to constitute a Superior Proposal, after consultation with outside counsel and taking into consideration the terms of any proposed
amendment or modification to this Agreement that Parent has irrevocably committed to make during the Notice Period; and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(iii) other than
in connection with an Acquisition Proposal, the Company Board or a committee thereof may make a Change of Board Recommendation in response to an Intervening Event if (A)&nbsp;the Company has notified Parent in writing that it intends to effect a
Change of Board Recommendation and (B)&nbsp;no earlier than the end of the Notice Period, the Company Board or any committee thereof determines in good faith, after consultation with outside counsel and considering the terms of any proposed
amendment or modification to this Agreement that Parent has irrevocably committed to make during the Notice Period, that the failure to effect a Change of Board Recommendation in response to such Intervening Event would reasonably be expected to be
inconsistent with its fiduciary duties under applicable Law. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The provisions of this <U>Section</U><U></U><U>&nbsp;6.3(e)</U> apply to any amendment to
the financial or other material terms of any applicable Superior Proposal with respect to <U>Section</U><U></U><U>&nbsp;6.3(e)(i)</U> and <U>Section</U><U></U><U>&nbsp;6.3(e)(ii)</U> and require a revised Determination Notice and a new Notice Period
pursuant to clause (i)(C) or (ii)(C) as the case may be. During the Notice Period, if requested by Parent, the Company shall negotiate, and shall instruct its Representatives to negotiate, in good faith with Parent regarding potential changes to
this Agreement in such a manner that would eliminate the need for taking the actions set forth in <U>Section</U><U></U><U>&nbsp;6.3(e)(i)</U> and <U>Section</U><U></U><U>&nbsp;6.3(e)(ii)</U> (and in respect of a Superior Proposal, would cause such
Superior Proposal to no longer constitute a Superior Proposal). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(f) Nothing contained in this Agreement prohibits (i)&nbsp;the Company
Board or a committee thereof from (A)&nbsp;taking and disclosing to the holders of Shares a position contemplated by Rule <FONT STYLE="white-space:nowrap">14e-2</FONT> or Rule <FONT STYLE="white-space:nowrap">14d-9</FONT> promulgated under the
Exchange Act or (B)&nbsp;making any public statement if the Company Board or a committee thereof determines in good faith, after consultation with outside counsel, </P>
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that the failure to make such statement would reasonably be expected to be inconsistent with its fiduciary duties under applicable Law or (ii)&nbsp;the Company or the Company Board from making
any disclosure required under the Exchange Act; <U>provided</U> that any such action that would otherwise constitute a Change of Board Recommendation shall be made only in compliance with <U>Section</U><U></U><U>&nbsp;6.3(d)</U> and
<U>Section</U><U></U><U>&nbsp;6.3(e)</U> (it being understood that: (x)&nbsp;any &#8220;stop, look and listen&#8221; letter or similar communication limited to the information described in Rule <FONT STYLE="white-space:nowrap">14d-9(f)</FONT> under
the Exchange Act and (y)&nbsp;any disclosure of information to the holders of Shares that only describes the Company&#8217;s receipt of an Acquisition Proposal and the operation of this Agreement with respect thereto and contains a statement that
the Company Board has not effected a Change of Board Recommendation, in each case, shall be deemed not to be a Change of Board Recommendation). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(g) The Company acknowledges and agrees that, for purposes of determining whether a breach of this <U>Section</U><U></U><U>&nbsp;6.3</U> has
occurred, the actions of the Company&#8217;s directors and Representatives acting in their authorized capacities on behalf of the Company shall be deemed to be the actions of the Company, and the Company shall be responsible for any breach of this
<U>Section</U><U></U><U>&nbsp;6.3</U> by its directors and Representatives acting in their authorized capacities on behalf of the Company. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.4. <U>Employment and Employee Benefits Matters</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) For twelve (12)&nbsp;months following the Closing Date (or, if earlier, until the date of the termination of employment of a Current
Employee, as defined below) (the &#8220;<U>Continuation Period</U>&#8221;), Parent shall, or shall cause the Surviving Corporation to provide each individual employed by the Company or its Subsidiaries immediately prior to the Effective Time (each,
a &#8220;<U>Current Employee</U>&#8221;), (i) base salary or wage rate and a target cash incentive compensation opportunity that is, in the aggregate, at least as favorable as the base salary or wage rate and target annual cash incentive opportunity
provided to the Current Employee as of immediately prior to the date hereof, and (ii)&nbsp;broad-based employee benefits (excluding long-term cash incentive opportunities, severance, equity and equity-based awards, retention, transaction, change in
control-related payments or benefits, nonqualified deferred compensation, defined benefit plan and post-employment or retiree welfare benefits (collectively, the &#8220;<U>Excluded Benefits</U>&#8221;)) that are substantially comparable in the
aggregate to those broad-based employee benefits (other than Excluded Benefits)&nbsp;(x) provided to the Current Employees under the Company Plans that are disclosed in <U>Section</U><U></U><U>&nbsp;4.16(a)</U> of the Company Disclosure Letter and
in effect as of immediately prior to the Effective Time, (y)&nbsp;provided to similarly situated employees of Parent, or (z)&nbsp;a combination of the foregoing, as determined in Parent&#8217;s sole discretion. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Parent shall use commercially reasonable efforts to, and shall use commercially reasonable efforts to cause the Surviving Corporation to,
cause service rendered by each Current Employee to the Company or its Subsidiaries prior to the Effective Time to be taken into account with respect to only the employee benefit plans of Parent and the Surviving Corporation which provide benefits
for vacation, paid <FONT STYLE="white-space:nowrap">time-off</FONT> or 401(k) savings (and for the avoidance of doubt, not for any purpose under any Excluded Benefit), for purposes of determining eligibility to participate, level of benefits and
vesting, to the same extent and for the same purpose as such service was taken into account under the corresponding Company Plans immediately prior to the Effective Time for those purposes; <U>provided</U> that the foregoing will not apply to
(i)&nbsp;the extent that its application would result in a duplication of benefits or compensation with respect to the same period of service, (ii)&nbsp;any benefit plan that is a frozen plan or that provides benefits to a grandfathered employee
population or (iii)&nbsp;to the extent such service would not be credited to similarly situated employees of Parent or its Affiliates. Without limiting the generality of the foregoing, for the plan year in which the Effective Time occurs, Parent
shall, or shall cause the Surviving Corporation to, use commercially reasonable efforts to waive for the Current Employees any eligibility requirements, waiting periods,
<FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">actively-at-work</FONT></FONT> requirements or <FONT STYLE="white-space:nowrap">pre-existing</FONT> condition limitations under any health plan of Parent or the Surviving Corporation
for any condition for which they would have been entitled to coverage under the corresponding Company Plan in which they participated immediately prior to the Effective Time. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) If requested by Parent, the Company shall, at least one (1)&nbsp;Business Day prior to
the Effective Time, (i)&nbsp;adopt written resolutions (or take other necessary and appropriate actions) to terminate each Company Plan intended to be qualified under Section&nbsp;401(a) of the Code (the &#8220;<U>401(k) Plan</U>&#8221;), (ii) cease
all contributions to the 401(k) Plan for any compensation paid after such termination date, and (iii)&nbsp;one hundred percent (100%) vest all participants under the 401(k) Plan, with such termination, cessation and vesting to be effective no later
than the Business Day preceding the Effective Time. The Company shall provide Parent with an advance copy of such proposed resolutions no later than five (5)&nbsp;Business Days prior the date the resolutions are to be approved and shall incorporate
any and all reasonable comments made by Parent to such resolutions. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) Without limiting the generality of
<U>Section</U><U></U><U>&nbsp;6.4</U>, no provision of this Agreement (i)&nbsp;prohibits Parent, Purchaser or the Surviving Corporation from amending, modifying or terminating any Company Plan or any other benefit or compensation plan, program,
contract, agreement, policy or arrangement, (ii)&nbsp;requires Parent, Purchaser or the Surviving Corporation to keep any Person employed or otherwise providing services for any period of time, or (iii)&nbsp;constitutes or shall be construed to
constitute the establishment or adoption of, or amendment to, any Company Plan or other benefit or compensation plan, program, contract, agreement, policy or arrangement. This <U>Section</U><U></U><U>&nbsp;6.4</U> shall not confer upon any Current
Employee or any other Person (including any beneficiary or dependent thereof) not a party to this Agreement any third-party beneficiary or similar rights or remedies. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.5. <U>Directors</U><U>&#8217;</U><U> and Officers</U><U>&#8217;</U><U> Indemnification and Insurance</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) Parent agrees that all rights to indemnification and exculpation from liability for acts or omissions occurring on or prior to the Closing
Date now existing in favor of any of the current or former directors, managers, officers or employees of the Company (each an &#8220;<U>Indemnified Party</U>&#8221; and collectively the &#8220;<U>Indemnified Parties</U>&#8221;), as provided in the
respective Organizational Documents or in indemnification agreements set forth on <U>Section</U><U></U><U>&nbsp;6.5(a)</U> of the Company Disclosure Letter, to the extent made available to Parent and as in effect as of the date of this Agreement,
shall survive the Effective Time and shall continue in full force and effect in accordance with their respective terms for a period of not less than six (6)&nbsp;years after the Closing Date. From and after the Effective Time, Parent shall cause the
Surviving Corporation and its subsidiaries to comply with and honor the foregoing obligations. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) On or prior to the Closing Date, the
Company shall pay (in full) for a <FONT STYLE="white-space:nowrap">non-cancelable</FONT> <FONT STYLE="white-space:nowrap">run-off</FONT> insurance policy of not less than the existing coverage amount, for a period of six (6)&nbsp;years after the
Closing Date to provide insurance coverage for events, acts or omissions occurring on or prior to the Closing Date for all Indemnified Parties and other persons who were covered under the directors&#8217; and officers&#8217; insurance policy
maintained by the Company as of the date of this Agreement and made available to Parent, which policy shall contain terms and conditions no less favorable in the aggregate to the insured persons than such coverage maintained by the Company. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) The covenants contained in this <U>Section</U><U></U><U>&nbsp;6.5</U> are intended to be for the benefit of, and shall be enforceable by,
each of the Indemnified Parties and their respective heirs and legal representatives and shall not be deemed exclusive of any other rights to which a Indemnified Party is entitled, whether pursuant to Law, Contract or otherwise. In the event that
the Surviving Corporation or its successors or assigns (i)&nbsp;consolidates with or merges into any other Person and shall not be the continuing or surviving corporation or entity of such consolidation or merger or (ii)&nbsp;transfers or conveys
all or substantially all of its properties and assets to any Person, then, and in each such case, Parent shall take all necessary action so that the successors or assigns of the Surviving Corporation shall succeed to the obligations set forth in
this <U>Section</U><U></U><U>&nbsp;6.5</U>. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.6. <U>Further Action; Efforts</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) Each of the Parties shall (i)&nbsp;use its reasonable best efforts to promptly make all filings and promptly obtain all authorizations,
consents, orders, clearances and approvals of all Governmental Bodies and officials that may be or become necessary or advisable for its execution and delivery of, and the performance of its obligations pursuant to, this Agreement,
(ii)&nbsp;cooperate fully with the other Party in promptly seeking to obtain all such authorizations, consents, orders, clearances and approvals and (iii)&nbsp;provide as promptly as practicable such information to any Governmental Body as such
Governmental Body may request in connection herewith. In furtherance of the foregoing, each Party hereto, as applicable, agrees to file promptly (but in no event later than twenty (20)&nbsp;Business Days after the date of this Agreement) the filings
and notifications required under any Antitrust and FDI Laws applicable to the transactions contemplated by this Agreement and to supply as promptly as practicable to the appropriate Governmental Authorities any additional information and documentary
material that may be requested pursuant to such Antitrust and FDI Laws. None of Company, on the one hand, or Parent, on the other hand, may, without the consent of the other (such consent not to unreasonably withheld, conditioned or delayed), (x)
cause any such filing or submission applicable to it to be withdrawn or refiled for any reason, including to provide the applicable Governmental Body with additional time to review any of the transactions contemplated by this Agreement or
(y)&nbsp;consent to any voluntary extension of any statutory deadline or waiting period or to any voluntary delay of the consummation of the transactions contemplated by this Agreement. Parent shall pay all filing fees required to be paid to a
Governmental Body in connection with the filings and notification required under Antitrust and FDI Laws applicable to the transactions contemplated by this Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Notwithstanding the foregoing provisions of this <U>Section</U><U></U><U>&nbsp;6.6</U> or anything in this Agreement to the contrary,
(i)&nbsp;neither Parent nor any of its Affiliates is required to (A)&nbsp;propose, negotiate, commit to or effect, by consent decree, hold separate order, or otherwise, the sale, license, divestiture or disposition of any assets of Parent or its
Affiliates or the Company, (B)&nbsp;enter into any behavioral limitations, conduct restrictions or other commitments with respect to any assets or business of Parent or its Affiliates or the Company, or (C)&nbsp;defend through litigation or
otherwise formally oppose any claim or determination (whether judicial or administrative in nature) by any Governmental Body or third party that would restrain, prevent, or delay the consummation of the transactions contemplated by this Agreement
and (ii)&nbsp;the Company shall not take or propose to undertake any divestiture, sale, disposition, license, hold separate or other structural or conduct relief without Parent&#8217;s prior written consent (which may be given or withheld in
Parent&#8217;s sole discretion). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) Each of Parent, on the one hand, and the Company, on the other hand, shall promptly notify the other
of any communication it or any of its Affiliates receives from any Governmental Body relating to the matters that are the subject of this Agreement and, to the extent practicable, permit the other to review in advance any proposed communication by
such Party to any Governmental Body (including any filings required under any Antitrust and FDI Laws). Parent, on the one hand, and the Company, on the other hand, shall, to the extent practicable, consult with the other in advance of, and, to the
extent permitted by the applicable Governmental Body, give the other an opportunity to participate in, any meeting with any Governmental Body in respect of any filings, investigation (including any settlement of the investigation), litigation or
other inquiry. Parent, on the one hand, and the Company, on the other hand, will coordinate and cooperate fully with each other in exchanging such information and providing such assistance as the other may reasonably request in connection with the
foregoing and in seeking early termination of any applicable waiting periods, including under any applicable Antitrust and FDI Laws. Parent, on the one hand, and the Company, on the other hand, will provide each other with copies of all
</P>
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correspondence, filings or communications between them or any of their Representatives, on the one hand, and any Governmental Body or members of its staff, on the other hand, with respect to this
Agreement and/or the transactions contemplated by this Agreement; provided, however, that such materials may be redacted, to the extent permitted by any applicable Law, (i)&nbsp;to remove references concerning the valuation of the business of the
Company or the value of the Company after the consummation of the transactions contemplated hereby, (ii)&nbsp;as necessary to comply with contractual arrangements in effect as of the execution of this Agreement and (iii)&nbsp;as necessary to address
reasonable attorney-client or other privilege or work product protection, to the extent that that such attorney-client or other privilege or work product protection are not governed by a common interest privilege or doctrine. Notwithstanding the
foregoing, in the event Parent and the Company disagree, Parent shall retain control over the strategy to gain regulatory clearance or approval before any Governmental Bodies or in any Action brought to enjoin the transactions contemplated hereby
pursuant to any FDI and Antitrust Law. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.7. <U>Public Announcements</U>. The Company shall not, and Parent shall not, and
shall cause each of its Subsidiaries to not, issue any press release or announcement or make any other public disclosure, including in any filings or submissions to the SEC, concerning the Contemplated Transactions without the prior consent of the
other (which consent may not be unreasonably withheld, conditioned, or delayed), except any release, announcement or disclosure required by applicable Law or any rule or regulation of Nasdaq, the New York Stock Exchange or any other stock exchange
to which the relevant party is subject, in which case the party required to make the release or announcement shall use commercially reasonable efforts to allow each other party reasonable time to comment on such release or announcement in advance of
such issuance and shall consider any comments in good faith; it being understood that the final form and content of any such release or announcement, to the extent so required, shall be at the final discretion of the disclosing party. The parties
hereto agree that the initial press release relating to this Agreement shall be a joint press release issued by the Company and Parent. The restrictions of this <U>Section</U><U></U><U>&nbsp;6.7</U> do not apply to communications by the Company or
Parent in connection with, or following, an Acquisition Proposal, Superior Proposal, Change of Board Recommendation, Intervening Event or any action taken pursuant thereto (or communications made or proposed to be made by Parent in response
thereto), in each case, that does not violate <U>Section</U><U></U><U>&nbsp;6.3</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.8. <U>Approval of Compensation
Actions</U>. Prior to the Acceptance Time, the Compensation Committee of the Company Board shall take all such actions as may be required to approve, as an &#8220;employment compensation, severance, or other employee benefit arrangement&#8221; in
accordance with Rule <FONT STYLE="white-space:nowrap">14d-10(d)(2)</FONT> under the Exchange Act and the instructions thereto, any and all Compensation Actions taken after January&nbsp;1, 2025 and prior to the Acceptance Time that have not already
been so approved. For the purposes of this Agreement, &#8220;<U>Compensation Action</U>&#8221; means any (a)&nbsp;granting by the Company to any present or former director or officer of any increase in compensation or benefits or of the right to
receive any severance or termination compensation or benefit; (b)&nbsp;entry by the Company into any employment, consulting, indemnification, termination, change of control, <FONT STYLE="white-space:nowrap">non-competition,</FONT> or severance
agreement with any present or former director or officer, or any approval, amendment, or modification of any such agreement; or (c)&nbsp;approval of, amendment to, or adoption of any Company Plan. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.9. <U>No Control of the Company</U><U>&#8217;</U><U>s Business</U>. Nothing contained in this Agreement gives Parent or
Purchaser, directly or indirectly, the right to control or direct the Company&#8217;s operations prior to the Effective Time. Prior to the Effective Time, the Company shall exercise, consistent with the terms and conditions of this Agreement,
complete control and supervision over its operations. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.10. <U>Stockholder Litigation</U>. The Company shall promptly (and
in any event within forty-eight (48)&nbsp;hours) notify Parent of any actions, suits, or claims instituted against the Company, its Subsidiaries or any of its or their respective directors or officers, in each case, relating to this Agreement or the
Contemplated Transactions (each such item described in this <U>Section</U><U></U><U>&nbsp;6.10</U>, &#8220;<U>Stockholder Litigation</U>&#8221;). </P>
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Parent shall have the right to participate in the defense and settlement of any such Stockholder Litigation, the Company shall consult with Parent (which advice the Company shall consider in good
faith) regarding the defense of any such Stockholder Litigation, and the Company shall not settle or compromise any Stockholder Litigation without the prior written consent of Parent, not to be unreasonably withheld, delayed or conditioned, unless
(i)&nbsp;such settlement is fully covered by the Company&#8217;s insurance policies (other than any applicable deductible) or (ii)&nbsp;such settlement relates solely to the provision of additional disclosure in the Schedule <FONT
STYLE="white-space:nowrap">14D-9,</FONT> but in each case only if such settlement would not result in the imposition of any restriction on the business or operations of the Company or its Affiliates or expose the Company to additional liability. The
Company shall notify Parent promptly of the commencement or written threat of any proceedings of which it has received notice or become aware and shall keep Parent promptly and reasonably informed regarding any such proceedings. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.11. <U>Regulatory Matters</U>. The Company has made available to Parent true, complete and accurate copies of all material data
and reports with respect to regulatory applications, studies and trials, and all other material information regarding the quality, efficacy and safety of the Products, including copies of all communications from Governmental Bodies relating to the
Products. Between the date of this Agreement and the earlier of the Effective Time or the termination of this Agreement, each of the Company and its Subsidiaries shall make available to Parent and its Representatives complete and accurate copies of
(a)&nbsp;all clinical and preclinical data set forth on <U>Section</U><U></U><U>&nbsp;6.11</U> of the Company Disclosure Letter and (b)&nbsp;all material written or oral correspondence or other communications between the Company or any of its
Subsidiaries, on the one hand, and the applicable Governmental Bodies, on the other hand, relating to the Products, in the case of each of clauses (a)&nbsp;and (b) above, that comes into the Company&#8217;s or any of its Subsidiaries&#8217;
possession or control during such time period promptly (and in any event no later than three (3)&nbsp;Business Days) after the Company obtains such possession or control thereof and subject to the limitations set forth in
<U>Section</U><U></U><U>&nbsp;6.2</U> (it being understood that data and correspondence in the possession of a contract research organization or similar third party acting on behalf of the Company shall not be deemed to be in possession of the
Company solely by reason of its being in the possession of such third party). The Company shall, and shall cause its Subsidiaries to, and shall direct its and their Representatives to reasonably consult and cooperate with Parent, as and to the
extent reasonably requested by Parent, and consider in good faith the views and comments of Parent in connection with any material communications (including meetings or teleconferences) with any Governmental Body relating to clinical and preclinical
trials related to the Products. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.12. <U>Cash Management</U>. Prior to the Effective Time, the Company shall convert all
Investment Securities to Cash and Cash Equivalents. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.13. <U>Stock Exchange
<FONT STYLE="white-space:nowrap">De-listing</FONT></U>. The Company shall cause the Company&#8217;s securities to be <FONT STYLE="white-space:nowrap">de-listed</FONT> from Nasdaq and <FONT STYLE="white-space:nowrap">de-registered</FONT> under the
Exchange Act as promptly as practicable following the Effective Time. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.14. <U>Termination of Certain Agreements</U>. At or
prior to the Effective Time, the Company shall terminate, or cause to be terminated, the Contracts set forth on <U>Section</U><U></U><U>&nbsp;6.14</U> of the Company Disclosure Letter, with such termination(s) becoming effective no later than as of
the Effective Time. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.15. <U>Merger Without a Stockholders Meeting</U>. As promptly as practicable following the
consummation of the Offer, the parties hereto shall take all necessary and appropriate actions to cause the Merger to become effective without a meeting of the stockholders of the Company, in accordance with Section&nbsp;251(h) of the DGCL. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">51 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.16. <U>FIRPTA Certificate</U>. Prior to the Effective Time, the Company shall
deliver an affidavit to Parent stating that the Company is not and has not been a United States real property holding corporation, in the form and substance required under Treasury Regulation <FONT STYLE="white-space:nowrap">&#167;1.897-2(h),</FONT>
as of the Effective Time. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.17. <U>Sales Agreement</U>. Within five (5)&nbsp;Business Days of the date of this Agreement,
the Company shall cause the Sales Agreement to be terminated. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE VII </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>CONDITIONS OF MERGER </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;7.1. <U>Conditions to Obligation of Each Party to Effect the Merger</U>. The respective obligations of each party to effect the
Merger are subject to the satisfaction at or prior to the Effective Time of each of the following conditions: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) No order, injunction,
investigation or decree issued by any Governmental Body of competent jurisdiction preventing the consummation of the Merger will be in effect. No statute, rule, regulation, order, injunction, or decree will have been enacted, entered, promulgated,
or enforced (and still be in effect) by any Governmental Body that prohibits or makes illegal the consummation of the Merger. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b)
Purchaser will have irrevocably accepted for purchase the Shares validly tendered (and not validly withdrawn) pursuant to the Offer. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE VIII </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>TERMINATION, AMENDMENT AND WAIVER </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.1. <U>Termination by Mutual Agreement</U>. This Agreement may be terminated, and the Offer and the Merger may be abandoned, at
any time prior to the Acceptance Time, by mutual written consent of Parent and the Company. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.2. <U>Termination by Either
Parent or the Company</U>. This Agreement may be terminated, and the Offer and the Merger may be abandoned, at any time prior to the Acceptance Time, by Parent or the Company if: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) any court of competent jurisdiction or other Governmental Body has issued an order, decree or ruling, or taken any other action
permanently restraining, enjoining, or otherwise prohibiting the Offer or the Merger, and such order, decree, ruling or other action has become final and <FONT STYLE="white-space:nowrap">non-appealable;</FONT> <U>provided</U>, <U>however</U>, that
the terms of this <U>Section</U><U></U><U>&nbsp;8.2</U> are not available to any party, if the issuance of such order, decree, ruling or other action is primarily attributable to the failure on the part of such party to comply with its obligations
under this Agreement in any material respect, including <U>Section</U><U></U><U>&nbsp;6.6</U>; or </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) the Acceptance Time has not
occurred on or prior to the date that is ninety (90)&nbsp;days after the date of this Agreement (the &#8220;<U>Outside Date</U>&#8221;); <U>provided</U>, <U>however</U>, that this termination right is not available to any party, if the failure of
the Acceptance Time to occur prior to the Outside Date is primarily attributable to the failure on the part of such party to comply in any material respect with its obligations under this Agreement, including <U>Section</U><U></U><U>&nbsp;6.6</U>.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.3. <U>Termination by the Company</U>. This Agreement may be terminated, and the Offer and the Merger may be abandoned, at
any time prior to the Acceptance Time, by the Company: </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) if (i)&nbsp;Purchaser fails to timely commence the Offer in violation of
<U>Section</U><U></U><U>&nbsp;1.1</U> (other than due to the failure of the Company to perform any covenants or obligations in this Agreement required to be performed by the Company for such commencement of the Offer), (ii) the Offer has expired or
has been terminated, without Purchaser having accepted for purchase the Shares validly tendered (and not validly withdrawn) pursuant to the Offer (subject to the rights and obligations of Parent or Purchaser to extend the Offer pursuant to
<U>Section</U><U></U><U>&nbsp;1.1</U>), (iii) Purchaser, in violation of the terms of this Agreement, fails to accept for purchase Shares validly tendered (and not validly withdrawn) pursuant to the Offer or (iv)&nbsp;there has been a breach of any
covenant or agreement made by Parent or Purchaser in this Agreement, or any representation or warranty of Parent or Purchaser is inaccurate or becomes inaccurate after the date of this Agreement, and such breach or inaccuracy gives rise to a
Purchaser Material Adverse Effect, and such breach or inaccuracy is not capable of being cured within thirty (30)&nbsp;days following receipt by Parent or Purchaser of written notice of such breach or inaccuracy or, if such breach or inaccuracy is
capable of being cured within such period, it has not been cured within such period; or </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) in order to enter into an Alternative
Acquisition Agreement with respect to a Superior Proposal in accordance with <U>Section</U><U></U><U>&nbsp;6.3(e)(i)</U>; <U>provided</U> that, promptly following such termination, the Company enters into an Alternative Acquisition Agreement in
respect of such Superior Proposal and pays (or causes to be paid) the termination fee due pursuant to <U>Section</U><U></U><U>&nbsp;8.5(b)</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.4. <U>Termination by Parent</U>. This Agreement may be terminated, and the Offer and the Merger may be abandoned, at any time
prior to the Acceptance Time, by Parent if: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) (i) Purchaser has complied with <U>Section</U><U></U><U>&nbsp;1.1</U> hereof and, due to
the failure of an Offer Condition to be satisfied, the Offer has expired or has been terminated without Purchaser having accepted for purchase the Shares validly tendered (and not validly withdrawn) pursuant to the Offer or (ii)&nbsp;there has been
a breach of any covenant or agreement made by the Company in this Agreement or under the Promissory Note, or any representation or warranty of the Company is inaccurate or becomes inaccurate after the date of this Agreement, and such breach or
inaccuracy would give rise to the failure of a condition set forth in <U>paragraph 2(b)</U> or <U>2(d)</U> of <U>Annex I</U>, and such breach or inaccuracy is not capable of being cured within thirty (30)&nbsp;days following receipt by the Company
of written notice of such breach or inaccuracy or, if such breach or inaccuracy is capable of being cured within such period, it has not been cured within such period; or </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) the Company Board or any committee thereof effects a Change of Board Recommendation. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.5. <U>Effect of Termination.</U> </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) In the event of termination of this Agreement pursuant to this <U>Article VIII</U>, this Agreement (other than
<U>Section</U><U></U><U>&nbsp;1.1(d)</U>, the last sentence of <U>Section</U><U></U><U>&nbsp;1.3</U>, <U>Section</U><U></U><U>&nbsp;6.2(b)</U>, <U>Article VIII</U> and <U>Article IX</U>, each of which will survive any termination hereof) will become
void and of no effect with no liability on the part of any party (or of any of its Representatives); <U>provided</U>, <U>however</U>, that except in a circumstance where the termination fee is paid by the Company pursuant to
<U>Section</U><U></U><U>&nbsp;8.5(b)</U> below, no such termination will relieve any Person of any liability for damages resulting from material breach of this Agreement that is a consequence of an act or omission intentionally undertaken by the
breaching party with the knowledge that such act or omission would result in a material breach of this Agreement (an &#8220;<U>Intentional Breach</U>&#8221;), including with respect to the making of a representation set forth herein, or would
constitute fraud. For purposes of this <U>Section</U><U></U><U>&nbsp;8.5(a)</U>, &#8220;fraud&#8221; means actual (and not constructive, including claims based on recklessness) common law fraud under Delaware law with respect to the making of an
express representation or warranty contained in this Agreement. Parent shall cause the Offer to be terminated immediately after any termination of this Agreement. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) In the event that: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(i) this Agreement is terminated by the Company pursuant to <U>Section</U><U></U><U>&nbsp;8.3(b)</U> (<I>Superior Proposal</I>); </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(ii) this Agreement is terminated by Parent pursuant to <U>Section</U><U></U><U>&nbsp;8.4(b)</U> (<I>Change of Board Recommendation</I>); or
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(iii) (A) this Agreement is terminated (x)&nbsp;by either Parent or the Company pursuant to <U>Section</U><U></U><U>&nbsp;8.2(b)</U>
(<I>Outside Date</I>) (but in the case of a termination by the Company, only if at such time Parent would not be prohibited from terminating this Agreement pursuant to the second proviso in <U>Section</U><U></U><U>&nbsp;8.2(b)</U> (<I>Outside
Date</I>)), (y) by Parent pursuant to (1)<U></U><U>&nbsp;Section</U><U></U><U>&nbsp;8.4(a)(i)</U> (<I>Offer Conditions Fail</I>) or (2)<U></U><U>&nbsp;Section</U><U></U><U>&nbsp;8.4(a)(ii)</U> (<I>Material Breach</I>) or (z)&nbsp;by the Company
pursuant to <U>Section</U><U></U><U>&nbsp;8.3(a)(ii)</U> (<I>Offer Expiration or Termination</I>), (B) any Person has publicly disclosed an Acquisition Proposal (which has not been irrevocably and publicly withdrawn at least three (3)&nbsp;days (1)
prior to the Outside Date in the case of <U>Section</U><U></U><U>&nbsp;8.5(b)(iii)(A)(x)</U>, (2) prior to the date the Offer expires or is terminated in the case of <U>Section</U><U></U><U>&nbsp;8.5(b)(iii)(A)(y)(1)</U> or
<U>Section</U><U></U><U>&nbsp;8.5(b)(iii)(A)(z)</U> or (3)&nbsp;prior to the date of such material breach in the case of <U>Section</U><U></U><U>&nbsp;8.5(b)(iii)(A)(y)(2)</U>) after the date of this Agreement and prior to such termination and
(C)&nbsp;within twelve (12)&nbsp;months after such termination, the Company enters into an Alternative Acquisition Agreement with respect to an Acquisition Proposal (and the transactions contemplated by such Acquisition Proposal are subsequently
consummated before or after the expiration of such twelve (12)-month period) or the Acquisition Proposal is consummated (<U>provided</U> that, for purposes of clause (C)&nbsp;of this <U>Section</U><U></U><U>&nbsp;8.5(b)(iii)</U>, references to
&#8220;20%&#8221; in the definition of Acquisition Proposal will be substituted with &#8220;50%&#8221;); </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Then, in any such case, the Company shall pay
(or cause to be paid to) Parent a termination fee of $4,000,000, by wire transfer of immediately available funds to the account or accounts designated by Parent. Any payment required to be made (1)&nbsp;pursuant to clause (i)&nbsp;of this
<U>Section</U><U></U><U>&nbsp;8.5(b)</U> will be paid concurrently with such termination, (2)&nbsp;pursuant to clause (ii)&nbsp;of this <U>Section</U><U></U><U>&nbsp;8.5(b)</U> will be paid no later than two (2)&nbsp;Business Days after such
termination and (3)&nbsp;pursuant to clause (iii)&nbsp;of this <U>Section</U><U></U><U>&nbsp;8.5(b)</U> will be payable to Parent upon entry into an Alternative Acquisition Agreement. The Company will not be required to pay the termination fee
pursuant to this <U>Section</U><U></U><U>&nbsp;8.5(b)</U> more than once. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) In the event the termination fee payable pursuant to
<U>Section</U><U></U><U>&nbsp;8.5(b)</U> is paid and payable to Parent in accordance with <U>Section</U><U></U><U>&nbsp;8.5(b)</U>, (i) Parent&#8217;s receipt of the termination fee shall be the sole and exclusive remedy of Parent and Purchaser in
respect of any breach of, or inaccuracy contained in, the Company&#8217;s covenants, agreements, representations or warranties in this Agreement and (ii)&nbsp;none of the Parent, Purchaser, any of their respective Affiliates or any other Person
shall be entitled to bring or maintain any other claim, action or proceeding against the Company or any of its Affiliates or any Representative of the Company or any of its Affiliates arising out of this Agreement, any of the Contemplated
Transactions or any matters forming the basis for such termination; <U>provided</U> that nothing in this <U>Section</U><U></U><U>&nbsp;8.5(c)</U> shall relieve the Company from liability for damages arising from an Intentional Breach of
<U>Section</U><U></U><U>&nbsp;6.3</U> or fraud as defined in <U>Section</U><U></U><U>&nbsp;8.5(a)</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) The Company acknowledges that
the agreements contained in <U>Section</U><U></U><U>&nbsp;8.5(b)</U> are an integral part of the Contemplated Transactions, and that, without these agreements, Parent and Purchaser would not have entered into this Agreement. Accordingly, if the
Company fails to promptly pay the amount due pursuant to <U>Section</U><U></U><U>&nbsp;8.5(b)</U> when due and, in order to obtain such payment, Parent or Purchaser commences a suit that results in a judgment against the Company for the amount set
forth in <U>Section</U><U></U><U>&nbsp;8.5(b)</U>, the Company shall pay to Parent or Purchaser interest on such amount at the prime rate as published in the Wall Street Journal in effect on the date such payment was required to be made through the
date of payment. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.6. <U>Expenses</U>. Except as otherwise specifically provided herein, each
party shall bear its own expenses in connection with this Agreement and the Contemplated Transactions. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;8.7. <U>Amendment and
Waiver</U>. This Agreement may not be amended except by an instrument in writing signed by the parties hereto prior to the Acceptance Time; <U>provided</U>, however that Purchaser expressly reserves the right at any time or from time to time, in its
sole discretion, to waive any Offer Condition or modify or amend the terms of the Offer, in whole or in part, including the Offer Price, except that, without the prior written consent of the Company (which consent will not be unreasonably withheld,
conditioned or delayed), Purchaser may not (A)&nbsp;decrease the Closing Amount or amend the terms of the CVRs or the CVR Agreement, (B)&nbsp;change the form of the consideration payable in the Offer, (C)&nbsp;decrease the maximum number of Shares
sought pursuant to the Offer, (D)&nbsp;amend or waive the Minimum Tender Condition or the condition set forth in <U>clause 2(e)</U> of <U>Annex I</U>, (E)&nbsp;add to the conditions set forth on <U>Annex I</U>, (F)&nbsp;modify the conditions set
forth on <U>Annex I</U> in a manner adverse to the holders of Shares (as a group in their capacity as such), (G) extend the Expiration Date of the Offer except as required or expressly permitted by <U>Section</U><U></U><U>&nbsp;1.1(a)(ii)</U> or
provide any &#8220;subsequent offering period&#8221; (or any extension thereof) within the meaning of Rule <FONT STYLE="white-space:nowrap">14d-11</FONT> promulgated under the Exchange Act, or (H)&nbsp;make any other change in the terms or
conditions of the Offer that is adverse in any material respect to the holders of Shares (as a group in their capacity as such). At any time prior to the Acceptance Time, the Company, on the one hand, and Parent and Purchaser, on the other hand, may
(a)&nbsp;extend the time for the performance of any of the obligations or other acts of the other, (b)&nbsp;waive any inaccuracies in the representations and warranties of the other contained herein or in any document delivered pursuant hereto and
(c)&nbsp;subject to the requirements of applicable Law, waive compliance by the other with any of the agreements or conditions contained herein, except that the Minimum Tender Condition and the condition set forth in <U>clause 2(e)</U> of <U>Annex
I</U> may only be waived by Parent or Purchaser with the prior written consent of the Company (which consent will not be unreasonably withheld, conditioned or delayed). Any such extension or waiver will be valid only if set forth in an instrument in
writing signed by the party or parties to be bound thereby. The failure of any party to assert any rights or remedies will not constitute a waiver of such rights or remedies. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE IX </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>GENERAL
PROVISIONS </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.1. <U><FONT STYLE="white-space:nowrap">Non-Survival</FONT> of Representations, Warranties, Covenants and
Agreements</U>. None of the representations, warranties, covenants and agreements in this Agreement or in any instrument delivered pursuant to this Agreement, including any rights arising out of any breach of such representations, warranties,
covenants and agreements, will survive the Effective Time, except for (a)&nbsp;those covenants and agreements contained herein that by their terms apply or are to be performed in whole or in part after the Effective Time and (b)&nbsp;this <U>Article
IX</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.2. <U>Notices</U>. All notices, requests, claims, demands and other communications hereunder must be in writing
and must be given (and will be deemed to have been duly given): (a) when delivered, if delivered in Person, (b)&nbsp;when delivered by email, which email must state that it is being delivered pursuant to this <U>Section</U><U></U><U>&nbsp;9.2</U>
and which notice will not be effective unless either (A)&nbsp;a duplicate copy of such email notice is sent on the same day for next Business Day delivery, fees prepaid, via a reputable nationwide overnight courier service or (B)&nbsp;the receiving
party delivers a written confirmation of receipt to the sender of such notice (excluding &#8220;out of office,&#8221; delivery failure or similar automated replies), (c) three (3)&nbsp;Business Days after sending, if sent by registered or certified
mail (postage prepaid, return receipt requested) and (d)&nbsp;one Business Day after sending, if sent by overnight courier, in each case, to the respective parties at the following addresses (or at such other address for a party as have been
specified by like notice): </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">55 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(i) if to Parent or Purchaser, to: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Eli Lilly and Company </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Lilly
Corporate Center </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Indianapolis, Indiana 46285 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Attention: Senior Vice President and Head of Corporate Business Development </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">with a copy (which shall not constitute notice) to: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Eli Lilly and Company </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Lilly
Corporate Center </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Indianapolis, Indiana 46285 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Attention: Senior Vice President&#8212;Transactions and Contracting </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">with an additional copy (which will not constitute notice) to: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Ropes&nbsp;&amp; Gray LLP </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">800
Boylston Street, Prudential Tower </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Boston, Massachusetts 02199-3600 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Attention: Emily J. Oldshue </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Email: Emily.Oldshue@ropesgray.com </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:13%; font-size:10pt; font-family:Times New Roman">(ii) if to the Company, to: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Adverum Biotechnologies, Inc. </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">100 Cardinal Way, Redwood City, California 94063 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Attention: Laurent Fischer, President and Chief Executive Officer </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">with a copy (which shall not constitute notice) to: </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Adverum Biotechnologies, Inc. </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">100 Cardinal Way, Redwood City, California 94063 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Attention: General Counsel </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Email: [Intentionally omitted] </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">with an additional copy (which will not constitute notice) to: </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Cooley LLP </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">55 Hudson Yards
</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">New York, New York 10001 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Attention: Bill Roegge; Jason Kent </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:15%; font-size:10pt; font-family:Times New Roman">Email: broegge@cooley.com; jkent@cooley.com </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.3. <U>Certain Definitions</U>. For purposes of this Agreement the term: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Acquisition Proposal</U>&#8221; means any indication of interest, request for <FONT STYLE="white-space:nowrap">non-public</FONT>
information, inquiry, offer or proposal made or renewed by a Person or Group (other than Parent or Purchaser) relating to any (a)&nbsp;direct or indirect issuance, exchange, purchase or other acquisition (in each case, whether in a single
transaction or a series of related transactions) by any Person or Group, whether from the Company or any other Person(s), of shares of Company Common Stock or other Company Securities representing </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">56 </P>

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more than twenty percent (20%) of the Company Common Stock or other voting or equity securities of the Company outstanding after giving effect to the consummation of such issuance, exchange,
purchase or other acquisition, including pursuant to a tender offer or exchange offer by any Person or Group that, if consummated in accordance with its terms, would result in such Person or Group beneficially owning more than twenty percent (20%)
of the Company Common Stock outstanding after giving effect to the consummation of such tender or exchange offer; (b)&nbsp;direct or indirect purchase, exchange, transfer or other acquisition (including by license, partnership, collaboration,
distribution, disposition or revenue-sharing arrangement) (in each case, whether in a single transaction or a series of related transactions) by any Person or Group, or stockholders of any such Person or Group, of more than twenty percent (20%) of
the consolidated total assets (including through the acquisition of stock in its Subsidiaries) of the Company and its Subsidiaries, taken as a whole (measured by the fair market value thereof as of the date of such purchase or acquisition); or
(c)&nbsp;merger, consolidation, business combination, recapitalization, reorganization, liquidation, dissolution or other transaction (in each case, whether in a single transaction or a series of related transactions) involving the Company or any of
its Subsidiaries pursuant to which any Person or Group, or stockholders of any such Person or Group (other than the Company), would hold shares of Company Common Stock or other Company Securities representing more than twenty percent (20%) of the
Company Common Stock or other Company Securities outstanding after giving effect to the consummation of such transaction. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Action</U>&#8221; means any charge, dispute, cause of action, claim, counterclaim, audit, assessment, examination, mediation,
action, suit, litigation, arbitration, proceeding, investigation, inquiry, or other legal proceeding. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Affiliate</U>&#8221; of
any particular Person means any other Person controlling, controlled by or under common control with such particular Person. For the purposes of this definition, &#8220;controlling,&#8221; &#8220;controlled&#8221; and &#8220;control&#8221; mean the
possession, directly or indirectly, of the power to direct the management and policies of a Person whether through the ownership of voting securities, contract or otherwise. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Antitrust and FDI Laws</U>&#8221; means (a)&nbsp;any Law regulating foreign investment screening, national security or trade
regulation and (b)&nbsp;the HSR Act, the Sherman Act, the Clayton Act, the Federal Trade Commission Act, and any other United States federal or state or foreign Laws that are designed to prohibit, restrict or regulate actions having the purpose or
effect of monopolization or restraint of trade. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>BLA</U>&#8221; means a Biologics License Application submitted to be approved
by the FDA pursuant to 21 C.F.R. Part 601 (as amended from time to time) with respect to the Products, or to the equivalent application or filing submitted to any equivalent agency or Governmental Body outside the United States of America (including
any supra-national agency such as the EMA), and all supplements, amendments, variations, extensions and renewals thereof that may be submitted with respect to the foregoing. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Business Day</U>&#8221; means any day on which the principal offices of the SEC in Washington, D.C. are open to accept filings;
<U>provided</U> that, in the case of determining a date on which any payment is due hereunder, &#8220;<U>Business Day</U>&#8221; shall mean any day (other than Saturday or Sunday) on which banks are open in New York, New York. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Cash and Cash Equivalents</U>&#8221; means the Company&#8217;s and its Subsidiaries&#8217; cash and cash equivalents which are
highly liquid investments with a maturity of three (3)&nbsp;months or less from the date of purchase determined in accordance with GAAP, applied on a basis consistent with the Company&#8217;s application thereof in the Company&#8217;s consolidated
financial statements. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Change of Board Recommendation</U>&#8221; means (a)&nbsp;the withdrawal,
qualification or modification (in a manner adverse to Parent or Purchaser) of the Company Board Recommendation or the public announcement of any proposal to withdraw, qualify or modify (in a manner adverse to Parent or Purchaser) the Company Board
Recommendation (or any resolution or agreement to take any such action), (b) the failure by the Company, within ten (10)&nbsp;Business Days of the commencement of a tender or exchange offer for Shares that constitutes an Acquisition Proposal by a
Person other than Parent or any of its Affiliates, to file a Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT> pursuant to Rule <FONT STYLE="white-space:nowrap">14e-2</FONT> and Rule <FONT STYLE="white-space:nowrap">14d-9</FONT> promulgated
under the Exchange Act recommending that the holders of the Shares reject such Acquisition Proposal and not tender any Shares into such tender or exchange offer, (c)&nbsp;the adoption, endorsement, approval or recommendation (or any public proposal
with respect to the same) of any Acquisition Proposal (or any resolution or agreement to take such action), (d) the failure to include the Company Board Recommendation in the Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT> when disseminated
to the holders of Shares pursuant to the terms herein or (e)&nbsp;the failure by the Company Board or a committee thereof to publicly reaffirm the Company Board Recommendation following receipt by the Company of a publicly announced Acquisition
Proposal by the earlier of (i)&nbsp;ten (10)&nbsp;Business Days following receipt of a written request from Parent to provide such public reaffirmation and (ii)&nbsp;two (2)&nbsp;Business Days prior to the then-scheduled Expiration Date;
<U>provided</U> that Parent may deliver only one such request with respect to any single Acquisition Proposal (other than with respect to material amendments, modifications or supplements thereto). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Company Balance Sheet Date</U>&#8221; means June&nbsp;30, 2025. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Company ESPP</U>&#8221; means the Company&#8217;s 2014 Employee Stock Purchase Plan. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Company Equity Plan</U>&#8221; means each of the Company&#8217;s 2024 Equity Incentive Award Plan, the Company&#8217;s 2014 Equity
Incentive Award Plan, the Company&#8217;s 2017 Inducement Plan, each as amended and restated. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Company Intellectual
Property</U>&#8221; means all Owned Intellectual Property, Exclusive Intellectual Property, and all other Intellectual Property used or held for use for the operation of the business of the Company and its Subsidiaries as currently conducted and
proposed to be conducted. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Company Material Adverse Effect</U>&#8221; means any state of facts, change, effect, event,
circumstance, result, development, condition, inaccuracy, occurrence or other matter that, alone or taken together, (x)&nbsp;has or would reasonably be expected to have, individually or in the aggregate, a material adverse effect on the business,
condition (financial or otherwise), assets and liabilities (taken as a whole), operations, prospects, or results of operations of the Company and its Subsidiaries, taken as a whole, or (y)&nbsp;prevents or materially impairs or delays the ability of
the Company to perform its obligations hereunder or consummate the Contemplated Transactions on or before the Outside Date; <U>provided</U> that for purposes of clause (x), any state of facts, changes, effects, events, circumstances, results,
developments, conditions, inaccuracies, occurrences, or other matters resulting from any of the following will not be deemed to constitute a Company Material Adverse Effect and will be disregarded in determining whether a Company Material Adverse
Effect has occurred: (a)&nbsp;matters generally affecting the U.S. or foreign economies, financial or securities markets, or political, legislative, or regulatory conditions, or the industry in which the Company and its Subsidiaries, taken as a
whole, operate, except to the extent such matters have a materially disproportionate adverse effect on the Company and its Subsidiaries, taken as a whole, relative to the impact on other companies in the industry in which the Company and its
Subsidiaries, taken as a whole, operate; (b)&nbsp;the announcement of this Agreement or the Contemplated Transactions (it being understood and agreed that this <U>clause (b)</U>&nbsp;will not apply to the representation or warranty contained in
<U>Section</U><U></U><U>&nbsp;4.4</U>); (c) any change in the market price or trading volume of the Shares; <U>provided</U> that this exception will not preclude a determination that a matter underlying such change has resulted in or contributed to
a Company Material Adverse Effect unless excluded under another clause; (d)&nbsp;acts of war or terrorism (including cyberattacks), national emergencies, natural disasters, force majeure events, weather or environmental events or health emergencies,
including pandemics or epidemics (or the escalation of any of the foregoing), except to the </P>
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extent such matters have a materially disproportionate adverse effect on the Company and its Subsidiaries, taken as a whole, relative to the impact on other companies in the industry in which the
Company and its Subsidiaries, taken as a whole, operate; (e)&nbsp;changes in Laws or regulations, or the authoritative interpretations thereof, except to the extent such changes have a materially disproportionate adverse effect on the Company and
its Subsidiaries, taken as a whole, relative to the impact on other companies in the industry in which the Company and its Subsidiaries, taken as a whole, operate; (f)&nbsp;any action taken by the Company or its Subsidiaries that is required by this
Agreement, including compliance with covenants set forth herein (excluding the requirement that the Company and its Subsidiaries operate in the ordinary course of business), or any action taken or omitted to be taken by the Company or its
Subsidiaries at the express written request or with the prior written consent of Parent or Purchaser; (g)&nbsp;the initiation or settlement of any legal proceedings commenced by any holder of Shares (on their own or on behalf of the Company or any
of its Subsidiaries) arising out of or related to this Agreement or the Contemplated Transactions; or (h)&nbsp;any failure by the Company or its Subsidiaries to meet any internal or analyst projections or forecasts or estimates of revenues,
earnings, or other financial metrics for any period; <U>provided</U> that this exception will not preclude a determination that a matter underlying such failure has resulted in or contributed to a Company Material Adverse Effect unless expressly
excluded under another clause. Without limiting the generality of the foregoing, any change, effect, event, inaccuracy, occurrence, or other matter (whether or not previously disclosed in any document filed with, or furnished to, the SEC, the
Company Disclosure Letter or otherwise) that, individually or in the aggregate, results in an issuance by the FDA of a clinical hold on the investigation of any Products, the result of which would reasonably be expected to result in the termination
of development of, or a delay of six (6)&nbsp;months or more in dosing patients in, such Products, shall be deemed to constitute a Company Material Adverse Effect. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Company Plan</U>&#8221; means a Plan that the Company or its Subsidiaries sponsors, maintains, contributes to or is obligated to
contribute to, in each case, for the benefit of any current or former officer, director, employee or individual independent contractor or other individual service provider of the Company or its Subsidiaries, or under or with respect to which the
Company or any of its Subsidiaries has or could reasonably be expected to have any Liability. For clarity, &#8220;<U>Company Plans</U>&#8221; includes the &#8220;<U>Company Equity Plans</U>&#8221; and the &#8220;<U>Company ESPP</U>.&#8221; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Company PSU</U>&#8221; means a restricted stock unit granted under a Company Equity Plan or otherwise that is subject solely to
performance-based vesting. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Company RSU</U>&#8221; means a restricted stock unit granted under a Company Equity Plan or
otherwise that is subject solely to time-based vesting. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Company Stock Option</U>&#8221; means an option to purchase Shares
granted under a Company Equity Incentive Plan or otherwise. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Confidentiality Agreement</U>&#8221; means the Confidentiality
Agreement, dated as of November&nbsp;4, 2024, by and between Parent and the Company. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Contemplated Transactions</U>&#8221; means
each of the transactions contemplated by this Agreement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Contract</U>&#8221; means any written, oral or other agreement,
contract, subcontract, lease, <FONT STYLE="white-space:nowrap">sub-lease,</FONT> occupancy agreement, binding understanding, obligation, promise, instrument, indenture, mortgage, note, option, warranty, purchase order, license, sublicense,
commitment or undertaking of any nature, which, in each case, is legally binding upon a party or on any of its Affiliates. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">59 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Copyrights</U>&#8221; means all works of authorship (whether or not copyrightable,
including all software, whether in source code or object code format, and documentation therefor) and all copyrights (whether or not registered), including all registrations thereof and applications therefor, and all renewals, extensions,
restorations and reversions of the foregoing. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Determination Notice</U>&#8221; means any notice delivered by the Company to
Parent pursuant to <U></U><U></U><U></U><U></U><U></U><U></U><U></U><U></U><U>Section 6.3(e)(i)(B), Section&nbsp;6.3(e)(ii)(B) or 6.3(e)(iii)(B)</U>, which (a)&nbsp;in respect of a Superior Proposal, shall specify the identity of the Person who made
such Superior Proposal and the material terms and conditions of such Superior Proposal and attach the most current version of the relevant transaction agreement and (b)&nbsp;in respect of an Intervening Event, shall include a reasonably detailed
description of the underlying facts giving rise to such action. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>EMA</U>&#8221; means the European Medicines Agency, or any
successor agency or authority thereto with comparable responsibilities. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Environmental Laws</U>&#8221; means any Law, relating
to (a)&nbsp;the protection, investigation, remediation or restoration of the environment, human health and safety (as it relates to exposure to Hazardous Substances), or natural resources or (b)&nbsp;the manufacture, handling, use, storage,
treatment, transport, disposal, marketing, distribution, sale, Release or threatened Release of any Hazardous Substance. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>ERISA
Affiliate</U>&#8221; means any trade or business (whether or not incorporated) which is, or has at any relevant time been, under common control, or treated as a single employer, with the Company or its Subsidiaries under Sections 414(b), (c), (m) or
(o)&nbsp;of the Code or is or was at the relevant time, a member of the same &#8220;controlled group&#8221; as the Company or its Subsidiaries pursuant to Section&nbsp;4001(a)(14) of ERISA. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Exclusive Intellectual Property</U>&#8221; means all Intellectual Property that is or has been exclusively licensed to the Company
or any of its Subsidiaries. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U><FONT STYLE="white-space:nowrap">Ex-Im</FONT> Laws</U>&#8221; means all U.S. and <FONT
STYLE="white-space:nowrap">non-U.S.</FONT> Laws relating to export, reexport, transfer, and import controls, including the Export Administration Regulations, the International Traffic in Arms Regulations, the customs and import Laws administered by
U.S. Customs and Border Protection, and the EU Dual Use Regulation. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>FDA</U>&#8221; means the United States Food and Drug
Administration, or any successor agency or authority thereto with comparable responsibilities. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>FDCA</U>&#8221; means the
Federal Food, Drug and Cosmetic Act of 1938, as amended (21 U.S.C. &#167;301 et seq.). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Federal Health Care Program</U>&#8221;
has the meaning set forth in 42 U.S.C. <FONT STYLE="white-space:nowrap">1320a-7b(f),</FONT> including but not limited to Medicare, Medicaid, TRICARE, CHAMPVA, any state health plan adopted pursuant to Title XIX of the Social Security Act (42 U.S.C.
1395 et seq.), any health insurance program for the benefit of federal employees, including those under chapter 89 of title 5, United States Code, and any other state or federal healthcare program administered by a Governmental Body. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Finance Leases</U>&#8221; means all obligations for finance leases (determined in accordance with GAAP). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>GAAP</U>&#8221; means U.S. generally accepted accounting principles as in effect on the date of this Agreement. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">60 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Good Clinical Practices</U>&#8221; means all applicable then-current Good Clinical
Practice requirements and standards for clinical trials (including all applicable requirements relating to protection of human subjects), as set forth in the Applicable Law, such as FDCA and the PHS Act and regulations set forth at 21 C.F.R. Parts
50, 54, 56, 210, 211, and 312, as well as (but not limited to) the requirements set forth in Directive 2001/20/EC of the European Parliament and of the Council of 4&nbsp;April 2001 and Commission Directive 2005/28/EC of 8&nbsp;April 2005, to the
extent applicable to a clinical trial regarding any Product, as such obligations are interpreted and enforced by the applicable Regulatory Authority, and as interpreted under prevailing industry standards, including standards of medical ethics,
applicable guidance documents issued by the FDA and any other Regulatory Authority, including ICH GCP and the equivalent legal requirements in other applicable jurisdictions, as the same may be amended from time to time. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Good Laboratory Practices</U>&#8221; means all applicable then-current requirements for laboratory activities for pharmaceuticals,
asset forth in the Applicable Law that govern the conduct of <FONT STYLE="white-space:nowrap">non-clinical</FONT> safety studies and which seek to ensure the quality, integrity and reliability of study data, including those set forth in 21 C.F.R.
Part 58 and the equivalent legal requirements in other applicable jurisdictions, as the same may be amended from time to time. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Good Manufacturing Practices</U>&#8221; means all applicable then-current Good Manufacturing Practices requirements as set forth in
the FDCA and the Public Health Service Act, and in applicable regulations, including 21 C.F.R. Parts 210, 211, 314 and 600, as in effect at the time when any Product is being manufactured for clinical development or commercial use, when any Product
is being sold or when any clinical trial regarding a Product is being conducted, provided, and to the extent applicable to such clinical trial, as such regulations are interpreted and enforced by the FDA, including as set forth in applicable
guidance documents issued by the FDA, and in accordance with applicable, generally accepted industry standards, and the equivalent legal requirements in other applicable jurisdictions, including the quality guidelines promulgated by the ICH,
including the ICH Q7A, titled &#8220;Q7A Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients&#8221; and the policies promulgated thereunder, all as the same may be amended from time to time. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Governmental Body</U>&#8221; means any federal, state, provincial, local, municipal, foreign, supranational, national or other
governmental or quasi-governmental authority or authority exercising legislative, judicial, regulatory or administrative functions of or pertaining to any of the foregoing, including, any arbitrator or arbitral body (whether public or private),
mediator and applicable securities exchanges, or any department, minister, agency, commission, commissioner, board, subdivision, bureau, instrumentality, court or other tribunal of any of the foregoing. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Group</U>&#8221; has the meaning as used in Section&nbsp;13 of the Exchange Act. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Hazardous Substance</U>&#8221; means any element, compound, chemical, waste or other substance that is defined, listed or classified
as a contaminant, pollutant or hazardous material (or any other words of similar intent of meaning) under, or otherwise regulated by, any Environmental Laws, including any petroleum product or <FONT STYLE="white-space:nowrap">by-product</FONT>
polychlorinated biphenyls, <FONT STYLE="white-space:nowrap">per-</FONT> and polyfluoroalkyl substances (PFAS), and radioactive materials. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Healthcare Laws</U>&#8221; means, any Law applicable to the conduct of Parent&#8217;s business or the Company&#8217;s or its
Subsidiaries&#8217; business, including (a)&nbsp;all federal and state fraud and abuse Laws, including, the federal Anti-Kickback Statute (42 U.S.C. &#167; <FONT STYLE="white-space:nowrap">1320a-7b(b)),</FONT> the Stark Law (42 U.S.C. &#167;
1395nn), the Federal False Claims Act (31 U.S.C. &#167; 3729 et seq.), Sections <FONT STYLE="white-space:nowrap">1320a-7</FONT> and <FONT STYLE="white-space:nowrap">1320a-7a</FONT> of Title 42 of the United States Code and the regulations
promulgated pursuant to such statutes, (b)&nbsp;Titles XVIII (42 U.S.C. &#167;1395 et seq.) and XIX (42 U.S.C. &#167;1396 et seq.) of the Social Security Act and the regulations promulgated thereunder and any other Law pertaining to or governing a
governmental health care program, and the regulations promulgated thereunder, (c)&nbsp;the Medicare Prescription Drug, Improvement, and Modernization Act of 2003 (42 U.S.C. <FONT STYLE="white-space:nowrap">&#167;1395w-101</FONT> et seq.) and the
regulations promulgated thereunder, (d)&nbsp;HIPAA, (e) </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">61 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
the U.S. Physician Payments Sunshine Act (42 U.S.C. &#167; <FONT STYLE="white-space:nowrap">1320a-7h)</FONT> and state or local Laws regulating or requiring reporting of interactions between
pharmaceutical manufacturers and members of the healthcare industry and regulations promulgated thereunder, (f)&nbsp;Laws governing government pricing or price reporting programs and regulations promulgated thereunder, including the Medicaid Drug
Rebate Program (42 U.S.C. &#167; <FONT STYLE="white-space:nowrap">1396r-8)</FONT> and any state supplemental rebate program, the Public Health Service Act (42 U.S.C. &#167; 256b), the VA Federal Supply Schedule (38 U.S.C. &#167; 8126) or any state
pharmaceutical assistance program or U.S. Department of Veterans Affairs agreement, and any successor government programs, (g)&nbsp;the FDCA, (h)&nbsp;the Public Health Service Act of 1944, as amended (42 U.S.C. &#167;201 et seq.), (i) applicable
regulations issued by the FDA, including, as applicable, those requirements relating to the FDA&#8217;s Good Manufacturing Practices, Good Laboratory Practices, Good Clinical Practices, investigational use,
<FONT STYLE="white-space:nowrap">pre-market</FONT> approval and applications to market a new pharmaceutical product, (j)&nbsp;Laws governing the development, conduct, monitoring, patient informed consent, auditing, analysis, use and reporting of
clinical trial data, (k)&nbsp;Laws governing data gathering activities relating to the detection and reporting of adverse events (including applicable pharmacovigilance and adverse event regulations of the FDA), and (l)&nbsp;all comparable state,
local, federal, <FONT STYLE="white-space:nowrap">non-U.S.</FONT> or other Laws relating to any of the foregoing, (m)&nbsp;any and all other health care Laws and regulations applicable to Parent, Parent&#8217;s Subsidiaries or the Company or the
Company&#8217;s Subsidiaries, or affecting their respective businesses, and (n)&nbsp;any rules, regulations, and legally binding directives, policy statements, or guidance promulgated or issued pursuant to such Laws, as each of the foregoing may be
amended from time to time. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>HIPAA</U>&#8221; means the Health Insurance Portability and Accountability Act of 1996, the Health
Information Technology for Economic and Clinical Health Act (Title XIII of the American Recovery and Reinvestment Act of 2009) as set forth at 42 USC &#167; 17931 et seq., as may be amended, and their implementing regulations. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>HSR Act</U>&#8221; means the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>IND</U>&#8221; means an Investigational New Drug Application submitted to the FDA pursuant to 21 C.F.R. Part 312 (as amended from
time to time) with respect to the Products, or the equivalent application or filing submitted to any equivalent Governmental Body, and all supplements, amendments, variations, extensions and renewals thereof that may be submitted with respect to the
foregoing. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Indebtedness</U>&#8221; means, with respect to any Person, without duplication: (a)&nbsp;the principal, accreted
value, accrued and unpaid interest, fees and prepayment premiums or penalties, unpaid fees or expenses and other monetary obligations in respect of (i)&nbsp;indebtedness of such Person for borrowed money and (ii)&nbsp;indebtedness evidenced by
notes, debentures, bonds, or other similar instruments for the payment of which such Person is liable; (b)&nbsp;all obligations of such Person with respect to deposits or advances of any kind or for the deferred purchase price of the acquisition of
a business or any property or services, including <FONT STYLE="white-space:nowrap">earn-out</FONT> obligations (other than trade payables or accruals incurred in the ordinary course of business, consistent with applicable Contracts); (c) all
obligations of such Person for the reimbursement of any obligor on any letter of credit, banker&#8217;s acceptance, performance bond, surety or similar credit transaction; (d)&nbsp;all obligations of such Person under Finance Leases;
(e)&nbsp;guarantees with respect to any indebtedness of any other Person, (f)&nbsp;all indebtedness of others secured by any Liens or other claim on property owned or acquired by such Person, whether or not the obligations secured thereby have been
assumed, (g)&nbsp;all obligations of such Person as an account party in respect of letters of credit and banker&#8217;s acceptance, (h)&nbsp;all obligations of such Person consisting of overdrafts (e.g., cash float reflected as a negative on the
cash line), (i) any currency swaps, forward contracts, currency or other derivative or hedging arrangements of such Person, and (j)&nbsp;any declared but unpaid dividends, or other distributions or loans payable by such Person to its equityholders
or Affiliates. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Intellectual Property</U>&#8221; means all rights, title and interests in and to,
or arising out of or associated with intellectual property or other proprietary rights, in each case, whether protected, created or arising under the Laws of the United States or any other jurisdiction worldwide and whether registered or
unregistered, including all rights in and to, arising out of, or associated therewith, including: (a)&nbsp;Trademarks; (b) Patents; (c)&nbsp;Trade Secrets; (d)&nbsp;Copyrights; and (e)&nbsp;Internet domain names and social media accounts and
handles. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Intervening Event</U>&#8221; means a change, effect, event, circumstance, result, development, condition, occurrence,
or other matter material to the Company that was not known or reasonably foreseeable to the Company Board or any committee thereof on the date of this Agreement (or if known, the consequences of which were not known or reasonably foreseeable to the
Company Board or any committee thereof as of the date of this Agreement), which change, effect, event, circumstance, result, development, condition, occurrence, or other matter, or any consequence thereof, becomes known to or reasonably foreseeable
by the Company Board or any committee thereof prior to the Acceptance Time; <U>provided</U>, <U>however</U>, that in no event will any Acquisition Proposal or any inquiry, offer, or proposal that constitutes or would reasonably be expected to lead
to an Acquisition Proposal constitute an Intervening Event; <U>provided</U>, <U>further</U>, that in no event shall any of the following constitute or contribute to an Intervening Event: (i)&nbsp;changes in the financial or securities markets or
general economic or political conditions in the United States, (ii)&nbsp;changes (including changes of applicable Law) or conditions generally affecting the industry in which the Company and its Subsidiaries, taken as a whole, operate, or
(iii)&nbsp;the Company&#8217;s meeting or exceeding any internal or published budgets, projections, forecasts or predictions of financial performance for any period. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Investment Securities</U>&#8221; means the Company&#8217;s and its Subsidiaries&#8217; investment securities, including available
for sale marketable debt securities, determined in accordance with GAAP, applied on a basis consistent with the Company&#8217;s application thereof in the Company&#8217;s consolidated financial statements. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>IP Contracts</U>&#8221; means all: (a)&nbsp;Contracts pursuant to which any Person grants to the Company or any of its Subsidiaries
any license, sublicense, consent, waiver, covenant not to sue or other right with respect to any Intellectual Property material to the business of the Company and its Subsidiaries as of the date of this Agreement, including all Exclusive
Intellectual Property (but excluding <FONT STYLE="white-space:nowrap">non-exclusive</FONT> licenses for <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">Off-the-Shelf</FONT></FONT> Software); (b) Contracts pursuant to which the
Company or any of its Subsidiaries grants any Person any license, sublicense, consent, waiver, covenant not to sue or other right with respect to any Intellectual Property material to the business of the Company and its Subsidiaries as of the date
of this Agreement; <FONT STYLE="white-space:nowrap">(c)&nbsp;co-existence</FONT> agreements and settlement agreements relating to any Owned Intellectual Property or Exclusive Intellectual Property; (d)&nbsp;Contracts that provide for the invention,
creation, conception or development of any Intellectual Property (i)&nbsp;by the Company or any of its Subsidiaries for any Person or (ii)&nbsp;by any other Person for the Company or any of its Subsidiaries (excluding employee agreements that
contain assignments of Intellectual Property to the Company or any of its Subsidiaries substantially on a written form made available to Parent prior the Closing); (e) Contracts that provide for the assignment or other transfer of any material
Intellectual Property (i)&nbsp;to the Company or any of its Subsidiaries by any Person (excluding consulting agreements or employee agreements that contain assignments of Intellectual Property to the Company or any of its Subsidiaries substantially
on a written form made available to Parent prior to the Closing) or (ii)&nbsp;by the Company or any of its Subsidiaries to any Person; and (f)&nbsp;Contracts pursuant to which the Company or any of its Subsidiaries is restricted from using or
practicing any Intellectual Property that is material to the continued operation of the business of the Company and its Subsidiaries as of the date of this Agreement (excluding customary confidentiality obligations); excluding, in each case
((a),(b), (d), (e) and (f)), Routine Services Contracts entered into in the ordinary course of business. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Knowledge</U>&#8221; of Parent or the Company, as applicable means the actual
knowledge, after reasonable inquiry, of the individuals listed in <U>Section</U><U></U><U>&nbsp;9.3(a)</U> of the Company Disclosure Letter. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Law</U>&#8221; means any applicable foreign or U.S. federal, state or local law (including common law), treaty, act, statute,
legislation, code, edict, order, ordinance, Permit, rule, regulation, judgment, injunction, decree, proclamation, directive, pronouncement, writ, constitution, treaty, convention, ruling, requirement (licensing or otherwise), specification,
determination, decision, opinion or interpretation that is, has been or may in the future be issued, enacted, adopted, passed, approved, promulgated, made, implemented or otherwise put into effect by or under the authority of any Governmental Body,
and, for the sake of clarity, includes, but is not limited to, Healthcare Laws and Environmental Laws. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Liability</U>&#8221;
means, with respect to any Person, any debt, liability, claim, demand, expense, commitment or obligation of that Person of any kind, character or description, whether known or unknown, absolute or contingent, accrued or unaccrued, asserted or
unasserted, disputed or undisputed, liquidated or unliquidated, secured or unsecured, joint or several, due or to become due, vested or unvested, primary or secondary, matured or unmatured, billed or unbilled, executory, determined, determinable or
otherwise, and whether or not the same is required to be accrued on the financial statements of that Person in accordance with GAAP. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Liens</U>&#8221; means any lien, mortgage, security interest, pledge, encumbrance, deed of trust, security interest, claim, lease,
license, charge, option, preemptive right, subscription right, easement, servitude, proxy, voting trust or agreement, transfer restriction under any shareholder or similar agreement, encumbrance or restriction. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>MAA</U>&#8221; means any new drug application or other similar marketing authorization application, in each case, filed with the
applicable Regulatory Authority in a country or other regulatory jurisdiction, which application is required to commercially market or sell a pharmaceutical or biologic product in such country or jurisdiction (and any amendments thereto), including
all BLAs and NDAs submitted to the FDA in the United States in accordance with the FDCA with respect to a biologic or pharmaceutical product or any analogous application or submission with any Regulatory Authority outside of the United States
including any EMA or MHRA marketing authorization application. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>MHRA</U>&#8221; means the Medicines Healthcare products
Regulatory Agency. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Milestone Payment Date</U>&#8221; has the meaning set forth in the CVR Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>NDA</U>&#8221; means a new drug application for a drug submitted to the FDA pursuant to 21 C.F.R. Part 314 (as amended from time to
time), and all amendments or supplements thereto, including all documents, data and other information concerning the applicable drug which are necessary for FDA approval to market such drug in the United States, and any equivalent application
submitted to any other Governmental Body. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Notice Period</U>&#8221; means the period beginning at 5:00 p.m. New York City Time
on the day of delivery by the Company to Parent of a Determination Notice (even if such Determination Notice is delivered after 5:00 p.m. New York City Time) and ending on the fourth (4th) Business Day thereafter at 5:00 p.m. New York City Time;
<U>provided</U> that, with respect to any change in the financial terms or any material terms of any Superior Proposal, the Notice Period will extend until 5:00 p.m. New York City Time on the second (2nd) Business Day after delivery of such revised
Determination Notice; <U>provided</U>, <U>further</U>, that if fewer than five (5)&nbsp;Business Days remain prior to the scheduled Expiration Date and Purchaser has not extended the Offer pursuant to <U>Section</U><U></U><U>&nbsp;1.1(a)(ii)</U>,
the Notice Period will be the period beginning upon delivery by the Company to Parent of a Determination Notice and ending twenty-four (24)&nbsp;hours thereafter. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">64 </P>

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<P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U><FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">Off-the-Shelf</FONT></FONT> Software</U>&#8221; means software,
other than open source software, obtained from a third party (a)&nbsp;on general, <FONT STYLE="white-space:nowrap">non-negotiated,</FONT> commercial terms and that continues to be widely available on such commercial terms, (b)&nbsp;that is not
distributed with or incorporated in any product or services of the Company or any of its Subsidiaries, (c)&nbsp;that is used for business infrastructure or other internal purposes and (d)&nbsp;was licensed for fixed payments of less than $500,000 in
the aggregate or annual payments of less than $500,000 per year. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Owned Intellectual Property</U>&#8221; means all Intellectual
Property that is owned or purported to be owned (in whole or in part) by the Company or any of its Subsidiaries. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Patents</U>&#8221; means all patents, issued patents (including issued utility and design patents), and any pending applications for
the same, including any divisionals, provisionals, revisions, supplementary protection certificates, continuations, <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">continuations-in-part,</FONT></FONT> reissues, <FONT
STYLE="white-space:nowrap">re-examinations,</FONT> substitutions, extensions and renewals thereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Permits</U>&#8221; means all
approvals, authorizations, certificates, registrations, exemptions, consents, licenses, orders, permits, waivers, and other similar authorizations of all Governmental Bodies and all other Persons. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Permitted Liens</U>&#8221; means (a)&nbsp;statutory Liens for current Taxes or other governmental charges not yet due and payable or
the amount or validity of which is being contested in good faith by appropriate proceedings and for which appropriate reserves are established in the financial statements in accordance with GAAP, (b)&nbsp;mechanics&#8217;, carriers&#8217;,
workers&#8217;, repairers&#8217;, contractors&#8217;, subcontractors&#8217;, suppliers&#8217; and similar statutory Liens arising or incurred in the ordinary course of business in respect of the construction, maintenance, repair or operation of
assets for amounts that are not delinquent, that are not, individually or in the aggregate, significant, and which do not and will not violate or constitute a breach of or default under any leases, covenants or other material agreements with respect
to the Company Real Property (with or without notice or lapse of time or both), (c) zoning, entitlement, building and other land use regulations imposed by governmental agencies having jurisdiction over the leased Company Real Property which are not
violated by the current use and operation of the leased Company Real Property, (d)&nbsp;covenants, conditions, restrictions, easements and other similar matters of record affecting title to the leased Company Real Property that do not impair the
occupancy, marketability or use of such leased real property for the purposes for which it is currently used or proposed to be used in connection with the Company&#8217;s or its Subsidiaries&#8217; business to more than a <I>de minimis </I>extent,
(e)&nbsp;Liens arising under workers&#8217; compensation, unemployment insurance and social security, (f)&nbsp;purchase money liens for personal property and liens securing rental payments under Finance Leases for personal property, (g)&nbsp;any <FONT
STYLE="white-space:nowrap">non-exclusive</FONT> license granted in the ordinary course of business and (h)&nbsp;those matters identified in the Permitted Liens <U>Section</U><U></U><U>&nbsp;9.3</U> of the Company Disclosure Letter, as applicable.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Person</U>&#8221; means an individual, a partnership, a corporation, a limited liability company, an unlimited liability
company, an association, a joint stock company, a trust, a joint venture, an unincorporated organization, any other entity, a governmental entity or any department, agency or political subdivision thereof. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Personal Information</U>&#8221; means any data or information in any media that, alone or in combination with other information,
(a)&nbsp;can be used to identify, or is otherwise associated with a natural person, or (b)&nbsp;that is considered &#8220;personally identifiable information,&#8221; &#8220;personal information,&#8221; &#8220;personal data,&#8221; &#8220;protected
health information,&#8221; or any similar term defined by any applicable Privacy Laws. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">65 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Plan</U>&#8221; means an &#8220;employee benefit plan&#8221; within the meaning of
Section&nbsp;3(3) of ERISA and any other compensation or benefit plan, policy, program, arrangement, contract or agreement, whether written or unwritten, funded or unfunded, subject to ERISA or not, and covering one or more natural Persons,
including any stock purchase, stock option, stock appreciation right, restricted stock, restricted stock unit, performance stock unit, other equity or equity-based, phantom equity, severance, separation, termination, retention, employment, offer
letter, consulting, change in control, bonus, incentive, deferred compensation, pension, profit sharing, retirement, supplemental retirement, employee loan, hospital, medical, health, welfare, 401(k), dental, vision, workers&#8217; compensation,
disability, life insurance, death benefit, vacation, paid time off, leave of absence, employee assistance, tuition assistance, tax gross up or reimbursement or other fringe benefit plan, policy, program, arrangement or agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Privacy Laws</U>&#8221; mean any applicable foreign or domestic Laws, legal requirements and self-regulatory guidelines relating to
the receipt, collection, compilation, use, storage, access, Processing, sharing, safeguarding, security (both technical and physical), disposal, destruction, disclosure or transfer (including cross-border) of Personal Information or relating to the
privacy, data, security or data protection of Personal Information. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Process</U>&#8221;, &#8220;<U>Processed</U>&#8221; or
&#8220;<U>Processing</U>&#8221; means any operation or set of operations which is or are performed on Personal Information, whether or not by automatic means, such as the use, collection, access, acquisition, creation, derivation, processing,
storage, maintenance, recording, organization, adaption, alteration, correction, transfer, transmission, retrieval, consultation, disclosure, making available, alignment, retention, dissemination, blocking, deletion, erasure, destruction, or
combination of such Personal Information. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Product</U>&#8221; any product that constitutes, incorporates or includes
(a)&nbsp;the product candidate referred to as ixoberogene soroparvovec, formerly referred to as <FONT STYLE="white-space:nowrap">ADVM-022,</FONT> (b) any other product candidate researched, developed, tested, labeled, manufactured, stored, imported,
exported, marketed or distributed by or on behalf of the Company or its Subsidiaries or any of its Affiliates and (c)&nbsp;any derivative of such product candidate described in <FONT STYLE="white-space:nowrap">sub-clause</FONT> (a)&nbsp;or (b). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Purchaser Material Adverse Effect</U>&#8221; means any change, effect, event, inaccuracy, occurrence, or other matter that has a
material adverse effect on the ability of Parent or Purchaser to timely perform its obligations under this Agreement or to timely consummate the Contemplated Transactions. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Regulatory Authority</U>&#8221; means any applicable government regulatory authority involved in granting approvals for the conduct
of clinical trials or the manufacturing, marketing, reimbursement or pricing, as applicable, of a pharmaceutical or biologic product. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Release</U>&#8221; means any release, spill, emission, discharge, leaking, pumping, injection, deposit, disposal, dispersal,
leaching, migration, or other movement or presence in, into or through the indoor or outdoor environment (including ambient air, surface water, groundwater and surface or subsurface strata) or at or from any property. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Representative</U>&#8221; means the officers, directors, managers, members, employees, accountants, consultants, legal counsel,
financial advisors and agents and other agents and representatives of a party. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Routine Services Contracts</U>&#8221; means
(a)&nbsp;materials transfer agreements, manufacturing services agreements, clinical contract services agreements, clinical scale agreements, master services agreements, clinical trial agreements, contract research agreements or other ordinary course
services agreements, in each case, that grant <FONT STYLE="white-space:nowrap">non-exclusive</FONT> rights to use Company Intellectual Property solely to conduct research, manufacturing, clinical trial activities, or other services within the scope
of the applicable agreement and that do not otherwise involve a grant of rights to use any Company Intellectual Property for the research, supply, manufacturing, development or commercialization of a Product or (b)&nbsp;Contracts pursuant to which
</P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">66 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
the Company or any of its Subsidiaries is granted <FONT STYLE="white-space:nowrap">non-exclusive</FONT> rights to use the Company Systems or any research tools and that do not otherwise involve
any assignment, transfer or grant of rights with respect to any Company Intellectual Property (except, with respect to research tools, <FONT STYLE="white-space:nowrap">non-exclusive</FONT> licenses to use modified versions of the research tools
granted back to the provider of such research tools). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Sales Agent</U>&#8221; means Cowen and Company, LLC, as sales agent
and/or principal under the Sales Agreement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Sales Agreement</U>&#8221; means that certain Sales Agreement, dated May&nbsp;11,
2023, by and between the Company and Sales Agent. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Sanctioned Country</U>&#8221; means a country or territory, or the government
thereof, which is currently or has in the last five (5)&nbsp;years been the subject or target of any Sanctions Laws, including at the time of this Agreement, Belarus, Cuba, the Crimea region and <FONT STYLE="white-space:nowrap">so-called</FONT>
Donetsk and Luhansk, People&#8217;s Republic of Ukraine, Iran, North Korea, Russia, Sudan, Syria and Venezuela. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Sanctioned
Person</U>&#8221; means a Person: (a)&nbsp;listed on any Sanctions Laws or <FONT STYLE="white-space:nowrap">Ex-Im</FONT> Laws-related list of designated Persons maintained by a Governmental Body, including OFAC&#8217;s Specially Designated Nationals
and Blocked Persons List, OFAC&#8217;s Foreign Sanctions Evaders List, OFAC&#8217;s Sectoral Sanctions Identifications List, the U.S. Department of Commerce&#8217;s Entity, Denied Persons, or Unverified Lists, the U.S. Department of State&#8217;s
Nonproliferation Sanctions Lists or Debarred List, the EU Consolidated List, the UN Security Council Consolidated List, or His Majesty&#8217;s Treasury&#8217;s Consolidated List of Financial Targets, (b)&nbsp;located, organized, or ordinarily
resident in, or a national of, or the government, or any agency or instrumentality of the government of, a Sanctioned Country, or (c)&nbsp;fifty percent (50%) or greater owned by controlled by, or otherwise acting for or on behalf of one or more
Persons described in <U>clauses (a)-(b)</U> above. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Sanctions Laws</U>&#8221; means any U.S. or
<FONT STYLE="white-space:nowrap">non-U.S.</FONT> laws related to economic or trade sanctions, including those administered by the Office of Foreign Assets Control of the U.S. Department of the Treasury (&#8220;<U>OFAC</U>&#8221;), the U.S.
Department of State, the European Union, any European Union Member State, the United Nations, and His Majesty&#8217;s Treasury of the United Kingdom. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Subsidiary</U>&#8221; means, with respect to any Person, any corporation, partnership, association, trust, limited liability
company, unlimited liability company or other business entity of which (a)&nbsp;if a corporation, a majority of the total voting power of shares of stock entitled (without regard to the occurrence of any contingency) to vote in the election of
directors, managers or trustees thereof is at the time owned or controlled, directly or indirectly, by that Person or one or more of the other Subsidiaries of that Person or a combination thereof or (b)&nbsp;if a partnership, association, trust,
limited liability company, or other business entity, a majority of the partnership or other similar ownership interests thereof is at the time owned or controlled, directly or indirectly, by any Person or one or more Subsidiaries of that Person or a
combination thereof. For purposes hereof, a Person or Persons will be deemed to have a majority ownership interest in a partnership, association, trust, limited liability company or other business entity if such Person or Persons are allocated a
majority of partnership, association, limited liability company or other business entity gains or losses or otherwise control the managing director, managing member, general partner or other managing Person of such partnership, association, trust,
limited liability company or other business entity. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Superior Proposal</U>&#8221; means any written <I>bona
fide</I><I></I>&nbsp;(as reasonably determined by the Company Board in good faith) Acquisition Proposal received after the date of this Agreement that did not, directly or indirectly, result from a material breach of
<U>Section</U><U></U><U>&nbsp;6.3(a)</U> (except the references in the definition thereof to &#8220;twenty percent (20%)&#8221; will be replaced by &#8220;one hundred percent (100%)&#8221;) that the Company Board or a committee thereof has
determined in good faith, after consultation with outside counsel and its independent </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">67 </P>

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financial advisor, is superior to the Acquisition Proposal reflected in this Agreement, and is reasonably likely to be consummated in accordance with its terms, taking into account all of the
terms and conditions (including all of the financial, regulatory, financing, conditionality, legal and other terms, as well as certainty of closing) and all other aspects of such Acquisition Proposal (including any changes to the terms of this
Agreement proposed by Parent). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Tax</U>&#8221; or &#8220;<U>Taxes</U>&#8221; means any and all federal, state, local, or <FONT
STYLE="white-space:nowrap">non-U.S.</FONT> income, gross receipts, license, payroll, employment, excise, severance, stamp, occupation, premium, windfall profits, environmental, customs duties, capital stock, franchise, profits, withholding, social
security (or similar, including FICA), unemployment, disability, tariff, escheat or unclaimed property, real property, personal property, sales, use, transfer, registration, value-added, alternative or <FONT STYLE="white-space:nowrap">add-on</FONT>
minimum, or other tax of any kind or any charge of any kind in the nature of (or similar to) taxes whatsoever, including any interest, penalty, or addition thereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Tax Returns</U>&#8221; means any return, report, election, designation, information return or other document (including schedules or
attachments thereto and any amendments thereof) filed or required to be filed with any Governmental Body in connection with the administration, determination, assessment or collection of any Tax. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Trade Secrets</U>&#8221; means any and all proprietary or confidential information, including trade secrets, <FONT
STYLE="white-space:nowrap">know-how,</FONT> customer, distributor, consumer and supplier lists and data, clinical and technical data, operational data, engineering information, biological, chemical, biochemical, toxicological, pharmacological and
metabolic material and information and data relating thereto, formulation, clinical, analytical and stability information and data, inventions (including conceptions or reductions to practice), invention and technical reports, pricing information,
research and development information, technology, techniques, procedures, processes, compositions, formulae, methods, formulations, discoveries, specifications, designs, drawings, algorithms, plans, improvements, models, techniques and
methodologies. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Trademarks</U>&#8221; means trademarks, service marks, corporate names, trade names, brand names, product names,
logos, slogans, trade dress and other indicia of source or origin, any applications and registrations for any of the foregoing and all renewals and extensions thereof, and all goodwill associated therewith and symbolized thereby. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Transfer Taxes</U>&#8221; means sales, transfer, stamp, stock transfer, documentary, registration, value added, use, real property
transfer and any similar Taxes and fees. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.4. <U>Terms Defined Elsewhere</U>. For purposes of this Agreement each of the
following terms (capitalized below) when used in this Agreement will have the meaning ascribed to such term in the Section set forth opposite such term: </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
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<TD VALIGN="top">401(k) Plan</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;6.4(c)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Acceleration Date</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.2(a)(ii)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Acceptance Time</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;1.1(a)(ii)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Affiliate Transaction</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.25</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Agreement</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Preamble</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Alternative Acquisition Agreement</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;6.3(d)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Book-Entry Share</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.5(b)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">CARES Act</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.11(c)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Certificate</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.5(b)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Certificate of Merger</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;2.2</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Closing</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;2.2</TD></TR>
</TABLE></DIV>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">68 </P>

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 <DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="96%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="51%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="48%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Closing Amount</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Closing Date</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;2.2</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Code</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.7</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Preamble</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company Board</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company Board Recommendation</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.2</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock Option</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.2(a)(i)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company Common Stock</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company Disclosure Letter</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Article IV</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company Material Contract</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.12(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company Organizational Documents</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.1(c)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company Real Property</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.10(b)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company Registered Intellectual Property</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.13(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company SEC Documents</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.6(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company Securities</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.3(f)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company Stock Options</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.2(a)(ii)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Company Systems</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.13(k)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Compensation Action</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;6.8</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Current Employees</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;6.4(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">CVR Agreement</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">CVRs</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">DGCL</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Dissenting Shares</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.4(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Effective Time</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;2.2</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">ERISA</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.16(d)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Exchange Act</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;1.1(a)(i)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Excluded Benefits</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;6.4(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Expiration Date</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;1.1(a)(i)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">FCPA</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(m)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">FDA</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">FDCA</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Healthcare Correspondence</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(f)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Indemnified Party</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;6.5(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Initial Expiration Date</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;1.1(a)(i)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Intentional Breach</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;8.5(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Labor Agreements</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.12(a)(ii)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Last Exercise Date</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.2(a)(ii)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Material Suppliers</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.20</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Measurement Date</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.3(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Merger</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Merger Consideration</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.1(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Minimum Tender Condition</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Annex I, Section&nbsp;1(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Nasdaq</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;1.1(a)(ii)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">OECD Convention</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(m)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Offer</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Offer Conditions</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;1.1(a)(i)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Offer Documents</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;1.1(b)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Offer Price</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"><FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">Out-of-the-Money</FONT></FONT></FONT> Option</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.2(a)(ii)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Outside Date</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;8.2(b)</TD></TR>
</TABLE></DIV>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">69 </P>

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<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="96%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="51%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="48%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Parent</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Preamble</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Paying Agent</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.5(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">PHSA</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"><FONT STYLE="white-space:nowrap">Pre-Closing</FONT> Period</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;6.1(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Privacy Policy</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(o)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Privacy Requirements</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(o)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Prohibited Payment</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(o)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Promissory Note</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Purchase Orders</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.12(a)(xi)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Purchaser</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Preamble</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Regulatory Authorizations</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Regulatory Correspondence</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Rights Agent</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Sarbanes-Oxley</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.9(d)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;1.2</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Schedule TO</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;1.1(b)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">SEC</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;1.1(a)(i)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Securities Act</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.6(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Security Incident</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.19(p)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Share</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Shares</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Recitals</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Stockholder List Date</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;1.3</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Stockholder Litigation</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.6(a)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Surviving Corporation</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;2.1</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Treasury Regulations</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;3.7</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">UK Bribery Act</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.3(h)</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">WARN</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right">Section&nbsp;4.18(b)</TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.5. <U>Severability</U>. If any term or other provision of this Agreement is determined by
a court of competent jurisdiction to be invalid, illegal, or incapable of being enforced by any rule, law or public policy, the remaining provisions of this Agreement will be enforced so as to conform to the original intent of the parties as closely
as possible in an acceptable manner so that the Contemplated Transactions are fulfilled to the fullest extent possible. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.6.
<U>Assignment</U>. Neither this Agreement nor any of the rights, interests or obligations under this Agreement shall be assigned, in whole or in part, by operation of law or otherwise by any of the parties without the prior written consent of the
other parties and any purported assignment without such consent shall be void; <U>provided</U> that (a)&nbsp;Purchaser may assign, in its sole discretion, any of or all its rights, interests and obligations under this Agreement to Parent or to any
direct or indirect wholly-owned subsidiary of Parent, but no such assignment shall relieve Purchaser of any of its obligations under this Agreement; and (b)&nbsp;Parent may assign, in its sole discretion, any of or all its rights, interests and
obligations under this Agreement to any of its direct or indirect wholly-owned subsidiaries, but no such assignment shall relieve Parent of any of its obligations under this Agreement; <U>provided</U>, that any such assignment pursuant to the
foregoing <U>clause (a)</U>&nbsp;or <U>clause (b)</U>&nbsp;shall not materially impede or delay the consummation of the Contemplated Transactions or otherwise materially impede the rights of the stockholders of the Company under this Agreement.
Subject to the preceding sentences, this Agreement will be binding upon, inure to the benefit of, and be enforceable by the parties and their respective permitted successors and assigns. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">70 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.7. <U>Entire Agreement; Third-Party Beneficiaries</U>. This Agreement
(together with the Company Disclosure Letter and the exhibits, annexes, and instruments referred to herein), the Promissory Note (together with the collateral documents, exhibits and instruments referred to therein) and the CVR Agreement constitute
the entire agreement and supersedes all prior agreements and understandings, both written and oral, among the parties with respect to the subject matter hereof; <U>provided</U>, <U>however</U>, that the Confidentiality Agreement will survive the
execution or termination of this Agreement and remains in full force and effect until the expiration thereunder; <U>provided</U><I>,</I> <U>further</U><I>,</I> that, if the Effective Time occurs, the Confidentiality Agreement shall automatically
terminate and be of no further force and effect. Except for (a)&nbsp;the rights of the holders of Shares to receive the Offer Price and the Merger Consideration, the holders of Company Stock Options, Company RSUs and Company PSUs to receive the
consideration described in <U>Section</U><U></U><U>&nbsp;3.2</U>, and the holders of Warrants to receive the consideration described in <U>Section</U><U></U><U>&nbsp;3.3</U>, (b) the right of the Company, on behalf of the holders of Shares and the
holders of Company Stock Options, Company RSUs and Company PSUs and Warrants (each of which are third party beneficiaries hereunder only to the extent required for this <U>clause (b)</U>&nbsp;to be enforceable), to pursue specific performance as set
forth in <U>Section</U><U></U><U>&nbsp;9.16</U> or, if specific performance is not sought or granted as a remedy, damages (which damages the parties agree may, if ordered by a court of competent jurisdiction, be based upon a decrease in share value
or lost premium) in the event of Parent&#8217;s or Purchaser&#8217;s breach of this Agreement, and (c)&nbsp;as provided in <U>Section</U><U></U><U>&nbsp;6.5</U> (which is intended for the benefit of each Indemnified Party, all of whom will be
third-party beneficiaries of these provisions), this Agreement is not intended to confer upon any Person other than the parties hereto any rights or remedies. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.8. <U>Governing Law</U>. This Agreement will be governed by, and construed in accordance with, the Laws of the State of
Delaware, regardless of the Laws that might otherwise govern under applicable principles of conflicts of laws thereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.9.
<U>Headings</U>. The descriptive headings contained in this Agreement are included for convenience of reference only and will not affect in any way the meaning or interpretation of this Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.10. <U>Counterparts</U>. This Agreement may be executed and delivered (including by executed signatures in electronic format
(including &#8220;pdf&#8221;) and other electronic signatures (including, DocuSign and AdobeSign) in each case transmitted by email) in two (2)&nbsp;or more counterparts, and by the different parties hereto in separate counterparts, each of which
when executed will be deemed to be an original but all of which taken together will constitute one and the same agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.11. <U>Performance Guaranty</U>. Parent hereby guarantees the due, prompt and faithful performance and discharge by, and
compliance with, all of the obligations, covenants, terms, conditions and undertakings of Purchaser under this Agreement in accordance with the terms hereof, including any such obligations, covenants, terms, conditions and undertakings that are
required to be performed discharged or complied with following the Effective Time. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.12. <U>Jurisdiction; Waiver of Jury
Trial</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) Each of the parties hereto hereby (i)&nbsp;expressly and irrevocably submits to the exclusive personal jurisdiction of the
Court of Chancery of the State of Delaware or if such Court of Chancery lacks subject matter jurisdiction, the United States District Court for the District of Delaware, in the event any dispute arises out of this Agreement, the Offer, the Merger,
or the Contemplated Transactions, (ii)&nbsp;agrees that it shall not attempt to deny or defeat such personal jurisdiction by motion or other request for leave from any such court and (iii)&nbsp;agrees that it shall not bring any action relating to
this Agreement, the Offer, the Merger, or the Contemplated Transactions in any court other than the Court of Chancery of the State of Delaware or if such Court of Chancery lacks subject matter jurisdiction, the United States District Court for the
District of Delaware; <U>provided</U> that each of the parties has the right to bring any action or proceeding for enforcement of a judgment entered by such court in any other court or jurisdiction. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">71 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) EACH PARTY HERETO ACKNOWLEDGES AND AGREES THAT ANY CONTROVERSY WHICH MAY ARISE UNDER
THIS AGREEMENT IS LIKELY TO INVOLVE COMPLICATED AND DIFFICULT ISSUES, AND THEREFORE SUCH PARTY HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN ANY LITIGATION ARISING OUT OF, RELATING TO OR IN CONNECTION
WITH THIS AGREEMENT. EACH PARTY CERTIFIES AND ACKNOWLEDGES THAT (I)&nbsp;NO REPRESENTATIVE, AGENT, OR ATTORNEY OF ANY PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING
WAIVER, (II)&nbsp;EACH PARTY UNDERSTANDS AND HAS CONSIDERED THE IMPLICATION OF THIS WAIVER, (III)&nbsp;EACH PARTY MAKES THIS WAIVER VOLUNTARILY AND (IV)&nbsp;EACH OTHER PARTY HAS BEEN INDUCED TO ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE
MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.13. <U>Service of Process</U>. Each party irrevocably consents to the
service of process outside the territorial jurisdiction of the courts referred to in <U>Section</U><U></U><U>&nbsp;9.12(a)</U> in any such action or proceeding by mailing copies thereof by registered United States mail, postage prepaid, return
receipt requested, to its address as specified in or pursuant to <U>Section</U><U></U><U>&nbsp;9.2</U>. However, the foregoing will not limit the right of a party to effect service of process on the other party by any other legally available method.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.14. <U>Remedies</U>. Except as otherwise provided in this Agreement, the rights and remedies provided in this Agreement
shall be cumulative and not exclusive of any rights or remedies provided by applicable Law, and the exercise by a party of any one remedy will not preclude the exercise of any other remedy. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.15. <U>Cooperation</U>. Except from and after a Change of Board Recommendation, or as any such actions may be limited by the
express terms hereof, the parties agree to provide reasonable cooperation with each other and to execute and deliver such further documents, certificates, agreements and instruments and to take such actions as may be reasonably requested by the
other parties to evidence or effect the Contemplated Transactions and to carry out the intent and purposes of this Agreement (including providing Parent with information reasonably requested to support calculations under Section&nbsp;280G of the
Code). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.16. <U>Specific Performance.</U> </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) The parties hereto acknowledge and agree that, in the event of any breach of this Agreement, irreparable harm would occur that monetary
damages could not make whole. It is accordingly agreed that (i)&nbsp;each party hereto will be entitled, in addition to any other remedy to which it may be entitled at law or in equity, to compel specific performance to prevent or restrain breaches
or threatened breaches of this Agreement in any action without the posting of a bond or undertaking and (ii)&nbsp;the parties hereto will, and hereby do, waive, in any action for specific performance, the defense of adequacy of a remedy at law and
any other objections to specific performance of this Agreement. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) Notwithstanding the parties&#8217; rights to specific performance
pursuant to <U>Section</U><U></U><U>&nbsp;9.16(a)</U>, each party may pursue any other remedy available to it at law or in equity, including monetary damages. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">72 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.17. <U>Interpretation</U>. When reference is made in this Agreement to an
Article, Section or Exhibit, such reference will refer to Articles and Sections of, and Exhibits to, this Agreement unless otherwise indicated. The word &#8220;extent&#8221; in the phrase &#8220;to the extent&#8221; shall mean the degree to which a
subject or other thing extends, and such phrase shall not mean simply &#8220;if.&#8221; All references to &#8220;dollars&#8221; or &#8220;$&#8221; shall refer to the lawful currency of the United States. Whenever the words &#8220;include,&#8221;
&#8220;includes,&#8221; or &#8220;including&#8221; are used in this Agreement, they will be deemed to be followed by the words &#8220;without limitation.&#8221; The words &#8220;hereof,&#8221; &#8220;herein,&#8221; &#8220;hereby,&#8221;
&#8220;hereto,&#8221; and &#8220;hereunder&#8221; and words of similar import when used in this Agreement will refer to this Agreement as a whole and not to any particular provision of this Agreement. The word &#8220;or&#8221; will not be exclusive.
The word &#8220;will&#8221; shall be construed to have the same meaning and effect as the word &#8220;shall.&#8221; Whenever used in this Agreement, any noun or pronoun will be deemed to include the plural as well as the singular and to cover all
genders. Any reference to any Person shall be construed to include such Person&#8217;s successors and assigns. The words &#8220;made available&#8221; and words of similar import refer to documents posted to the virtual data room hosted by Datasite
titled &#8220;Project Alaska,&#8221; or otherwise delivered via <FONT STYLE="white-space:nowrap">e-mail</FONT> by or on behalf of the Company to Parent or Purchaser, in each case, at least two (2)&nbsp;Business Days prior to the execution hereof (or
after such time if Parent or any of its Representatives confirms receipt of such documents or information in writing). The words &#8220;ordinary course of business&#8221; shall mean the ordinary course of business consistent with past practice. This
Agreement will be construed without regard to any presumption or rule requiring construction or interpretation against the party drafting or causing any instrument to be drafted. The parties hereto have participated jointly in the negotiation and
drafting of this Agreement and, in the event an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as jointly drafted by the parties hereto and no presumption of burden of proof shall arise favoring or
disfavoring any party by virtue of the authorship of this Agreement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Remainder of Page Left Blank Intentionally</I>] </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">73 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, each of Parent, Purchaser and the Company has caused this Agreement to
be executed as of the date first written above by their respective officers thereunto duly authorized. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="12%"></TD>

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<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"><B>ELI LILLY AND COMPANY</B></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Andrew Charles Adams</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Andrew Charles Adams</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Group Vice President &#8211; Molecule Discovery Lilly Research Laboratories</TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Signature Page to Agreement and Plan of Merger</I>] </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, each of Parent, Purchaser and the Company has caused this Agreement to
be executed as of the date first written above by their respective officers thereunto duly authorized. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


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<TD VALIGN="top" COLSPAN="3"><B>FLYING TIGERS ACQUISITION CORPORATION</B></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Jonathan Haug</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Jonathan Haug</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">President</TD></TR>
</TABLE></DIV>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Signature Page to
Agreement and Plan of Merger</I>] </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, each of Parent, Purchaser and the Company has caused this Agreement to
be executed as of the date first written above by their respective officers thereunto duly authorized. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
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<TD VALIGN="top" COLSPAN="3"><B>ADVERUM BIOTECHNOLOGIES, INC.</B></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Laurent Fischer</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Laurent Fischer, M.D.</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">President and Chief Executive Officer</TD></TR>
</TABLE></DIV>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Signature Page to
Agreement and Plan of Merger</I>] </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B><U>Annex I </U></B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><U>CONDITIONS TO THE OFFER </U></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Capitalized terms used in this <U>Annex I</U> and not otherwise defined herein have the meanings assigned to them in the Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">1. Purchaser is not required to accept for payment or, subject to any applicable rules and regulations of the SEC, including Rule <FONT
STYLE="white-space:nowrap">14e-l(c)</FONT> under the Exchange Act (relating to Purchaser&#8217;s obligation to pay for or return tendered Shares promptly after the termination or withdrawal of the Offer), to pay for any Shares validly tendered and
not validly withdrawn in connection with the Offer, unless, immediately prior to the then applicable Expiration Date: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) there have been
validly tendered in the Offer (excluding Shares tendered pursuant to guaranteed delivery procedures, if permitted by the terms of the Offer, that have not yet been &#8220;received&#8221; by the &#8220;depositary&#8221; as such terms are defined in
Section&nbsp;251(h) of the DGCL), and not validly withdrawn prior to the Expiration Date that number of Shares that, together with the number of Shares, if any, then owned beneficially by Parent and Purchaser (together with their wholly owned
Subsidiaries), represents a majority of the Shares outstanding as of the consummation of the Offer (such condition in this Paragraph 1(a) being, the &#8220;<U>Minimum Tender Condition</U>&#8221;); </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) (i)&nbsp;any notices, approvals or clearances applicable to or advisable for the consummation of the Contemplated Transactions in
accordance with Antitrust and FDI Laws shall have been given and obtained and (ii)&nbsp;any agreement with a Governmental Body not to consummate or to delay consummation of the Contemplated Transactions shall have expired or been terminated; and
</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) there is not, and has been no, Triggering Event (as defined in the Promissory Note) under the Promissory Note. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">2. Additionally, Purchaser is not required to accept for payment or, subject to any applicable rules and regulations of the SEC, including
Rule <FONT STYLE="white-space:nowrap">14e-l(c)</FONT> under the Exchange Act (relating to Purchaser&#8217;s obligation to pay for or return tendered Shares promptly after the termination or withdrawal of the Offer), to pay for any Shares validly
tendered and not validly withdrawn in connection with the Offer if, immediately prior to the then applicable Expiration Date, any of the following conditions exist: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) (i) any court of competent jurisdiction or other Governmental Body has issued an order, decree, or ruling, enacted any Law or taken any
other action restraining, enjoining, or otherwise prohibiting the Offer or the Merger, or (ii)&nbsp;any Law applicable to the Offer or the Merger restraining, enjoining or otherwise prohibiting the Offer or the Merger shall be in effect; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) (i) the Company has breached or failed to comply in any material respect with any of its agreements or covenants to be performed or
complied with by it under the Agreement on or before the Acceptance Time, (ii)&nbsp;the representations and warranties of the Company contained in the Agreement (other than the representations and warranties set forth in
<U>Section</U><U></U><U>&nbsp;4.1</U> (Organization and Corporate Power), <U>Section</U><U></U><U>&nbsp;4.2</U> (Authorization; Valid and Binding Agreement), <U>Section</U><U></U><U>&nbsp;4.3</U> (Capital Stock),
<U>Section</U><U></U><U>&nbsp;4.4(a)</U> (No Breach), <U>Section</U><U></U><U>&nbsp;4.8(a)</U> (Absence of Company Material Adverse Effect); <U>Section</U><U></U><U>&nbsp;4.21</U> (Brokerage), <U>Section</U><U></U><U>&nbsp;4.23</U> (Opinion) and
<U>Section</U><U></U><U>&nbsp;4.24</U> (No Vote Required)) that (x)&nbsp;are not made as of a specific date, are not true and correct as of the Expiration Date, as though made on and as of the Expiration Date and (y)&nbsp;are made as of a specific
date, are not true as of such date, except, in the case of (x)&nbsp;or (y), where the failure of such representations and warranties to be true and correct (without giving effect to any limitation as to &#8220;materiality&#8221; or &#8220;Company
Material Adverse Effect&#8221;) has not had a Company Material Adverse Effect, (iii) </P>
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the representation set forth in <U>Section</U><U></U><U>&nbsp;4.8(a)</U> (Absence of Company Material Adverse Effect) is not true in all respects, as of the date of this Agreement and the
Expiration Date as though made on and as of such date and time, (iv)&nbsp;the representations and warranties set forth in <U>Section</U><U></U><U>&nbsp;4.1</U> (Organization and Corporate Power), <U>Section</U><U></U><U>&nbsp;4.2</U> (Authorization;
Valid and Binding Agreement), <U>Section</U><U></U><U>&nbsp;4.3</U> (other than <U>Section</U><U></U><U>&nbsp;4.3(a)</U>, <U>(b)</U> or <U>(f)</U>) (Capital Stock),<U> Section</U><U></U><U>&nbsp;4.4(a)</U> (No Breach),
<U>Section</U><U></U><U>&nbsp;4.21</U> (Brokerage), <U>Section</U><U></U><U>&nbsp;4.23</U> (Opinion) and <U>Section</U><U></U><U>&nbsp;4.24</U> (No Vote Required) are not true and correct in all respects, except for immaterial inaccuracies, as of
the Expiration Date as though made on and as of such date and time (except to the extent that any such representation and warranty expressly speaks as of an earlier date, in which case such representation and warranty is not true and correct, except
for immaterial inaccuracies, as of such earlier date), or (v)&nbsp;the representations set forth in <U>Section</U><U></U><U>&nbsp;4.3(a)</U>, <U>(b)</U> and <U>(f)</U> (Capital Stock) are not true and correct in all respects, except for
any<I></I><I>&nbsp;de minimis</I> inaccuracies, as of the Expiration Date as though made on and as of such date and time; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) the Company
has not delivered to Parent a certificate dated as of the Expiration Date signed on behalf of the Company by a senior executive officer of the Company in his or her capacity as such an officer to the effect that the conditions set forth in
<U>Paragraphs 2(b)</U> and <U>2(d)</U> have been satisfied as of the Expiration Date; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) since the date of the Agreement, there has
occurred any change, event, occurrence or effect that has had a Company Material Adverse Effect; or </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) the Agreement has been terminated
pursuant to its terms. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The conditions set forth in <U>Paragraph 2</U> of this <U>Annex I</U> are for the benefit of Parent and Purchaser
and may be waived by Parent or Purchaser in whole or in part at any time or from time to time prior to the Expiration Date (except for the conditions set forth in <U>clauses 1(a)</U> and<U> 2(e)</U> may only be waived by Parent or Purchaser with the
prior written consent of the Company, not to be unreasonably withheld, conditioned or delayed), in each case, subject to the terms and conditions of the Agreement and the applicable rules and regulations of the SEC. </P>
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<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><U>CERTIFICATE OF INCORPORATION OF THE SURVIVING CORPORATION </U></P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Second Amended and Restated Certificate of Incorporation of Adverum Biotechnologies, Inc.
</B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">1. The name of the corporation is Adverum Biotechnologies, Inc. (the &#8220;<U>Corporation</U>&#8221;). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">2. The address of the Corporation&#8217;s registered office in the State of Delaware is 1209 Orange Street, Wilmington, New Castle County,
Delaware 19801, and the name of the Corporation&#8217;s registered agent at such address is National Registered Agents, Inc. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">3. The
nature of the business and the purposes to be conducted and promoted by the Corporation are to conduct any lawful business, to promote any lawful purpose and to engage in any lawful act or activity for which corporations may be organized under the
General Corporation Law of the State of Delaware (the &#8220;<U>DGCL</U>&#8221;), as from time to time amended. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">4. The total number of
shares of stock which the Corporation shall have authority to issue is one hundred (100)&nbsp;shares of common stock, $0.0001 par value per share (the &#8220;<U>Common Stock</U>&#8221;). Shares of the Common Stock may be issued from time to time as
the Board of Directors of the Corporation (the &#8220;<U>Board</U>&#8221;) shall determine and on such terms and for such consideration as shall be fixed by the Board. The amount of the authorized Common Stock of the Corporation may be increased or
decreased by the affirmative vote of the holders of a majority of the outstanding shares of Common Stock of the Corporation entitled to vote. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">5. Except as otherwise provided by law, the Common Stock shall have the exclusive right to vote for the election of directors and for all
other purposes. Each share of Common Stock shall have one vote, and the Common Stock shall vote together as a single class. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">6. Elections
of directors need not be by written ballot unless required by the Bylaws of the Corporation (the &#8220;<U>Bylaws</U>&#8221;). Any director may be removed from office either with or without cause at any time by the affirmative vote of the holders of
a majority of the outstanding Common Stock of the Corporation entitled to vote, given at a meeting of the stockholders called for that purpose, or by the consent of the holders of a majority of the outstanding Common Stock of the Corporation
entitled to vote, given in accordance with DGCL Section&nbsp;228. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">7. In furtherance and not in limitation of the powers conferred upon
the Board by law, the Board shall have the power to make, adopt, alter, amend and repeal from time to time the Bylaws by a majority vote at any regular or special meeting or by written consent, subject to the power of the stockholders to alter,
amend and repeal Bylaws made by the Board. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">8. To the maximum extent permitted by the DGCL, as the same exists or as may hereafter be
amended, a director of the Corporation&nbsp;shall&nbsp;not be personally&nbsp;liable&nbsp;to the Corporation or its stockholders for monetary damages for breach of fiduciary duty as a director. If the DGCL is amended after approval by the
stockholders of this Section&nbsp;8 to authorize corporate action further eliminating or limiting the personal liability of directors, then the liability of a director of the Corporation shall be eliminated or limited to the fullest extent permitted
by the DGCL as so amended. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">9. The Corporation may indemnify to the fullest extent permitted by law any person made or threatened to be
made a party to an action or proceeding, whether criminal, civil,&nbsp;administrative or investigative, by reason of the fact that he or she, or his or her testator or intestate is or was a director, officer, employee or agent of the Corporation or
any predecessor of the Corporation, or serves or served at any other enterprise as a director, officer, employee or agent at the request of the Corporation or any predecessor to the Corporation. Neither any amendment nor repeal of this
Section&nbsp;9, nor the adoption of any provision of the Corporation&#8217;s certificate of incorporation inconsistent with this Section&nbsp;9, shall eliminate or reduce the effect of this Section&nbsp;9 in respect of any matter occurring, or any
action or proceeding accruing or arising or that, but for this Section&nbsp;9, would accrue or arise,&nbsp;prior to such amendment, repeal or adoption of an inconsistent provision. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">10. The Board reserves the right to amend, alter, change or repeal any provision contained in this Second Amended and Restated Certificate of
Incorporation, in the manner now or hereafter prescribed by statute, and all rights conferred upon stockholders herein are granted subject to this reservation. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B><U>Annex III </U></B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><U>BYLAWS OF THE SURVIVING CORPORATION </U></P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>SECOND AMENDED AND RESTATED BYLAWS </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>OF </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ADVERUM
BIOTECHNOLOGIES, INC. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">(a Delaware corporation) </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>(Adopted as of &#8195;) </I></P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE I </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>STOCKHOLDERS
</B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1. <U>Annual Meetings</U>. The annual meeting of the stockholders of Adverum Biotechnologies, Inc. (the
&#8220;<U>Corporation</U>&#8221;) for the election of directors and for the transaction of such other business as may properly come before the meeting shall be held each year at such date and time, within or without the State of Delaware, as the
board of directors of the Corporation (the &#8220;<U>Board of Directors</U>&#8221;) shall determine. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2. <U>Special
Meetings</U>. Special meetings of stockholders for the transaction of such business as may properly come before the meeting may be called by order of the Board of Directors or by stockholders holding together at least a majority of all the shares of
the Corporation entitled to vote at the meeting, and shall be held at such date and time, within or without the State of Delaware, as may be specified by such order. Whenever the directors shall fail to fix such place, the meeting shall be held at
the principal executive office of the Corporation. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3. <U>Notice of Meetings</U>. Written notice of all meetings of the
stockholders, stating the place, date and hour of the meeting, the means of remote communications, if any, by which stockholders and proxy holders may be deemed to be present in person and vote at such meeting, and the place within the city or other
municipality or community at which the list of stockholders may be examined, shall be mailed or delivered to each stockholder entitled to vote at such meeting not less than 10 nor more than 60 days prior to the meeting. Notice of any special meeting
shall state in general terms the purpose or purposes for which the meeting is to be held. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4. <U>Stockholder Lists</U>. The
officer who has charge of the stock ledger of the Corporation shall prepare and make, at least 10 days before every meeting of stockholders, a complete list of the stockholders entitled to vote at the meeting, arranged in alphabetical order, and
showing the address of each stockholder and the number and class of shares registered in the name of each stockholder. Such list shall be open to the examination of any stockholder, for any purpose germane to the meeting, either at a place within
the city where the meeting is to be held, which place shall be specified in the notice of the meeting, or, if not so specified, at the place where the meeting is to be held. The list shall also be produced and kept at the time and place of the
meeting during the whole time thereof, and may be inspected by any stockholder who is present. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The stock ledger shall be the only
evidence as to who are the stockholders entitled to examine the stock ledger, the list required by this section or the books of the Corporation, or to vote in person or by proxy at any meeting of stockholders. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5. <U>Quorum</U>. Except as otherwise provided by law or the Corporation&#8217;s certificate of incorporation (the
&#8220;<U>Certificate of Incorporation</U>&#8221;), a quorum for the transaction of business at any meeting of stockholders shall consist of the holders of record of a majority of the issued and outstanding shares of the capital stock of the
Corporation entitled to vote at the meeting, present in person or represented by proxy. At all meetings of the stockholders at which a quorum is present, all matters, except as otherwise provided by law or the Certificate of Incorporation, shall be
decided by the vote of the holders of a majority of the shares entitled to vote thereat present in person or by proxy. If there be no such quorum, the holders of a majority of such shares so present or represented may adjourn the meeting from time
to time, without further notice, until a quorum shall have been obtained. When a quorum is once present it is not broken by the subsequent withdrawal of any stockholder. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6. <U>Organization</U>. Meetings of stockholders shall be presided over by the Chairman, if any, or if none or in the
Chairman&#8217;s absence the Vice Chairman, if any, or if none or in the Vice Chairman&#8217;s absence, the President, if any, or if none or in the President&#8217;s absence a Vice President, or, if none of the foregoing is present, by a chairman to
be chosen by the stockholders entitled to vote who are present in person or by proxy at the meeting. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The Secretary of the Corporation, or in the
Secretary&#8217;s absence, the presiding officer of the meeting shall appoint any person present to act as secretary of the meeting. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;7. <U>Voting; Proxies; Required Vote</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) At each meeting of stockholders, every stockholder entitled to vote at such meeting shall be entitled to vote in person or by proxy
appointed by instrument in writing, subscribed by such stockholder or by such stockholder&#8217;s duly authorized <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">attorney-in-fact</FONT></FONT> (but no such proxy shall be voted or
acted upon after three years from its date, unless the proxy provides for a longer period), and, unless the Certificate of Incorporation provides otherwise, shall have one vote for each share of stock entitled to vote registered in the name of such
stockholder on the books of the Corporation on the applicable record date fixed pursuant to these Second Amended and Restated Bylaws (&#8220;<U>Bylaws</U>&#8221;). At all elections of directors the voting may be, but need not be, by ballot and a
plurality of the votes cast there shall elect such directors. Except as otherwise required by law or the Certificate of Incorporation, any other action shall be authorized by a majority of the votes cast. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Any action required or permitted to be taken at any meeting of stockholders may, except as otherwise required by law or the Certificate of
Incorporation, be taken without a meeting, without prior notice and without a vote, if a consent in writing, setting forth the action so taken, shall be signed by the holders of record of the issued and outstanding capital stock of the Corporation
having the number of votes that would be necessary to authorize or take such action at a meeting at which all shares entitled to vote thereon were present and voted, and the writing or writings are filed with the permanent records of the
Corporation. Prompt notice of the taking of corporate action without a meeting by less than unanimous written consent shall be given to those stockholders who have not consented in writing. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Where a separate vote is to be taken by a class or classes, the presence in person or by proxy of a majority of the holders of record of
such class or classes shall constitute a quorum and the affirmative vote of the majority of shares of such class or classes present in person or represented by proxy at the meeting shall be the act of such class, unless otherwise provided in the
Certificate of Incorporation. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;8. <U>Inspectors</U>. The Board of Directors, in advance of any meeting, may, but need not,
appoint one or more inspectors of election to act at the meeting or any adjournment thereof. If an inspector or inspectors are not so appointed, the person presiding at the meeting may, but need not, appoint one or more inspectors. In case any
person who may be appointed as an inspector fails to appear or act, the vacancy may be filled by appointment made by the directors in advance of the meeting or at the meeting by the person presiding thereat. Each inspector, if any, before entering
upon the discharge of his or her duties, shall take and sign an oath faithfully to execute the duties of inspector at such meeting with strict impartiality and according to the best of his or her ability. The inspectors, if any, shall determine the
number of shares of stock outstanding and the voting power of each, the shares of stock represented at the meeting, the existence of a quorum, and the validity and effect of proxies, and shall receive votes, ballots or consents, hear and determine
all challenges and questions arising in connection with the right to vote, count and tabulate all votes, ballots or consents, determine the result, and do such acts as are proper to conduct the election or vote with fairness to all stockholders. On
request of the person presiding at the meeting, the inspector or inspectors, if any, shall make a report in writing of any challenge, question or matter determined by such inspector or inspectors and execute a certificate of any fact found by such
inspector or inspectors. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE II </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>BOARD OF DIRECTORS </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1. <U>General Powers</U>. The business, property and affairs of the Corporation shall be managed by, or under the direction of,
the Board of Directors. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2. <U>Qualification; Number; Term; Compensation</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) Each director shall be at least 18 years of age. A director need not be a stockholder, a citizen of the United States or a resident of the
State of Delaware. The number of directors constituting the entire Board of Directors shall be fixed initially by the incorporator and thereafter by the Board of Directors and shall be at least one, or such larger number as may be fixed initially by
the incorporator and thereafter from time to time by the Board of Directors, one of whom may be selected by the Board of Directors to be its Chairman. The use of the phrase &#8220;entire Board of Directors&#8221; herein refers to the total number of
directors which the Corporation would have if there were no vacancies. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Directors who are elected at an annual meeting of stockholders, and directors who are
elected in the interim to fill vacancies and newly created directorships, shall hold office until the next annual meeting of stockholders and until their successors are elected and qualified or until their earlier resignation or removal. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Unless otherwise restricted by the Certificate of Incorporation or these Bylaws, the Board of Directors shall have the authority to fix
the compensation of directors. The directors may be paid their expenses, if any, of attendance at each meeting of the Board of Directors and may be paid a fixed sum for attendance at each meeting of the Board of Directors or a stated salary as
director. No such payment shall preclude any director from serving the Corporation in any other capacity and receiving compensation therefor. Members of special or standing committees may be allowed like compensation for attending committee
meetings. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3. <U>Quorum and Manner of Voting</U>. Except as otherwise provided by law, a majority of the entire Board of
Directors shall constitute a quorum. A majority of the directors present, whether or not a quorum is present, may adjourn a meeting from time to time to another time and place without notice. The vote of the majority of the directors present at a
meeting at which a quorum is present shall be the act of the Board of Directors. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4. <U>Places of Meetings</U>. Meetings of
the Board of Directors may be held at any place within or without the State of Delaware, as may from time to time be fixed by resolution of the Board of Directors, or as may be specified in the notice of meeting. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5. <U>Annual Meeting</U>. Following the annual meeting of stockholders, the newly elected Board of Directors shall meet for the
purpose of the election of officers and the transaction of such other business as may properly come before the meeting. Such meeting may be held without notice immediately after the annual meeting of stockholders at the same place at which such
stockholders&#8217; meeting is held. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6. <U>Regular Meetings</U>. Regular meetings of the Board of Directors shall be held at
such times and places as the Board of Directors shall from time to time determine by resolution. Notice need not be given of regular meetings of the Board of Directors held at times and places fixed by resolution of the Board of Directors. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;7. <U>Special Meetings</U>. Special meetings of the Board of Directors shall be held whenever called by the Chairman of the Board
of Directors, the President or by a majority of directors then in office. Notice of the place, date and time and the purpose or purposes of each special meeting of the Board of Directors shall be given to each director by mailing the same at least
two days before the meeting, or by telephoning or emailing the same or by delivering the same personally not later than the day before the day of the meeting. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;8. <U>Meetings by Means of Conference Telephone</U>. Unless otherwise provided by the Certificate of Incorporation or these
Bylaws, members of the Board of Directors, or any committee designated by the Board of Directors, may participate in a meeting of the Board of Directors or such committee by means of a conference telephone or similar communication equipment by means
of which all persons participating in the meeting can hear each other, and such participation in a meeting pursuant to this Section&nbsp;8 shall constitute presence at such meeting. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9. <U>Organization</U>. The Chairman of the Board of Directors, if there be one, or if none or in the Chairman&#8217;s absence or
inability to act the Vice Chairman, if any, or if none or in the Vice Chairman&#8217;s absence or inability to act the President, or in the President&#8217;s absence or inability to act any Vice President who is a member of the Board of Directors,
or in such Vice President&#8217;s absence or inability to act, a chairman chosen by the directors, shall preside at all meetings of the Board of Directors and shall have such other powers and duties as may from time to time be assigned by the Board
of Directors. The Secretary of the Corporation shall act as secretary at all meetings of the Board of Directors when present, and, in the Secretary&#8217;s absence, the presiding officer may appoint any person to act as secretary. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;10. <U>Resignation; Removal</U>. Any director may resign at any time upon
written notice to the Corporation and such resignation shall take effect upon receipt thereof by the President or Secretary, unless otherwise specified in the resignation. Any or all of the directors may be removed, with or without cause, by the
holders of a majority of the shares of stock outstanding and entitled to vote for the election of directors. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;11.
<U>Vacancies</U>. Unless otherwise provided in these Bylaws, vacancies on the Board of Directors, whether caused by resignation, death, disqualification, removal, an increase in the authorized number of directors or otherwise, may be filled by the
affirmative vote of a majority of the remaining directors, although less than a quorum, or by a sole remaining director, or at a special meeting of the stockholders, by the holders of shares entitled to vote for the election of directors. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;12. <U>Action by Written Consent</U>. Any action required or permitted to be taken at any meeting of the Board of Directors may
be taken without a meeting if all the directors consent thereto in writing, and the writing or writings are filed with the minutes of proceedings of the Board of Directors. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE III </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>COMMITTEES
</B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1. <U>Appointment</U>. From time to time the Board of Directors by a resolution adopted by a majority of the entire
Board of Directors may appoint any committee or committees for any purpose or purposes, to the extent lawful, which shall have powers as shall be determined and specified by the Board of Directors in the resolution of appointment. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2. <U>Procedures, Quorum and Manner of Acting</U>. Each committee shall fix its own rules of procedure, and shall meet where and
as provided by such rules or by resolution of the Board of Directors. Except as otherwise provided by law, the presence of a majority of the then appointed members of a committee shall constitute a quorum for the transaction of business by that
committee, and in every case where a quorum is present the affirmative vote of a majority of the members of the committee present shall be the act of the committee. Each committee shall keep minutes of its proceedings, and actions taken by a
committee shall be reported to the Board of Directors. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3. <U>Action by Written Consent</U>. Any action required or permitted
to be taken at any meeting of any committee of the Board of Directors may be taken without a meeting if all the members of the committee consent thereto in writing, and the writing or writings are filed with the minutes of proceedings of the
committee. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4. <U>Term; Termination</U>. In the event any person shall cease to be a director of the Corporation, such person
shall simultaneously therewith cease to be a member of any committee appointed by the Board of Directors. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE IV </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>OFFICERS </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1.
<U>Election and Qualifications</U>. The Board of Directors shall elect the officers of the Corporation, which shall include a President and a Secretary, and may include, by election or appointment, one or more Vice Presidents (any one or more of
whom may be given an additional designation of rank or function), a Treasurer and such Assistant Secretaries, such Assistant Treasurers and such other officers as the Board of Directors may from time to time deem proper. Each officer shall have such
powers and duties as may be prescribed by these Bylaws and as may be assigned by the Board of Directors or the President. Any two or more offices may be held by the same person. The Chairman of the Board of Directors, if one is appointed, shall, if
present, preside at all meetings of the stockholders. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2. <U>Term of Office and Remuneration</U>. All officers shall hold
office until their successors are elected and qualified. Any vacancy in any office arising from any cause may be filled for the unexpired portion of the term by the Board of Directors. The remuneration of all officers of the Corporation may be fixed
by the Board of Directors or in such manner as the Board of Directors shall provide. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3. <U>Resignation; Removal</U>. Any officer may resign at any time upon written
notice to the Corporation and such resignation shall take effect upon receipt thereof by the President or Secretary, unless otherwise specified in the resignation. Any officer shall be subject to removal, with or without cause, at any time by vote
of a majority of the entire Board of Directors. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4. <U>President</U>. The President shall, subject to control of the Board of
Directors, have direction and control of the business and officers of the Corporation, shall have the general powers and duties of management usually vested in the president of a corporation, and shall have such other powers and duties as may from
time to time be assigned by the Board of Directors. The President may appoint and remove assistant officers and other agents and employees; and may execute and deliver in the name of the Corporation powers of attorney, contracts, bonds and other
obligations and instruments. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5. <U>Vice President</U>. A Vice President may execute and deliver in the name of the
Corporation contracts and other obligations and instruments pertaining to the regular course of the duties of said office, and shall have such other authority as from time to time may be assigned by the Board of Directors. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6. <U>Treasurer</U>. The Treasurer (if any) shall in general have all duties incident to the position of Treasurer and such other
duties as may be assigned by the Board of Directors. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;7. <U>Secretary</U>. The Secretary shall in general have all the duties
incident to the office of Secretary and such other duties as may be assigned by the Board of Directors. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;8. <U>Other
Officers</U>. Such other officers as the Board of Directors may choose shall perform such duties and have such powers as from time to time may be assigned to them by the Board of Directors. The Board of Directors may delegate to any other officer of
the Corporation the power to choose such other officers and to prescribe their respective duties and powers. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE V </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>BOOKS AND RECORDS </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1. <U>Location</U>. The books and records of the Corporation may be kept at such place or places within or outside the State of
Delaware as the Board of Directors or the respective officers in charge thereof may from time to time determine. The record books containing the names and addresses of all stockholders, the number and class of shares of stock held by each and the
dates when they respectively became the owners of record thereof shall be kept by the Secretary as prescribed in these Bylaws and by such officer or agent as shall be designated by the Board of Directors. </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2. <U>Addresses of Stockholders</U>. Notices of meetings and all other corporate notices may be delivered personally or mailed to
each stockholder at the stockholder&#8217;s address as it appears on the records of the Corporation. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3. <U>Fixing Date for
Determination of Stockholders of Record</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) In order that the Corporation may determine the stockholders entitled to notice of or to
vote at any meeting of stockholders or any adjournment thereof, the Board of Directors may fix a record date, which record date shall not precede the date upon which the resolution fixing the record date is adopted by the Board of Directors and
which record date shall not be more than 60 nor less than 10 days before the date of such meeting. If no record date is fixed by the Board of Directors, the record date for determining stockholders entitled to notice of or to vote at a meeting of
stockholders shall be at the close of business on the day next preceding the day on which notice is given, or, if notice is waived, at the close of business on the day next preceding the day on which the meeting is held. A determination of
stockholders of record entitled to notice of or to vote at a meeting of stockholders shall apply to any adjournment of the meeting; <I>provided, however</I>, that the Board of Directors may fix a new record date for the adjourned meeting. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) In order that the Corporation may determine the stockholders entitled to consent to
corporate action in writing without a meeting, the Board of Directors may fix a record date, which record date shall not precede the date upon which the resolution fixing the record date is adopted by the Board of Directors and if no record date has
been fixed by the Board of Directors, the record date for determining stockholders entitled to consent to corporate action in writing without a meeting, when no prior action by the Board of Directors is required, shall be the first date on which a
signed written consent setting forth the action taken or proposed to be taken is delivered to the Corporation by delivery to its registered office in this State, its principal place of business, or an officer or agent of the Corporation having
custody of the book in which proceedings of meetings of stockholders are recorded. Delivery made to the Corporation&#8217;s registered office shall be by hand or by certified or registered mail, return receipt requested. If no record date has been
fixed by the Board of Directors and prior action by the Board of Directors is required by this article, the record date for determining stockholders entitled to consent to corporate action in writing without a meeting shall be at the close of
business on the day on which the Board of Directors adopts the resolution taking such prior action. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) In order that the Corporation may
determine the stockholders entitled to receive payment of any dividend or other distribution or allotment of any rights or the stockholders entitled to exercise any rights in respect of any change, conversion or exchange of stock, or for the purpose
of any other lawful action, the Board of Directors may fix a record date, which record date shall not precede the date upon which the resolution fixing the record date is adopted and if no record date is fixed, the record date for determining
stockholders for any such purpose shall be at the close of business on the day on which the Board of Directors adopts the resolution relating thereto. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE VI </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>CERTIFICATES
REPRESENTING STOCK </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1. <U>Certificates; Signatures</U>. Unless, to the extent permitted by applicable law, the Board of
Directors has resolved that any series or class of shares of capital stock of the Corporation shall be uncertificated, upon request every holder of shares shall be entitled to have a certificate, signed by or in the name of the Corporation by any
two officers of the Corporation, representing the number of shares registered in such holder&#8217;s name. Any and all signatures on any such certificate may be facsimiles. In case any officer, transfer agent or registrar who has signed or whose
facsimile signature has been placed upon a certificate shall have ceased to be such officer, transfer agent or registrar before such certificate is issued, it may be issued by the Corporation with the same effect as if he were such officer, transfer
agent or registrar at the date of issue. The name of the holder of record of the shares represented thereby, with the number of such shares and the date of issue, shall be entered on the books of the Corporation. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2. <U>Transfers of Stock</U>. Upon compliance with provisions restricting the transfer or registration of transfer of shares of
stock, if any, shares of capital stock shall be transferable on the books of the Corporation only by the holder of record thereof in person, or by a duly authorized attorney, upon surrender and cancellation of certificates for a like number of
shares, properly endorsed, and the payment of all taxes due thereon. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3. <U>Fractional Shares</U>. The Corporation may, but
shall not be required to, issue certificates for fractions of a share where necessary to effect authorized transactions, or the Corporation may pay in cash the fair value of fractions of a share as of the time when those entitled to receive such
fractions are determined, or it may issue scrip in registered or bearer form over the manual or facsimile signature of an officer of the Corporation or of its agent, exchangeable as therein provided for full shares, but such scrip shall not entitle
the holder to any rights of a stockholder except as therein provided. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4. <U>Rules and Regulations</U>. The Board of
Directors shall have power and authority to make all such rules and regulations as it may deem expedient concerning the issue, transfer and registration of certificates representing shares of the Corporation. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5. <U>Lost, Stolen or Destroyed Certificates</U>. The Corporation may issue a new certificate of stock in place of any
certificate, theretofore issued by it, alleged to have been lost, stolen or destroyed, and the Board of Directors may require the owner of any lost, stolen or destroyed certificate, or his legal representative, to give the Corporation a bond
sufficient to indemnify the Corporation against any claim that may be made against it on account of the alleged loss, theft or destruction of any such certificate or the issuance of any such new certificate. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE VII </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>DIVIDENDS </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Subject always
to the provisions of applicable law and the Certificate of Incorporation, the Board of Directors shall have full power to determine whether any, and, if any, what part of any, funds legally available for the payment of dividends shall be declared as
dividends and paid to stockholders; the division of the whole or any part of such funds of the Corporation shall rest wholly within the lawful discretion of the Board of Directors, and it shall not be required at any time, against such discretion,
to divide or pay any part of such funds among or to the stockholders as dividends or otherwise; and before payment of any dividend, there may be set aside out of any funds of the Corporation legally available for dividends such sum or sums as the
Board of Directors from time to time, in its absolute discretion, deems proper as a reserve or reserves to meet contingencies, or for equalizing dividends, or for repairing or maintaining any property of the Corporation, or for such other purpose as
the Board of Directors shall think conducive to the interest of the Corporation, and the Board of Directors may modify or abolish any such reserve in the manner in which it was created. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE VIII </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>RATIFICATION </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Any
transaction, questioned in any lawsuit on the ground of lack of authority, defective or irregular execution, adverse interest of director, officer or stockholder, <FONT STYLE="white-space:nowrap">non-disclosure,</FONT> miscomputation, or the
application of improper principles or practices of accounting, may be ratified before or after judgment, by the Board of Directors or by the stockholders, and if so ratified shall have the same force and effect as if the questioned transaction had
been originally duly authorized. Such ratification shall be binding upon the Corporation and its stockholders and shall constitute a bar to any claim or execution of any judgment in respect of such questioned transaction. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE IX </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>CORPORATE
SEAL </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Corporation may have a corporate seal. The corporate seal shall have inscribed thereon the name of the Corporation and the
year of its incorporation, and shall be in such form and contain such other words and/or figures as the Board of Directors shall determine. The corporate seal may be used by printing, engraving, lithographing, stamping or otherwise making, placing
or affixing, or causing to be printed, engraved, lithographed, stamped or otherwise made, placed or affixed, upon any paper or document, by any process whatsoever, an impression, facsimile or other reproduction of said corporate seal. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE X </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>FISCAL YEAR
</B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The fiscal year of the Corporation shall be fixed, and shall be subject to change, by the Board of Directors. Unless otherwise fixed
by the Board of Directors, the fiscal year of the Corporation shall be the calendar year. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE XI </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>WAIVER OF NOTICE </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Whenever
notice is required to be given by these Bylaws or by the Certificate of Incorporation or by law, a written waiver thereof, signed by the person or persons entitled to such notice, whether before or after the time stated therein, shall be deemed
equivalent to notice. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE XII </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>BANK ACCOUNTS, DRAFTS, CONTRACTS, ETC. </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1. <U>Bank Accounts and Drafts</U>. In addition to such bank accounts as may be authorized by the Board of Directors, the primary
financial officer or any person designated by said primary financial officer or otherwise authorized by the Board of Directors, whether or not an employee of the Corporation, may authorize such bank accounts to be opened or maintained in the name
and on behalf of the Corporation as he may deem necessary or appropriate, payments from such bank accounts to be made upon and according to the check of the Corporation in accordance with the written instructions of said primary financial officer,
or other person so authorized. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2. <U>Contracts</U>. The Board of Directors may authorize any person or persons, in the name
and on behalf of the Corporation, to enter into or execute and deliver any and all deeds, bonds, mortgages, contracts and other obligations or instruments (including powers of attorney), and such authority may be general or confined to specific
instances. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3. <U>Proxies; Powers of Attorney; Other Instruments</U>. The Chairman, the President or any other person
designated by either of them shall have the power and authority to execute and deliver proxies, powers of attorney and other instruments on behalf of the Corporation in connection with the rights and powers incident to the ownership of stock by the
Corporation. The Chairman, the President or any other person authorized by proxy or power of attorney executed and delivered by either of them on behalf of the Corporation may attend and vote at any meeting of stockholders of any company in which
the Corporation may hold stock, and may exercise on behalf of the Corporation any and all of the rights and powers incident to the ownership of such stock at any such meeting, or otherwise as specified in the proxy or power of attorney so
authorizing any such person. The Board of Directors, from time to time, may confer like powers upon any other person. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.
<U>Financial Reports</U>. The Board of Directors may appoint the primary financial officer or other fiscal officer or any other officer to cause to be prepared and furnished to stockholders entitled thereto any special financial notice and/or
financial statement, as the case may be, which may be required by any provision of law. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE XIII </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>INDEMNIFICATION </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1. <U>Indemnification of Directors and Officers</U>. The Corporation shall indemnify and hold harmless, to the fullest extent
permitted by the General Corporation Law of the State of Delaware (the &#8220;<U>DGCL</U>) as it presently exists or may hereafter be amended, any director or officer of the Corporation who was or is made or is threatened to be made a party or is
otherwise involved in any action, suit or proceeding, whether civil, criminal, administrative or investigative (a &#8220;<U>Proceeding</U>&#8221;) by reason of the fact that he or she, or a person for whom he or she is the legal representative, is
or was a director or officer of the Corporation or is or was serving at the request of the Corporation as a director, officer, employee or agent of another corporation or of a partnership, joint venture, trust, enterprise <FONT
STYLE="white-space:nowrap">or&nbsp;non-profit&nbsp;entity,</FONT> including service with respect to employee benefit plans, against all liability and loss suffered and expenses (including attorneys&#8217; fees) reasonably incurred by such person in
connection with any such Proceeding. Notwithstanding the preceding sentence, except as otherwise provided in <U>Article XIII, Section</U><U></U><U>&nbsp;4</U>, the Corporation shall be required to indemnify a person in connection with a Proceeding
initiated by such person only if the Proceeding was authorized in the specific case by the Board of Directors. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.
<U>Indemnification of Others</U>. The Corporation shall have the power to indemnify and hold harmless, to the extent permitted by applicable law as it presently exists or may hereafter be amended, any employee or agent of the Corporation who was or
is made or is threatened to be made a party or is otherwise involved in any Proceeding by reason of the fact that he or she, or a person for whom he or she is the legal representative, is or was an employee or agent of the Corporation or is or was
serving at the request of the Corporation as a director, officer, employee or agent of another corporation or of a partnership, joint venture, trust, enterprise <FONT STYLE="white-space:nowrap">or&nbsp;non-profit&nbsp;entity,</FONT> including
service with respect to employee benefit plans, against all liability and loss suffered and expenses reasonably incurred by such person in connection with any such Proceeding. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3. <U>Prepayment of Expenses</U>. The Corporation shall to the fullest extent not prohibited by applicable law pay the expenses
(including attorneys&#8217; fees) incurred by any officer or director of the Corporation, and may pay the expenses incurred by any employee or agent of the Corporation, in defending any Proceeding in advance of its final disposition; provided,
however, that, to the extent required by law, such payment of expenses in advance of the final disposition of the Proceeding shall be made only upon receipt of an undertaking by the person to repay all amounts advanced if it should be ultimately
determined that the person is not entitled to be indemnified under this <U>Article XIII</U> or otherwise. </P> <P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4. <U>Determination; Claim</U>. If a claim for indemnification (following the
final disposition of such Proceeding) or advancement of expenses under this <U>Article XIII</U> is not paid in full within sixty (60)&nbsp;days after a written claim therefor has been received by the Corporation the claimant may file suit to recover
the unpaid amount of such claim and, if successful in whole or in part, shall be entitled to be paid the expense of prosecuting such claim to the fullest extent permitted by law. In any such action the Corporation shall have the burden of proving
that the claimant was not entitled to the requested indemnification or payment of expenses under applicable law. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5. <U><FONT
STYLE="white-space:nowrap">Non-Exclusivity</FONT> of Rights</U>. The rights conferred on any person by this <U>Article XIII</U> shall not be exclusive of any other rights which such person may have or hereafter acquire under any statute, provision
of the Certificate of Incorporation, these Bylaws, agreement, vote of stockholders or disinterested directors or otherwise. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6. <U>Insurance</U>. The Corporation may purchase and maintain insurance on behalf of any person who is or was a director,
officer, employee or agent of the Corporation, or is or was serving at the request of the Corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust enterprise
<FONT STYLE="white-space:nowrap">or&nbsp;non-profit&nbsp;entity</FONT> against any liability asserted against him or her and incurred by him or her in any such capacity, or arising out of his or her status as such, whether or not the Corporation
would have the power to indemnify him or her against such liability under the provisions of the DGCL. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;7. <U>Other
Indemnification</U>. The Corporation&#8217;s obligation, if any, to indemnify or advance expenses to any person who was or is serving at its request as a director, officer, employee or agent of another corporation, partnership, joint venture, trust,
enterprise <FONT STYLE="white-space:nowrap">or&nbsp;non-profit&nbsp;entity</FONT> shall be reduced by any amount such person may collect as indemnification or advancement of expenses from such other corporation, partnership, joint venture, trust,
enterprise <FONT STYLE="white-space:nowrap">or&nbsp;non-profit&nbsp;enterprise.</FONT> </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;8. <U>Continuation of
Indemnification</U>. The rights to indemnification and to prepayment of expenses provided by, or granted pursuant to, this <U>Article XIII</U> shall continue notwithstanding that the person has ceased to be a director or officer of the Corporation
and shall inure to the benefit of the estate, heirs, executors, administrators, legatees and distributees of such person. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;9.
<U>Amendment or Repeal</U>. The provisions of this <U>Article XIII</U> shall constitute a contract between the Corporation, on the one hand, and, on the other hand, each individual who serves or has served as a director or officer of the Corporation
(whether before or after the adoption of these Bylaws), in consideration of such person&#8217;s performance of such services, and pursuant to this <U>Article XIII </U>the Corporation intends to be legally bound to each such current or former
director or officer of the Corporation. With respect to current and former directors and officers of the Corporation, the rights conferred under this <U>Article XIII</U> are present contractual rights and such rights are fully vested, and shall be
deemed to have vested fully, immediately upon adoption of theses Bylaws. With respect to any directors or officers of the Corporation who commence service following adoption of these Bylaws, the rights conferred under this provision shall be present
contractual rights and such rights shall fully vest, and be deemed to have vested fully, immediately upon such director or officer commencing service as a director or officer of the Corporation. Any repeal or modification of the foregoing provisions
of this <U>Article XIII</U> shall not adversely affect any right or protection (i)&nbsp;hereunder of any person in respect of any act or omission occurring prior to the time of such repeal or modification or (ii)&nbsp;under any agreement providing
for indemnification or advancement of expenses to an officer or director of the Corporation in effect prior to the time of such repeal or modification. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE XIV </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>AMENDMENTS
</B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Subject to the limitations set forth in <U>Article XIII, Section</U><U></U><U>&nbsp;9</U>, the Board of Directors shall have the
power to adopt, amend or repeal these Bylaws. Bylaws adopted by the Board of Directors may be repealed or changed, and new Bylaws made, by the stockholders, and the stockholders may prescribe that any Bylaw made by them shall not be altered, amended
or repealed by the Board of Directors. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B><U>Annex IV </U></B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><U>CONTINGENT VALUE RIGHTS AGREEMENT </U></P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>CONTINGENT VALUE RIGHTS AGREEMENT </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">This CONTINGENT VALUE RIGHTS AGREEMENT, dated as of [&#149;], 2025 (this &#8220;<U>Agreement</U>&#8221;), is entered into by and among Eli
Lilly and Company, an Indiana corporation (&#8220;<U>Parent</U>&#8221;), and [&#149;], a [&#149;], as Rights Agent (as defined herein). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>RECITALS </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">WHEREAS,
Parent, Flying Tigers Acquisition Corporation, a Delaware corporation and direct wholly owned subsidiary of Parent (&#8220;<U>Purchaser</U>&#8221;) and Adverum Biotechnologies, Inc., a Delaware corporation (the &#8220;<U>Company</U>&#8221;), have
entered into an Agreement and Plan of Merger, dated as of October&nbsp;24, 2025 (as it may be amended, supplemented or otherwise modified from time to time pursuant to the terms thereof, the &#8220;<U>Merger Agreement</U>&#8221;), pursuant to which
Purchaser (a)&nbsp;has made a tender offer (the &#8220;<U>Offer</U>&#8221;) to acquire all of the issued and outstanding shares of common stock, par value $0.0001 per share, of the Company (&#8220;<U>Company Common Stock</U>&#8221;) and
(b)&nbsp;following the acceptance of the shares of Company Common Stock pursuant to the Offer, will merge with and into the Company (the &#8220;<U>Merger</U>&#8221;), with the Company surviving the Merger as a subsidiary of Parent; and </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">WHEREAS, as an integral part of the consideration of the Offer and the Merger, pursuant to and subject to the terms and conditions of the
Merger Agreement, (a)&nbsp;holders of Company Common Stock (other than any shares of Company Common Stock described in Section&nbsp;3.1(b) of the Merger Agreement and Dissenting Shares), (b) holders of Company RSUs, (c)&nbsp;holders of Company PSUs,
(d)&nbsp;holders of Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock Options and (e)&nbsp;holders of Warrants (other than Warrants that have an exercise price that equals or exceeds the Merger Consideration and accordingly shall be
cancelled as of Closing for no consideration in accordance with the terms of the Merger Agreement), in each case, as of immediately prior to the Effective Time (any such holders described in the immediately foregoing <U>clauses (a)</U>&nbsp;through
<U>(e)</U>, the &#8220;<U>Initial Holders</U>&#8221;), will become entitled to receive up to two contingent cash payments, each such payment being contingent upon, and subject to, the achievement of the applicable Milestone (as defined below) prior
to the earlier of the applicable Milestone Expiration (as defined below) and Termination (as defined below), subject to and in accordance with the terms of this Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">NOW, THEREFORE, in consideration of the foregoing and the consummation of the transactions referred to above, the parties agree, for the equal
and proportionate benefit of all Holders (as defined herein), as follows: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman" ALIGN="center">ARTICLE I </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>DEFINITIONS; CERTAIN RULES OF CONSTRUCTION </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1.1. <U>Definitions</U>. Capitalized terms used but not defined herein shall have the meaning assigned to such terms in the
Merger Agreement. As used in this Agreement, the following terms will have the following meanings: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Acting Holders</U>&#8221;
means, at the time of determination, Holders of not less than twenty percent (20%) of outstanding CVRs as set forth in the CVR Register. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Agreement</U>&#8221; has the meaning set forth in the preamble hereto. </P>
<P STYLE="font-size:18pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Assignee</U>&#8221; has the meaning set forth in
<U>Section</U><U></U><U>&nbsp;6.3</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Audit Expiration Date</U>&#8221; has the meaning set forth in
<U>Section</U><U></U><U>&nbsp;3.4</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Change of Control</U>&#8221; means (a)&nbsp;a sale or other disposition of all or
substantially all of the assets of Parent on a consolidated basis (other than to any Subsidiary (direct or indirect) of Parent), (b) a merger or consolidation involving Parent in which Parent is not the surviving entity, and (c)&nbsp;any other
transaction involving Parent in which Parent is the surviving or continuing entity but in which the stockholders of Parent immediately prior to such transaction (as stockholders of Parent) own less than fifty percent (50%) of Parent&#8217;s voting
power immediately after the transaction. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Combination CVR Product</U>&#8221; means (a)&nbsp;any single product comprising both
(i)&nbsp;the CVR Product and (ii)&nbsp;one or more other compounds, moieties or substances that are not a CVR Compound, including any such compounds, moieties or substances that are conjugated, <FONT STYLE="white-space:nowrap">co-formulated,</FONT> <FONT
STYLE="white-space:nowrap">co-packaged</FONT> with such CVR Compound wherein (i)&nbsp;and (ii) are sold either as a fixed dose or as separate doses in a single package; (b)&nbsp;any CVR Product sold together with one (1)&nbsp;or more other therapies
or products that are not CVR Products for a single invoice price, whether sold in a single package for a single price or as separately packaged products invoiced for a single price; or (c)&nbsp;any CVR Product sold as part of a bundle with one
(1)&nbsp;or more other therapies or products that are not CVR Products, where the sale of the CVR Product is only available from the seller with the purchase of such other therapies or products, for a single invoice price, to the extent not
described in clause (a)&nbsp;or (b). The CVR Compound portion of any Combination Product will be deemed the &#8220;CVR Component&#8221; and the other portion of such Combination Product will be deemed the &#8220;Other Component,&#8221; and each
Combination Product will be deemed a CVR Product hereunder. For clarity, the <FONT STYLE="white-space:nowrap">co-administration</FONT> of separate products comprising a CVR Product containing a CVR Compound and no Other Component, on the one hand,
with another therapy or pharmaceutically active compound or substance on the other hand will either be (A)&nbsp;a Combination Product, if sold together as reflected in clause (b)&nbsp;or (c) or (B)&nbsp;two (2) separate products, one (1)&nbsp;a CVR
Product and the other, a product that does not generate Net Sales under this Agreement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Commercially Reasonable
Efforts</U>&#8221; means that level of efforts, expertise and resources commonly applied by Parent to carry out a particular task or obligation, consistent with the general practice followed by Parent relating to other pharmaceutical compounds,
products or therapies owned by it, or to which it has exclusive rights, which are of similar market potential at a similar stage in their development or product life, taking into account all relevant factors, including issues of safety and efficacy;
product profile; the expected probability of technical success of the applicable compound, product or therapy; the progress and outcome of any development efforts with respect to the applicable compound, product or therapy; the competitiveness of
other compounds, products or therapies in development and in the marketplace (including other compounds, products and therapies that are being developed or commercialized by or on behalf of Parent or its Affiliates); supply chain management
considerations; the proprietary position of the compound, product or therapy (including with respect to patent or regulatory exclusivity); the regulatory structure involved; the expected cost and profitability of the applicable compound, product or
therapy (including pricing and reimbursement status achieved or expected to be achieved and including the obligation to make Milestone Payments under this Agreement); and other relevant commercial, technical, legal, scientific or medical factors.
Parent and Company agree that (i)&nbsp;the level of efforts that constitute Commercially Reasonable Efforts may change over </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-2- </P>

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time, reflecting changes in the status of a product, compound or therapy, (ii)&nbsp;the use of Commercially Reasonable Efforts may result in Parent and its Affiliates ceasing the research,
development, commercialization or other exploitation of a particular compound, product or therapy (in whole or in part), (iii) the use of Commercially Reasonable Efforts does not require that Parent or its Affiliates to act in a manner which would
otherwise be contrary to prudent business judgment, including business judgment as exercised in Parent&#8217;s or Affiliate&#8217;s ordinary course of business, and (iv)&nbsp;once research, development, commercialization or other exploitation for a
particular compound, product or therapy has ceased in compliance with this Agreement, the use of Commercially Reasonable Efforts does not require the continued reevaluation of whether development, commercialization or exploitation must be
reinitiated for such compound, product or therapy. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Company</U>&#8221; has the meaning set forth in the Recitals hereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Company Common Stock</U>&#8221; has the meaning set forth in the Recitals hereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>CVR Compound</U>&#8221; means the product candidate referred to as ixoberogene soroparvovec, formerly referred to as <FONT
STYLE="white-space:nowrap">ADVM-022.</FONT> </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>CVR Product</U>&#8221; means any pharmaceutical product that contains or
incorporates the CVR Compound, alone or in combination with one (1)&nbsp;or more other therapeutically active ingredients, including all formulations, dosages, or modes of delivery thereof. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>CVR Register</U>&#8221; has the meaning set forth in <U>Section</U><U></U><U>&nbsp;2.3(b)</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>CVRs</U>&#8221; means the rights of Holders hereunder (granted to Initial Holders as part of the consideration of the Offer and the
Merger pursuant to the terms of the Merger Agreement) to receive contingent cash payments on the terms and subject to the conditions of this Agreement and the Merger Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Depositary</U>&#8221; means [&#149;], or any successor thereto appointed pursuant to the [Paying Agent Agreement, dated [&#149;],
2025, by and among Parent and [&#149;], as may be amended from time to time]. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>DTC</U>&#8221; means The Depository Trust Company
or any successor thereto. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Equity Award CVR</U>&#8221; means a CVR received by an Initial Holder in respect of Company <FONT
STYLE="white-space:nowrap">Cash-Out</FONT> Stock Options, Company RSUs, or Company PSUs. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Final Determination</U>&#8221; means
with respect to (a)&nbsp;U.S. federal income Taxes, a &#8220;determination&#8221; within the meaning of Section&nbsp;1313(a) of the Code or execution of an Internal Revenue Service Form <FONT STYLE="white-space:nowrap">870-AD</FONT> and
(b)&nbsp;Taxes other than U.S. federal income Taxes, any final determination of liability in respect of a Tax that, under applicable Law, is not subject to further appeal, review or modification through proceedings or otherwise (including the
expiration of a statute of limitations or a period for the filing of claims for refunds, amended returns or appeals from adverse determinations). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>First Milestone</U>&#8221; means receipt of Regulatory Approval in the United States for a CVR Product for the treatment of wet <FONT
STYLE="white-space:nowrap">age-related</FONT> macular degeneration. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-3- </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>First Milestone Expiration</U>&#8221; means 12:00 a.m. New York City Time on the
seventh (7<SUP STYLE="font-size:75%; vertical-align:top">th</SUP>) anniversary of the Closing Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>First Milestone
Payment</U>&#8221; means (a)&nbsp;if the First Milestone is achieved before both (i)&nbsp;the First Milestone Expiration and (ii)&nbsp;Termination, an amount equal to $1.78 <U>minus</U> any Milestone Offset Amount (if any), in cash, without
interest, per CVR, and (b)&nbsp;if the First Milestone is achieved at or after (i)&nbsp;the First Milestone Expiration and (ii)&nbsp;Termination, $0 per CVR. For the avoidance of doubt, the First Milestone Payment shall only be due once, if at all,
subject to the achievement of the First Milestone prior to the earlier of the First Milestone Expiration and Termination. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Funds</U>&#8221; has the meaning set forth in <U>Section</U><U></U><U>&nbsp;2.6</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Generic Product</U>&#8221; means any biologic or pharmaceutical product that is sold by a Third Party (other than a (sub)licensee of
Parent or any of its Affiliates) and that is approved for marketing or sale by a Regulatory Authority as a generic, biosimilar, or interchangeable biological version of a CVR Product, whether or not such Regulatory Approval was based upon clinical
data generated or owned by Parent, its Affiliates, or their (sub)licensees or was obtained using an abbreviated, expedited or other process in reliance, in whole or in part, on the prior approval (or on safety or efficacy data submitted in support
of the prior approval) of a CVR Product, including any such product that is authorized for sale (i)&nbsp;in the U.S. pursuant to Sections 505(j) or 505(b)(2) of the FD&amp;C Act (21 U.S.C. &#167;&#167;&nbsp;355(j), 355(b)(2)) or Section&nbsp;351(k)
of the Public Health Service Act (42 U.S.C. &#167; 262(k)); (ii)&nbsp;in the European Union pursuant to a provision of Articles 10, 10a or 10b of Parliament and Council Directive 2001/83/EC as amended (including an application under Article 6.1 of
Parliament and Council Regulation (EC) No 726/2004 that relies for its content on any such provision); or (iii)&nbsp;any similar laws of any other country or regulatory jurisdiction. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Holder</U>&#8221; means a Person in whose name a CVR is registered in the CVR Register as of the applicable date and time of
determination. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Initial Holders</U>&#8221; has the meaning set forth in the Recitals hereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>IRS</U>&#8221; means the Internal Revenue Service. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Licensee</U>&#8221; means a Third Party that is granted a license or sublicense to research, develop, manufacture, commercialize, or
otherwise exploit a CVR Product, beyond the mere right to purchase a CVR Product from Parent and its Affiliates, and excludes (i)&nbsp;Parent&#8217;s Affiliates or Third Party subcontractors that act solely for Parent or its Affiliates in the supply
chain or that perform discrete services (as opposed to being granted broad rights or responsibilities) on behalf of Parent or its Affiliates and (ii)&nbsp;any Third Party to which Parent has granted such license or sublicense as a result of a
Generic Product litigation settlement or a compulsory license. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Merger</U>&#8221; has the meaning set forth in the Recitals
hereto. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Merger Agreement</U>&#8221; has the meaning set forth in the Recitals hereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Milestone(s)</U>&#8221; means each of the First Milestone and the Second Milestone. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Milestone Expiration</U>&#8221; means, as applicable, (a)&nbsp;with respect to the
First Milestone, the First Milestone Expiration and (b)&nbsp;with respect to the Second Milestone, the Second Milestone Expiration. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Milestone Notice</U>&#8221; has the meaning set forth in <U>Section</U><U></U><U>&nbsp;2.4(a)</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Milestone Offset Amount</U>&#8221; means an amount equal to (a)&nbsp;fifty percent (50%) of any payments that Parent or any of its
Affiliates or their respective successors or permitted assigns makes or is obligated to make in exchange for any license to, or other right to use or practice, any Necessary IP <U>divided by</U> (b)&nbsp;the total number of CVRs held by all Holders
as reflected on the CVR Register as of the close of business on the date of the Milestone Notice; <U>provided</U> that the Milestone Offset Amount shall in no event exceed $0.50.<B><I> </I></B> </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Milestone Payment</U>&#8221; means, as applicable, (a)&nbsp;with respect to the First Milestone, the First Milestone Payment and
(b)&nbsp;with respect to the Second Milestone, the Second Milestone Payment. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Milestone Payment Amount</U>&#8221; means, for a
given Holder, the product of (a)&nbsp;the applicable Milestone Payment and (b)&nbsp;the number of CVRs held by such Holder as reflected on the CVR Register as of the close of business on the date of the applicable Milestone Notice. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Milestone Payment Date</U>&#8221; has the meaning set forth in <U>Section</U><U></U><U>&nbsp;2.4(a)</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Necessary IP</U>&#8221; means any Intellectual Property that is licensed to Parent or its Subsidiaries following the Closing Date
and that is necessary or reasonably useful to develop, manufacture or commercialize a CVR Product.<B><I> </I></B> </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Net
Sales</U>&#8221; means, with respect to a CVR Product, the gross amount received by Parent or its Affiliates or its and their Licensees to unrelated Third Parties, excluding any other Licensee, for such CVR Product, less: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) trade, quantity and cash discounts allowed; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) discounts, refunds, rebates, chargebacks, retroactive price adjustments, and any other allowances that effectively reduce the net selling
price; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) CVR Product returns and allowances; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) that portion of the sales value associated with drug delivery devices; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) (i) any tax imposed on the production, sale, delivery or use of a CVR Product, including sales, use, excise or value added taxes, or the
annual fee imposed on the pharmaceutical manufacturers by the U.S. government, or (ii)&nbsp;customs, duties, fees and taxes on the import of a CVR Product or any drug product and other raw materials used in the manufacture of finished CVR Product;
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(f) wholesaler inventory management fees; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(g) allowance for distribution expenses; and </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(i) any other similar and customary deductions which are in accordance with GAAP. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Such amounts will be determined from the books and records of Parent or its applicable Affiliate or Licensee, maintained in accordance with
GAAP or, in the case of Licensees, such similar accounting principles, consistently applied. Parent further agrees that in determining such amounts, it will use Parent&#8217;s then-current standard procedures and methodology, including
Parent&#8217;s then-current standard exchange rate methodology for the translation of foreign currency sales into US Dollars or, in the case of Licensees, such similar methodology, consistently applied. Without limiting the generality of the
foregoing, Net Sales exclude: (i)&nbsp;transfers of CVR Product to Third Parties as bona fide samples, as donations, for the performance of clinical trials or for similar purposes in accordance with applicable Law pertaining to any expanded access
program, any compassionate sales or use program (including named patient program or single patient program) or any indigent program, (ii)&nbsp;intercompany transfer to an Affiliate of Parent or between such entities and a Licensee; <U>provided</U>
that subsequent sale to an unaffiliated Third Party by such Affiliate or Licensee is not considered an intercompany transfer, and (iii)&nbsp;similar <FONT STYLE="white-space:nowrap">non-commercial</FONT> sales for nominal or no consideration. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If Parent or any of its Affiliate or Licensees sells the CVR Product as a CVR Component of a Combination CVR Product in a country in the
Territory in any Calendar Quarter, then Net Sales for the purposes of determining Milestone Payments will be calculated by multiplying the Net Sales of the Combination CVR Product during such Calendar Quarter by the fraction A / (A+B), where A is
the weighted average sale price of the CVR Component when sold separately in such country in such Calendar Quarter and B is the weighted average sale price of the Other Component(s) included in the Combination CVR Product when sold separately in
such country in such Calendar Quarter. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">In the event that the weighted average sale price of the CVR Component of a Combination CVR
Product in a country can be determined but the weighted average sale price of the Other Component(s) cannot be determined, Net Sales for the purposes of determining Milestone Payments will be calculated by multiplying the Net Sales of the
Combination CVR Product in such country by the fraction A / C, where A is the weighted average sale price of the CVR Component when sold separately in finished form in such country and C is the weighted average sale price of the Combination CVR
Product in such country. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">In the event that the weighted average sale price of the Other Component(s) in such country can be determined
but the weighted average sale price of the CVR Component in such country cannot be determined, Net Sales for purposes of determining Milestone Payments will be calculated by multiplying the Net Sales of the Combination CVR Product by the following
formula: one (1)<U>&nbsp;minus</U> (B / C), where B is the weighted average sale price of the Other Component(s) when sold separately in finished form in such country and C is the weighted average sale price of the Combination CVR Product in such
country. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">In the event that the weighted average sale price of both the CVR Component and the Other Component(s) in the Combination CVR
Product cannot be determined, then the percentage of Net Sales attributable to the CVR Component will be determined in good faith by Parent. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-6- </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The weighted average sale price for a CVR Component, Other Component(s), or Combination CVR
Product in a country will be calculated once each Calendar Year and such price will be used during all applicable Milestone reporting periods for the entire following Calendar Year. When determining the weighted average sale price of a CVR
Component, Other Component(s), or Combination CVR Product in a country, the weighted average sale price will be calculated by dividing the sales in US Dollars (translated into US Dollars) by the units of active ingredient sold during the twelve
(12)&nbsp;months (or the number of months sold in a partial Calendar Year) of the preceding Calendar Year for the respective CVR Component, Other Component(s), or Combination CVR Product in a country. In the initial Calendar Year, a forecasted
weighted average sale price will be used for the CVR Component, Other Component(s), or Combination CVR Product. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Offer</U>&#8221; has the meaning set forth in the Recitals hereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Officer&#8217;s Certificate</U>&#8221; means a certificate signed by an authorized officer of Parent, in his or her capacity as such
an officer, and delivered to the Rights Agent. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Parent</U>&#8221; has the meaning set forth in the preamble hereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Permitted CVR Transfer</U>&#8221; means a transfer of CVRs: (a)&nbsp;by will or intestacy upon death of a Holder; (b)&nbsp;by
instrument to an<I> inter vivos</I> or testamentary trust in which the CVRs are to be passed to beneficiaries upon the death of the settlor; (c)&nbsp;pursuant to a court order; (d)&nbsp;by operation of law (including by consolidation or merger of
the Holder) or if effectuated without consideration in connection with the dissolution, liquidation or termination of any Holder that is a corporation, limited liability company, partnership or other entity; (e)&nbsp;in the case of CVRs held in
book-entry or other similar nominee form, from a nominee to a beneficial owner, and if applicable, through an intermediary; (f)&nbsp;if the Holder is a partnership or limited liability company, a distribution by the transferring partnership or
limited liability company to its partners or members, as applicable (<U>provided</U> that such distribution does not subject the CVRs to a requirement of registration under the Securities Act of 1933, as amended, or the Securities Exchange Act of
1934, as amended); or (g)&nbsp;as provided in <U>Section</U><U></U><U>&nbsp;2.7</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Purchaser</U>&#8221; has the meaning set
forth in the recitals hereto. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Regulatory Approval</U>&#8221; means, with respect to a particular country or other regulatory
jurisdiction, the approvals from the necessary Regulatory Authority to import, export, market, promote, distribute, and sell a pharmaceutical or biologic product in such country or region, including pricing approvals and reimbursement approvals that
are necessary for the commercial sale of a pharmaceutical or biologic product in a given country or regulatory jurisdiction. For clarity, in the United States, Regulatory Approval includes any approval of a Biologics License Application (as defined
in 42 U.S.C. &#167; 262) or New Drug Application (as defined in 21 CFR 314.50, et seq.). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Rights Agent</U>&#8221; means the
Rights Agent named in the preamble of this Agreement, until a successor Rights Agent is appointed pursuant to the applicable provisions of this Agreement, and thereafter &#8220;Rights Agent&#8221; will mean such successor Rights Agent. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Rights Agent Account</U>&#8221; has the meaning set forth in <U>Section</U><U></U><U>&nbsp;2.4(a)</U>. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-7- </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Second Milestone</U>&#8221; means the event in which annual worldwide Net Sales of
the CVR Product sold by Parent or its Affiliates or Licensees first exceed One Billion Dollars ($1,000,000,000). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Second
Milestone Expiration</U>&#8221; means the tenth (10<SUP STYLE="font-size:75%; vertical-align:top">th</SUP>) anniversary of the Closing Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Second Milestone Payment</U>&#8221; means (a)&nbsp;if the Second Milestone is achieved before both (i)&nbsp;the Second Milestone
Expiration and (ii)&nbsp;Termination, an amount equal to $7.13 <U>minus</U> any Milestone Offset Amount (if any and to the extent not deducted from the First Milestone Payment), in cash, without interest, per CVR, and (b)&nbsp;if the Second
Milestone is achieved at or after (i)&nbsp;the Second Milestone Expiration or (ii)&nbsp;Termination, $0 per CVR. For the avoidance of doubt, the Second Milestone Payment shall only be due once, if at all, subject to the achievement of the Second
Milestone prior to the earlier of the Second Milestone Expiration and Termination. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;<U>Termination</U>&#8221; has the meaning set
forth in <U>Section</U><U></U><U>&nbsp;6.8</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1.2. <U>Rules of Construction</U>. When reference is made in this Agreement
to an Article, Section or Exhibit, such reference will refer to Articles and Sections of, and Exhibits to, this Agreement unless otherwise indicated. The word &#8220;extent&#8221; in the phrase &#8220;to the extent&#8221; shall mean the degree to
which a subject or other thing extends, and such phrase shall not mean simply &#8220;if.&#8221; All references to &#8220;dollars&#8221; or &#8220;$&#8221; shall refer to the lawful currency of the United States. Whenever the words
&#8220;include,&#8221; &#8220;includes,&#8221; or &#8220;including&#8221; are used in this Agreement, they will be deemed to be followed by the words &#8220;without limitation.&#8221; The words &#8220;hereof,&#8221; &#8220;herein,&#8221;
&#8220;hereby,&#8221; &#8220;hereto,&#8221; and &#8220;hereunder&#8221; and words of similar import when used in this Agreement will refer to this Agreement as a whole and not to any particular provision of this Agreement. The word &#8220;or&#8221;
will not be exclusive. The word &#8220;will&#8221; shall be construed to have the same meaning and effect as the word &#8220;shall.&#8221; Whenever used in this Agreement, any noun or pronoun will be deemed to include the plural as well as the
singular and to cover all genders. Any reference to any Person shall be construed to include such Person&#8217;s successors and assigns. The words &#8220;ordinary course of business&#8221; shall mean the ordinary course of business consistent with
past practice. This Agreement will be construed without regard to any presumption or rule requiring construction or interpretation against the party drafting or causing any instrument to be drafted. The parties hereto have participated jointly in
the negotiation and drafting of this Agreement and, in the event an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as jointly drafted by the parties hereto and no presumption of burden of proof shall
arise favoring or disfavoring any party by virtue of the authorship of this Agreement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">ARTICLE II </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">CONTINGENT VALUE RIGHTS </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.1. <U>CVRs</U>. Each CVR represents the contractual right of a Holder (granted to each Initial Holder as part of the
consideration of the Offer and the Merger pursuant to the terms of the Merger Agreement) to receive the Milestone Payments pursuant to, and subject to the terms and conditions of, this Agreement. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.2. <U>Nontransferable</U>. The CVRs shall not be sold, assigned, transferred,
pledged, encumbered or in any other manner transferred or disposed of, in whole or in part, other than through a Permitted CVR Transfer; the foregoing restrictions shall apply notwithstanding that certain of the CVRs will be held through DTC. Any
attempted sale, assignment, transfer, pledge, encumbrance or disposition of CVRs, in whole or in part, in violation of this <U>Section</U><U></U><U>&nbsp;2.2</U> shall be void ab initio and of no effect. The CVRs will not be listed on any quotation
system or traded on any securities exchange. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.3. <U>No Certificate; Registration; Registration of Transfer; Change of
Address</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) The CVRs will not be evidenced by a certificate or other instrument. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) The Rights Agent will create and maintain a register (the &#8220;<U>CVR Register</U>&#8221;) for the purpose of (i)&nbsp;identifying the
Holders of CVRs and (ii)&nbsp;registering CVRs in book-entry position and Permitted CVR Transfers thereof. The CVR Register shall set forth (x)&nbsp;with respect to holders of Company Common Stock that hold such shares in book-entry form through DTC
immediately prior to the Effective Time, one (1)&nbsp;position for Cede&nbsp;&amp; Co. (as nominee of DTC) representing all such shares of Company Common Stock that were tendered in the Offer or converted into the right to receive the Offer Price as
a consequence of the Merger in accordance with the terms of the Merger Agreement, and (y)&nbsp;with respect to (A)&nbsp;holders of shares of Company Common Stock that hold such shares in certificated form immediately prior to the Effective Time that
were tendered in the Offer or converted into the right to receive the Offer Price as a consequence of the Merger in accordance with the terms of the Merger Agreement, upon delivery to the Depositary by each such holder of the applicable stock
certificates, together with a validly executed letter of transmittal and such other customary documents as may be reasonably requested by the Depositary, in accordance with the Merger Agreement, (B)&nbsp;holders of shares of Company Common Stock
that hold such shares in book-entry form through the Company&#8217;s transfer agent immediately prior to Effective Time, (C)&nbsp;holders of Company RSUs, (D)&nbsp;holders of Company PSUs, (E)&nbsp;holders of Company
<FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock Options and (F)&nbsp;holders of Warrants (other than Warrants that have an exercise price that equals or exceeds the Merger Consideration and accordingly shall be cancelled as of Closing for no
consideration in accordance with the terms of the Merger Agreement)], in each case of <U>clauses (A)</U>, through <U>(F)</U>, the applicable number of CVRs to which each such holder is entitled pursuant to the Merger Agreement (other than, in the
case of the foregoing clauses (x), (y)(A) and (y)(B), those who have perfected their appraisal rights in accordance with Section&nbsp;262 of the General Corporation Law of the State of Delaware). The CVR Register will be updated as necessary by the
Rights Agent to reflect the addition or removal of Holders (pursuant to any Permitted Transfers), upon the written receipt of such information by the Rights Agent. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Subject to the restrictions on transferability set forth in <U>Section</U><U></U><U>&nbsp;2.2</U>, every request made to transfer a CVR
must be in writing and accompanied by a written instrument of transfer, in form reasonably satisfactory to the Rights Agent pursuant to its guidelines, duly executed by the Holder thereof, the Holder&#8217;s attorney duly authorized in writing, the
Holder&#8217;s personal representative duly authorized in writing, or the Holder&#8217;s survivor (with written documentation evidencing such person&#8217;s status as the Holder&#8217;s survivor), and setting forth in reasonable detail the
circumstances relating to the requested transfer. Upon receipt of such written notice, the Rights Agent will, subject to its reasonable determination that the transfer instrument is in proper form and the transfer otherwise complies with the other
terms and conditions of this Agreement (including the provisions of <U>Section</U><U></U><U>&nbsp;2.2</U>), register the transfer of the CVRs in the CVR Register. As a condition of such transfer, Parent and the Rights Agent may require a
transferring Holder or </P>
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its transferee to pay to the applicable Governmental Body any transfer, stamp or other similar Tax or governmental charge that is imposed in connection with any such registration of transfer. The
Rights Agent shall have no duty or obligation to take any action under any section of this Agreement that requires the payment by a Holder of a CVR of such applicable Taxes or charges unless and until the Rights Agent is reasonably satisfied that
all such Taxes or charges have been paid or that such Taxes or charges are not applicable. All CVRs duly transferred in accordance with <U>Section</U><U></U><U>&nbsp;2.2</U> that are registered in the CVR Register will be the valid obligations of
Parent and will entitle the transferee to the same benefits and rights under this Agreement as those held immediately prior to the transfer by the transferor. No transfer of a CVR will be valid until registered in the CVR Register in accordance with
this Agreement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) A Holder may make a written request to the Rights Agent to change such Holder&#8217;s address of record in the CVR
Register. The written request must be duly executed by the Holder. Upon receipt of such written notice, the Rights Agent will promptly record the change of address in the CVR Register. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.4. <U>Payment Procedures; Notices</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) If a Milestone is achieved prior to both the applicable Milestone Expiration and before Termination, then (i)&nbsp;in the case of the
First Milestone, on or prior to the date that is forty-five (45)&nbsp;days following the achievement of such Milestone and (ii)&nbsp;in the case of the Second Milestone, on or prior to the date that is sixty (60)&nbsp;days after the end of the
Parent fiscal year in which such Milestone is achieved (such date, the &#8220;<U>Milestone Payment Date</U>&#8221;), (A) Parent shall deliver to the Rights Agent (x)&nbsp;a written notice indicating that such Milestone has been achieved (the
&#8220;<U>Milestone Notice</U>&#8221;) and an Officer&#8217;s Certificate certifying (1)&nbsp;in the case of the First Milestone, the date of such achievement and (ii)&nbsp;in the case of the Second Milestone, the last day of the Parent fiscal
quarter in which such Milestone was achieved, and that the Holders are entitled to receive such Milestone Payment, (y)&nbsp;any letter of instruction reasonably required by the Rights Agent, which shall set forth the applicable Milestone Payment in
respect of such Milestone as of the date of the applicable Milestone Notice, and (B)&nbsp;Parent shall deliver to the Rights Agent (or to the Surviving Corporation or another of its Affiliates in the case of payments with respect to Equity Award
CVRs, if such payments will not be made by Parent) the payment required by <U>Section</U><U></U><U>&nbsp;4.2</U>, if being delivered to the Rights Agent to the account set forth on <U>Annex I</U> hereto, which account information may be updated from
time to time by the Rights Agent by prior written notice to Parent (the &#8220;<U>Rights Agent Account</U>&#8221;). For the avoidance of doubt, (i)&nbsp;each Milestone Payment will only be due once, if at all, subject to the conditions set forth
herein, (ii)&nbsp;each of the Milestone Payments will become payable upon the first achievement of the associated Milestone, regardless of the number of CVR Products that achieve such Milestone and (iii)&nbsp;no amounts will be due for subsequent or
repeated achievements of any Milestone. For clarity, the achievement of the First Milestone prior to the First Milestone Expiration and before Termination is not a condition to the achievement of the Second Milestone. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) The Rights Agent will promptly, and in any event within ten (10)&nbsp;days<B><I> </I></B>after receipt of a Milestone Notice and the
payment required by <U>Section</U><U></U><U>&nbsp;4.2</U>, as well as any letter of instruction reasonably required by the Rights Agent, send each Holder at its registered address a copy of such Milestone Notice and pay the applicable Milestone
Payment Amount to each Holder (other than a Holder of an Equity Award CVR)&nbsp;(i) by check mailed to the address of each Holder as reflected </P>
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in the CVR Register as of the close of business on the date of such Milestone Notice, or (ii)&nbsp;with respect to any such Holder that is due an amount in excess of $100,000 in the aggregate who
has provided the Rights Agent wiring instructions in writing as of the close of business on the date of such Milestone Notice, by wire transfer of immediately available funds to the account specified on such instruction. Parent will pay, or will
cause the Surviving Corporation or another of its Affiliates to pay, the applicable Milestone Payment Amount to each Holder of an Equity Award CVR within ten (10)&nbsp;days of the delivery of the applicable Milestone Notice to the Rights Agent,
subject to <U>Section</U><U></U><U>&nbsp;2.4(c)</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Parent and its Affiliates (including the Surviving Corporation) and the Rights
Agent shall be entitled to deduct and withhold from any Milestone Payment Amount or any other amounts otherwise payable pursuant to this Agreement such amounts as are required to be deducted and withheld therefrom under applicable Law. With respect
to Initial Holders who received Equity Award CVRs, any such withholding may be made, or caused to be made, by Parent through the Surviving Corporation&#8217;s or its Affiliates&#8217; payroll system or any successor payroll system. Prior to paying
any Milestone Payment Amount to the Holders, the Rights Agent shall provide the opportunity for each Holder to provide a copy of a duly executed IRS Form <FONT STYLE="white-space:nowrap">W-9</FONT> or appropriate IRS Form <FONT
STYLE="white-space:nowrap">W-8,</FONT> as applicable, or any other forms or information that the Rights Agent may reasonably request in order to avoid or reduce any applicable withholding amount. Unless otherwise directed by Parent, the Rights Agent
shall promptly and timely remit, or cause to be remitted, any amounts withheld in respect of Taxes to the appropriate Governmental Body. To the extent any amounts are so deducted and withheld and properly remitted, such amounts shall be treated for
all purposes of this Agreement as having been paid to the person in respect of whom such deduction and withholding was made. The parties intend that each Equity Award CVR is exempt from or in compliance with Section&nbsp;409A of the Code, and this
Agreement shall be interpreted and administered in accordance therewith. Notwithstanding anything to the contrary in this Agreement, no Milestone Payment that constitutes nonqualified deferred compensation subject to Section&nbsp;409A of the Code
shall be allocated or paid in respect of any Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock Option, Company RSU, or Company PSU except to the extent permissible under Treasury Regulation
<FONT STYLE="white-space:nowrap">Section&nbsp;1.409A-3(i)(5)(iv)(A),</FONT> including that no such Milestone Payment that constitutes nonqualified deferred compensation subject to Section&nbsp;409A of the Code shall be allocated or paid in respect
of any Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock Option, Company RSU, or Company PSU following the fifth (5th)&nbsp;anniversary of the Closing Date. None of the parties to this Agreement nor any of their employees, directors or
representatives shall have any liability to a Holder or transferee or other Person in respect of Section&nbsp;409A of the Code. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) Any
portion of a Milestone Payment Amount that remains undistributed six (6)&nbsp;months after the date of the delivery of the applicable Milestone Notice will be delivered by the Rights Agent to Parent, upon demand, and any Holder will thereafter look
only to Parent for payment of the applicable Milestone Payment Amount, without interest, but such Holder will have no greater rights against Parent than those accorded to general unsecured creditors of Parent under applicable Law. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) None of Parent, any of its Affiliates (including the Surviving Corporation) or the
Rights Agent will be liable to any person in respect of any Milestone Payment Amount or portion thereof delivered to a public official pursuant to any applicable abandoned property, escheat or similar Law. If, despite efforts by the Rights Agent to
deliver a Milestone Payment Amount to the applicable Holder pursuant to the Rights Agent&#8217;s customary unclaimed funds procedures, such Milestone Payment Amount has not been paid prior to the two (2)&nbsp;year anniversary of the applicable
Milestone Payment Date (or immediately prior to such earlier date on which such Milestone Payment Amount would otherwise escheat to or become the property of any Governmental Body), such Milestone Payment Amount will, to the extent permitted by
applicable Law, become the property of Parent, free and clear of all claims or interest of any person previously entitled thereto. In addition to and not in limitation of any other indemnity obligation herein, Parent agrees to indemnify and hold
harmless the Rights Agent with respect to any liability, penalty, cost or expense the Rights Agent may incur or be subject to in connection with transferring such property to Parent. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(f) The Rights Agent shall be responsible for information reporting required under applicable Law with respect to the CVRs, including on
Internal Revenue Service Form <FONT STYLE="white-space:nowrap">1099-B</FONT> or other applicable form to the extent required under applicable Law. Parent shall provide the Rights Agent with properly completed &#8220;Standard Tax Reporting
Instructions&#8221; contained in Annex II hereto, and the Parent shall use commercially reasonable efforts to cooperate with the Rights Agent to provide any other information reasonably necessary for the Rights Agent to carry out its obligations in
this <U>Section</U><U></U><U>&nbsp;2.4(f)</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.5. <U>No Voting, Dividends or Interest; No Equity or Ownership Interest in
Parent or any of its Affiliates</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) The CVRs will not have any voting or dividend rights, and interest will not accrue on any
amounts payable on the CVRs to any Holder. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) The CVRs will not represent any equity or ownership interest in Parent, any constituent
corporation party to the Merger Agreement or any of their respective Affiliates or Subsidiaries (including the Surviving Corporation). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) None of Parent or its directors and officers or other Affiliates will be deemed to have any fiduciary or similar duties to any Holder by
virtue of this Agreement or the CVRs. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.6. <U>Holding of Funds</U>. All funds received by the Rights Agent under this
Agreement that are to be distributed or applied by the Rights Agent in the performance of its services hereunder (the &#8220;<U>Funds</U>&#8221;) shall be held by the Rights Agent as agent for Parent and deposited in one or more segregated bank
accounts to be maintained by the Rights Agent in its name as agent for Parent. Until paid pursuant to the terms of this Agreement, the Rights Agent will hold the Funds through such accounts in deposit accounts of commercial banks with Tier 1 capital
exceeding $1&nbsp;billion or with an average rating above investment grade by S&amp;P (LT Local Issuer Credit Rating), Moody&#8217;s (Long Term Rating) and Fitch Ratings, Inc. (LT Issuer Default Rating) (each as reported by Bloomberg Finance L.P.).
The Rights Agent shall keep funds received by it under this Agreement separate on its books and records so that such deposits can be subsequently identified on an individual basis and any such funds shall not be invested by the Rights Agent and
shall not be used for any purpose not expressly provided for this Agreement or the Merger Agreement. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.7. <U>Ability to Abandon CVR</U>. A Holder may at any time, at such
Holder&#8217;s option, abandon all of such Holder&#8217;s remaining rights in a CVR by transferring such CVR to Parent without consideration therefor, which a Holder may effect via delivery of a written abandonment notice to Parent. Nothing in this
Agreement shall prohibit Parent or any of its Affiliates (including the Surviving Corporation) from offering to acquire or acquiring any CVRs for consideration from the Holders, in private transactions or otherwise, in its sole discretion. Any CVRs
acquired by Parent or any of its Affiliates (including the Surviving Corporation) shall be automatically deemed extinguished and no longer outstanding or entitled to any Milestone Payment for purposes of this Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;2.8. <U>Tax Treatment</U>. The parties hereto agree to treat the CVRs (other than the Equity Award CVRs) for all U.S. federal,
and applicable state and local income Tax purposes as (a)&nbsp;except to the extent treated as imputed interest, additional consideration for, or in respect of, the Company Common Stock pursuant to the Merger Agreement, and (b)&nbsp;a &#8220;closed
transaction&#8221; in which the fair market value of the CVRs, as determined by Parent in its sole discretion, is included in income in the taxable year of the Closing, and, in each case, none of the parties hereto will take any position to the
contrary on any Tax Return, any other filing with a Governmental Body related to Taxes or for other Tax purposes except as otherwise required by a Final Determination. Parent, the Surviving Corporation and Rights Agent, as applicable, shall report
imputed interest on the CVRs pursuant to Section&nbsp;483 of the Code, to the extent required by applicable Law and in accordance with properly completed &#8220;Standard Tax Reporting Instructions&#8221; contained in <U>Annex II</U> hereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">ARTICLE III </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">THE RIGHTS AGENT </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.1. <U>No Liability</U>. The Rights Agent will not have any liability for any actions taken or not taken in connection with this
Agreement, except to the extent such liability arises as a result of its willful or intentional misconduct, bad faith, gross negligence or fraud. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.2. <U>Certain Duties and Responsibilities</U>. The Rights Agent shall not have any duty or responsibility in the case of the
receipt of any written demand from any Holder with respect to any action or default by any person or entity, including, without limiting the generality of the foregoing, any duty or responsibility to initiate or attempt to initiate any proceedings
at law or otherwise or to make any demand upon Parent or any of its Affiliates; <U>provided</U> that this <U>Section</U><U></U><U>&nbsp;3.2</U> shall not affect the Rights Agent&#8217;s obligation to make payments in accordance with and subject to
<U>Section</U><U></U><U>&nbsp;2.4</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.3. <U>Certain Rights of the Rights Agent</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Rights Agent undertakes to perform such duties and only such duties as are specifically set forth in this Agreement, and no implied
covenants or obligations will be read into this Agreement against the Rights Agent. In addition: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) the Rights Agent may rely and will
be protected and held harmless by Parent in acting or refraining from acting upon any resolution, certificate, statement, instrument, opinion, report, notice, request, direction, consent, order or other paper or document believed by it in good faith
to be genuine and to have been signed or presented by the proper party or parties; </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) whenever the Rights Agent will deem it desirable that a matter be proved or established
prior to taking, suffering or omitting any action hereunder, the Rights Agent may rely upon an Officer&#8217;s Certificate, which certificate shall be full authorization and protection to the Rights Agent, and the Rights Agent shall, in the absence
of bad faith, gross negligence, fraud or willful or intentional misconduct on its part, incur no liability and be held harmless by Parent for or in respect of any action taken, suffered or omitted to be taken by it under the provisions of this
Agreement in reliance upon such certificate; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) the Rights Agent may engage and consult with counsel of its selection and the written
advice of such counsel or any opinion of counsel will be full and complete authorization and protection to the Rights Agent and the Rights Agent shall be held harmless by Parent in respect of any action taken, suffered or omitted by it hereunder in
good faith and in reliance thereon; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) the permissive rights of the Rights Agent to do things enumerated in this Agreement will not be
construed as a duty; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) the Rights Agent will not be required to give any note or surety in respect of the execution of such powers or
otherwise in respect of the premises; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(f) the Rights Agent shall not be liable for or by reason of, and shall be held harmless by Parent
with respect to, any of the statements of fact or recitals contained in this Agreement or be required to verify the same, but all such statements and recitals are and shall be deemed to have been made by Parent only; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(g) the Rights Agent will have no liability and shall be held harmless by Parent in respect of the validity of this Agreement or the execution
and delivery hereof (except the due execution and delivery hereof by the Rights Agent and the enforceability of this Agreement against the Rights Agent assuming the due execution and delivery hereof by Parent); nor shall it be responsible for any
breach by Parent of any covenant or condition contained in this Agreement; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(h) Parent agrees to indemnify the Rights Agent for, and hold
the Rights Agent harmless against, any loss, liability, claim, demand, suit or expense arising out of or in connection with the Rights Agent&#8217;s performance of its duties under this Agreement (excluding any Taxes, interest, penalties or other
costs or expenses imposed on the payment of fees hereunder), including the reasonable and documented <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">out-of-pocket</FONT></FONT> costs and expenses of defending the Rights Agent
against any claims, charges, demands, suits or loss arising out of or in connection with the execution, administration, exercise and performance of its duties under this Agreement, unless such loss has been determined by a court of competent
jurisdiction to have resulted from the Rights Agent&#8217;s willful or intentional misconduct, bad faith, gross negligence or fraud; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(i)
Parent agrees (i)&nbsp;to pay the reasonable and documented <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">out-of-pocket</FONT></FONT> fees and expenses of the Rights Agent in connection with this Agreement, as agreed upon in
writing by the Rights Agent and Parent on or prior to the date hereof, and (ii)&nbsp;to reimburse the Rights Agent for all Taxes and governmental charges paid or incurred by it in connection with the administration by the Rights Agent of its duties
hereunder (other than Taxes imposed on or measured by the Rights Agent&#8217;s net income and franchise or similar Taxes imposed on it (in lieu of net income Taxes)); <U>provided</U> that, if the Rights Agent determines in good faith that it has
received a refund of any Tax or governmental charge borne by Parent pursuant to this <U>clause (ii)</U>, then the Rights Agent shall promptly repay such refund to Parent; and </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(j) no provision of this Agreement shall require the Rights Agent to expend or risk its own
funds or otherwise incur any financial liability in the performance of any of its duties hereunder or in the exercise of its rights if there shall be reasonable grounds for believing that repayment of such funds or adequate indemnification against
such risk or liability is not reasonably assured to it. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.4. <U>Auditing Rights</U>. From the date of the first commercial
sale of the first CVR Product until the earlier of (a)&nbsp;the achievement of the Second Milestone and (b)&nbsp;the Second Milestone Expiration (such earlier date, the &#8220;<U>Audit Expiration Date</U>&#8221;), Parent shall keep, and shall cause
its Affiliates to keep, reasonable records in the ordinary course of business pursuant to record-keeping procedures normally used by Parent and its Affiliates regarding its activities with respect to achievement of the Second Milestone to verify
whether the Second Milestone Payment is due hereunder. From the date of the first commercial sale of the first CVR Product until the date that is sixty (60)&nbsp;days after the end of the calendar year in which the Second Milestone Expiration
occurs, the Rights Agent shall have the right once per calendar year to have Parent&#8217;s then-current auditors (or if such auditors decline to do so, another independent accounting firm mutually agreeable to Parent and the Rights Agent) inspect
Parent&#8217;s records for the purpose of determining the accuracy of the calculations used to determine whether the Second Milestone was achieved. No period will be audited more than once and each audit must be reasonable in scope. Such auditors
will keep confidential any information obtained during such inspection and will report to the Rights Agent and Parent in writing whether the Second Milestone Payment is due and payable (without disclosing to the Rights Agent any confidential or
commercially sensitive information used or generated by the auditors during the course of the audit). The Rights Agent (on behalf of the Holders) shall bear the full cost of such audit unless such audit determines as a result of such audit that the
Second Milestone Payment was due and payable, in which case, Parent will bear the cost of such audit and will remit in accordance with <U>Section</U><U></U><U>&nbsp;4.2</U> the Second Milestone Payment within thirty (30)&nbsp;days of the date the
auditors&#8217; written report is received. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.5. <U>Resignation and Removal; Appointment of Successor</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) The Rights Agent may resign at any time by giving written notice thereof to Parent specifying a date when such resignation will take
effect, which notice will be sent at least sixty (60)&nbsp;days prior to the date so specified but in no event will such resignation become effective until a successor Rights Agent has been appointed. Parent has the right to remove the Rights Agent
at any time by specifying a date when such removal will take effect and such removal will become effective on the date so specified. Notice of such removal will be given by Parent to the Rights Agent, which notice will be sent at least sixty
(60)&nbsp;days prior to the date so specified. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) If the Rights Agent provides notice of its intent to resign, is removed pursuant to
<U>Section</U><U></U><U>&nbsp;3.5(a)</U> or becomes incapable of acting, Parent will as soon as is reasonably possible, appoint a qualified successor Rights Agent who, unless otherwise consented to in writing by the Acting Holders, shall be a stock
transfer agent of national reputation or the corporate trust department of a commercial bank. The successor Rights Agent so appointed will, forthwith upon its acceptance of such appointment in accordance with <U>Section</U><U></U><U>&nbsp;3.6</U>,
become the successor Rights Agent. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Parent will give notice of each resignation and each removal of a Rights Agent and each
appointment of a successor Rights Agent by mailing written notice of such event by first-class mail to the Holders as their names and addresses appear in the CVR Register. Each notice will include the name and address of the successor Rights Agent.
If Parent fails to send such notice within ten (10)&nbsp;Business Days after acceptance of appointment by a successor Rights Agent in accordance with <U>Section</U><U></U><U>&nbsp;3.6</U>, the successor Rights Agent will cause the notice to be
mailed at the expense of Parent; <U>provided</U> that failure to give any notice provided for in this <U>Section</U><U></U><U>&nbsp;3.5(c)</U>, shall not affect the legality or validity of the resignation or removal of the Rights Agent or the
appointment of the successor Rights Agent, as the case may be, in each case, in accordance with this <U>Section</U><U></U><U>&nbsp;3.4</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) The Rights Agent will cooperate with Parent and any successor Rights Agent as reasonably requested in connection with the transition of
the duties and responsibilities of the Rights Agent to the successor Rights Agent, including transferring the CVR Register to the successor Rights Agent. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;3.6. <U>Acceptance of Appointment by Successor</U>. Every successor Rights Agent appointed pursuant to
<U>Section</U><U></U><U>&nbsp;3.5(b)</U> hereunder will execute, acknowledge and deliver to Parent and to the retiring Rights Agent an instrument accepting such appointment and a counterpart of this Agreement, and thereupon such successor Rights
Agent, without any further act, deed or conveyance, will become vested with all the rights, powers, trusts and duties of the retiring Rights Agent and all references to the &#8220;Rights Agent&#8221; herein shall be deemed to refer to such successor
Rights Agent. On request of Parent or the successor Rights Agent, the retiring Rights Agent will execute and deliver an instrument transferring to the successor Rights Agent all the rights, powers and trusts of the retiring Rights Agent. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">ARTICLE IV </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">COVENANTS </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.1. <U>List of Holders</U>. Parent will furnish or cause to be furnished to the Rights Agent in such form as Parent receives
from the Company&#8217;s transfer agent (or other agent performing similar services for the Company with respect to other shares of Company Common Stock, Company RSUs, Company PSUs, Company <FONT STYLE="white-space:nowrap">Cash-Out</FONT> Stock
Options or Warrants) the names and addresses of the Initial Holders of CVRs within thirty (30)&nbsp;Business Days after the Effective Time. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.2. <U>Payment of Milestone Payment Amounts</U>. If a Milestone has been achieved prior to the earlier of (x)&nbsp;the
applicable Milestone Expiration and (y)&nbsp;Termination, Parent shall, or shall cause the Surviving Corporation to, in accordance with and subject to the achievement of such Milestone prior to the earlier of the applicable Milestone Expiration and
Termination, on or prior to the applicable Milestone Payment Date, (i)&nbsp;deposit in the Rights Agent Account, for payment to the Holders who are not Holders of Equity Award CVRs, in accordance with <U>Section</U><U></U><U>&nbsp;2.4</U>, the
aggregate amount necessary to pay the applicable Milestone Payment Amount to each </P>
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Holder who is not a Holder of an Equity Award CVR and (ii)&nbsp;deposit with Parent, Surviving Corporation, or their Affiliates, for payment to the Holders of Equity Award CVRs, in accordance
with <U>Section</U><U></U><U>&nbsp;2.4</U>, the aggregate amount necessary to pay the applicable Milestone Payment Amount to each Holder of an Equity Award CVR. For the avoidance of doubt, each Milestone Payment Amount shall only be paid one time,
if at all, subject to the achievement of the applicable Milestone prior to the earlier of the applicable Milestone Expiration and Termination, and the maximum aggregate potential amount payable under this Agreement per CVR shall be $1.78 with
respect to the First Milestone and $7.13 with respect to the Second Milestone. Without prejudice to any rights of the Rights Agent or the Holders under this Agreement in the case of Parent&#8217;s breach of its obligations under this Agreement, if a
Milestone has not been achieved prior to the applicable Milestone Expiration, then Parent will not be required to make any payment to the Rights Agent or the Holders pursuant to this Agreement in respect of such Milestone. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;4.3. <U>Additional Covenants</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) From the Closing Date until the First Milestone Expiration, Parent shall, and shall cause its Subsidiaries, including the Surviving
Corporation, to use Commercially Reasonable Efforts to achieve the First Milestone prior to the First Milestone Expiration; <U>provided</U> that use of Commercially Reasonable Efforts does not guarantee that Parent will achieve the First Milestone
by a specific date or at all. For the avoidance of doubt, neither Parent nor any of its Subsidiaries has any obligation to use Commercially Reasonable Efforts or any other level of efforts to achieve the Second Milestone Event. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Parent owes no obligation or duty, as a fiduciary or otherwise, to the Rights Agent, any Holder or any other Person in connection with its
operation of the Surviving Corporation&#8217;s business following the Closing except as expressly stated herein. The Rights Agent (on behalf of itself and on behalf of the Holders) acknowledges that (i)&nbsp;Parent makes (x)&nbsp;no guarantees or
promises that any Milestone will be achieved at all or by a specific date or is achievable and (y)&nbsp;no assessments or predictions regarding the likelihood of any Milestone being achieved, (ii)&nbsp;there is no assurance that the Holders will
receive any payment as described under <U>Section</U><U></U><U>&nbsp;4.2</U> unless the applicable Milestone is achieved, (iii)&nbsp;Parent has not, prior to or after the date hereof, promised or projected any amounts to be received by the Holders
in respect of any payments described in <U>Section</U><U></U><U>&nbsp;4.2</U>, (iv) subject to the obligations in <U>Section</U><U></U><U>&nbsp;4.3(a)</U>, none of the Rights Agent and any Holder is relying on or has relied on any promises,
projections, representation or warranty of any kind or other information, documents or materials (or absence thereof) in respect of any payments described in <U>Section</U><U></U><U>&nbsp;4.2</U> including with respect to the operation of the
Surviving Corporation&#8217;s business following the Closing, (v)&nbsp;except for Parent&#8217;s obligations set forth in <U>Section</U><U></U><U>&nbsp;4.3(a)</U>, Parent shall have the right to own, operate, use, license, develop and otherwise
commercialize the assets of the Surviving Corporation&#8217;s business in any way that Parent deems appropriate in its sole business judgment and (vi)&nbsp;except for Parent&#8217;s obligations set forth in <U>Section</U><U></U><U>&nbsp;4.3(a)</U>,
Parent does not have any obligation, express or implied, to own, operate, use, license, develop or otherwise commercialize the assets of the Surviving Corporation&#8217;s business in order to maximize or expedite the payments described in
<U>Section</U><U></U><U>&nbsp;4.2</U>, including any obligation to pursue particular business opportunities, engage in particular advertising or marketing campaigns or otherwise. Except for Parent&#8217;s obligations set forth in
<U>Section</U><U></U><U>&nbsp;4.3(a)</U>, the Rights Agent (on behalf of itself and on behalf of the Holders) hereby (x)&nbsp;disclaims reliance on any such promises, projections, representations, warranties or other information, documents or
materials (or absence thereof), and (y)&nbsp;understands and agrees that any such promises, representations, warranties, projections and other information, documents and materials (or absence thereof) are specifically disclaimed by Parent. The
Parties intend the express provisions of <U>Section</U><U></U><U>&nbsp;4.2</U> and <U>Section</U><U></U><U>&nbsp;4.3</U> to govern their contractual relationship and to supersede any standard of efforts or implied covenant of good faith and fair
dealing that might otherwise be imposed by any court or other Governmental Body or otherwise. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) In the event that a Milestone has not yet been achieved and Parent desires to consummate
a Change of Control prior to the applicable Milestone Expiration, Parent will cause the Person acquiring Parent to assume Parent&#8217;s obligations, duties and covenants under this Agreement (including, for the avoidance of doubt,
<U>Section</U><U></U><U>&nbsp;6.11</U>). No later than five (5)&nbsp;Business Days prior to the consummation of any Change of Control, Parent will deliver to the Rights Agent an Officer&#8217;s Certificate, stating that such Change of Control
complies with this <U>Section</U><U></U><U>&nbsp;4.3(c)</U> and that all conditions precedent herein relating to such transaction have been complied with. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">ARTICLE V </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">AMENDMENTS </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.1. <U>Amendments without Consent of Holders</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) Without the consent of any Holders or the Rights Agent, Parent and the Surviving Corporation, at any time and from time to time, may enter
into one or more amendments hereto, without the consent of any Holders or the Rights Agent, for any of the following purposes: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(i) to
evidence the succession of another Person to Parent and the assumption by any such successor of the covenants of Parent herein as provided in <U>Section</U><U></U><U>&nbsp;6.3</U>; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(ii) to add to the covenants of Parent such further covenants, restrictions, conditions or provisions as Parent and the Rights Agent will
consider to be for the protection of the Holders; <U>provided</U> that, in each case, such provisions do not adversely affect the interests of the Holders (as a group and in their capacity as such); </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(iii) to cure any ambiguity, to correct or supplement any provision herein that may be defective or inconsistent with any other provision
herein, or to make any other provisions with respect to matters or questions arising under this Agreement; <U>provided</U> that, in each case, such provisions do not adversely affect the interests of the Holders (as a group and in their capacity as
such); </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(iv) as may be necessary or appropriate to ensure that the CVRs are not subject to registration under the Securities Act of 1933,
as amended, or the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder, and to ensure that the CVRs are not subject to any similar registration or prospectus requirement under applicable securities Laws
outside of the United States; <U>provided</U> that, in each case, such provisions do not change any Milestone, Milestone Expiration or Milestone Payment; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(v) to evidence the succession of another Person as a successor Rights Agent and the assumption by any such successor of the covenants and
obligations of the Rights Agent herein in accordance with <U>Section</U><U></U><U>&nbsp;3.5</U> and <U>Section</U><U></U><U>&nbsp;3.6</U>; </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(vi) any other amendments hereto for the purpose of adding, eliminating or changing any
provisions of this Agreement, unless such addition, elimination or change is adverse to the interests of the Holders (as a group and in their capacity as such); or </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) without the consent of any Holders, Parent and the Rights Agent, at any time and from time to time, may enter into one or more amendments
hereto to reduce the number of CVRs in the event any Holder agrees to abandon or renounce such Holder&#8217;s rights under this Agreement in accordance with <U>Section</U><U></U><U>&nbsp;2.7</U> or <U>Section</U><U></U><U>&nbsp;6.4</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Promptly after the execution by Parent and the Rights Agent of any amendment pursuant to the provisions of this
<U>Section</U><U></U><U>&nbsp;5.1</U>, Parent will mail (or cause the Rights Agent to mail) a notice thereof by first class mail to the Holders at their addresses as they appear on the CVR Register, setting forth the terms of such amendment. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.2. <U>Amendments with Consent of Holders</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) Subject to <U>Section</U><U></U><U>&nbsp;5.1</U> (which amendments pursuant to <U>Section</U><U></U><U>&nbsp;5.1</U> may be made without
the consent of the Holders), with the consent of the Acting Holders, whether evidenced in writing or taken at a meeting of the Holders, Parent and the Rights Agent may enter into one or more amendments hereto for the purpose of adding, eliminating
or changing any provisions of this Agreement, even if such addition, elimination or change is materially adverse to the interest of the Holders. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Promptly after the execution by Parent and the Rights Agent of any amendment pursuant to the provisions of this
<U>Section</U><U></U><U>&nbsp;5.2</U>, Parent will mail (or cause the Rights Agent to mail) a notice thereof by first class mail to the Holders at their addresses as they appear on the CVR Register, setting forth such amendment. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.3. <U>Rights Agent Execution of Amendments</U>. In executing any amendment permitted by this <U>Article V</U>, the Rights Agent
will be entitled to receive, and will be fully protected in relying upon, an opinion of counsel selected by Parent (which may include internal counsel) stating that the execution of such amendment is authorized or permitted by this Agreement. The
Rights Agent may, but is not obligated to, enter into any such amendment that materially and adversely affects the Rights Agent&#8217;s own rights, privileges, covenants or duties under this Agreement or otherwise. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;5.4. <U>Effect of Amendments</U>. Upon the execution of any amendment under this <U>Article V</U>, this Agreement will be
modified in accordance therewith, such amendment will form a part of this Agreement for all purposes and every Holder will be bound thereby. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">ARTICLE VI </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">OTHER PROVISIONS OF GENERAL APPLICATION </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.1. <U>Notices</U>. All notices, requests, claims, demands and other communications hereunder must be in writing and must be
given (and will be deemed to have been duly given): (a) when delivered, if delivered in Person, (b)&nbsp;when delivered by email, which email must state that it is being delivered pursuant to this Section&nbsp;6.1 and which notice will not be
effective unless either (A)&nbsp;a duplicate copy of such email notice is sent on the same day for next Business Day delivery, fees prepaid, via a reputable nationwide overnight courier service or (B)&nbsp;the receiving party delivers a written
confirmation of receipt to the sender of such notice (excluding &#8220;out of office,&#8221; delivery failure or similar automated replies), (c) three (3)&nbsp;Business Days after sending, if sent by registered or certified mail (postage prepaid,
return receipt requested) and (d)&nbsp;one Business Day after sending, if sent by overnight courier, in each case, to the respective parties at the following addresses (or at such other address for a party as have been specified by like notice):
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If to the Rights Agent, to it at: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">[_____] </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Telephone:
&#8195;[_____] </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Email:&#8195;&#8195;&#8201;&#8194; [_____] </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Attention:&#8195;&#8196; [_____] </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">If to Parent, to it at: </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Eli
Lilly and Company </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Lilly Corporate Center </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Indianapolis, Indiana 46285 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Attention:&#8195; Senior Vice President and Head of Corporate Business Development </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">With a copy (which shall not constitute notice) to: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Eli Lilly and Company </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Lilly
Corporate Center </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Indianapolis, Indiana 46285 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Attention:&#8195; Senior Vice President&#8212;Transactions and Contracting </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Ropes&nbsp;&amp; Gray LLP
</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Prudential Tower </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">800
Boylston Street </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Boston, MA 02199 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Attention:&#8195; Emily Oldshue </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Telephone:&#8195; (617) <FONT STYLE="white-space:nowrap">951-7241</FONT> </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Email:&#8195; emily.oldshue@ropesgray.com </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.2. <U>Notice to Holders</U>. Where this Agreement provides for notice to Holders, such notice will be sufficiently given
(unless otherwise herein expressly provided) if in writing and mailed, first-class postage prepaid, to each Holder affected by such event, at the Holder&#8217;s address as it appears in the CVR Register, not later than the latest date, and not
earlier than the earliest date, if any, prescribed for the giving of such notice. In any case where notice to Holders is given by mail, neither the failure to mail such notice, nor any defect in any notice so mailed, to any particular Holder will
affect the sufficiency of such notice with respect to other Holders. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.3. <U>Successors and Assigns</U>. Neither this Agreement nor any of the
rights, interests or obligations under this Agreement shall be assigned, in whole or in part, by operation of law or otherwise by either party without the prior written consent of the other party and any purported assignment without such consent
shall be void; <U>provided</U> that Parent may assign, in its sole discretion, any of or all its rights, interests and obligations under this Agreement (a)&nbsp;to any of its direct or indirect wholly-owned subsidiaries; (b)&nbsp;to any purchaser,
transferee, licensee, or sublicensee that is a company in the pharmaceutical industry of substantially all of the Intellectual Property and other rights (including, without limitation, all data, marketing authorizations and applications for
marketing authorization), assets, rights, powers, privileges and Contracts, in each case, (x)&nbsp;held, owned or entered into by Parent or its Subsidiaries immediately after the Effective Time and (y)&nbsp;necessary for the production, development
or sale of the CVR Products; (c)&nbsp;in compliance with <U>Section</U><U></U><U>&nbsp;4.3(c)</U>; (d)&nbsp;otherwise with the prior written consent of the Acting Holders, to any other Person (any permitted assignee under <U>clauses
(a)</U>&nbsp;through <U>(d)</U>, an &#8220;<U>Assignee</U>&#8221;), in each case, <U>provided</U> that the Assignee agrees to assume and be bound by all of the terms of this Agreement; <U>provided</U>, <U>further</U>, that any such assignment shall
not materially impede or delay the consummation of the transactions contemplated hereby or otherwise materially impede the rights of the Holders under this Agreement. Any Assignee may thereafter assign any or all of its rights, interests and
obligations hereunder in the same manner as Parent pursuant to the prior sentence. In connection with any assignment to an Assignee described in <U>clauses (a)</U>&nbsp;or <U>(b)</U> above in this <U>Section</U><U></U><U>&nbsp;6.3</U>, Parent (and
any subsequent assignor) shall agree to remain liable for the performance by each Assignee (and such other assignor, if applicable) of all obligations of Parent hereunder with such Assignee substituted for Parent under this Agreement. Subject to the
preceding sentences, this Agreement will be binding upon, inure to the benefit of, and be enforceable by the parties and their respective permitted successors and assigns. Subject to compliance with the requirements set forth in this
<U>Section</U><U></U><U>&nbsp;6.3</U> relating to assignments and <U>Section</U><U></U><U>&nbsp;4.3(c)</U>, this Agreement shall not restrict Parent&#8217;s, any Assignee&#8217;s or any of their respective successors&#8217; ability to merge or
consolidate with, or sell, issue, license or dispose of its stock or other equity interests or assets to, any other Person, or <FONT STYLE="white-space:nowrap">spin-off</FONT> or <FONT STYLE="white-space:nowrap">split-off.</FONT> Each of
Parent&#8217;s successors and Assignees shall expressly assume by an instrument supplemental hereto, executed and delivered to the Rights Agent, the due and punctual payment of the CVRs and the due and punctual performance and observance of all of
the covenants and obligations of this Agreement to be performed or observed by Parent. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.4. <U>Benefits of Agreement</U>.
Nothing in this Agreement, express or implied, will give to any Person (other than the Rights Agent, Parent, Parent&#8217;s successors and Assignees, the Holders and the Holders&#8217; successors and assigns pursuant to a Permitted CVR Transfer) any
benefit or any legal or equitable right, remedy or claim under this Agreement or under any covenant or provision herein contained, all such covenants and provisions being for the sole benefit of the foregoing. The rights of Holders and their
successors and assigns pursuant to Permitted CVR Transfers are limited to those expressly provided in this Agreement. Notwithstanding anything to the contrary contained herein, any Holder or Holder&#8217;s successor or assign pursuant to a Permitted
CVR Transfer may agree to renounce, in whole or in part, its rights under this Agreement by written notice to the Rights Agent and Parent, which notice, if given, shall be irrevocable. The Acting Holders will have the sole right, on behalf of all
Holders, by virtue of or under any provision of this Agreement, to institute any action or proceeding with respect to this Agreement, and no individual Holder or other group of Holders will be entitled to exercise such rights (<U>provided</U> that
the foregoing shall not limit the ability of an individual Holder to seek a payment due from the applicable party pursuant to <U>Section</U><U></U><U>&nbsp;4.2</U> solely to the extent such payment, and the amount of such payment, has been finally
determined to be due and payable in accordance with this Agreement and has not been paid within the period contemplated by this Agreement). The Holders shall not be entitled to specific enforcement of <U>Section</U><U></U><U>&nbsp;4.3</U>.
Reasonable expenditures incurred by such Holders in connection with any enforcement action hereunder may be deducted from any damages or settlement obtained prior to the distribution of any remainder to Holders generally. The Holders acting pursuant
to this provision on behalf of all Holders shall have no liability to the other Holders for such actions. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.5. <U>Governing Law; Jurisdiction; Waiver of Jury Trial</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) This Agreement will be governed by, and construed in accordance with, the Laws of the State of Delaware, regardless of the Laws that might
otherwise govern under applicable principles of conflicts of laws thereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Each of the parties hereto hereby (i)&nbsp;expressly and
irrevocably submits to the exclusive personal jurisdiction of the Court of Chancery of the State of Delaware or if such Court of Chancery lacks subject matter jurisdiction, the United States District Court for the District of Delaware, in the event
any dispute arises out of this Agreement or the transactions contemplated hereby, (ii)&nbsp;agrees that it shall not attempt to deny or defeat such personal jurisdiction by motion or other request for leave from any such court and (iii)&nbsp;agrees
that it shall not bring any action relating to this Agreement or the transactions contemplated hereby in any court other than the Court of Chancery of the State of Delaware or if such Court of Chancery lacks subject matter jurisdiction, the United
States District Court for the District of Delaware; <U>provided</U> that each of the parties has the right to bring any action or proceeding for enforcement of a judgment entered by such court in any other court or jurisdiction. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) EACH PARTY HERETO ACKNOWLEDGES AND AGREES THAT ANY CONTROVERSY WHICH MAY ARISE UNDER THIS AGREEMENT IS LIKELY TO INVOLVE COMPLICATED AND
DIFFICULT ISSUES, AND THEREFORE SUCH PARTY HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN ANY LITIGATION ARISING OUT OF, RELATING TO OR IN CONNECTION WITH THIS AGREEMENT. EACH PARTY CERTIFIES AND
ACKNOWLEDGES THAT (I)&nbsp;NO REPRESENTATIVE, AGENT, OR ATTORNEY OF ANY PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER, (II)&nbsp;EACH PARTY UNDERSTANDS AND
HAS CONSIDERED THE IMPLICATION OF THIS WAIVER, (III)&nbsp;EACH PARTY MAKES THIS WAIVER VOLUNTARILY AND (IV)&nbsp;EACH OTHER PARTY HAS BEEN INDUCED TO ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS
SECTION <U>6.5(c)</U>. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) In the event of any litigation or other proceeding between the parties to this Agreement arising out of or in
any way related to a Milestone or payment thereof, the prevailing party in such litigation or other proceeding shall be entitled to recover its reasonable attorneys&#8217; fees, costs and expenses incurred in connection with such litigation or other
proceeding, in addition to any other relief to which such party may be entitled; <U>provided</U>, <U>however</U>, that in no event will any party to this Agreement be required to pay any contingency based attorneys&#8217; fees. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.6. <U>Severability</U>. If any term or other provision of this Agreement is
determined by a court of competent jurisdiction to be invalid, illegal, or incapable of being enforced by any rule, law or public policy, the remaining provisions of this Agreement will be enforced so as to conform to the original intent of the
parties as closely as possible in an acceptable manner so that the terms hereof, and the transactions contemplated hereby, are fulfilled to the fullest extent possible. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.7. <U>Counterparts</U>. This Agreement may be executed and delivered (including by executed signatures in electronic format
(including &#8220;pdf&#8221;) and other electronic signatures (including DocuSign and AdobeSign) in each case transmitted by email) in two (2)&nbsp;or more counterparts, and by the different parties hereto in separate counterparts, each of which
when executed will be deemed to be an original but all of which taken together will constitute one and the same agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.8. <U>Termination</U>. This Agreement will automatically terminate and be of no force or effect, the parties hereto will have
no liability or obligations hereunder (other than with respect to monies due and owing by Parent to the Rights Agent in respect of the Rights Agent&#8217;s services hereunder and any services to be performed by the Rights Agent under
<U>Section</U><U></U><U>&nbsp;2.4(f)</U> hereof), and no payments will be required to be made, upon the earliest to occur of (such time, the &#8220;<U>Termination</U>&#8221;) (a) the date that is sixty (60)&nbsp;days after the end of the calendar
year in which the Second Milestone Expiration occurs, (b)&nbsp;(i) the mailing by the Rights Agent to the address or (ii)&nbsp;the payment by the Rights Agent by wire transfer of immediately available funds to the account of each Holder as reflected
in the CVR Register the last of the Milestone Payment Amounts (if any) required to be paid under the terms of this Agreement, and (c)&nbsp;the delivery of a written notice of termination duly executed by Parent and the Acting Holders;
<U>provided</U>, that in the event that an audit is pending under <U>Section</U><U></U><U>&nbsp;3.4,</U> the Termination shall not be deemed to occur until five (5)&nbsp;Business Days after the completion of such audit. For the avoidance of doubt,
the right of any Holder to receive a Milestone Payment with respect to a Milestone, and any covenants and obligations of Parent (other than pursuant to <U>Section</U><U></U><U>&nbsp;2.4(d)</U>), shall be irrevocably terminated and extinguished if
such Milestone is not achieved before Termination. Notwithstanding the foregoing, no termination shall affect any rights, obligations or liabilities accrued prior to the effective date of such termination or <U>Sections 6.4</U>, <U>6.5</U>,
<U>6.6</U>, <U>6.7</U>, <U>6.9</U>, <U>6.11</U> or this <U>Section</U><U></U><U>&nbsp;6.8</U>, which shall survive the termination of this Agreement, or the resignation, replacement or removal of the Rights Agent. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.9. <U>Entire Agreement</U>. This Agreement and the Merger Agreement (including the schedules, annexes and exhibits thereto and
the documents and instruments referred to therein) contain the entire understanding of the parties hereto and thereto with reference to the transactions and matters contemplated hereby and thereby and supersede all prior agreements, written or oral,
among the parties with respect hereto and thereto. If and to the extent that any provision of this Agreement is inconsistent or conflicts with the Merger Agreement, then solely with respect to the Rights Agent, this Agreement will govern and be
controlling. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.10. <U>Further Assurances</U>. Subject to the provisions of this Agreement, Parent and the Rights Agent will,
from time to time, do all commercially reasonable acts and things and execute and deliver all such further documents and instruments, as Parent and the Rights Agent may reasonably require for the carrying out or performing by the Rights Agent of the
provisions of this Agreement. </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.11. <U>Force Majeure</U>. Notwithstanding anything to the contrary contained
herein, none of the Rights Agent, Parent or any of its Subsidiaries will be liable for any delays or failures in performance resulting from acts beyond its reasonable control including acts of God, pandemics, epidemics, terrorist acts, shortage of
supply, breakdowns or malfunctions, interruptions or malfunctions of computer facilities, or loss of data due to power failures or mechanical difficulties with information storage or retrieval systems, labor disputes, strikes, or shortages, war or
civil unrest, it being understood that such parties shall use commercially reasonable efforts to resume performance as soon as reasonably practicable under the circumstances. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.12. <U>Legal Holiday</U>. In the event that a Milestone Payment Date shall not be a Business Day, then, notwithstanding any
provision of this Agreement to the contrary, any payment required to be made in respect of the CVRs on such date need not be made on such date, but may be made on the next succeeding Business Day with the same force and effect as if made on such
Milestone Payment Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Section&nbsp;6.13. <U>Confidentiality</U>. The Rights Agent and Parent agree that all books, records, information
and data pertaining to the business of the other party that are exchanged or received pursuant to the negotiation or the carrying out of this Agreement shall remain confidential, and shall not be voluntarily disclosed to any other person, except as
may be required by a valid order of a Governmental Body of competent jurisdiction or as is otherwise required by Law. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Remainder of
Page Left Blank Intentionally</I>] </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, each of the parties has caused this Agreement to be executed on its
behalf by its duly authorized officers as of the day and year first above written. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" COLSPAN="3">ELI LILLY AND COMPANY</TD></TR>
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<TD HEIGHT="16"></TD>
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<TD VALIGN="top">By:</TD>
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<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD></TR>
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<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Signature Page to Contingent Value Rights Agreement</I>] </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, each of the parties has caused this Agreement to be executed on its
behalf by its duly authorized officers as of the day and year first above written. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top">Name:</TD>
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<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Exhibit 10.1 </B></P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>SECURED PROMISSORY NOTE </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">October&nbsp;24, 2025 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">For value
received, Adverum Biotechnologies, Inc., a Delaware corporation (herein called the &#8220;<B><U>Maker</U></B>&#8221;), hereby promises to pay to Eli Lilly and Company, an Indiana corporation, or its permitted assigns (hereinafter referred to as the
&#8220;<B><U>Holder</U></B>&#8221;), the principal sum of up to $65,000,000 or so much thereof as remains outstanding from time to time. The Maker also agrees to pay interest on the principal amount of each Advance (as defined below) that is
outstanding from time to time at a rate per annum equal to SOFR plus 10.0%. Interest shall commence on the date of the first Advance hereunder and accrue <FONT STYLE="white-space:nowrap">bi-weekly</FONT> in arrears and shall continue accruing on the
unpaid principal and accrued but unpaid interest amount until paid in full. All accrued interest shall be calculated on the basis of a 360 day year and actual days elapsed. All accrued interest shall compound and be added to the principal balance on
the last Business Day of each <FONT STYLE="white-space:nowrap">bi-weekly</FONT> period. Capitalized terms used but not otherwise defined in this Note shall have the respective meanings given to them in the Merger Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">SECTION&nbsp;1. <B><U>Definitions</U></B>. As used herein, the following terms will be deemed to have the meanings set forth below. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Advance</U></B>&#8221; means any advance made under this Note pursuant to Section&nbsp;2(a). </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Affiliate</U></B>&#8221; means, with respect to any Person, another Person that directly, or indirectly through one or more
intermediaries now or hereafter, Controls or is Controlled by or is under common Control with the Person specified. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Bankruptcy Code</U></B>&#8221; means the United States Bankruptcy Code. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Business Day</U></B>&#8221; means any day that is not a Saturday, Sunday, or other day on which commercial banks in the State of
New York are authorized or required to close. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Collateral</U></B>&#8221; means the following, whether now owned and existing
or hereafter acquired or arising, wherever located: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(a) all bank accounts, deposit accounts and securities accounts; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(b) all receivables, accounts receivable, notes and instruments; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(c) all securities and investment property; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(d) all money, cash and cash equivalents; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(e) all general intangibles; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(f)
all goods, inventory, equipment and fixtures; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(g) all real property; </P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(h) all intellectual property rights (including, without limitation, all patents, patent
applications, trademarks, trademark applications, copyrights, copyright applications and all rights in connection with any licensing agreements, inventions, rights to sue for past, present and future infringements thereof, trade secrets, and all
other confidential or proprietary information and <FONT STYLE="white-space:nowrap">know-how</FONT> protectable by applicable law); </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(i) all
supporting obligations and <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">letter-of-credit</FONT></FONT> rights; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(j)
all books and records; and </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(k) to the extent not otherwise included, all proceeds, tort claims listed on <U>Schedule 1.1</U>, insurance
claims and other rights to payments not otherwise included in the foregoing and products of the foregoing and all accessions to, substitutions and replacements for, and rents and profits of, each of the foregoing, whether now existing or hereafter
acquired. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">All terms used in this definition, to the extent not otherwise defined in this Note, shall have the meanings provided for such
terms in the UCC. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Collateral Documents</U></B>&#8221; means each of the agreements (including, for the avoidance of doubt,
this Note), instruments or documents that creates or purports to create or perfect a lien in favor of the Holder with respect to the obligations of the Maker or the Guarantors under this Note. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Control</U></B>&#8221; means the possession, directly or indirectly, of the power to direct or cause the direction of the
management and policies of a Person, whether through the ability to exercise voting power, by contract or otherwise. &#8220;<B><U>Controlling</U></B>&#8221; and &#8220;<B><U>Controlled</U></B>&#8221; have meanings correlative thereto. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Guarantors</U></B>&#8221; means each of (i)&nbsp;Avalanche Australia PTY LTD, a private limited company organized under the laws
of Australia, (ii)&nbsp;Annapurna Therapeutics Limited, a private limited company organized under the laws of Ireland with company number 564722 ((i) and (ii), collectively, the &#8220;<B><U>Foreign Guarantors</U></B>&#8221;), and (iii)&nbsp;Adverum
NC, LLC, a Delaware limited liability company (the &#8220;<B><U>US Guarantor</U></B>&#8221;). </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Indebtedness</U></B>&#8221;
means, as to any Person, without duplication, all of the following, (a)&nbsp;all obligations of such Person for borrowed money and all obligations of such Person evidenced by bonds, debentures, notes, loan agreements or other similar instruments;
(b)&nbsp;all direct or contingent payment obligations of such Person arising under letters of credit (including standby and commercial), bankers&#8217; acceptances, bank guaranties, surety bonds and similar instruments; (c)&nbsp;net payment or
delivery obligations of such Person under any hedging agreement; (d)&nbsp;all payment obligations of such Person to pay the deferred purchase price of property or services (other than trade accounts payable in the ordinary course of business and, in
each case, either (x)&nbsp;not past due for more than ninety (90)&nbsp;days after the date on which such trade account payable was created or </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">2 </P>

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(y) subject to a good faith dispute (solely to the extent of such good faith disputed amount)); (e)&nbsp;indebtedness (excluding prepaid interest thereon) secured by a Lien on property owned or
being purchased by such Person (including indebtedness arising under conditional sales or other title retention agreements), whether or not such indebtedness shall have been assumed by such Person or is limited in recourse; (f)&nbsp;capital leases
and or finance leases; (g)&nbsp;all obligations of such Person to purchase, redeem, retire, defease or otherwise make any payment in respect of any equity interest in such Person or any other Person, valued, in the case of a redeemable preferred
interest, at the greater of its voluntary or involuntary liquidation preference plus accrued and unpaid dividends; and (h)&nbsp;all guarantees of such Person in respect of any of the foregoing. For all purposes hereof, the Indebtedness of any Person
shall include the Indebtedness of any partnership or joint venture (other than a joint venture that is itself a corporation or limited liability company) in which such Person is a general partner or a joint venturer, unless such Indebtedness is
expressly made <FONT STYLE="white-space:nowrap">non-recourse</FONT> to such Person. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Insolvency Proceeding</U></B>&#8221;
means, with respect to any Person, (a)&nbsp;any case, action or proceeding with respect to such Person before any court or other governmental agency or authority relating to bankruptcy, reorganization, insolvency, liquidation, receivership,
dissolution, <FONT STYLE="white-space:nowrap">winding-up</FONT> or relief of debtors or (b)&nbsp;any general assignment for the benefit of creditors, composition, marshalling of assets for creditors, or other, similar arrangement in respect of its
creditors generally or any substantial portion of its creditors, in either case undertaken under U.S. Federal, state or foreign law. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Investment</U></B>&#8221; means, as to any Person, all investments by such Person in other Persons (including Affiliates) in the
form of loans (including guarantees), advances or capital contributions, purchases or other acquisitions for consideration of Indebtedness, equity interests or other securities issued by any other Person and the purchase or other acquisition (in one
transaction or a series of transactions) of all or substantially all of the property and assets or business of another Person or assets constituting a business unit, line of business or division of such Person. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Lien</U></B>&#8221; means any mortgage, pledge, hypothecation, collateral assignment, encumbrance, lien (statutory or other),
charge, or preference, priority or other security interest or preferential arrangement in the nature of a security interest of any kind or nature whatsoever (including any conditional sale or other title retention agreement, any easement, right of
way or other encumbrance on title to real property, and any instrument or arrangement having substantially the same economic effect as any of the foregoing). </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Maker</U></B>&#8221; has the meaning set forth in the introductory paragraph of this Note and includes any Person that succeeds to
or assumes the obligations of the Maker under this Note in accordance with terms of this Note. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Maturity Date</U></B>&#8221;
means January&nbsp;22, 2026. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">3 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Merger Agreement</U></B>&#8221; means that certain Agreement and Plan of
Merger, dated as of the date hereof, by and among Holder, Maker and Flying Tigers Acquisition Corporation, a Delaware corporation. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Note</U></B>&#8221; means this secured promissory note issued by the Maker and guaranteed by the Guarantors. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Person</U></B>&#8221; means any person, corporation, general or limited partnership, joint venture, trust, limited liability
company, association or other entity or organization, including a government or political subdivision or any agency or instrumentality thereof. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Prepayment Premium</U></B>&#8221; means 5.0% of the principal amount outstanding under this Note. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Signing Date</U></B>&#8221; means October&nbsp;24, 2025. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>SOFR</U></B>&#8221; means, the rate <I>per annum</I> determined by the Holder as the forward-looking term rate for a <FONT
STYLE="white-space:nowrap">one-month</FONT> tenor published by the Federal Reserve Bank of New York. SOFR shall be determined on the first day of each calendar month and shall <FONT STYLE="white-space:nowrap">re-set</FONT> on the first calendar day
of each month. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>SOFR Administrator</U></B>&#8221; means the NYFRB (or a successor administrator of the secured overnight
financing rate). </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>Triggering Event</U></B>&#8221; means: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(a) Failure by the Maker or the Guarantors to make any payment hereunder when due and payable; or </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(b) The Maker or any Guarantor (i)&nbsp;except (A) as required by applicable Law, (B)&nbsp;as required by this Note or the Merger Agreement, or
(C)&nbsp;with the prior written consent of Holder, ceases to conduct its business in the ordinary course; (ii)&nbsp;commences an Insolvency Proceeding with respect to itself or (iii)&nbsp;takes any action to effectuate or authorize any of the
foregoing; or </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(c)&nbsp;(i) Any involuntary Insolvency Proceeding is commenced with respect to or filed against the Maker or a Guarantor,
or any writ, judgment, warrant of attachment, execution or similar process, is issued or levied against all or a substantial part of the Maker&#8217;s or a Guarantor&#8217;s assets or properties, and any such proceeding or petition shall not be
dismissed, or such writ, judgment, warrant of attachment, execution or similar process shall not be released, vacated or fully bonded within 30 days after commencement, filing or levy; (ii)&nbsp;the Maker or a Guarantor admits the allegations of a
petition against it in any Insolvency Proceeding, or an order for relief (or similar order under <FONT STYLE="white-space:nowrap">non-U.S.</FONT> law) is ordered in any Insolvency Proceeding; or (iii)&nbsp;the Maker or a Guarantor acquiesces in the
appointment of a receiver, trustee, custodian, conservator, liquidator, mortgagee in possession (or agent therefor), or other similar person for itself or a substantial portion of its assets, property or business; or </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">4 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(d) any representation, warranty, certification or statement of fact made or deemed made by
the Maker or the Guarantors herein, in any Collateral Document, or in any document required to be delivered in connection herewith or therewith shall be untrue in any material respect when made or deemed made; or </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(e) the Maker or a Guarantor fails to perform or observe in any material respect any term, covenant or agreement contained in this Note, any
Collateral Document or the Merger Agreement; or </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(f) any provision of this Note or any Collateral Document at any time after its execution
and delivery and for any reason ceases to be in full force and effect; or the Maker or a Guarantor contests in writing the validity or enforceability of this Note or the Collateral Documents, or denies in writing that it has any or further liability
or obligation under this Note or the Collateral Documents; or </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(g) any Collateral Document ceases to create, or any lien purported to be
created by any Collateral Document shall be asserted in writing by the Maker or a Guarantor not to be, a valid and perfected first priority lien on and security interest in the Collateral purported to be covered thereby; or </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(h)&nbsp;(x) there is entered against the Maker or a Guarantor, a final judgment in excess of $500,000 and such judgment or order shall not
have been satisfied, vacated, discharged or stayed or bonded pending an appeal for a period of 30 consecutive days or (y)&nbsp;the Maker or a Guarantor fails to make any payment beyond the applicable grace period, if any, whether by scheduled
maturity, required prepayment, acceleration, demand, or otherwise, in respect of any Indebtedness having an aggregate outstanding principal amount in excess of $500,000; or </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(i) the Merger Agreement is terminated. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;<B><U>UCC</U></B>&#8221; or &#8220;<B><U>Uniform Commercial Code</U></B>&#8221; shall mean the Uniform Commercial Code as in effect from
time to time in the State of New York; <U>provided</U> that if a term is defined in Article 9 of the Uniform Commercial Code differently than in another Article thereof, the term shall have the meaning set forth in Article 9; <U>provided</U>,
<U>further</U>, that, if by reason of mandatory provisions of law, perfection, or the effect of perfection or <FONT STYLE="white-space:nowrap">non-perfection,</FONT> of a security interest in any Collateral or the availability of any remedy
hereunder is governed by the Uniform Commercial Code as in effect in a jurisdiction other than New York, &#8220;UCC&#8221; or &#8220;Uniform Commercial Code&#8221; shall mean the Uniform Commercial Code as in effect in such other jurisdiction from
time to time for purposes of the provisions hereof relating to such perfection or effect of perfection or <FONT STYLE="white-space:nowrap">non-perfection</FONT> or availability of such remedy, as the case may be. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">5 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">SECTION&nbsp;2. <B><U>Advances</U></B>. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) Subject to the terms and conditions set forth herein, the Holder agrees to make up to four advances, on the terms and subject to the
conditions set forth herein: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(i) one installment of $5,000,000 on October&nbsp;28, 2025 (such installment, the &#8220;<B><U>First
Advance</U></B>&#8221;); </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(ii) one installment of $15,000,000 on November&nbsp;7, 2025; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(iii) one installment of $20,000,000 on November&nbsp;21, 2025; and </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(iv) one installment of $25,000,000 on December&nbsp;5, 2025 (such installment, the &#8220;<B><U>Final Installment</U></B>&#8221;); </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Any Advance or any portion thereof, once prepaid or repaid, may not be reborrowed. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) To request any Advance pursuant to Section&nbsp;2(a)(ii)-(iii), the Maker shall notify the Holder of such request no later than 10:00 a.m.
Eastern time five Business Days prior to the date of such requested Advance (or at such later date and/or time agreed to by the Holder). Such notice of a request for any Advance shall be in writing. If notice is given after 10:00 a.m. Eastern time,
it shall be deemed to have been given on the next succeeding Business Day. Holder acknowledges that the First Advance has been deemed requested for all purposes under this Note as of the date hereof. Each notice as provided in this Section&nbsp;2(c)
shall be irrevocable and binding on the Maker. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) Any Advance is subject to satisfaction or waiver of the following conditions precedent
(provided that only the Final Installment shall be subject to satisfaction or waiver of the condition in <U>clause (ix)</U>), which the Maker shall certify to the Holder in any Advance request: </P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(i)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">the Maker and any Guarantor shall not have breached in any material respect any of its obligations under each
of the Merger Agreement and the Note; </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(ii)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">the representations and warranties made by Maker and any Guarantor under the Note and the Merger Agreement
(other than the representations and warranties set forth in Section&nbsp;4.8(a) of the Merger Agreement) are true and correct in all material respects without regard to any &#8220;materiality,&#8221; &#8220;Company Material Adverse Effect&#8221; or
similar qualifiers, and the representations and warranties made by Maker set forth in Section&nbsp;4.8(a) of the Merger Agreement are true and correct in all respects; </P></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(iii)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">there has not been any Change of Board Recommendation under the Merger Agreement; </P></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(iv)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">there is not, and has been no, Triggering Event under this Note; </P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">6 </P>

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<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(v)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">the Maker shall have delivered a completed and accurate perfection certificate on the Signing Date (and to the
extent necessary to supplement such information after the Signing Date to maintain its accuracy, on such Advance request date), in the form of <U>Exhibit A</U> hereto; </P></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(vi)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">(i) on the Signing Date, the Holder shall have received a customary written opinion of Cooley LLP, counsel to
the Maker and the US Guarantor, in form and substance reasonably satisfactory to Holder and (ii)&nbsp;prior to any Advance, other than the First Advance (or by such later date as may be agreed by the Holder), the Holder shall have received a
customary written opinion of counsel to the Foreign Guarantors, in form and substance reasonably satisfactory to Holder; </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(vii)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">on the Signing Date, the Holder shall have received (i)&nbsp;a copy of each organizational document of the
Maker and the Guarantors as of the Signing Date and, to the extent applicable, certified as of a recent date by the appropriate governmental official; (ii)&nbsp;signature and incumbency certificates of the officers of such Person executing this Note
and the Collateral Documents to which each such Person is a party as of the Signing Date; (iii)&nbsp;resolutions of the board of directors or similar governing body of the Maker and the Guarantors approving and authorizing the execution, delivery
and performance as of the Signing Date of this Note and the Collateral Documents to which such Person is a party; and (iv)&nbsp;a good standing certificate (to the extent such concept is applicable in the relevant jurisdiction) from the applicable
governmental authority of the Maker and the applicable Guarantors&#8217; respective jurisdictions of incorporation, organization or formation dated a recent date prior to the Signing Date, in each case, certified as of the Signing Date by the Maker
and the Guarantors as being in full force and effect without modification or amendment; </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(viii)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">any Advance (other than the First Advance) shall be deposited into an account subject to a deposit account
control agreement in favor of Holder; </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(ix)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">with respect to the Final Installment, as of the date of such Advance request, the Maker&#8217;s cash outlay
identified in the Financial Report in respect of the Itemized Funding Plan shall not exceed by 10% or more the cash outlays projected by the Maker on the Signing Date in the Itemized Funding Plan (in each case, on a cumulative basis).
</P></TD></TR></TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">SECTION 3. <B><U>Payments</U></B>. The principal amount of this Note may be repaid, in whole but not in part, together
with all accrued but unpaid interest, at the option of the Maker. Otherwise, the principal amount, and any accrued but unpaid interest shall be due on the Maturity Date in U.S. dollars, at such address or to such account, as applicable, as shall be
designated to the Maker by the Holder. The Prepayment Premium will be due and payable by the Maker in connection with (A)&nbsp;any prepayment of the Advances prior to the Maturity Date and (B)&nbsp;any acceleration of the obligations hereunder
pursuant to <U>Section</U><U></U><U>&nbsp;5</U> hereof. Notwithstanding </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">7 </P>

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anything to the contrary, the entire unpaid principal balance, all accrued but unpaid interest on this Note, and any Prepayment Premium, if applicable, will be made in full on the Maturity Date
or, if earlier, on the date of the acceleration of the obligations hereunder pursuant to <U>Section</U><U></U><U>&nbsp;5</U> hereof, in U.S. dollars, at such address or to such account, as applicable, as shall be designated to the Maker by the
Holder. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">SECTION 4. <B><U>Taxes</U></B>. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) If Maker is required to withhold any amounts in respect of taxes under applicable law, Maker shall notify the Holder of such requirement
and shall cooperate fully with the Holder to reduce or eliminate any such withholding taxes. The Maker shall provide the Holder with any information reasonably requested by the Holder to comply with its tax filing obligations in connection with the
Note. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Maker shall pay any present or future stamp, transfer, or documentary taxes or any other excise or property taxes, charges, or
similar levies, and any penalties, additions to tax, or interest due with respect thereto, that may be imposed by any jurisdiction in connection with the execution, delivery, enforcement or registration of this Note. If at any time any governmental
authority, applicable law, regulation or international agreement requires Maker to make any withholding or deduction for tax from any such payment or other sum payable hereunder to Holder, Maker hereby covenants and agrees that the amount due from
Maker with respect to such payment or other sum payable hereunder will be increased to the extent necessary to ensure that, after the making of such required withholding or deduction, Holder receives a net sum equal to the sum which it would have
received had no withholding or deduction been required, and Maker shall pay the full amount withheld or deducted to the relevant governmental authority. The agreements and obligations of Maker contained in this <U>Section</U><U></U><U>&nbsp;4
</U>shall survive the termination of this Note. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">SECTION&nbsp;5. <B><U>Acceleration</U></B>. Upon the occurrence of a Triggering Event and
during the continuation thereof, the entire principal balance of this Note, together with all accrued and unpaid interest thereon and the Prepayment Premium, shall, at the Holder&#8217;s election, immediately become due and payable, without
presentment, notice, or demand of any kind; <U>provided</U>, that upon the occurrence of a Triggering Event under clause (b)&nbsp;or (c) of said definition, the entire principal balance of this Note shall immediately become due and payable without
any action on the part of the Holder. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">SECTION 6. <B><U>Representations and Warranties</U></B>. Each of the Maker and the Guarantors
hereby represent and warrant as follows: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) Such Person has taken all necessary corporate or other organizational action to authorize the
execution, delivery and performance of this Note. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) This Note has been duly executed and delivered by such Person and constitutes a
legal, valid and binding obligation of such Person, enforceable against such Person in accordance with its terms, subject to applicable bankruptcy, insolvency, reorganization, moratorium or other laws affecting creditors&#8217; rights generally and
subject to general principles of equity, regardless of whether considered in a proceeding in equity or at law. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">8 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Except as set forth on <U>Schedule 6(c)</U>, no approval, consent, exemption,
authorization or other action by, or notice to, or filing with, any governmental authority or any other Person is necessary or required in connection with the execution, delivery or performance by, or enforcement against, the Maker and the
Guarantors of this Note. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) Such Person (i)&nbsp;is a Person duly formed and registered, validly existing and, if applicable, in good
standing under the laws of its jurisdiction of incorporation, formation, organization, or equivalent, (ii)&nbsp;has all organizational power and authority to (x)&nbsp;own or lease its assets and carry on its business as currently conducted and
(y)&nbsp;execute, deliver and perform its obligations under this Note, (iii)&nbsp;is duly qualified and, if applicable, in good standing under the laws of each jurisdiction where its ownership, lease or operation of properties or the conduct of its
business as currently conducted requires such qualification, except to the extent any noncompliance could not reasonably be expected, individually or in the aggregate, to (A)&nbsp;materially and adversely affect the business, assets, results of
operations, condition (financial or otherwise) or prospects of the Maker or the Guarantors or (B)&nbsp;impair the ability of the Maker or the Guarantors to perform its and their obligations hereunder or (C)&nbsp;adversely affect the validity,
legality or enforceability of this Note, any provision herein, or the rights or remedies of the Holder hereunder, and (iv)&nbsp;is in compliance in all material respects with all applicable laws, orders, writs, injunctions and orders. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) No intellectual property of the Maker or the Guarantors is subject to any Liens (other than the Liens created hereunder). </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(f) The provisions of the Collateral Documents, together with such filings and other actions required to be taken hereby or by the applicable
Collateral Documents, are effective to create in favor of the Holder, except as otherwise permitted by Section&nbsp;7(f), a legal, valid, enforceable and perfected first priority Lien on all right, title and interest of the Maker and the respective
Guarantors in the Collateral described therein, in each case subject to exceptions and limitations otherwise set forth in this Note and the Collateral Documents. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(g) The Itemized Funding Plan fully and accurately presents all payments necessary to appropriately conduct the ongoing clinical trials of the
Maker and to support <FONT STYLE="white-space:nowrap">Ixo-vec</FONT> registrational development activities from the period commencing on the Signing Date through the last day of the period depicted in the Itemized Funding Plan. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">SECTION 7. <B><U>Covenants</U></B>. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) Each of the Maker and the Guarantors shall at all times preserve and keep in full force and effect its (i)&nbsp;existence and (ii)&nbsp;all
rights, franchises and other governmental approvals. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Each of the Maker and the Guarantors shall maintain with financially sound and
reputable insurance companies insurance in at least such amounts, of such character and against at least such risks as is usually maintained by companies of established repute engaged in the same or a similar business in the same general area. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">9 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Each of the Maker and the Guarantors shall, and shall cause each of their subsidiaries
to, conduct its business in compliance in all material respects with all applicable law and all its contractual obligations except to the extent any noncompliance could not reasonably be expected, individually or in the aggregate, to have a material
adverse effect on (i)&nbsp;the business, assets, results of operations, condition (financial or otherwise) or prospects of the Maker or the Guarantors or (ii)&nbsp;the ability of the Maker or the Guarantors to perform its obligations hereunder or
(iii)&nbsp;the validity, legality or enforceability of this Note, any provision herein, or the rights or remedies of the Holder hereunder. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) Each of the Maker and the Guarantors shall not directly or indirectly make, declare or pay any dividends or distribution of any kind or
repurchase any of its equity interests. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) The Maker shall at all times, directly or indirectly, own 100% of the outstanding equity
interests of each of the Guarantors. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(f) Neither the Maker nor the Guarantors shall create, incur, assume or suffer to exist any Lien upon
the Collateral, subject to the existing pledges and guarantees on <U>Schedule 7(f)</U>. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(g) Except as set forth on <U>Schedule 7(g)</U> to
this Note, the Maker and the Guarantors shall not incur or assume any Indebtedness, other than the Advances. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(h) The Maker and the
Guarantors shall not sell, lease or otherwise transfer any property or assets to, or purchase, lease or otherwise acquire any property or assets from, or otherwise engage in any other transactions with, any of its Affiliates, other than transactions
among the Maker and the Guarantors in the ordinary course of business. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(i) The Maker and the Guarantors shall not sell, lease or otherwise
transfer any property or assets that constitute Collateral other than ordinary course sales of products. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(j) The Maker shall (x)&nbsp;from
and after the Signing Date, operate its business to complete, initiate, effectuate and otherwise comply with the business plan set forth on <U>Exhibit D</U> hereto (the &#8220;<U>Operating Plan</U>&#8221;) and (y)&nbsp;use the proceeds of the
Advances to finance the working capital needs as set forth on <U>Exhibit E</U> hereto (as it may be updated from time to time by mutual agreement of the Maker and the Holder, the &#8220;<U>Itemized Funding Plan</U>&#8221;) and for no other purpose.
</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(k) The Maker shall (x)&nbsp;furnish to the Holder on the date hereof, and every Tuesday of each week thereafter (in each case, as such
date may be extended by the Holder in its sole discretion), (i) a statement of the cash balances of the Maker and the Guarantors and (ii)&nbsp;a report in the form of <U>Exhibit B</U> hereto (the &#8220;<U>Financial Report</U>&#8221;), which report
shall (a)&nbsp;indicate the expenses paid by the Maker and the Guarantors for the prior week (with copies of invoices to the extent such expense is greater than $100,000), (b) indicate the expenses that the Maker and the Guarantors will pay during
the following week (with copies of invoices to the extent such expense is greater than $100,000) and (c)&nbsp;project (1) initially, the expenses (on a weekly basis) to be paid through the end of the calendar year ending December&nbsp;31, 2025, and
(2)&nbsp;commencing on December&nbsp;22, 2025, the expenses (on a weekly basis) to be paid during the following two calendar months and (y)&nbsp;upon the reasonable request of the Holder, cause its chief financial officer or other duly appointed
officer reasonably requested by the Holder to participate in a call with the Holder to review the information provided pursuant to this <U>Section</U><U></U><U>&nbsp;7(k)</U> and discuss such other matters as the Holder may reasonably request. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">10 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(l) If requested by Maker, on a monthly basis promptly after the end of each calendar month,
the Holder shall furnish to the Maker its calculation of accrued and unpaid interest owed hereunder. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(m) Except as set forth on
<U>Schedule 7(m)</U> to this Note, the Maker and the Guarantors shall not make any Investments. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(n) The Maker shall, promptly upon the
reasonable request of the Holder, (i)&nbsp;correct any material defect or error that may be discovered in the execution, acknowledgment, filing or recordation of any Collateral Document or other document or instrument relating to any Collateral, and
(ii)&nbsp;do, execute, acknowledge, deliver, record, <FONT STYLE="white-space:nowrap">re-record,</FONT> file, <FONT STYLE="white-space:nowrap">re-file,</FONT> register and <FONT STYLE="white-space:nowrap">re-register</FONT> any and all such further
acts, deeds, certificates, assurances and other instruments as the Holder may reasonably request from time to time in order to carry out more effectively the purposes of the Collateral Documents. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(o) Commencing on October&nbsp;31, 2025, the Maker and any Guarantor shall make all payments of accounts payable in compliance with of the
terms of all applicable contracts to which such Person is a party (including all amounts past due pursuant to the terms of such contracts as of such date), except, in each case, to the extent that any accounts payable are subject to a good faith
dispute (solely to the extent of such good faith disputed amount). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">SECTION 8. <B><U>Security Interest and Related Provisions</U></B>.
</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) In order to secure all of the Maker&#8217;s and the Guarantors&#8217; obligations under this Note, each of the Maker and the
Guarantors hereby grant and assign to the Holder a security interest in the Collateral. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) In order to perfect the security interest
contemplated hereby, the Maker and the Guarantors shall (i)&nbsp;within two weeks of the Signing Date (or such later date as the Holder may agree in its reasonable discretion), enter into deposit account control agreements or a securities account
control agreements, as applicable, in favor of the Holder, with respect to any deposit or securities account located in the United States, (ii)&nbsp;(x) as of the Signing Date, enter into and deliver intellectual property security agreements in the
form of Exhibit <FONT STYLE="white-space:nowrap">C1-C3</FONT> with respect to all intellectual property registered and/or applied for in the United States, Canada, Australia, the European Union, Great Britain and Japan and (y)&nbsp;within one week
of the Signing Date, execute and deliver customary agreements, filings, registrations or other documentation (in, each case, in the sole discretion of Holder) to permit Holder to possess a legal, valid, enforceable and perfected first priority Lien
in all intellectual property registered and/or applied for in the European Union, Great Britain and Japan, (iii)&nbsp;enter into and deliver supplements to such intellectual property security agreements to perfect the security interest in any
intellectual property registered and/or applied for in the United States, Canada, Australia, the European Union, Great Britain and Japan subsequent to the date hereof and (iv)&nbsp;within 2 Business Days of the date hereof, deliver all certificated
securities, if any, constituting Collateral to the Holder. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">11 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) After the occurrence and during the continuation of a Triggering Event or failure to pay
the accrued principal and interest on an applicable Maturity Date, upon written notice from the Holder to the Maker, the Holder shall be entitled to (i)&nbsp;inspect and appraise the Collateral and to prepare, repair, assemble or process the
Collateral for sale, lease or other disposition; (ii)&nbsp;cause any or all of the Collateral to be transferred of record into the name of the Holder or its nominee; (iii)&nbsp;remove Collateral to the premises of the Holder or any other location
selected by the Holder, for such time as the Holder may desire, for any purpose not prohibited hereby or by applicable law; and (iv)&nbsp;exercise any and all other rights, powers, privileges and remedies of an owner of the Collateral. To the extent
permitted by law, the Maker hereby waives notice of the time and place of any public sale or the time after which any private sale or other disposition of all or any part of the Collateral may be made. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) After the occurrence and during the continuation of a Triggering Event or failure to pay the accrued principal and interest on an
applicable Maturity Date, upon written notice from the Holder, all rights of the Maker and the Guarantors to exercise the voting and other consensual rights which it would otherwise be entitled to exercise as the record owner of the any of the
Collateral constituting securities shall immediately cease to be effective upon its receipt of notice from the Holder of the Holder&#8217;s intent to exercise its rights hereunder, and upon delivery of such notice all such voting and other
consensual rights shall become vested in the Holder who shall thereupon have the sole right to exercise such voting and other consensual rights. Each of the Maker and the Guarantors hereby grants to the Holder an irrevocable proxy, with full power
of substitution, coupled with an interest, to exercise the voting and other consensual rights pertaining to such Collateral, exercisable if and to the extent that the Holder is entitled to exercise such rights pursuant to this Section&nbsp;8(d).
</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) If a Triggering Event has occurred and is then continuing: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(i) The Holder may exercise in respect of the Collateral, in addition to all other rights and remedies provided for herein or otherwise
available to it under applicable law, all the rights and remedies of a secured party upon default under the laws of the United States of America, and the Holder may also sell the Collateral at public or private sale, at any exchange, broker&#8217;s
board or elsewhere, for cash, on credit or for future delivery, and upon such other terms as the Holder may deem advisable. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(ii) Any cash
held by the Holder as Collateral and all cash proceeds received by the Holder in respect of any sale of, collection from, or other realization upon all or any part of the Collateral shall be applied to the payment of the obligations of the Maker or
the Guarantors due to the Holder hereunder in the manner determined by the Holder in its sole discretion. Any surplus of such cash or cash proceeds held by the Holder and remaining after payment in full of such obligations shall be paid over to the
Maker, the Guarantors or to whomsoever may be lawfully entitled to receive such surplus. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(f) Each of the Maker and the Guarantors hereby
irrevocably appoints the Holder and its employees and agents as the Maker&#8217;s and the Guarantors&#8217; true and lawful <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">attorneys-in-fact,</FONT></FONT> with full power of
substitution, to do (i)&nbsp;all things required to be done by the Maker or the Guarantors under this Note, and (ii)&nbsp;all things that the Holder may deem necessary or advisable to assure the attachment, perfection and first priority of the
security interest granted hereunder or otherwise to exercise rights and remedies of the Holder hereunder or carry out the intent of this Note, including, without limitation, (A)&nbsp;after a Triggering Event has occurred, to discharge past due
taxes, assessments, charges, fees or liens on the Collateral and (B)&nbsp;after a Triggering Event </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">12 </P>

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has occurred, to endorse and collect any cash proceeds of the Collateral and to apply the proceeds of any Collateral received by the Holder to the Maker&#8217;s or the Guarantors&#8217;
obligations as provided herein. Without limitation, the Holder and its employees and agents shall be entitled to file financing statements and amendments thereto in respect of the Collateral, including financing statements describing such property
as &#8220;all assets&#8221; or &#8220;all personal property,&#8221; whether now owned or hereafter acquired. The Holder shall be under no obligation whatsoever to take any of the foregoing actions, and absent gross negligence or willful misconduct
as determined by a court of competent jurisdiction in a final and nonappealable judgment, the Holder and its shareholders, directors, officers, employees and agents shall have no liability or responsibility for any act taken or omitted with respect
thereto. A copy of this Note shall be conclusive evidence of the Holder&#8217;s right to act under this Section&nbsp;8 as against all third parties. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(g) Each of the Maker and the Guarantors shall, at its own expense, perform promptly upon the reasonable request of the Holder such acts as may
be necessary or advisable, or that the Holder may request at any time, to assure the attachment, perfection and first priority of the security interest granted hereunder, to exercise rights and remedies hereunder, or to carry out the intent of this
Note, including, without limitation, updating a Guarantor&#8217;s shareholder registers (or equivalent) over LLC interests, making filings with the US Patent and Trademark Office, the US Copyright Office and any other filing office to update the
chain of title of the Collateral (including updating assignee records, correcting errors in record and recording releases of former security interests in Collateral) and providing any notices, making any filings and taking any other action as may be
required by any applicable law. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(h) Except for the exercise of reasonable care in the custody of any Collateral in its possession and the
accounting for moneys actually received by them hereunder, the Holder shall have no duty of care with respect to the Collateral. The Holder shall be deemed to have exercised reasonable care in the custody and preservation of Collateral in its
possession if such Collateral is accorded treatment substantially equal to that which the Holder accords its own property. In addition, the Holder shall have no obligation to take any actions to preserve rights against other parties or property with
respect to any Collateral. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(i) The Holder shall not have any duties or responsibilities except those expressly set forth in this Note and
in the Collateral Documents. Without limiting the generality of the foregoing, the Holder: (x)&nbsp;shall not be subject to any fiduciary or other implied duties, regardless of whether a Triggering Event has occurred and is continuing and, without
limiting the generality of the foregoing, the use of the term &#8220;agent&#8221; herein and in the other Collateral Documents with reference to the Holder is not intended to connote any fiduciary or other implied (or express) obligations arising
under agency doctrine of any applicable law, (y)&nbsp;shall not have any duty to take any discretionary action or exercise any discretionary powers, and (z)&nbsp;shall not be liable for any action taken or not taken by it in the absence of its gross
negligence or willful misconduct as determined by the final and <FONT STYLE="white-space:nowrap">non-appealable</FONT> judgment of a court of competent jurisdiction. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">13 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">SECTION&nbsp;9. <B><U>Guarantee</U></B>. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) Each of the Guarantors irrevocably, absolutely and unconditionally guarantees, jointly and severally, as a primary obligor and not merely
as a surety, the due and punctual payment and performance of the Maker&#8217;s obligations under this Note, whether at maturity, by acceleration or otherwise. Each of the Guarantors further agrees that the Maker&#8217;s obligations may be extended,
increased or renewed, amended or modified, in whole or in part, without notice to, or further assent from, the Guarantors and that such Guarantor will remain bound upon its guarantee hereunder notwithstanding any such extension, increase, renewal,
amendment or modification. To the fullest extent permitted by applicable law, each of the Guarantors (i)&nbsp;waives promptness, presentment to, demand of payment from, and protest to, the Maker of any of the Maker&#8217;s obligations, and
(ii)&nbsp;also waives notice of acceptance of its guarantee and notice of protest for nonpayment. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Each of the Guarantors further
agrees that its guarantee hereunder constitutes a guarantee of payment when due (whether or not any bankruptcy or similar proceeding shall have stayed the accrual of collection of any of the guaranteed obligations or operated as a discharge thereof)
and not of collection, and waives any right to require that any resort be had by the Holder to any security held for the payment of any of the guaranteed obligations. The obligations of the Guarantors hereunder are independent of the obligations of
the Maker, and a separate action or actions may be brought and prosecuted against the Guarantors whether or not action is brought against the Maker and whether or not the Maker is joined in any such action or actions. Any payment required to be made
by the Guarantors hereunder may be required by the Holder on any number of occasions. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Anything contained in this Note to the contrary
notwithstanding, the obligations of the Guarantors under this Note shall be limited to an aggregate amount equal to the largest amount that would not render its obligations under this Note subject to avoidance as a fraudulent transfer or conveyance
under Section&nbsp;548 of the Bankruptcy Code of the United States or any comparable provisions of any similar federal or state law. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d)
The obligations of the Guarantors hereunder shall not be affected by (i)&nbsp;the failure of the Holder or any other Person to assert any claim or demand or to enforce any right or remedy under the provisions of this Note, any Collateral Document or
otherwise; (ii)&nbsp;any rescission, waiver, amendment or modification of, or any release from any of the terms or provisions of, this Note or any Collateral Document; (iii)&nbsp;the release of, or any impairment of any security held by the Holder
for the guaranteed obligations; (iv)&nbsp;any default, failure or delay, willful or otherwise, in the performance of the guaranteed obligations; (v)&nbsp;the failure to perfect any security interest in, or the release of, any of the Collateral held
by or on behalf of the Holder; (vi)&nbsp;any change in the corporate existence, structure or ownership of the Maker, the lack of legal existence of the Maker or legal obligation to discharge any of the guaranteed obligations by the Maker for any
reason whatsoever, including, without limitation, in any insolvency, bankruptcy or reorganization of the Maker; (vii)&nbsp;the existence of any claim, <FONT STYLE="white-space:nowrap">set-off</FONT> or other rights that the Guarantors may have at
any time against the Maker or the Holder, whether in connection with this Note or any unrelated transaction; or (viii)&nbsp;any other circumstance (including statute of limitations), any act or omission that may or might in any manner or to any
extent vary the risk of any Guarantor or otherwise operate as a defense (other than a defense of payment in full) to, or discharge of, the Maker as a matter of law or equity. To the fullest extent permitted by applicable law, the Guarantors waive
any defense based on or arising out of any defense of the Maker or the unenforceability of the guaranteed obligations or any part thereof from any cause, or the cessation from any cause of the liability of the Maker. To the fullest extent permitted
by applicable law, the Guarantors waive any defense arising out of any such election even though such election operates, pursuant to applicable law, to impair or to extinguish any right of reimbursement or subrogation or other right or remedy. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">14 </P>

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<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) Upon the formation or acquisition of any new direct or indirect subsidiary by the Maker
or any of the Guarantors, the Maker or such Guarantor shall within ten (10)&nbsp;days after such formation, acquisition: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(i) cause each
such subsidiary to duly execute and deliver to the Holder joinders to this Note as Guarantors, intellectual property security agreements and other security agreements and documents as reasonably requested by and in form and substance reasonably
satisfactory to the Holder, in each case granting Liens required hereunder; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(ii) cause each such subsidiary to deliver any and all
certificates and instruments representing Collateral that are required to be delivered hereunder, accompanied by undated stock powers or other appropriate instruments of transfer executed in blank; and </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(iii) take and cause such subsidiary and each direct or indirect parent of such subsidiary to take whatever action (including the filing of UCC
financing statements and delivery of stock and membership interest certificates) as may be necessary in the reasonable opinion of the Holder to vest in the Holder (or in any representative of the Holder designated by it) valid and perfected Liens to
the extent required hereunder, and to otherwise comply with the requirements of this Note. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">SECTION&nbsp;10. <B><U>Miscellaneous</U></B>.
</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) Any notice required by the provisions of this Note shall be given in writing and shall be personally delivered or sent by registered
or certified mail, postage prepaid, return receipt requested, or by email, with confirmation of receipt, to the Holder, the Maker or the Guarantors, as the case may be, at its address set forth on the signature page hereof. All notices sent in
accordance with this section shall be deemed received on the earlier of the date of actual receipt or three (3)&nbsp;Business Days after the deposit thereof in the mail. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) In no event shall the interest rate or rates payable under this Note exceed the highest rate permissible under any law that a court of
competent jurisdiction shall, in a final determination, deem applicable. The Maker by its issuance hereof, each Guarantor by its guarantee hereof, and the Holder by its acceptance hereof intend to legally agree upon the rate of interest and manner
of payments stated herein; <U>provided</U>, <U>however</U>, that, anything contained herein to the contrary notwithstanding, if said rate or rates of interest or manner of payment exceeds the maximum rate allowable under applicable law, then,
<U>ipso</U> <U>facto</U> as of the date of this Note, each of the Maker and each Guarantor is and shall be liable only for the payment of such maximum amount as allowed by law, and payment received from the Maker or the Guarantors in excess of such
legal maximum, whenever received, shall be applied to reduce the principal balance of this Note to the extent of such excess. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Each of
the Maker and the Guarantors and any endorsers of this Note hereby consent to renewals and extensions of time at or after the maturity hereof, without notice, and hereby waive diligence, presentment, protest, demand, and notice of every kind and, to
the full extent permitted by law, the right to plead any statute of limitations as a defense to any demand hereunder. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">15 </P>

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<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) This Note shall be governed by and construed in accordance with laws of the State of New
York. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) Each party hereto hereby irrevocably and unconditionally submits, for itself and its property, to the exclusive jurisdiction of
any U.S. federal or New York State court in each case sitting in the Borough of Manhattan in New York City in any action or proceeding arising out of or relating to this Note or any Collateral Document, or for recognition or enforcement of any
judgment, and each of the parties hereto hereby irrevocably and unconditionally agrees that all claims in respect of any such action or proceeding may be heard and determined in such New York State or, to the extent permitted by law, in such federal
court. Each of the parties hereto agrees that a final judgment in any such action or proceeding shall be conclusive and may be enforced in other jurisdictions by suit on the judgment or in any other manner provided by law. Nothing in this Note or
any Collateral Document shall affect any right that Holder may otherwise have to bring any action or proceeding relating to this Note or any Collateral Document against the Maker or its properties in the courts of any jurisdiction. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(f) Each party hereto hereby irrevocably and unconditionally waives, to the fullest extent it may legally and effectively do so, any objection
which it may now or hereafter have to the laying of venue of any suit, action or proceeding arising out of or relating to this Note or any Collateral Document in any court referred to in <U>Subsection (e)</U>&nbsp;of this
<U>Section</U><U></U><U>&nbsp;10</U>. Each of the parties hereto hereby irrevocably waives, to the fullest extent permitted by law, the defense of an inconvenient forum to the maintenance of such action or proceeding in any such court. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(g) Each party hereto irrevocably consents to service of process in the manner provided for notices in <U>Section</U><U></U><U>&nbsp;10(a)</U>
hereunder. Nothing in this Note or any Collateral Document will affect the right of any party hereto to serve process in any other manner permitted by applicable law. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(h) EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN
ANY LEGAL PROCEEDING DIRECTLY OR INDIRECTLY ARISING OUT OF OR RELATING TO THIS NOTE OR ANY COLLATERAL AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY (WHETHER BASED ON CONTRACT, TORT OR ANY OTHER THEORY). EACH PARTY HERETO
(A)&nbsp;CERTIFIES THAT NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PERSON HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PERSON WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER AND (B)&nbsp;ACKNOWLEDGES
THAT IT AND THE OTHER PARTIES HERETO HAVE BEEN INDUCED TO ENTER INTO THIS NOTE AND THE OTHER LOAN DOCUMENTATION BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 10(h). </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">16 </P>

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<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(i) The Maker shall maintain a separate register for the registration of the Note (the
&#8220;<B><U>Register</U></B>&#8221;). The Register shall contain (i)&nbsp;the names and addresses of each person that holds any interest in this Note (including for the avoidance of doubt any person to which the Holder (or any of its successors or
assigns) transfer any interest in the Note), (ii) the principal amounts (and stated interest) of the Note owing to each such person pursuant to the terms hereof from time to time, (iii)&nbsp;the date and amount of each interest payment by Maker to
Holder and (iv)&nbsp;the date and amount of each payment of any principal amount by Maker to Holder. Notwithstanding anything to the contrary in this Note, the entries in the Register shall be conclusive absent manifest error, and the Holder and the
Maker shall treat each person whose name is recorded in the Register pursuant to the terms hereof as a lender hereunder for all purposes of this Note. The Register shall be available for inspection by the Holder at any reasonable time and from time
to time upon reasonable prior notice. The parties intend the loan to be in registered form under <FONT STYLE="white-space:nowrap">Section&nbsp;5f.103-1(c)</FONT> of the United States Treasury Regulations and this Note shall be interpreted in
accordance with such intent. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(j) This Note shall be binding upon the successors and assigns of the Maker and the Guarantors and shall
inure to the benefit of the Holder and its successors and assigns; <U>provided</U>, <U>however</U>, that none of the Maker nor the Guarantors may assign this Note without the prior written consent of the Holder; <U>provided</U>, <U>further</U>, that
the Holder may not assign this Note prior to the occurrence of a Triggering Event, and any assignment in violation hereof shall be void <U>ab</U> <U>initio</U>. The Maker shall record any assignment permitted by this paragraph in the Register
pursuant to the rules under <FONT STYLE="white-space:nowrap">Section&nbsp;1.871-14(c)(1)(i)</FONT> of the United States Treasury Regulations. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>Remainder of page left intentionally blank. </I></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">17 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, the undersigned has executed and delivered this Note effective on the
date first above written. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


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<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"><B>Maker:</B></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"><B>ADVERUM BIOTECHNOLOGIES, INC.</B>,</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">a Delaware corporation</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Laurent Fisher</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Name: Laurent Fisher, M.D.</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Title: President and Chief Executive Officer</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Address for Notices:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Adverum Biotechnologies, Inc.</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">100 Cardinal Way, Redwood City, CA 94063</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Attention: Laurent Fischer, President and Chief Executive Officer</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">with a copy (which shall not constitute notice) to:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Adverum Biotechnologies, Inc.</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">100 Cardinal Way, Redwood City, CA 94063</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Attention: General Counsel</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Email: [Intentionally omitted]</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">with a copy (which shall not constitute notice) to:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Cooley LLP</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">55 Hudson Yards</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">New York, NY 10001-2157</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Attention: Bill Roegge; Jason Kent; Addison Pierce</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Email: broegge@cooley.com; jkent@cooley.com; afpierce@cooley.com</TD></TR>
</TABLE></DIV>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">18 </P>

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 <DIV ALIGN="right">
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<TD VALIGN="top" COLSPAN="3"><B>Guarantors:</B></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"><B>ADVERUM NC, LLC</B></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Linda Rubinstein</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Name: Linda Rubinstein</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Title: Chief Financial Officer</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Address for Notices:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Adverum Biotechnologies, Inc.</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">100 Cardinal Way, Redwood City, CA 94063</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Attention: Laurent Fischer, President and Chief Executive Officer</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">with a copy (which shall not constitute notice) to:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Adverum Biotechnologies, Inc.</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">100 Cardinal Way, Redwood City, CA 94063</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Attention: General Counsel</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Email: [Intentionally omitted]</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">with a copy (which shall not constitute notice) to:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Cooley LLP</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">55 Hudson Yards</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">New York, NY 10001-2157</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Attention: Bill Roegge; Jason Kent; Addison Pierce</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Email: broegge@cooley.com; jkent@cooley.com; afpierce@cooley.com</TD></TR>
</TABLE></DIV>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">19 </P>

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<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Executed by <B>Avalanche Australia Pty Ltd (ACN</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>155 723 738)</B> in accordance with section 127 of</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">the
<I>Corporations Act 2001 </I>(Cth) by:</P></TD></TR></TABLE> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Kishor Peter Soparkar</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Marc Douglas Tobit Peskett</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Signature of director</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Signature of director/secretary</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Kishor Peter Soparkar</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Marc Douglas Tobit Peskett</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"><DIV STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000">&nbsp;</DIV> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">Name of director (print)</P></TD>

<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><DIV STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000">&nbsp;</DIV> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">Name of director/secretary
(print)</P></TD></TR>
</TABLE> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="100%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Address for Notices:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Adverum Biotechnologies, Inc.</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">100 Cardinal Way,
Redwood City, CA 94063</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Attention: Laurent Fischer, President and Chief</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Executive Officer</P> <P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">with a copy (which shall not constitute notice) to:</P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Adverum Biotechnologies, Inc.</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">100 Cardinal Way,
Redwood City, CA 94063</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Attention: General Counsel</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Email: [Intentionally omitted]</P> <P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">with a copy (which shall not constitute notice) to:</P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Cooley LLP 55</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">Hudson Yards</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">New York, NY 10001-2157</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Attention: Bill Roegge; Jason Kent; Addison Pierce</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Email: broegge@cooley.com; jkent@cooley.com;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">afpierce@cooley.com</P></TD></TR>
</TABLE></DIV>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">20 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="38%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="22%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="38%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>SIGNED AND DELIVERED </B>for and on behalf of</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">and as the <B>DEED</B> of:</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"><B>ANNAPURNA THERAPEUTICS LIMITED</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">by its lawfully appointed
attorney<B>&nbsp;
</B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B>
</B><B></B><B></B><B></B><B></B><B></B><B></B><B></B><B></B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Kishor Peter Soparkar</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"><B>Attorney Signature</B></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">Kishor Peter Soparkar</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"><B>Attorney Name</B></TD></TR></TABLE> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="100%"></TD></TR>

<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">in the presence of:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Kathryn Ask</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">(Witness Signature)</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"><U>100 Cardinal Way,</U></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"><U>Redwood City, CA 94063</U></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">(Witness Address)</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">Executive Assistant</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">(Witness Occupation)</TD></TR>
</TABLE> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="100%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Address for Notices:</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Adverum Biotechnologies, Inc.</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">100 Cardinal Way, Redwood City, CA 94063</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Attention: Laurent Fischer, President and Chief Executive Officer</P> <P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">with a copy (which shall not constitute notice) to:</P> <P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:1pt">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Adverum Biotechnologies, Inc.</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">100 Cardinal Way,
Redwood City, CA 94063</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Attention: General Counsel</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Email: [Intentionally omitted]</P> <P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">with a copy (which shall not constitute notice) to:</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Cooley LLP</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">55 Hudson Yards</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">New York, NY 10001-2157</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Attention: Bill Roegge; Jason Kent; Addison Pierce</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Email: broegge@cooley.com; jkent@cooley.com; afpierce@cooley.com</TD></TR>
</TABLE></DIV>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">21 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Acknowledged and Agreed:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"><B>Holder:</B></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"><B>ELI LILLY AND COMPANY,</B></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">an Indiana corporation</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Andrew Charles Adams</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Name: Andrew Charles Adams</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Title: Group Vice President - Molecule Discovery</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">&#8195;&#8195;&#8194;Lilly Research Laboratories</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Address for Notices:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Eli Lilly and Company</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Lilly Corporate Center</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Indianapolis, Indiana 46285</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Attention: Senior Vice President and Head of Corporate Business Development</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">with a copy (which shall not constitute notice) to:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Eli Lilly and Company</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Lilly Corporate Center</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Indianapolis, Indiana 46285</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Attention: Senior Vice President - Transactions and Contracting</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">with an additional copy (which will not constitute notice) to:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Ropes&nbsp;&amp; Gray LLP</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">800 Boylston Street, Prudential Tower</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Boston, MA 02199-3600</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Attention: Emily J. Oldshue; Daniel Coyne</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Email: Emily.Oldshue@ropesgray.com; Daniel.Coyne@ropesgray.com</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">22 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><U>Exhibit A </U></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">Perfection Certificate </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><U>Exhibit B </U></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">Financial Reporting Template </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><U>Exhibit <FONT STYLE="white-space:nowrap">C-1</FONT> </U></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">US Patent Security Agreements </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><U>Exhibit <FONT STYLE="white-space:nowrap">C-2</FONT> </U></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">US Trademark Security Agreements </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
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<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">US Copyright Security Agreements </P>
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</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">October&nbsp;24, 2025 </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top"><B>For&nbsp;Release:</B></TD>
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<TD VALIGN="top">Immediately</TD></TR>
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<TD VALIGN="top"><B>Refer&nbsp;to:</B></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Ashley&nbsp;Hennessey;&nbsp;<U>gentry_ashley_jo@lilly.com</U>&nbsp;;&nbsp;317-416-4363&nbsp;(Media)<B>&nbsp;</B></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
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<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Jason&nbsp;Awe,&nbsp;PhD;&nbsp;j<U>awe@adverum.com</U><B>;</B>&nbsp;(Adverum)</TD></TR>
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<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Michael&nbsp;Czapar;&nbsp;<U>czapar_michael_c@lilly.com</U>;&nbsp;317-617-0983&nbsp;(Investors)&nbsp;<B></B></TD></TR>
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</TABLE> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Lilly to Acquire Adverum Biotechnologies </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman"><I>Adverum&#8217;s lead program, <FONT STYLE="white-space:nowrap">Ixo-vec,</FONT> is a Phase 3 gene therapy designed to treat vision loss
associated with wet <FONT STYLE="white-space:nowrap">age-related</FONT> macular degeneration with a single intravitreal dose </I></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman"><I>Acquisition aligns Lilly&#8217;s genetic medicine capabilities with opportunity to expand gene therapy&#8217;s potential to alleviate the
burden of <FONT STYLE="white-space:nowrap">age-related</FONT> diseases </I></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">INDIANAPOLIS and REDWOOD CITY, Calif.,&nbsp;October 24, 2025&nbsp;&#8211; Eli
Lilly and Company (NYSE: LLY) and Adverum Biotechnologies, Inc. (Nasdaq: ADVM), a clinical-stage company pioneering the use of intravitreal gene therapy with the aim of preserving sight for life in highly prevalent ocular diseases, today announced a
definitive agreement for Lilly to acquire Adverum Biotechnologies, Inc. (&#8220;Adverum&#8221;), including its lead product candidate, <FONT STYLE="white-space:nowrap">Ixo-vec.</FONT> </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Adverum is developing a pipeline of intravitreal single-administration gene therapies with the aspiration of developing functional cures to restore vision and
prevent blindness. Its lead product candidate, <FONT STYLE="white-space:nowrap">Ixo-vec,</FONT> is an intravitreal gene therapy being developed for the treatment of wet <FONT STYLE="white-space:nowrap">age-related</FONT> macular degeneration (wAMD).
This serious, chronic and progressive retinal disease affects millions of people worldwide. <FONT STYLE="white-space:nowrap">Ixo-vec</FONT> is designed as a single <FONT STYLE="white-space:nowrap">one-time</FONT> treatment to deliver continuous and
stable intraocular aflibercept levels, thereby reducing the significant patient burden associated with current chronic anti-VEGF therapies, while also potentially leading to improved vision outcomes. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><FONT STYLE="white-space:nowrap">Ixo-vec</FONT> is being evaluated in the ARTEMIS Phase 3 clinical trial, which has completed screening. The program has been
granted Fast Track and Regenerative Medicine Advanced Therapy (RMAT) designations by the U.S. Food and Drug Administration, as well as PRIME designation by </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">the European Medicines Agency and the Innovation Passport from the United Kingdom&#8217;s Medicines and Healthcare Products Regulatory Agency for the
treatment of wAMD. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt;margin-bottom:0pt" ALIGN="center">


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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><FONT STYLE="white-space:nowrap">&#8220;Ixo-vec</FONT> has the potential to transform wAMD treatment from a
paradigm of chronic care with repeated intravitreal injections to a convenient <FONT STYLE="white-space:nowrap">one-time</FONT> therapy,&#8221; said Andrew Adams, Lilly group vice president, Molecule Discovery. &#8220;We are eager to welcome Adverum
colleagues to Lilly and to help accelerate this innovative medicine to patients.&#8221; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">&#8220;We are excited about the potential to join Lilly, with a
proven track record in the discovery, development, and commercialization of innovative medicines for chronic and <FONT STYLE="white-space:nowrap">age-related</FONT> conditions,&#8221; said Laurent Fischer, M.D., president and chief executive officer
of Adverum Biotechnologies. &#8220;We share Lilly&#8217;s commitment to healthy aging and genetic medicines innovation. Their scientific depth and global reach offer the opportunity to accelerate our vision to deliver a transformative One and Done<SUP
STYLE="font-size:75%; vertical-align:top">&#153;</SUP> therapy that can potentially restore and preserve vision for millions of patients living with wAMD. My deepest appreciation goes out to the entire Adverum team for their expertise, creativity
and commitment. We are also grateful to the investigators, patients and caregivers who have contributed to the success of <FONT STYLE="white-space:nowrap">Ixo-vec</FONT> thus far.&#8221; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Under the terms of the merger agreement, Lilly will commence a tender offer to acquire all of the outstanding shares of Adverum common stock for a per share
price of (1)&nbsp;$3.56 per share in cash payable at closing plus (2)&nbsp;one <FONT STYLE="white-space:nowrap">non-transferrable</FONT> contingent value right (CVR) that entitles the holder to receive up to an additional $8.91 per CVR in cash upon
the achievement of two milestones described below, for total potential per share consideration of up to $12.47. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The CVR provides payments if and when the
following milestones are achieved: </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="5%">&nbsp;</TD>
<TD WIDTH="3%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt">Up to $1.78 per CVR in cash payable upon U.S. approval of <FONT STYLE="white-space:nowrap">Ixo-vec</FONT> prior
to the seventh anniversary of closing. </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="5%">&nbsp;</TD>
<TD WIDTH="3%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt">Up to $7.13 per CVR in cash payable upon the first achievement of annual worldwide net sales of <FONT
STYLE="white-space:nowrap">Ixo-vec</FONT> by Lilly, its affiliates or licensees exceeding $1.0&nbsp;billion dollars prior to the tenth anniversary of closing. </P></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The transaction is subject to closing conditions that appear in the merger agreement and tender offer documents that will be filed with the SEC, including the
tender of&nbsp;a majority of&nbsp;the outstanding shares of Adverum&#8217;s common stock. These conditions do not include a financing condition. The transaction is expected to close in the&nbsp;fourth quarter of 2025, subject to satisfaction of the
closing conditions.&nbsp;If the tender offer successfully closes, then Lilly would acquire any shares of Adverum that are not tendered in the tender offer through a second-step merger for the same consideration as is paid in the tender offer. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">2 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">In conjunction with the transaction, Adverum has entered into a Promissory Note (the &#8220;Promissory
Note&#8221;) with Lilly. The Promissory Note is secured by all of Adverum&#8217;s assets, including all of its intellectual property rights, and enables Adverum to receive a loan of up to $65&nbsp;million from Lilly, drawable by Adverum in four
installments, subject to specified conditions, to support ongoing <FONT STYLE="white-space:nowrap">Ixo-vec</FONT> clinical trials and registrational development activities prior to the anticipated closing of the transaction. Funding obligations
cease and the Promissory Note immediately becomes due if the transaction is terminated, including as a result of the minimum tender condition not being satisfied. Absent funds provided by Lilly under the Promissory Note, Adverum&#8217;s remaining
cash and cash equivalents were expected to finance only its October 2025 operations and wind down activities. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The transaction was unanimously approved by
Adverum&#8217;s board of directors following a comprehensive evaluation of strategic alternatives. This evaluation process included numerous discussions with potential partners and buyers. In addition, the board of directors evaluated a range of
potential sources of additional capital and financing options. It was determined that the merger agreement with Lilly, inclusive of the potential upside for Adverum&#8217;s stockholders of the CVR as Lilly advances development of <FONT
STYLE="white-space:nowrap">Ixo-vec,</FONT> is in the best interests of Adverum and its stockholders. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">For&nbsp;Lilly, Ropes&nbsp;&amp; Gray LLP is acting
as legal counsel. For Adverum, Aquilo Partners, L.P. is acting as exclusive financial advisor and Cooley LLP is acting as legal counsel. </P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>About Lilly
</B></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Lilly is a medicine company turning science into healing&nbsp;to make life better for people around the world. We&#8217;ve been pioneering
life-changing discoveries for nearly 150 years, and today our medicines help tens of millions of people across the globe. Harnessing the power of biotechnology, chemistry and genetic medicine, our scientists are urgently advancing new discoveries to
solve some of the world&#8217;s most significant health challenges: redefining diabetes care; treating obesity and curtailing its most devastating long-term effects; advancing the fight against Alzheimer&#8217;s disease; providing solutions to some
of the most debilitating immune system disorders; and transforming the most <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">difficult-to-treat</FONT></FONT> cancers into manageable diseases. With each step toward a healthier world,
we&#8217;re motivated by one thing: making life better for millions more people. That includes delivering innovative clinical trials that reflect the diversity of our world and working to ensure our medicines are accessible and affordable. <FONT
STYLE="white-space:nowrap">F-LLY</FONT> </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">3 </P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>About Adverum Biotechnologies </B></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Adverum Biotechnologies (NASDAQ: ADVM) is a clinical-stage company that aims to establish gene therapy as a new standard of care for highly prevalent ocular
diseases with the aspiration of developing functional cures to restore vision and prevent blindness. Leveraging the capabilities of its proprietary intravitreal platform, Adverum is developing durable, single-administration therapies, designed to be
delivered in physicians&#8217; offices, to eliminate the need for frequent ocular injections to treat these diseases. Adverum is evaluating its novel gene therapy candidate, ixoberogene soroparvovec <FONT STYLE="white-space:nowrap">(Ixo-vec,</FONT>
formerly referred to as <FONT STYLE="white-space:nowrap">ADVM-022),</FONT> as a <FONT STYLE="white-space:nowrap">one-time,</FONT> IVT injection for patients with neovascular or wet <FONT STYLE="white-space:nowrap">age-related</FONT> macular
degeneration. Additionally, by overcoming the challenges associated with current treatment paradigms for debilitating ocular diseases, Adverum aspires to transform the standard of care, preserve vision, and create a profound societal impact around
the globe. </P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>About <FONT STYLE="white-space:nowrap">Ixo-vec</FONT> in Wet AMD </B></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Adverum is developing ixoberogene soroparvovec <FONT STYLE="white-space:nowrap">(Ixo-vec,</FONT> formerly referred to as
<FONT STYLE="white-space:nowrap">ADVM-022),</FONT> its clinical-stage gene therapy product candidate, for the treatment of wet AMD. <FONT STYLE="white-space:nowrap">Ixo-vec</FONT> utilizes a proprietary vector capsid, AAV.7m8, carrying an
aflibercept coding sequence under the control of a proprietary expression cassette. Unlike other ophthalmic gene therapies that require surgery to administer the gene therapy under the retina <FONT STYLE="white-space:nowrap">(sub-retinal</FONT>
approach), <FONT STYLE="white-space:nowrap">Ixo-vec</FONT> is designed to be administered as a <FONT STYLE="white-space:nowrap">one-time</FONT> IVT injection in the physician&#8217;s office, deliver long-term efficacy, reduce the burden of frequent
anti-VEGF, optimize patient compliance, and improve vision outcomes for patients with wet AMD. In recognition of the need for new treatment options for wet AMD, FDA granted Fast Track and Regenerative Medicine Advanced Therapy (RMAT) designations
for <FONT STYLE="white-space:nowrap">Ixo-vec</FONT> for the treatment of wet AMD. <FONT STYLE="white-space:nowrap">Ixo-vec</FONT> has also received PRIME designation from the EMA and the Innovation Passport from the United Kingdom&#8217;s Medicines
and Healthcare Products Regulatory Agency for the treatment of wet AMD. </P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>Forward-looking Statements </B></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">This press release contains forward-looking statements regarding Lilly&#8217;s proposed acquisition of Adverum, regarding prospective benefits of the proposed
acquisition and Adverum&#8217;s gene editing programs for retinal disease, regarding potential contingent consideration amounts and terms, regarding the anticipated occurrence, manner and timing of the proposed tender offer and the closing of the
proposed acquisition, regarding Adverum&#8217;s cash runway and prospects, regarding the potential availability of financing under the Promissory Note to Adverum, regarding Adverum&#8217;s product candidates and ongoing clinical and preclinical
development, and regarding Lilly&#8217;s development of programs for ophthalmology and advancement of gene therapies. All statements other than </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">4 </P>

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statements of historical fact are statements that could be deemed forward-looking statements. Forward-looking statements involve inherent risks and uncertainties, including with respect to
consummating the proposed acquisition and any competing offers or acquisition proposals for Adverum, drug research, development and commercialization, Adverum&#8217;s prospects, uncertainties as to how many of Adverum&#8217;s stockholders will
tender their stock in the tender offer, the effects of the proposed acquisition (or the announcement thereof) on Adverum&#8217;s stock price, relationships with key third parties or governmental entities, regulatory changes and developments, the
impact of global&nbsp;macroeconomic conditions, including trade and other global disputes and interruptions, including related to tariffs, trade protection measures, and similar restrictions, transaction costs, risks that the proposed acquisition
disrupts current plans and operations or adversely affects employee retention, potentially diverting management&#8217;s attention from Adverum&#8217;s ongoing business operations, changes in Adverum&#8217;s business during the period between
announcement and closing of the proposed acquisition, and any legal proceedings that may be instituted related to the proposed acquisition. Actual results could differ materially due to various factors, risks and uncertainties. Among other things,
there can be no guarantee that the proposed acquisition will be completed in the anticipated timeframe or at all, that the conditions required to complete the proposed acquisition or provide Adverum financing under the Promissory Note will be met,
that any event, change or other circumstance that could give rise to the termination of the merger agreement or the Promissory Note will not occur, that Lilly will realize the expected benefits of the proposed acquisition, that product candidates
will be approved on anticipated timelines or at all, that any products, if approved, will be commercially successful, that all or any of the contingent consideration will become payable on the terms described herein or at all, that Lilly&#8217;s
financial results will be consistent with its expected 2025 guidance or that Lilly can reliably predict the impact of the proposed acquisition on its financial results or financial guidance. For further discussion of these and other risks and
uncertainties, see Lilly&#8217;s and Adverum&#8217;s most recent Form <FONT STYLE="white-space:nowrap">10-K</FONT> and Form <FONT STYLE="white-space:nowrap">10-Q</FONT> filings with the&nbsp;U.S. Securities and Exchange Commission (SEC). Except as
required by law, neither Lilly nor Adverum undertakes any duty to update forward-looking statements to reflect events after the date of this filing. </P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>Additional Information about the Acquisition and Where to Find It </B></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The tender offer for all of the outstanding shares of Adverum described in this communication has not yet commenced. This press release is for informational
purposes only, is not a recommendation and is neither an offer to purchase nor a solicitation of an offer to sell any securities, nor is it a substitute for the tender offer materials that Lilly and its acquisition subsidiary will file with the SEC
upon commencement of the tender offer. A solicitation and offer to buy outstanding shares of Adverum will only be made pursuant to the tender offer materials that Lilly and its acquisition subsidiary intend to file with the SEC. At the time the
tender offer is commenced, Lilly and its acquisition subsidiary will file tender offer materials on Schedule TO, and Adverum will file a Solicitation/Recommendation Statement on Schedule <FONT STYLE="white-space:nowrap">14D-9</FONT> with the SEC
with respect to the tender offer. THE TENDER OFFER MATERIALS (INCLUDING AN OFFER TO PURCHASE, A RELATED LETTER OF TRANSMITTAL AND CERTAIN OTHER TENDER OFFER DOCUMENTS) AND THE SOLICITATION/RECOMMENDATION STATEMENT WILL CONTAIN IMPORTANT INFORMATION
ABOUT THE PROPOSED ACQUISITION AND THE PARTIES THERETO. INVESTORS AND STOCKHOLDERS OF ADVERUM ARE URGED TO READ THESE DOCUMENTS CAREFULLY WHEN THEY BECOME AVAILABLE (AND EACH AS IT MAY BE AMENDED OR SUPPLEMENTED FROM TIME TO TIME) BECAUSE THEY WILL
CONTAIN IMPORTANT INFORMATION THAT INVESTORS AND STOCKHOLDERS OF ADVERUM SHOULD CONSIDER BEFORE MAKING ANY DECISION REGARDING TENDERING THEIR SHARES OF COMMON STOCK IN THE TENDER OFFER. The tender offer materials (including the Offer to Purchase and
the related Letter of Transmittal), as well as the Solicitation/Recommendation Statement, will be made available to all stockholders of Adverum at no expense to them at Lilly&#8217;s website at investor.lilly.com and (once they become available)
will be mailed to the stockholders of Adverum free of charge. The information contained in, or that can be accessed through, Lilly&#8217;s website is not a part of, or incorporated by reference herein. The tender offer materials (including the Offer
to Purchase and the related Letter of Transmittal), as well as the Solicitation/Recommendation Statement, will also be made available for free on the SEC&#8217;s website at www.sec.gov. In addition to the Offer to Purchase, the related Letter of
Transmittal and certain other tender offer documents, as well as the Solicitation/Recommendation Statement, Lilly and Adverum file annual, quarterly, and current reports, proxy statements and other information with the SEC. You may read any reports,
statements or other information filed by Lilly and Adverum with the SEC for free on the SEC&#8217;s website at www.sec.gov. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">5 </P>

</DIV></Center>

</BODY></HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.SCH
<SEQUENCE>5
<FILENAME>advm-20251024.xsd
<DESCRIPTION>XBRL TAXONOMY EXTENSION SCHEMA
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii"?>
<!-- DFIN - https://www.dfinsolutions.com/ -->
<!-- CTU Version: Release 2512 Build:20250722.1 -->
<!-- Creation date: 10/24/2025 5:09:25 PM Eastern Time -->
<!-- Copyright (c) 2025 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
<xsd:schema
  xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric"
  xmlns:num="http://www.xbrl.org/dtr/type/numeric"
  xmlns:us-types="http://fasb.org/us-types/2025"
  xmlns:advm="http://www.adverum.com/20251024"
  xmlns:dei="http://xbrl.sec.gov/dei/2025"
  xmlns:xbrli="http://www.xbrl.org/2003/instance"
  xmlns:link="http://www.xbrl.org/2003/linkbase"
  xmlns:xlink="http://www.w3.org/1999/xlink"
  xmlns:xbrldt="http://xbrl.org/2005/xbrldt"
  attributeFormDefault="unqualified"
  elementFormDefault="qualified"
  targetNamespace="http://www.adverum.com/20251024"
  xmlns:xsd="http://www.w3.org/2001/XMLSchema">
    <xsd:import schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/instance" />
    <xsd:import schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/linkbase" />
    <xsd:import schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd" namespace="http://xbrl.sec.gov/dei/2025" />
    <xsd:import schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" namespace="http://www.xbrl.org/dtr/type/numeric" />
    <xsd:import schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" namespace="http://www.xbrl.org/dtr/type/non-numeric" />
    <xsd:import schemaLocation="https://xbrl.sec.gov/naics/2025/naics-2025.xsd" namespace="http://xbrl.sec.gov/naics/2025" />
    <xsd:import schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" namespace="http://xbrl.org/2005/xbrldt" />
  <xsd:annotation>
    <xsd:appinfo>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="advm-20251024_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:title="Label Links, all" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="advm-20251024_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:title="Presentation Links, all" xlink:type="simple" />
      <link:roleType roleURI="http://www.adverum.com//20251024/taxonomy/role/DocumentDocumentAndEntityInformation" id="Role_DocumentDocumentAndEntityInformation">
        <link:definition>100000 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xsd:appinfo>
  </xsd:annotation>
</xsd:schema>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.LAB
<SEQUENCE>6
<FILENAME>advm-20251024_lab.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION LABEL LINKBASE
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii" standalone="yes"?>
<!-- DFIN - https://www.dfinsolutions.com/ -->
<!-- CTU Version: Release 2512 Build:20250722.1 -->
<!-- Creation date: 10/24/2025 5:09:25 PM Eastern Time -->
<!-- Copyright (c) 2025 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
<link:linkbase
  xmlns:link="http://www.xbrl.org/2003/linkbase"
  xmlns:xlink="http://www.w3.org/1999/xlink"
  xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
  xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:labelLink xlink:role="http://www.xbrl.org/2003/role/link" xlink:type="extended">
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract" xlink:type="locator" xlink:label="dei_CoverAbstract" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_CoverAbstract" xlink:to="dei_CoverAbstract_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_CoverAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Cover [Abstract]</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_CoverAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cover [Abstract]</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName" xlink:type="locator" xlink:label="dei_SecurityExchangeName" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_SecurityExchangeName" xlink:to="dei_SecurityExchangeName_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_SecurityExchangeName_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Security Exchange Name</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_SecurityExchangeName_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Security Exchange Name</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag" xlink:type="locator" xlink:label="dei_AmendmentFlag" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_AmendmentFlag" xlink:to="dei_AmendmentFlag_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_AmendmentFlag_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Amendment Flag</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_AmendmentFlag_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amendment Flag</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey" xlink:type="locator" xlink:label="dei_EntityCentralIndexKey" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityCentralIndexKey" xlink:to="dei_EntityCentralIndexKey_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Central Index Key</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Central Index Key</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType" xlink:type="locator" xlink:label="dei_DocumentType" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentType" xlink:to="dei_DocumentType_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_DocumentType_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Document Type</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_DocumentType_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Type</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate" xlink:type="locator" xlink:label="dei_DocumentPeriodEndDate" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentPeriodEndDate" xlink:to="dei_DocumentPeriodEndDate_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Document Period End Date</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Period End Date</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName" xlink:type="locator" xlink:label="dei_EntityRegistrantName" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityRegistrantName" xlink:to="dei_EntityRegistrantName_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityRegistrantName_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Registrant Name</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityRegistrantName_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Registrant Name</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode" xlink:type="locator" xlink:label="dei_EntityIncorporationStateCountryCode" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityIncorporationStateCountryCode" xlink:to="dei_EntityIncorporationStateCountryCode_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityIncorporationStateCountryCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Incorporation State Country Code</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityIncorporationStateCountryCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Incorporation State Country Code</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber" xlink:type="locator" xlink:label="dei_EntityFileNumber" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityFileNumber" xlink:to="dei_EntityFileNumber_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityFileNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity File Number</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityFileNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity File Number</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber" xlink:type="locator" xlink:label="dei_EntityTaxIdentificationNumber" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityTaxIdentificationNumber" xlink:to="dei_EntityTaxIdentificationNumber_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityTaxIdentificationNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Tax Identification Number</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityTaxIdentificationNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Tax Identification Number</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1" xlink:type="locator" xlink:label="dei_EntityAddressAddressLine1" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressAddressLine1" xlink:to="dei_EntityAddressAddressLine1_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressAddressLine1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, Address Line One</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressAddressLine1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, Address Line One</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown" xlink:type="locator" xlink:label="dei_EntityAddressCityOrTown" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressCityOrTown" xlink:to="dei_EntityAddressCityOrTown_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressCityOrTown_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, City or Town</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressCityOrTown_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, City or Town</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince" xlink:type="locator" xlink:label="dei_EntityAddressStateOrProvince" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressStateOrProvince" xlink:to="dei_EntityAddressStateOrProvince_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressStateOrProvince_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, State or Province</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressStateOrProvince_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, State or Province</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode" xlink:type="locator" xlink:label="dei_EntityAddressPostalZipCode" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressPostalZipCode" xlink:to="dei_EntityAddressPostalZipCode_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressPostalZipCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, Postal Zip Code</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressPostalZipCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, Postal Zip Code</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode" xlink:type="locator" xlink:label="dei_CityAreaCode" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_CityAreaCode" xlink:to="dei_CityAreaCode_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_CityAreaCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">City Area Code</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_CityAreaCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">City Area Code</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber" xlink:type="locator" xlink:label="dei_LocalPhoneNumber" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_LocalPhoneNumber" xlink:to="dei_LocalPhoneNumber_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_LocalPhoneNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Local Phone Number</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_LocalPhoneNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Local Phone Number</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications" xlink:type="locator" xlink:label="dei_WrittenCommunications" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_WrittenCommunications" xlink:to="dei_WrittenCommunications_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_WrittenCommunications_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Written Communications</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_WrittenCommunications_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Written Communications</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial" xlink:type="locator" xlink:label="dei_SolicitingMaterial" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_SolicitingMaterial" xlink:to="dei_SolicitingMaterial_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_SolicitingMaterial_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Soliciting Material</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_SolicitingMaterial_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Soliciting Material</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer" xlink:type="locator" xlink:label="dei_PreCommencementTenderOffer" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_PreCommencementTenderOffer" xlink:to="dei_PreCommencementTenderOffer_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_PreCommencementTenderOffer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Pre Commencement Tender Offer</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_PreCommencementTenderOffer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pre Commencement Tender Offer</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer" xlink:type="locator" xlink:label="dei_PreCommencementIssuerTenderOffer" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_PreCommencementIssuerTenderOffer" xlink:to="dei_PreCommencementIssuerTenderOffer_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_PreCommencementIssuerTenderOffer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Pre Commencement Issuer Tender Offer</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_PreCommencementIssuerTenderOffer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pre Commencement Issuer Tender Offer</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle" xlink:type="locator" xlink:label="dei_Security12bTitle" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_Security12bTitle" xlink:to="dei_Security12bTitle_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_Security12bTitle_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Security 12b Title</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_Security12bTitle_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Security 12b Title</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol" xlink:type="locator" xlink:label="dei_TradingSymbol" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_TradingSymbol" xlink:to="dei_TradingSymbol_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_TradingSymbol_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Trading Symbol</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_TradingSymbol_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trading Symbol</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany" xlink:type="locator" xlink:label="dei_EntityEmergingGrowthCompany" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityEmergingGrowthCompany" xlink:to="dei_EntityEmergingGrowthCompany_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityEmergingGrowthCompany_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Emerging Growth Company</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityEmergingGrowthCompany_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Emerging Growth Company</link:label>
  </link:labelLink>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.PRE
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<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="include/report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
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<span style="display: none;">v3.25.3</span><table class="report" border="0" cellspacing="2" id="id2">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Document and Entity Information<br></strong></div></th>
<th class="th"><div>Oct. 24, 2025</div></th>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CoverAbstract', window );"><strong>Cover [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NASDAQ<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_AmendmentFlag', window );">Amendment Flag</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityCentralIndexKey', window );">Entity Central Index Key</a></td>
<td class="text">0001501756<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentType', window );">Document Type</a></td>
<td class="text">8-K<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentPeriodEndDate', window );">Document Period End Date</a></td>
<td class="text">Oct. 24,  2025<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityRegistrantName', window );">Entity Registrant Name</a></td>
<td class="text">Adverum Biotechnologies, Inc.<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityIncorporationStateCountryCode', window );">Entity Incorporation State Country Code</a></td>
<td class="text">DE<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityFileNumber', window );">Entity File Number</a></td>
<td class="text">001-36579<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityTaxIdentificationNumber', window );">Entity Tax Identification Number</a></td>
<td class="text">20-5258327<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine1', window );">Entity Address, Address Line One</a></td>
<td class="text">100 Cardinal Way<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressCityOrTown', window );">Entity Address, City or Town</a></td>
<td class="text">Redwood City<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressStateOrProvince', window );">Entity Address, State or Province</a></td>
<td class="text">CA<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressPostalZipCode', window );">Entity Address, Postal Zip Code</a></td>
<td class="text">94063<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CityAreaCode', window );">City Area Code</a></td>
<td class="text">(650)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_LocalPhoneNumber', window );">Local Phone Number</a></td>
<td class="text">656-9323<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_WrittenCommunications', window );">Written Communications</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SolicitingMaterial', window );">Soliciting Material</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementTenderOffer', window );">Pre Commencement Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementIssuerTenderOffer', window );">Pre Commencement Issuer Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Security 12b Title</a></td>
<td class="text">Common Stock<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">ADVM<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityEmergingGrowthCompany', window );">Entity Emerging Growth Company</a></td>
<td class="text">false<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_AmendmentFlag">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AmendmentFlag</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
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<td><strong> Balance Type:</strong></td>
<td>na</td>
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<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CityAreaCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Area code of city</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CityAreaCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
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<td><strong> Balance Type:</strong></td>
<td>na</td>
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<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CoverAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Cover page.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CoverAbstract</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
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<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
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</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentPeriodEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period. The format of the date is YYYY-MM-DD.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentPeriodEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:dateItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
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<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentType</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:submissionTypeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 1 such as Attn, Building Name, Street Name</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressCityOrTown">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the City or Town</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressCityOrTown</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressPostalZipCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Code for the postal or zip code</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressPostalZipCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressStateOrProvince">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the state or province.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressStateOrProvince</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:stateOrProvinceItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCentralIndexKey">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCentralIndexKey</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:centralIndexKeyItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityEmergingGrowthCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate if registrant meets the emerging growth company criteria.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityEmergingGrowthCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityFileNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityFileNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:fileNumberItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityIncorporationStateCountryCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Two-character EDGAR code representing the state or country of incorporation.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityIncorporationStateCountryCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarStateCountryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityRegistrantName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityRegistrantName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityTaxIdentificationNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityTaxIdentificationNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:employerIdItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_LocalPhoneNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Local phone number for entity.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_LocalPhoneNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementIssuerTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 13e<br> -Subsection 4c<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementIssuerTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14d<br> -Subsection 2b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_Security12bTitle">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Title of a 12(b) registered security.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_Security12bTitle</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:securityTitleItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SecurityExchangeName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the Exchange on which a security is registered.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection d1-1<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SecurityExchangeName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarExchangeCodeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SolicitingMaterial">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.</p></div>
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