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Stock-Based Compensation (Tables)
3 Months Ended
Mar. 31, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Summary of Assumptions Used for Valuation of Fair Value of Stock Options
The Black-Scholes option-pricing model was used to estimate the fair value of stock options granted during the three months ended March 31, 2022 and 2021 with the following weighted average assumptions:
 
   
                    
 
                    
 
  
Three Months Ended March 31,
 
  
2022
  
2021
   
                    
 
                    
Risk-free interest rate
  
1.71%
  
0.4% - 0.5%
Expected term (in years)
   6.1    5.3 - 6.1
Expected volatility
   90%    90%
Expected dividend yield
   0%    0%
Summary of Stock Option Activity
The following table reflects summarized stock option activity:
 
     
                        
     
                        
     
                        
     
                        
 
 
  
Stock Options
 
  
Weighted Average
Exercise Price
 
  
Weighted Average
Remaining
Contractual Life
(in years)
 
  
Aggregate Intrinsic
Value (in thousands)
 
Outstanding at December 31, 2021
     3,835,618      $  2.51                    
Granted
     1,104,550        5.19                    
Forfeited
     (18,149      1.19                    
    
 
 
                            
Outstanding at March 31, 2022
     4,922,019      $ 3.11        8.6      $  9,562  
    
 
 
    
 
 
    
 
 
    
 
 
 
Vested and exercisable at March 31, 2022
     1,755,794      $ 1.54        7.5      $ 4,805  
    
 
 
    
 
 
    
 
 
    
 
 
 
Summary of Share-Based Compensation Expense Related to Stock Options
The Company recorded stock-based compensation expense related to stock options in the following expense categories of its condensed statements of operations for the periods shown (in thousands):
 
     
                
     
                
 
 
  
Three Months Ended March 31,
 
 
  
2022
 
  
2021
 
General and administrative
   $ 453      $ 79  
Research and development
     166        47  
    
 
 
    
 
 
 
Total stock-based compensation
   $ 618      $  126