    <SEC-DOCUMENT>0001047469-21-000233-index.html : 20210201
    <SEC-HEADER>0001047469-21-000233.hdr.sgml : 20210201
    <ACCEPTANCE-DATETIME>20210201081328
    ACCESSION NUMBER:		0001047469-21-000233
    CONFORMED SUBMISSION TYPE:	F-1/A
    PUBLIC DOCUMENT COUNT:		55
    FILED AS OF DATE:		20210201
    DATE AS OF CHANGE:		20210201

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Adagene Inc.
    		CENTRAL INDEX KEY:			0001818838
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			E9
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		F-1/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-252210
    		FILM NUMBER:		21574430

    	BUSINESS ADDRESS:
    		STREET 1:		4F, BUILDING C14, NO. 218, XINGHU STREET
    		STREET 2:		SUZHOU INDUSTRIAL PARK
    		CITY:			JIANGSU
    		STATE:			F4
    		ZIP:			00000
    		BUSINESS PHONE:		86-512-87773632

    	MAIL ADDRESS:
    		STREET 1:		4F, BUILDING C14, NO. 218, XINGHU STREET
    		STREET 2:		SUZHOU INDUSTRIAL PARK
    		CITY:			JIANGSU
    		STATE:			F4
    		ZIP:			00000
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>F-1/A
    <SEQUENCE>1
    <FILENAME>a2242824zf-1a.htm
    <DESCRIPTION>F-1/A
    <TEXT>
    Document 1 - file: a2242824zf-1a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-3.2
    <SEQUENCE>2
    <FILENAME>a2242824zex-3_2.htm
    <DESCRIPTION>EX-3.2
    <TEXT>
    Document 2 - file: a2242824zex-3_2.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.14
    <SEQUENCE>3
    <FILENAME>a2242824zex-10_14.htm
    <DESCRIPTION>EX-10.14
    <TEXT>
    Document 3 - file: a2242824zex-10_14.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>4
    <FILENAME>a2242824zex-23_1.htm
    <DESCRIPTION>EX-23.1
    <TEXT>
    Document 4 - file: a2242824zex-23_1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>g705756.jpg
    <DESCRIPTION>G705756.JPG
    <TEXT>
    Document 5 - file: g705756.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>g836147.jpg
    <DESCRIPTION>G836147.JPG
    <TEXT>
    Document 6 - file: g836147.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>g314883.jpg
    <DESCRIPTION>G314883.JPG
    <TEXT>
    Document 7 - file: g314883.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>g340646.jpg
    <DESCRIPTION>G340646.JPG
    <TEXT>
    Document 8 - file: g340646.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>g178576.jpg
    <DESCRIPTION>G178576.JPG
    <TEXT>
    Document 9 - file: g178576.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>g762069.jpg
    <DESCRIPTION>G762069.JPG
    <TEXT>
    Document 10 - file: g762069.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>g609923.jpg
    <DESCRIPTION>G609923.JPG
    <TEXT>
    Document 11 - file: g609923.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>g706861.jpg
    <DESCRIPTION>G706861.JPG
    <TEXT>
    Document 12 - file: g706861.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>g879587.jpg
    <DESCRIPTION>G879587.JPG
    <TEXT>
    Document 13 - file: g879587.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>g498056.jpg
    <DESCRIPTION>G498056.JPG
    <TEXT>
    Document 14 - file: g498056.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>15
    <FILENAME>g872988.jpg
    <DESCRIPTION>G872988.JPG
    <TEXT>
    Document 15 - file: g872988.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>g321006.jpg
    <DESCRIPTION>G321006.JPG
    <TEXT>
    Document 16 - file: g321006.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>17
    <FILENAME>g299228.jpg
    <DESCRIPTION>G299228.JPG
    <TEXT>
    Document 17 - file: g299228.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>18
    <FILENAME>g62211.jpg
    <DESCRIPTION>G62211.JPG
    <TEXT>
    Document 18 - file: g62211.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>19
    <FILENAME>g816723.jpg
    <DESCRIPTION>G816723.JPG
    <TEXT>
    Document 19 - file: g816723.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>20
    <FILENAME>g514725.jpg
    <DESCRIPTION>G514725.JPG
    <TEXT>
    Document 20 - file: g514725.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>21
    <FILENAME>g515401.jpg
    <DESCRIPTION>G515401.JPG
    <TEXT>
    Document 21 - file: g515401.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>22
    <FILENAME>g465293.jpg
    <DESCRIPTION>G465293.JPG
    <TEXT>
    Document 22 - file: g465293.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>23
    <FILENAME>g809625.jpg
    <DESCRIPTION>G809625.JPG
    <TEXT>
    Document 23 - file: g809625.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>24
    <FILENAME>g900185.jpg
    <DESCRIPTION>G900185.JPG
    <TEXT>
    Document 24 - file: g900185.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>25
    <FILENAME>g662876.jpg
    <DESCRIPTION>G662876.JPG
    <TEXT>
    Document 25 - file: g662876.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>26
    <FILENAME>g408902.jpg
    <DESCRIPTION>G408902.JPG
    <TEXT>
    Document 26 - file: g408902.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>27
    <FILENAME>g133668.jpg
    <DESCRIPTION>G133668.JPG
    <TEXT>
    Document 27 - file: g133668.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>28
    <FILENAME>g336902.jpg
    <DESCRIPTION>G336902.JPG
    <TEXT>
    Document 28 - file: g336902.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>29
    <FILENAME>g766726.jpg
    <DESCRIPTION>G766726.JPG
    <TEXT>
    Document 29 - file: g766726.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>30
    <FILENAME>g895358.jpg
    <DESCRIPTION>G895358.JPG
    <TEXT>
    Document 30 - file: g895358.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>31
    <FILENAME>g593559.jpg
    <DESCRIPTION>G593559.JPG
    <TEXT>
    Document 31 - file: g593559.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>32
    <FILENAME>g348093.jpg
    <DESCRIPTION>G348093.JPG
    <TEXT>
    Document 32 - file: g348093.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>33
    <FILENAME>g779657.jpg
    <DESCRIPTION>G779657.JPG
    <TEXT>
    Document 33 - file: g779657.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>34
    <FILENAME>g964339.jpg
    <DESCRIPTION>G964339.JPG
    <TEXT>
    Document 34 - file: g964339.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>35
    <FILENAME>g189723.jpg
    <DESCRIPTION>G189723.JPG
    <TEXT>
    Document 35 - file: g189723.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>36
    <FILENAME>g397522.jpg
    <DESCRIPTION>G397522.JPG
    <TEXT>
    Document 36 - file: g397522.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>37
    <FILENAME>g601073.jpg
    <DESCRIPTION>G601073.JPG
    <TEXT>
    Document 37 - file: g601073.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>38
    <FILENAME>g37138.jpg
    <DESCRIPTION>G37138.JPG
    <TEXT>
    Document 38 - file: g37138.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>39
    <FILENAME>g841036.jpg
    <DESCRIPTION>G841036.JPG
    <TEXT>
    Document 39 - file: g841036.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>40
    <FILENAME>g728775.jpg
    <DESCRIPTION>G728775.JPG
    <TEXT>
    Document 40 - file: g728775.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>41
    <FILENAME>g767377.jpg
    <DESCRIPTION>G767377.JPG
    <TEXT>
    Document 41 - file: g767377.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>42
    <FILENAME>g506507.jpg
    <DESCRIPTION>G506507.JPG
    <TEXT>
    Document 42 - file: g506507.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>43
    <FILENAME>g721330.jpg
    <DESCRIPTION>G721330.JPG
    <TEXT>
    Document 43 - file: g721330.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>44
    <FILENAME>g103210.jpg
    <DESCRIPTION>G103210.JPG
    <TEXT>
    Document 44 - file: g103210.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>45
    <FILENAME>g154314.jpg
    <DESCRIPTION>G154314.JPG
    <TEXT>
    Document 45 - file: g154314.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>46
    <FILENAME>g252679.jpg
    <DESCRIPTION>G252679.JPG
    <TEXT>
    Document 46 - file: g252679.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>47
    <FILENAME>g432762.jpg
    <DESCRIPTION>G432762.JPG
    <TEXT>
    Document 47 - file: g432762.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>48
    <FILENAME>g177295.jpg
    <DESCRIPTION>G177295.JPG
    <TEXT>
    Document 48 - file: g177295.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>49
    <FILENAME>g819917.jpg
    <DESCRIPTION>G819917.JPG
    <TEXT>
    Document 49 - file: g819917.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>50
    <FILENAME>g270592.jpg
    <DESCRIPTION>G270592.JPG
    <TEXT>
    Document 50 - file: g270592.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>51
    <FILENAME>g595141.jpg
    <DESCRIPTION>G595141.JPG
    <TEXT>
    Document 51 - file: g595141.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>52
    <FILENAME>g239698.jpg
    <DESCRIPTION>G239698.JPG
    <TEXT>
    Document 52 - file: g239698.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>53
    <FILENAME>g315135.jpg
    <DESCRIPTION>G315135.JPG
    <TEXT>
    Document 53 - file: g315135.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>54
    <FILENAME>g934962.jpg
    <DESCRIPTION>G934962.JPG
    <TEXT>
    Document 54 - file: g934962.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>55
    <FILENAME>g140919.jpg
    <DESCRIPTION>G140919.JPG
    <TEXT>
    Document 55 - file: g140919.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>