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NET LOSS PER SHARE | 12 Months Ended
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Dec. 31, 2022
NET LOSS PER SHARE |
NET LOSS PER SHARE | 12. NET LOSS PER SHARE Basic and diluted net loss per share for the years ended December 31, 2020, 2021 and 2022 were calculated as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | For the Year Ended December 31,
​ | ​ | 2020 | ​ | 2021 | ​ | 2022
​ |  | US$ |  | US$ |  | US$
Numerator: |  |  |  |  |  |
Net loss attributable to Adagene Inc.’s shareholders |  | (42,397,279) |  | (73,177,935) |  | (79,971,847)
Accretion of convertible redeemable preferred shares to redemption value |  | (248,113) |  | (28,553) |  | —
Net loss attributable to ordinary shareholders |  | (42,645,392) |  | (73,206,488) |  | (79,971,847)
Denominator: |  | ​ |  |  |  |
Weighted‑average number of ordinary shares outstanding—basic and diluted |  | 15,950,698 |  | 50,032,009 |  | 54,135,084
Net Loss per share—basic and diluted |  | (2.67) |  | (1.46) |  | (1.48)
​ The effects of all outstanding convertible redeemable preferred shares and share options have been excluded from the computation of diluted loss per share for the years ended December 31, 2020, 2021 and 2022 as their effects would be anti-dilutive. The potentially dilutive securities that have not been included in the calculation of diluted net loss per share as their inclusion would be anti-dilutive are as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | For the Year Ended December 31,
​ |  | 2020 |  | 2021 |  | 2022
Convertible redeemable preferred shares |  | 27,249,824 |  | — |  | —
Share options and share grant |  | 1,795,932 |  | 1,739,882 |  | 530,298
​

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