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Note 2 - Significant Accounting Policies (Tables)
9 Months Ended
Sep. 30, 2020
Notes Tables  
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
  

Three Months Ended

  

Nine Months Ended

 
  

September 30,

  

September 30,

 
  

2020

  

2019

  

2020

  

2019

 

Research and development

 $935  $386  $2,682  $972 

General and administrative

  1,870   411   5,887   881 

Cost of goods sold

  350   -   1,218   - 

Total share-based compensation expense

 $3,155  $797  $9,787  $1,853 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
  Three Months Ended
September 30,
 Nine Months Ended
September 30,
  2020 2019 

2020

  2019 

Dividend yield

  -   -   -   - 

Expected volatility

  87%  90%-91% 87%-91% 80%-91%

Risk-free interest rate

 0.33%-0.44% 1.59%-1.89% 0.33%-1.87% 1.59%-2.64%

Expected life (in years)

 5.38-6.25 5.38-6.25 5.38-10 5.38-10

Weighted-average grant date fair value per share

  12.46   5.66   12.05   5.14