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Note 2 - Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2021
Notes Tables |
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Year Ended December 31, |
|  | 2021 |  |  | 2020 |  |  | 2019 |
Research and development |  | $ | 2,020 |  |  | $ | 3,558 |  |  | $ | 1,635 |
General and administrative |  |  | 2,162 |  |  |  | 7,537 |  |  |  | 1,723 |
Cost of goods sold |  |  | 282 |  |  |  | 1,486 |  |  |  | - |
Total share-based compensation expense |  | $ | 4,464 |  |  | $ | 12,581 |  |  | $ | 3,358 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Year Ended December 31, |
|  |  | 2021 |  |  |  | 2020 |  |  |  | 2019 |
Weighted-average grant date fair value per share |  |  |  | $9.29 |  |  |  |  |  | $12.23 |  |  |  |  |  | $9.36 |  |
Expected volatility |  |  | 83% | - | 91% |  |  |  | 87% | - | 97% |  |  |  | 80% | - | 97% |
Risk-free interest rate |  |  | 0.5% | - | 1.4% |  |  |  | 0.3% | - | 1.9% |  |  |  | 1.4% | - | 2.6% |
Expected life (in years) |  |  | 5.38 | - | 6.25 |  |  |  | 5.38 | - | 10 |  |  |  | 5.38 | - | 10 |
Dividend yield |  |  |  | — |  |  |  |  |  | — |  |  |  |  |  | — |  |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=122041274&loc=d3e301413-122809 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5047-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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