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Note 3 - Revenue (Details Textual) $ in Thousands |  | 12 Months Ended
--- | --- | ---
Dec. 30, 2019 | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Revenue from Contract with Customer, Including Assessed Tax |  | $ 18,394 | $ 43,997 | $ 0
Clinical Trial Service Revenue [Member] |  |  |  |
Revenue from Contract with Customer, Including Assessed Tax |  | 394 | 25,975 | 0
Manufacturing Revenue [Member] |  |  |  |
Revenue from Contract with Customer, Including Assessed Tax |  | $ 18,000 | 18,000 | $ 0
Janssen [Member] | Clinical Trial Service Revenue [Member] |  |  |  |
Transition Services Agreement, Number of Ongoing Clinical Trials Entered Into | 2 |  |  |
Transition Services Agreement, Markup Percentage | 30.00% |  |  |
Proceeds from Customers |  |  | 26,000 |
Janssen [Member] | Manufacturing Revenue [Member] |  |  |  |
Proceeds from Customers |  |  | $ 18,000 |

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