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v3.22.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Operating activities |  |  |
Net income (loss) | $ (17,414) | $ (11,221) | $ 668,629
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation | 2,648 | 2,238 | 2,361
Share-based compensation expense | 4,463 | 12,581 | 3,358
Gain from Janssen Transaction | 0 | 0 | (675,000)
Changes in operating assets and liabilities: |  |  |
Account receivable | 4,113 | (4,113) | 0
Income tax receivable | (2,380) | (6,574) | 0
Deferred cost of goods sold | 2,177 | (2,177) | 0
Escrow receivable | 75,063 | (63) | (75,000)
Prepaid expenses and other current assets | (352) | 1,087 | (472)
Deferred tax asset | 533 | (90) | (444)
Accounts payable | (514) | (334) | 496
Accrued expenses | 23 | (2,829) | 2,888
Contract liabilities | 0 | (4,500) | 4,500
Deferred rent | 0 | 0 | (3)
Income tax payable | 212 | 65 | 1,056
Deferred tax liability | 873 | (49,219) | 49,361
Net cash used in operating activities | 69,445 | (65,149) | (18,270)
Investing activities |  |  |
Purchase of property and equipment | (3,525) | (3,727) | (204)
Cash received from Janssen Transaction | 0 | 0 | 675,000
Net cash provided by investing activities | (3,525) | (3,727) | 674,796
Financing activities |  |  |
Issuance of common stock and warrants, net | 0 | (420,000) | 38,062
Dividends | (75,003) | 0 | 0
Issuance of common stock under stock option plan | 7,995 | 10,276 | 3,732
Collection of subscription receivable | 0 | 0 | 302
Net cash provided by financing activities | (67,008) | (409,724) | 42,096
Effect of foreign exchange rate on cash and cash equivalents | 705 | 1,372 | 149
Net change in cash and cash equivalents | (383) | (477,228) | 698,771
Cash and cash equivalents, beginning of period | 237,366 | 714,594 | 15,823
Cash and cash equivalents, end of period | 236,983 | 237,366 | 714,594
Supplemental Information: |  |  |
Accrued purchases of property and equipment | 93 | 676 | 0
Subscription receivable | 0 | 0 | 302
Income tax paid | $ 0 | $ 54,087 | $ 0

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