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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Operating activities      
Net income (loss) $ (17,414) $ (11,221) $ 668,629
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:      
Depreciation 2,648 2,238 2,361
Share-based compensation expense 4,463 12,581 3,358
Gain from Janssen Transaction 0 0 (675,000)
Changes in operating assets and liabilities:      
Account receivable 4,113 (4,113) 0
Income tax receivable (2,380) (6,574) 0
Deferred cost of goods sold 2,177 (2,177) 0
Escrow receivable 75,063 (63) (75,000)
Prepaid expenses and other current assets (352) 1,087 (472)
Deferred tax asset 533 (90) (444)
Accounts payable (514) (334) 496
Accrued expenses 23 (2,829) 2,888
Contract liabilities 0 (4,500) 4,500
Deferred rent 0 0 (3)
Income tax payable 212 65 1,056
Deferred tax liability 873 (49,219) 49,361
Net cash used in operating activities 69,445 (65,149) (18,270)
Investing activities      
Purchase of property and equipment (3,525) (3,727) (204)
Cash received from Janssen Transaction 0 0 675,000
Net cash provided by investing activities (3,525) (3,727) 674,796
Financing activities      
Issuance of common stock and warrants, net 0 (420,000) 38,062
Dividends (75,003) 0 0
Issuance of common stock under stock option plan 7,995 10,276 3,732
Collection of subscription receivable 0 0 302
Net cash provided by financing activities (67,008) (409,724) 42,096
Effect of foreign exchange rate on cash and cash equivalents 705 1,372 149
Net change in cash and cash equivalents (383) (477,228) 698,771
Cash and cash equivalents, beginning of period 237,366 714,594 15,823
Cash and cash equivalents, end of period 236,983 237,366 714,594
Supplemental Information:      
Accrued purchases of property and equipment 93 676 0
Subscription receivable 0 0 302
Income tax paid $ 0 $ 54,087 $ 0