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Note 2 - Significant Accounting Policies (Tables)
3 Months Ended
Mar. 31, 2022
Notes Tables  
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
  

Three Months Ended

 
  

March 31,

 
  

2022

  

2021

 

Research and development

 $990  $363 

General and administrative

  458   512 

Cost of goods sold

  -   61 

Total share-based compensation expense

 $1,448  $936 
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
  

Three Months Ended

 
  

March 31,

 
  

2022

  

2021

 

Dividend yield

  -   - 

Expected volatility

 82%-83% 85%-86%

Risk-free interest rate

 1.5%-2.4% 0.5%-1.1%

Expected life (in years)

  6.25   6.25 

Weighted-average grant date fair value per share

  $7.14   $13.82