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Note 2 - Significant Accounting Policies - Stock Option Valuation Assumptions (Details) - $ / shares
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Dividend yield 0.00% 0.00%
Expected life (Year) 6 years 3 months 6 years 3 months
Weighted-average grant date fair value per share (in dollars per share) $ 7.14 $ 13.82
Minimum [Member]    
Expected volatility 82.00% 85.00%
Risk-free interest rate 1.50% 0.50%
Maximum [Member]    
Expected volatility 83.00% 86.00%
Risk-free interest rate 2.40% 1.10%