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Warrants (Details Narrative) - $ / shares
Apr. 08, 2019
Jul. 22, 2016
Jun. 02, 2016
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Number of common stock shares sold 1,542,000    
Pre-funded Warrants [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Purchase of warrants 3,385,680    
Exercise price of warrants $ 0.01    
Common Warrants [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Purchase of warrants 4,927,680    
Exercise price of warrants $ 3.85    
Warrants and rights outstanding, term 5 years    
June Purchase Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Number of common stock shares sold     20,850
Purchase of warrants     7,298
Purchase of common stock warrants     0.35
Common stock combined purchase price per share     $ 92.00
Exercise price of warrants     $ 121.60
Warrants and Rights Outstanding, Maturity Date     Dec. 03, 2021
Warrants and rights outstanding, term     5 years
Number of exercised warrants     0
Second Amended Purchase Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Number of common stock shares sold   29,750  
Purchase of warrants   8,925  
Purchase of common stock warrants   0.30  
Common stock combined purchase price per share   $ 135.00  
Exercise price of warrants   $ 187.20  
Warrants and Rights Outstanding, Maturity Date   Jan. 23, 2022  
Warrants and rights outstanding, term   5 years  
Number of exercised warrants   0