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Commitments and Contingencies, Wistar License Agreement (Details) - Wistar License Agreement [Member]
12 Months Ended
Dec. 31, 2017
Extension
Wistar License Agreement [Abstract]  
Maximum reduction in royalty payments 50.00%
Number of one-year extensions 3
Minimum [Member]  
Wistar License Agreement [Abstract]  
Royalty rates on amount of cumulative net sales 3.00%
Maximum [Member]  
Wistar License Agreement [Abstract]  
Royalty rates on amount of cumulative net sales 5.00%