<SEC-DOCUMENT>0001415889-25-013264.txt : 20250515
<SEC-HEADER>0001415889-25-013264.hdr.sgml : 20250515
<ACCEPTANCE-DATETIME>20250515174629
ACCESSION NUMBER:		0001415889-25-013264
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20250515
DATE AS OF CHANGE:		20250515

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Applied Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001697532
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91017
		FILM NUMBER:		25956177

	BUSINESS ADDRESS:	
		STREET 1:		545 FIFTH AVENUE, SUITE 1400
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017
		BUSINESS PHONE:		212-220-9226

	MAIL ADDRESS:	
		STREET 1:		545 FIFTH AVENUE, SUITE 1400
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Applied Therapeutics Inc.
		DATE OF NAME CHANGE:	20170208

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Venrock Healthcare Capital Partners III, L.P.
		CENTRAL INDEX KEY:			0001738048
		ORGANIZATION NAME:           	
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		530 FIFTH AVENUE, 22ND FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
		BUSINESS PHONE:		212-444-4100

	MAIL ADDRESS:	
		STREET 1:		530 FIFTH AVENUE, 22ND FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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    <submissionType>SCHEDULE 13G/A</submissionType>
		<previousAccessionNumber>0001104659-23-057142</previousAccessionNumber>
	    <filerInfo>
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		<amendmentNo>4</amendmentNo>
	      <securitiesClassTitle>Common Stock $0.0001 par value per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/31/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001697532</issuerCik>        <issuerName>Applied Therapeutics, Inc.</issuerName>        <issuerCusip>03828A101</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>545 Fifth Avenue</com:street1>
                    <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
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	   				        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
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    <reportingPersonName>VHCP Co-Investment Holdings III, LLC</reportingPersonName>

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		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
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	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>Venrock Healthcare Capital Partners EG, L.P.</reportingPersonName>

	  		<memberGroup>a</memberGroup>


		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

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                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>5567709.00</sharedVotingPower>
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                         <sharedDispositivePower>5567709.00</sharedDispositivePower>
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    <reportingPersonName>VHCP Management III, LLC</reportingPersonName>

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		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

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                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>5567709.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>5567709.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

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	        <typeOfReportingPerson>OO</typeOfReportingPerson>



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	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>VHCP Management EG, LLC</reportingPersonName>

	  		<memberGroup>a</memberGroup>


		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>5567709.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>5567709.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

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	        <typeOfReportingPerson>OO</typeOfReportingPerson>



    </coverPageHeaderReportingPersonDetails>
	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>Nimish Shah</reportingPersonName>

	  		<memberGroup>a</memberGroup>


		 <citizenshipOrOrganization>X1</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>5567709.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>5567709.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

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	        <typeOfReportingPerson>IN</typeOfReportingPerson>




    </coverPageHeaderReportingPersonDetails>
	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>Bong Y Koh</reportingPersonName>

	  		<memberGroup>a</memberGroup>


		 <citizenshipOrOrganization>X1</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>5567709.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>5567709.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

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     	    <classPercent>4.1</classPercent>










	        <typeOfReportingPerson>IN</typeOfReportingPerson>




    </coverPageHeaderReportingPersonDetails>

    <items>
      <item1>
        <issuerName>Applied Therapeutics, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>545 Fifth Avenue, New York, NY, 10017.</issuerPrincipalExecutiveOfficeAddress>
      </item1>

      <item2>
        <filingPersonName>The names of the persons filing this report (collectively, the "Reporting Persons") are:

Venrock Healthcare Capital Partners III, L.P. ("VHCP III")
VHCP Co-Investment Holdings III, LLC ("VHCP Co-Investment III")
Venrock Healthcare Capital Partners EG, L.P. ("VHCP EG")
VHCP Management III, LLC ("VHCP Management III")
VHCP Management EG, LLC ("VHCP Management EG")
Nimish Shah ("Shah")
Bong Koh ("Koh")

The Reporting Persons are members of a group for the purposes of this Schedule 13G.
</filingPersonName>        <principalBusinessOfficeOrResidenceAddress>New York Office:
7 Bryant Park, 23rd Floor
New York, NY 10018

Palo Alto Office:
3340 Hillview Avenue
Palo Alto, CA 94304
</principalBusinessOfficeOrResidenceAddress>        <citizenship>All of the entities were organized in Delaware. Shah and Koh are both United States citizens.</citizenship>      </item2>

        <item3>
		        <notApplicableFlag>Y</notApplicableFlag>

      </item3>



    <item4>
    <amountBeneficiallyOwned>Row 9 of each Reporting Person's cover page to this Schedule 13G sets forth the aggregate number of shares of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference.

The Reporting Persons' ownership of the Issuer's securities consists of (i) 1,457,592 shares of Common Stock held by VHCP III, (ii) 145,832 shares of Common Stock held by VHCP Co-Investment III, and (iii) 3,964,285 shares of Common Stock held by VHCP EG.

VHCP Management III is the general partner of VHCP III and the manager of VHCP Co-Investment III. VHCP Management EG is the general partner of VHCP EG. Messrs. Shah and Koh are the voting members of VHCP Management III and VHCP Management EG.</amountBeneficiallyOwned>    <classPercent>Row 11 of each Reporting Person's cover page to this Schedule 13G sets forth the percentages of the shares of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference. The percentage set forth in Row 11 of each Reporting Person's cover page is based upon 137,228,741 shares of the Issuer's Common Stock outstanding as of December 31, 2024, as reported in the Issuer's Annual Report on Form 10-K filed with the Securities and Exchange Commission (the "SEC") on April 15, 2024.</classPercent>
      <numberOfSharesPersonHas>
        <solePowerOrDirectToVote>Row 5 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference.</solePowerOrDirectToVote>
        <sharedPowerOrDirectToVote>Row 6 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference.</sharedPowerOrDirectToVote>
        <solePowerOrDirectToDispose>Row 7 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference.</solePowerOrDirectToDispose>
        <sharedPowerOrDirectToDispose>Row 8 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2025 and is incorporated by reference.</sharedPowerOrDirectToDispose>
      </numberOfSharesPersonHas>
    </item4>


        <item5>

            <notApplicableFlag>N</notApplicableFlag>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>

    </item5>


        <item6>
	  	  <notApplicableFlag>Y</notApplicableFlag>
		        </item6>


        <item7>
	  	  <notApplicableFlag>Y</notApplicableFlag>


    </item7>


          <item8>
                <notApplicableFlag>Y</notApplicableFlag>

              </item8>


            <item9>
                <notApplicableFlag>Y</notApplicableFlag>
                      </item9>


      <item10>
                <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>

      </item10>
    </items>

		<exhibitInfo>Exhibit 24.1	Power of Attorney for Nimish Shah (incorporated by reference to Exhibit B to Schedule 13G filed on May 8, 2023)

Exhibit 24.2	Power of Attorney for Bong Koh (incorporated by reference to Exhibit C to Schedule 13G filed on May 8, 2023)

Exhibit 99.1	Joint Filing Agreement

</exhibitInfo>

	    <signatureInformation>
      <reportingPersonName>Venrock Healthcare Capital Partners III, L.P.</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By VHCP Management III, LLC, its General Partner, By Sherman G. Souther, Authorized Signatory</title>
        <date>05/15/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>VHCP Co-Investment Holdings III, LLC</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By VHCP Management III, LLC, its Manager, By Sherman G. Souther, Authorized Signatory</title>
        <date>05/15/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Venrock Healthcare Capital Partners EG, L.P.</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By VHCP Management EG, LLC, its General Partner, By Sherman G. Souther, Authorized Signatory</title>
        <date>05/15/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>VHCP Management III, LLC</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By Sherman G. Souther, Authorized Signatory</title>
        <date>05/15/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>VHCP Management EG, LLC</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By Sherman G. Souther, Authorized Signatory</title>
        <date>05/15/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Nimish Shah</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By Sherman G. Souther, Attorney-in-fact</title>
        <date>05/15/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Bong Y Koh</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By Sherman G. Souther, Attorney-in-fact</title>
        <date>05/15/2025</date>
      </signatureDetails>

    </signatureInformation>



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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>ex-99-05152025_090531.htm
<DESCRIPTION>JOINT FILING AGREEMENT
<TEXT>
<!DOCTYPE html PUBLIC "-//IETF//DTD HTML//EN">
<html><head><title>ex-99-05152025_090531.htm</title></head><body style="margin-top:0;font-family:Times New Roman; font-size:10pt; color:#000000">
<p style="margin-top:0px; margin-bottom:16px" align="center"><b>EXHIBIT 99.1 </b></p>
<p style="margin-top:0px; margin-bottom:16px" align="center">JOINT FILING AGREEMENT</p>
<p style="margin-top:0px; margin-bottom:16px" align="justify">In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the Common Stock of Applied Therapeutics, Inc. and further agree that this agreement be included as an exhibit to such filing. Each party to the agreement expressly authorizes each other party to file on its behalf any and all amendments to such statement. Each party to this agreement agrees that this joint filing agreement may be signed in counterparts.</p>
<p style="margin-top:0px; margin-bottom:16px" align="justify">In evidence whereof, the undersigned have caused this Agreement to be executed on their behalf this 15<sup>th</sup> day of May, 2025.</p>
<table style="margin-top:0px; font-size:10pt" cellpadding="0" cellspacing="0" align="center"><tr style="font-size:0"><td width="314.667"></td><td width="309.333"></td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="314.667" height="123"><p style="margin:0px"><b>Venrock Healthcare Capital Partners III, L.P.</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By:</p>
<p style="margin:0px; text-indent:-2px">VHCP Management III, LLC</p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; clear:left; float:left">Its:</p>
<p style="margin:0px; text-indent:-2px">General Partner</p>
<p style="margin:0px; clear:left"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By:</p>
<p style="margin:0px; text-indent:-2px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px; text-indent:36px; clear:left">Name: Sherman G. Souther</p>
<p style="margin:0px; text-indent:36px">Its: Authorized Signatory</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="309.333" height="123"><p style="margin:0px"><b>Venrock Healthcare Capital Partners EG, L.P.</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By:</p>
<p style="margin:0px; text-indent:-2px">VHCP Management EG, LLC</p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; clear:left; float:left">Its:</p>
<p style="margin:0px; text-indent:-2px">General Partner</p>
<p style="margin:0px; clear:left"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By: </p>
<p style="margin:0px; text-indent:-2px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px; text-indent:36px; clear:left">Name: Sherman G. Souther</p>
<p style="margin:0px; text-indent:36px">Its: Authorized Signatory</p>
<p style="margin:0px"><br></p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="314.667"><p style="margin:0px"><b>VHCP Co-Investment Holdings III, LLC</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By:</p>
<p style="margin:0px; text-indent:-2px">VHCP Management III, LLC</p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; clear:left; float:left">Its:</p>
<p style="margin:0px; text-indent:-2px">Manager</p>
<p style="margin:0px; clear:left"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By: </p>
<p style="margin:0px; text-indent:-2px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px; text-indent:36px; clear:left">Name: Sherman G. Souther</p>
<p style="margin:0px; text-indent:36px">Its: Authorized Signatory</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="309.333"><p style="margin:0px"><br></p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="314.667"><p style="margin:0px"><b>VHCP Management III, LLC</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By: </p>
<p style="margin:0px; text-indent:-2px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px; text-indent:36px; clear:left">Name: Sherman G. Souther</p>
<p style="margin:0px; text-indent:36px">Its: Authorized Signatory</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="309.333"><p style="margin:0px"><b>VHCP Management EG, LLC</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By: </p>
<p style="margin:0px; text-indent:-2px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px; text-indent:36px; clear:left">Name: Sherman G. Souther</p>
<p style="margin:0px; text-indent:36px">Its: Authorized Signatory</p>
<p style="margin:0px"><br></p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="314.667"><p style="margin:0px"><b>Nimish Shah</b></p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px">Sherman G. Souther, Attorney-in-fact</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><b>Bong Koh</b></p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px">Sherman G. Souther, Attorney-in-fact</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="309.333"><p style="margin:0px"><br></p>
</td></tr></table><p style="margin-top:0px; margin-bottom:16px"><br></p>
<p style="margin-top:0px; margin-bottom:16px"><br><br></p>
<div style="width:268.8px">
<p style="line-height:10pt; margin:0px; width:268.8px; font-family:Arial; font-size:7pt">313805880 v1</p>
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