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License Agreements - Additional Information (Detail) - USD ($)	1 Months Ended	6 Months Ended
	Sep. 30, 2017	Dec. 31, 2021	Dec. 31, 2020	Jun. 30, 2021	May 31, 2020
Related Party Transaction [Line Items]
Milestone payments payable amount		$ 20,000,000.0
Performance obligation revenue recognised		1,264,000	$ 4,260,000
Kyowa Kirin Co
Related Party Transaction [Line Items]
Total upfront payment receivable for grant of rights					$ 100,000,000.0
Kyowa Kirin Co | Potential Payments on Achievement of Development Regulatory and Commercial Milestones | Maximum
Related Party Transaction [Line Items]
Milestone payment receivable amount		582,500,000
Presage License Agreement | Presage Biosciences, Inc.
Related Party Transaction [Line Items]
Compensation payable for grant of rights	$ 4,900,000
Payment for license	2,900,000
Presage License Agreement | Presage Biosciences, Inc. | Incremental Payment
Related Party Transaction [Line Items]
Compensation payable for grant of rights	2,000,000.0
Presage License Agreement | Presage Biosciences, Inc. | Potential Payments on Achievement of Development Regulatory and Commercial Milestones
Related Party Transaction [Line Items]
Milestone payment receivable amount	$ 179,000,000
Kkc Agreements [Member] | Kyowa Kirin Co
Related Party Transaction [Line Items]
Upfront payment		100,000,000.0
Transaction price relating to the performance obligation		191,500,000
Expected milestone payment receivable		20,000,000.0
Estimated development cost sharing recovered through earnings		66,300,000
Deferred revenue		5,200,000
Kkc Agreements [Member] | Kyowa Kirin Co | Ex US License
Related Party Transaction [Line Items]
Performance obligation revenue recognised		21,000,000.0
License Obligation Account Transaction Price Allocated		64,500,000
Kkc Agreements [Member] | Kyowa Kirin Co | Development Services
Related Party Transaction [Line Items]
Deferred revenue		33,400,000		$ 14,700,000
Kkc Agreements [Member] | Kyowa Kirin Co | Maximum
Related Party Transaction [Line Items]
Estimated development cost sharing recovered through earnings		$ 228,500

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