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Share-Based Compensation (Tables)
9 Months Ended
Sep. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Share-Based Payment Arrangement, Expensed and Capitalized, Amount Share-based compensation expense related to the issuance of stock options was as follows for the three and nine months ended September 30, 2022 and 2021:
Three months ended September 30,Nine months ended September 30,
2022202120222021
Research and development$14,349 $17,775 $74,256 $56,677 
General and administrative262,172 133,300 658,547 224,049 
$276,521 $151,075 $732,803 $280,726 
Schedule of Assumptions Used to Determine Fair Value of Share-Based Awards
The weighted average assumptions used in the Black-Scholes option pricing model to determine the fair value of share-based awards granted to employees during the nine months ended September 30, 2022 and 2021, respectively, were as follows:
 
 20222021
Expected stock price volatility87.02%97.50%
Risk-free interest rate2.17%1.03%
Expected term (in years)5.955.77
Expected dividend yield—  —  
Schedule of Share-Based Award Activity
The following table summarizes the share-based award activity for the periods presented:
 
 Number of Options Weighted Average
Exercise Price Per
Share
Weighted Average
Remaining
Contractual Term
(years)
Outstanding at January 1, 2022506,691$5.68 9.3
Granted890,058$1.85  
     Forfeited
(55,245)$2.52 
Outstanding at September 30, 2022
1,341,504$3.27 9.1
Vested and exercisable at September 30, 2022
275,061$5.90 8.5
Vested and expected to vest at September 30, 2022
1,341,504$3.27 9.1