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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Operating activities:    
Net loss $ (18,149,000) $ (14,298,000)
Adjustments to reconcile net loss to cash used in operating activities:    
Depreciation and amortization 34,000 15,000
Stock-based compensation 2,108,000 2,137,000
Net unrealized loss on foreign currency transactions 107,000 34,000
Non-cash consulting expense   81,000
Amortization of term loan discount and issuance costs 126,000 130,000
Realized gain on investments 0 (13,000)
Amortization of discount on investments, net 205,000 8,000
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 1,252,000 890,000
Accounts payable (971,000) (100,000)
Accrued expenses 350,000 (334,000)
Net cash used in operating activities (14,938,000) (11,450,000)
Investing activities:    
Purchases of property and equipment (23,000) (15,000)
Purchases of short-term investments (7,605,000) (2,225,000)
Maturities of short-term investments 41,455,000 23,700,000
Net cash provided by investing activities 33,827,000 21,460,000
Financing activities:    
Proceeds from registered direct offering, net of offering costs 29,909,000  
Proceeds from exercise of stock options 626,000  
Proceeds from ESPP purchase 127,000 96,000
Net cash provided by financing activities 30,662,000 871,000
Effect of exchange rate changes on cash and cash equivalents (8,000) (17,000)
Net increase in cash and cash equivalents 49,543,000 10,864,000
Cash and cash equivalents at beginning of period 23,982,000 13,219,000
Cash and cash equivalents at end of period 73,525,000 24,083,000
Supplemental disclosures of non-cash activities:    
Unsettled stock option exercises 174,000  
Amounts included in accounts payable for purchases of property and equipment $ 25,000  
ATM Facility    
Financing activities:    
Proceeds from issuance of common stock, net of issuance costs   775,000
Lincoln Park Capital Fund, LLC    
Supplemental disclosures of non-cash activities:    
Issuance of commitment shares to Lincoln Park pursuant to agreement   $ 171,000