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Income Taxes - Reconciliation of Expected Statutory Federal Income Tax Provision to Actual Income Tax Provision (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]    
Income taxes at statutory rates $ (13,110) $ (8,201)
Stock-based compensation 533 451
Permanent items 128 31
Federal research and orphan drug credits (1,152) (1,713)
Foreign rate differential 425 72
Transaction costs 89  
Acquired in-process research and development 4,840  
Change in federal valuation allowance 8,247 9,360
Income tax expense (benefit) $ 0 $ 0