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CONSOLIDATED STATEMENT OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities |  |
Net loss | $ (34,115) | $ (44,256)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities |  |
Depreciation expense | 544 | 300
Stock-based compensation | 5,177 | 1,797
Non-cash research and development expense for in-process research and development acquired in acquisition |  | 11,140
Non-cash lease expense | 1,174 | 964
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | (1,452) | 297
Accounts payable | 361 | 519
Accrued expenses and other current liabilities | 1,298 | 1,585
Lease liability | (740) | (978)
Deferred revenue | (30,985) | (9,194)
Deposits and other assets | (1,514) |
Net cash flows used in operating activities | (60,252) | (37,826)
Cash flows from investing activities |  |
Cash obtained in asset acquisition |  | 3,688
Payments to acquire property and equipment | (1,760) | (766)
Net cash flows (used in) provided by investing activities | (1,760) | 2,922
Cash flows from financing activities |  |
Proceeds from issuance of preferred stock, net of offering costs | (146) | 116,171
Proceeds from initial public offering, net of offering costs | 131,302 | (57)
Proceeds from exercise of stock options | 582 | 70
Net cash flows provided by financing activities | 131,738 | 116,184
Net increase in cash and cash equivalents | 69,726 | 81,280
Cash, cash equivalents and restricted cash, beginning of year | 163,363 | 82,083
Cash, cash equivalents and restricted cash, end of year | 233,089 | 163,363
Cash and cash equivalents | 232,217 | 162,491
Restricted cash included in other assets | 872 | 872
Cash, cash equivalents and restricted cash, end of year | 233,089 | 163,363
Supplemental disclosure of non-cash activities |  |
Assets obtained in asset acquisition |  | 34
Liabilities assumed in asset acquisition |  | 970
Fair value of equity instruments issued in connection with asset acquisition |  | 13,892
Purchases of property and equipment in accounts payable and accrued expenses | 13 | 367
Deferred transaction costs in accounts payable and accrued liabilities |  | 591
Right-of-use assets recognized upon adoption of ASC 842 |  | $ 956
Right-of-use assets and lease liabilities recognized upon lease inception | $ 7,541 |

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