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Stock-Based Compensation | 6 Months Ended
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Jun. 30, 2022
Share-Based Payment Arrangement [Abstract] |
Stock-Based Compensation | 9. Stock-Based Compensation The Company grants stock options under the 2021 Stock Incentive Plan (the “2021 Plan”). The Company also has stock options outstanding under the 2016 Stock Incentive Plan (“2016 Plan”), but is no longer granting awards under such plan. All shares of common stock underlying any awards that are forfeited, cancelled, expired, repurchased, or otherwise terminated under the 2021 and 2016 Plans are added back to the shares of common stock available for issuance under the 2021 Plan. On January 1, 2022 the number of shares available for issuance under the 2021 Plan increased by 1,439,001 shares as a result of the evergreen provision. As of June 30, 2022, 2,653,884 shares of common stock remain available for future issuance under the 2021 Plan. The total compensation expense recognized in the statements of operations associated with all the stock-based compensation awards granted by the Company is as follows (in thousands):
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2022 |  |  | 2021 |  |  | 2022 |  |  | 2021 |
Research and development |  | $ | 1,069 |  |  | $ | 535 |  |  | $ | 2,066 |  |  | $ | 948 |
General and administrative |  |  | 886 |  |  |  | 727 |  |  |  | 1,789 |  |  |  | 1,199 |
Total |  | $ | 1,955 |  |  | $ | 1,262 |  |  | $ | 3,855 |  |  | $ | 2,147 |
The weighted-average fair value of the stock options granted during the six months ended June 30, 2022 was $6.04. As of June 30, 2022, the total unrecognized stock-based compensation expense for unvested options was $22.0 million which is expected to be recognized over a weighted average period of 2.9 years. The following table summarizes stock option activity under the Plan for the six months ended June 30, 2022:
|  | Number of Options |  |  | Weighted- Average Exercise Price |  |  | Weighted- Average Remaining Contractual Term (Years) |  |  | Aggregate Intrinsic Value (thousands) |
Outstanding as of December 31, 2021 |  |  | 5,822,373 |  |  | $ | 7.17 |  |  |  | 8.27 |  |  | $ | 33,275 |
Granted |  |  | 1,504,465 |  |  |  | 8.47 |  |  |  |  |  |  |
Exercised |  |  | (276,943 | ) |  |  | 3.86 |  |  |  |  |  |  |
Cancelled or forfeited |  |  | (468,869 | ) |  |  | 8.03 |  |  |  |  |  |  |
Outstanding as of June 30, 2022 |  |  | 6,581,026 |  |  | $ | 7.54 |  |  |  | 8.07 |  |  | $ | 2,123,446 |
Vested or expected to vest as of June 30, 2022 |  |  | 6,581,026 |  |  | $ | 7.54 |  |  |  | 8.07 |  |  | $ | 2,123,446 |
Options exercisable as of June 30, 2022 |  |  | 2,532,151 |  |  | $ | 5.02 |  |  |  | 6.65 |  |  | $ | 1,981,985 |
The aggregate intrinsic value of options exercised for the six months ended June 30, 2022 and 2021 was $1.2 million and $0.6 million, respectively. The fair value of each option award granted is estimated on the date of grant using the Black-Scholes option pric ing model and the weighted average assumptions. The underlying assumptions used to value stock options granted to participants using the Black-Scholes option-pricing were as follows:
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2022 |  |  | 2021 |  |  | 2022 |  |  | 2021 |
Risk-free interest rate |  | 3.01% - 3.03% |  |  | 1.03% - 1.07% |  |  | 1.67 - 3.03% |  |  | 0.88% - 1.07% |
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Expected option term (in years) range |  | 5.5 - 6.08 |  |  | 6.0 - 6.08 |  |  | 5.15 - 6.08 |  |  | 6.0 - 6.08 |
Expected stock price volatility |  | 0.85% |  |  | 69.76% - 70.03% |  |  | 0.84% - 0.85% |  |  | 69.76% - 73.30% |
Employee Stock Purchase Plan On March 20, 2021, the Company’s stockholders approved the 2021 Employee Stock Purchase Plan (the “ESPP”), which became effective on March 30, 2021. The ESPP initially provides participating employees with the opportunity to purchase up to an aggregate of 346,613 shares of the Company’s common stock. An annual increase in the number of shares of common stock reserved and available for issuance under the ESPP shall be equal to 1% of the number of shares of common stock outstanding on the immediately preceding December 31; and such lesser number of shares as determined by the Administrator as provided in the ESPP. As of June 30, 2022, no shares have been purchased by employees under the ESPP.

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