EXHIBIT 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the Registration Statements:

(1)Registration Statement (Form S-8 No. 333-254858) pertaining to the 2016 Stock Incentive Plan, 2021 Stock Option and Incentive Plan and 2021 Employee Stock Purchase Plan of Ikena Oncology, Inc.,

(2)Registration Statement (Form S-8 No. 333-263640), pertaining to the 2021 Employee Stock Purchase Plan of Ikena Oncology, Inc.,

(3)Registration Statement (Form S-3 No. 333-264517), of Ikena Oncology, Inc.;

of our report dated March 14, 2023, with respect to the consolidated financial statements of Ikena Oncology, Inc., included in this Annual Report (Form 10-K) of Ikena Oncology, Inc. for the year ended December 31, 2022.

/s/ Ernst & Young LLP

Boston, Massachusetts

March 14, 2023

ACTIVE/115337866.2