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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Cash flows from operating activities    
Net loss $ (48,677) $ (54,668)
Adjustments to reconcile net loss to net cash used in operating activities    
Depreciation 715 541
Amortization of premiums and discounts on marketable securities (1,709) 103
Stock-based compensation 5,877 5,666
Non-cash operating lease expense 1,152 953
Loss on disposal of property and equipment 5 173
Net realized loss on marketable securities   12
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 1,271 682
Accounts payable (987) (206)
Accrued expenses and other current liabilities (5,308) 2,816
Lease liability (1,333) (954)
Deferred revenue (8,501) (10,168)
Deposits and other assets (429) (1,404)
Net cash flows used in operating activities (57,924) (56,454)
Cash flows from investing activities    
Purchases of property and equipment (152) (1,200)
Sale of property and equipment 4  
Purchase of marketable securities (65,217) (189,863)
Sales and maturities of marketable securities 109,133 81,280
Net cash flows provided by (used in) investing activities 43,768 (109,783)
Cash flows from financing activities    
Cash and cash equivalents acquired in connection with the acquisition of Pionyr, net of issuance costs paid 39,970  
Cash consideration paid in connection with the acquisition of Pionyr (944)  
Proceeds from issuance of common stock for underwritten registered offering, net of offering costs 37,421  
Repurchase of common stock (663)  
Proceeds from exercise of stock options 136 1,094
Net cash flows provided by financing activities 75,920 1,094
Net increase (decrease) in cash and cash equivalents and restricted cash 61,764 (165,143)
Cash, cash equivalents and restricted cash, beginning of period 60,791 233,089
Cash, cash equivalents and restricted cash, end of period 122,555 67,946
Reconciliation of cash, cash equivalents, and restricted cash to the condensed consolidated balance sheets    
Cash and cash equivalents 121,277 67,074
Restricted cash included in other assets 1,278 872
Cash, cash equivalents and restricted cash, end of period $ 122,555 $ 67,946