<SEC-DOCUMENT>0001803794-26-000002.txt : 20260728
<SEC-HEADER>0001803794-26-000002.hdr.sgml : 20260728
<ACCEPTANCE-DATETIME>20260728160506
ACCESSION NUMBER:		0001803794-26-000002
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20260725
FILED AS OF DATE:		20260728
DATE AS OF CHANGE:		20260728

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Yarema Kristin
		CENTRAL INDEX KEY:			0001803794
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40287
		FILM NUMBER:		261211827

	MAIL ADDRESS:	
		STREET 1:		C/O IMAGENEBIO, INC.
		STREET 2:		12526 HIGH BLUFF DRIVE
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ImageneBio, Inc.
		CENTRAL INDEX KEY:			0001835579
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				811697316
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		12526 HIGH BLUFF DRIVE
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
		BUSINESS PHONE:		857-343-8292

	MAIL ADDRESS:	
		STREET 1:		12526 HIGH BLUFF DRIVE
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Ikena Oncology, Inc.
		DATE OF NAME CHANGE:	20201208
</SEC-HEADER>
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<SEQUENCE>1
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    <periodOfReport>2026-07-25</periodOfReport>

    <issuer>
        <issuerCik>0001835579</issuerCik>
        <issuerName>ImageneBio, Inc.</issuerName>
        <issuerTradingSymbol>IMA</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

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        <reportingOwnerId>
            <rptOwnerCik>0001803794</rptOwnerCik>
            <rptOwnerName>Yarema Kristin</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
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            <rptOwnerStreet1>C/O IMAGENEBIO, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>12526 HIGH BLUFF DRIVE, SUITE 345</rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92130</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>Chief Executive Officer</officerTitle>
            <otherText></otherText>
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                <natureOfOwnership>
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        </derivativeTransaction>
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    <footnotes>
        <footnote id="F1">On July 28, 2025, the Reporting Person was granted restricted stock units (&quot;RSUs&quot;), which RSUs were previously reported in Table II. Effective with this filing, the Reporting Person has elected to report grants of RSUs that are settleable solely in shares of the Issuer's common stock in Table I as acquisitions of common stock, rather than in Table II as derivative securities. Previously reported unvested RSUs that had been reported in Table II are included in the amount of securities beneficially owned shown in Column 5 of Table I. The 115,129 unvested RSUs carried over from prior Table II reporting represent grant awarded on July 28, 2025 that vests on the schedule described in footnote 3. As reported in Column 9 of Table II, there are no remaining RSUs that settle in common stock.</footnote>
        <footnote id="F2">Each RSU represents a contingent right to receive one share of the Issuer's common stock.</footnote>
        <footnote id="F3">The RSUs vest over four years, with 25% of the shares subject to RSUs vesting on the one-year anniversary of the vesting commencement date and the remaining 75% of the shares vesting in equal quarterly installments over the following 12 quarterly dates.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Kristin Yarema</signatureName>
        <signatureDate>2026-07-28</signatureDate>
    </ownerSignature>
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</SEC-DOCUMENT>
